| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuning Sun, Daochun Sun, Fang Li, Linlin Tian, Chunrong Li, Lu Li, Ruxian Lin, Shengqi Wan. Downregulation of Sirt1 by antisense oligonucleotides induces apoptosis and enhances radiation sensitization in A549 lung cancer cells. Lung cancer (Amsterdam, Netherlands). vol 58. issue 1. 2008-04-11. PMID:17624472. |
the inhibition of sirt1 obviously decreased a549 cells survival, induced g1 arrest as well as apoptosis. |
2008-04-11 |
2023-08-12 |
human |
| Liang Bai, Wei-Jun Pang, Yan-Jun Yang, Gong-She Yan. Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes. Molecular and cellular biochemistry. vol 307. issue 1-2. 2008-04-10. PMID:17851734. |
sirt1, a nad(+)-dependent histone deacetylase, may regulate senescence, metabolism, and apoptosis. |
2008-04-10 |
2023-08-12 |
cattle |
| Nicole Engel, Ulrich Mahlknech. Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. International journal of molecular medicine. vol 21. issue 2. 2008-03-07. PMID:18204789. |
sirt1 regulates different cellular processes such as proliferation, differentiation and apoptosis through deacetylation of important regulatory proteins such as p53, foxo3a and nfkappab. |
2008-03-07 |
2023-08-12 |
human |
| Wenhui Zhao, Jan-Philipp Kruse, Yi Tang, Sung Yun Jung, Jun Qin, Wei G. Negative regulation of the deacetylase SIRT1 by DBC1. Nature. vol 451. issue 7178. 2008-03-05. PMID:18235502. |
our study demonstrates that dbc1 promotes p53-mediated apoptosis through specific inhibition of sirt1. |
2008-03-05 |
2023-08-12 |
mouse |
| Xiaoling Li, Songwen Zhang, Gil Blander, Jeanette G Tse, Monty Krieger, Leonard Guarent. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Molecular cell. vol 28. issue 1. 2008-02-11. PMID:17936707. |
the mammalian ortholog sirt1 regulates physiological processes including apoptosis, fat metabolism, glucose homeostasis, and neurodegeneration. |
2008-02-11 |
2023-08-12 |
Not clear |
| Chintana Chirathaworn, Wisatre Kongcharoensuntorn, Thitiporn Dechdoungchan, Alisa Lowanitchapat, Pattaratida Sa-nguanmoo, Yong Poovorawa. Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. vol 90. issue 11. 2008-01-25. PMID:18181330. |
methanolic extract induces apoptosis in a human leukemia cell line through sirt1 mrna downregulation. |
2008-01-25 |
2023-08-12 |
human |
| Hidetaka Ota, Masahiro Akishita, Masato Eto, Katsuya Iijima, Masao Kaneki, Yasuyoshi Ouch. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. Journal of molecular and cellular cardiology. vol 43. issue 5. 2008-01-23. PMID:17916362. |
mammalian sirt1 nad(+)-dependent protein deacetylase, the closest homolog of sir2, regulates cell cycle, cellular senescence, apoptosis and metabolism, by functional interactions with a number of biological molecules such as p53. |
2008-01-23 |
2023-08-12 |
human |
| Walter Stünkel, Bee Keow Peh, Yong Cheng Tan, Vasantha M Nayagam, Xukun Wang, Manuel Salto-Tellez, BinHui Ni, Michael Entzeroth, Jeanette Woo. Function of the SIRT1 protein deacetylase in cancer. Biotechnology journal. vol 2. issue 11. 2008-01-07. PMID:17806102. |
we further characterized sirt1 in p53-wild-type and -mutant cell lines and show that sirt1 mrna-knockdown leads to a p53-independent decrease of cell proliferation and induction of apoptosis. |
2008-01-07 |
2023-08-12 |
human |
| Yonghua Yang, Wei Fu, Jiandong Chen, Nancy Olashaw, Xiaohong Zhang, Santo V Nicosia, Kapil Bhalla, Wenlong Ba. SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nature cell biology. vol 9. issue 11. 2008-01-04. PMID:17934453. |
stress-inducing agents promoted the association of sirt1 with senp1 and cells depleted of senp1 (but not of senp1 and sirt1) were more resistant to stress-induced apoptosis than control cells. |
2008-01-04 |
2023-08-12 |
Not clear |
| L-H Li, L-J Wu, S-I Tashiro, S Onodera, F Uchiumi, T Ikejim. Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis. Journal of Asian natural products research. vol 9. issue 3-5. 2008-01-03. PMID:17566917. |
