| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Li, Rong Xu, Xiu-min Zhang, Dian-dong Li, Qi-yang H. [Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 43. issue 10. 2010-01-13. PMID:19127863. |
the mechanism of apoptosis induced by sirt1 deacetylase inhibitors in both human breast cancer mcf-7 and mcf-7 doxorubicin-resistant cells was studied. |
2010-01-13 |
2023-08-12 |
human |
| Neha Kabra, Zhenyu Li, Lihong Chen, Baozong Li, Xiaohong Zhang, Chuangui Wang, Timothy Yeatman, Domenico Coppola, Jiandong Che. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. The Journal of biological chemistry. vol 284. issue 27. 2009-10-27. PMID:19433578. |
paradoxically, sirt1 inhibition also sensitizes cells to apoptosis by chemotherapy drugs. |
2009-10-27 |
2023-08-12 |
Not clear |
| Brittney Jung-Hynes, Nihal Ahma. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 9. 2009-10-23. PMID:19439501. |
sirt1, a nicotinamide adenine dinucleotide (nad(+))-dependent sirtuin, has been shown to promote cell survival by inhibiting apoptosis or cellular senescence in mammalian cells. |
2009-10-23 |
2023-08-12 |
Not clear |
| Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kurod. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis and rheumatism. vol 60. issue 9. 2009-10-19. PMID:19714620. |
sirt1 regulation of apoptosis of human chondrocytes. |
2009-10-19 |
2023-08-12 |
human |
| Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kurod. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis and rheumatism. vol 60. issue 9. 2009-10-19. PMID:19714620. |
sirt1 is known to inhibit apoptosis and to promote survival of various types of cells. |
2009-10-19 |
2023-08-12 |
human |
| Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kurod. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis and rheumatism. vol 60. issue 9. 2009-10-19. PMID:19714620. |
however, the roles of sirt1 in apoptosis of human chondrocytes have never been reported. |
2009-10-19 |
2023-08-12 |
human |
| Koji Takayama, Kazunari Ishida, Takehiko Matsushita, Norifumi Fujita, Shinya Hayashi, Ken Sasaki, Katsumasa Tei, Seiji Kubo, Tomoyuki Matsumoto, Hiroyuki Fujioka, Masahiro Kurosaka, Ryosuke Kurod. SIRT1 regulation of apoptosis of human chondrocytes. Arthritis and rheumatism. vol 60. issue 9. 2009-10-19. PMID:19714620. |
we undertook this study to investigate the relationship of sirt1 to apoptosis of human chondrocytes, which is a characteristic feature of osteoarthritis (oa). |
2009-10-19 |
2023-08-12 |
human |
| Brittney Jung-Hynes, Nihal Ahma. Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells. Cell cycle (Georgetown, Tex.). vol 8. issue 10. 2009-10-13. PMID:19377286. |
however, an interesting observation of our study was that sirt1 inhibition resulted in an increase in senescence in pc3-p53 cells whereas it resulted in an increase in apoptosis in pc3 cells. |
2009-10-13 |
2023-08-12 |
human |
| M Wojcik, K Mac-Marcjanek, L A Woznia. Physiological and pathophysiological functions of SIRT1. Mini reviews in medicinal chemistry. vol 9. issue 3. 2009-05-01. PMID:19275731. |
a variety of sirt1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. |
2009-05-01 |
2023-08-12 |
human |
| M Wojcik, K Mac-Marcjanek, L A Woznia. Physiological and pathophysiological functions of SIRT1. Mini reviews in medicinal chemistry. vol 9. issue 3. 2009-05-01. PMID:19275731. |
this review emphasizes catalytic properties of sirt1 and its role in apoptosis, insulin pathway, and neuron survival. |
2009-05-01 |
2023-08-12 |
human |
| Munekazu Yamakuchi, Charles J Lowenstei. MiR-34, SIRT1 and p53: the feedback loop. Cell cycle (Georgetown, Tex.). vol 8. issue 5. 2009-04-28. PMID:19221490. |
sirt1 also regulates p53 dependent apoptosis through deacetylating and stabilizing p53. |
2009-04-28 |
2023-08-12 |
human |
| Munekazu Yamakuchi, Charles J Lowenstei. MiR-34, SIRT1 and p53: the feedback loop. Cell cycle (Georgetown, Tex.). vol 8. issue 5. 2009-04-28. PMID:19221490. |
we also discovered that sirt1 mediates mir-34a activation of apoptosis by regulating p53 activity. |
2009-04-28 |
2023-08-12 |
human |
| Barbara Zschoernig, Ulrich Mahlknech. Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2. Biochemical and biophysical research communications. vol 381. issue 3. 2009-04-16. PMID:19236849. |
previous analyses of the sirtuin family of histone deacetylases and its most prominent member sirt1 have focused primarily on the identification of cellular targets exploring the underlying molecular mechanisms of its implicated function in the control of metabolic homeostasis, differentiation, apoptosis and cell survival. |
2009-04-16 |
2023-08-12 |
Not clear |
| Lilly Y W Bourguignon, Weiliang Xia, Gabriel Won. Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells. The Journal of biological chemistry. vol 284. issue 5