activation of the sirt1 pathway and modulation of the cell cycle were involved in silymarin's protection against uv-induced a375-s2 cell apoptosis. |
2008-01-03 |
2023-08-12 |
human |
| L-H Li, L-J Wu, S-I Tashiro, S Onodera, F Uchiumi, T Ikejim. Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis. Journal of Asian natural products research. vol 9. issue 3-5. 2008-01-03. PMID:17566917. |
consequently, that silymarin protected a375-s2 cell against uv-induced apoptosis was partially through sirt1 pathway and modulation of the cell cycle distribution. |
2008-01-03 |
2023-08-12 |
human |
| Simon J Allison, Jo Milne. SIRT3 is pro-apoptotic and participates in distinct basal apoptotic pathways. Cell cycle (Georgetown, Tex.). vol 6. issue 21. 2007-12-31. PMID:17957139. |
previously we have identified sirt1 and jnk2 as constitutive suppressors of apoptosis in hct116 cells. |
2007-12-31 |
2023-08-12 |
human |
| Hiyaa S Ghosh, James V Spencer, Bobby Ng, Michael W McBurney, Paul D Robbin. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. The Biochemical journal. vol 408. issue 1. 2007-11-20. PMID:17680780. |
sirt1 is an nad+-dependent deacetylase that plays a role in cellular processes such as transcriptional regulation, stress response, longevity and apoptosis. |
2007-11-20 |
2023-08-12 |
Not clear |
| Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi, Qiwei Zha. Cytoplasm-localized SIRT1 enhances apoptosis. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17516504. |
cytoplasm-localized sirt1 enhances apoptosis. |
2007-10-26 |
2023-08-12 |
Not clear |
| Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi, Qiwei Zha. Cytoplasm-localized SIRT1 enhances apoptosis. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17516504. |
here, we showed that endogenous and exogenous sirt1 were both able to partially localize in cytoplasm in certain cell lines, and cytoplasm-localized sirt1 was associated with apoptosis and led to increased sensitivity to apoptosis. |
2007-10-26 |
2023-08-12 |
Not clear |
| Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi, Qiwei Zha. Cytoplasm-localized SIRT1 enhances apoptosis. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17516504. |
by truncation of two predicted nuclear localization signals or fusion with an exogenous nuclear export signal, sirt1 was partially localized in cytoplasm of hela cells and resulted in increased sensitivity to apoptosis. |
2007-10-26 |
2023-08-12 |
Not clear |
| Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi, Qiwei Zha. Cytoplasm-localized SIRT1 enhances apoptosis. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17516504. |
the apoptosis enhanced by cytoplasm-localized sirt1 was independent of its deacetylase activity, but dependent on caspases. |
2007-10-26 |
2023-08-12 |
Not clear |
| Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi, Qiwei Zha. Cytoplasm-localized SIRT1 enhances apoptosis. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17516504. |
sirt1 was distributed in cytoplasm at metaphase during mitosis, and overexpression of sirt1 significantly augmented apoptosis for cells at metaphase. |
2007-10-26 |
2023-08-12 |
Not clear |
| Qihuang Jin, Tingting Yan, Xinjian Ge, Cheng Sun, Xianglin Shi, Qiwei Zha. Cytoplasm-localized SIRT1 enhances apoptosis. Journal of cellular physiology. vol 213. issue 1. 2007-10-26. PMID:17516504. |
in summary, we found sirt1 is able to localize in cytoplasm, and cytoplasm-localized sirt1 enhances apoptosis. |
2007-10-26 |
2023-08-12 |
Not clear |
| Yasutoshi Hida, Yoshiaki Kubo, Kazutoshi Murao, Seiji Aras. Strong expression of a longevity-related protein, SIRT1, in Bowen's disease. Archives of dermatological research. vol 299. issue 2. 2007-09-20. PMID:17180656. |
we suppose that sirt1 could be one of the critical targets for future therapy with the aim of inhibiting cell proliferation and promoting apoptosis in non-melanoma skin cancers. |
2007-09-20 |
2023-08-12 |
human |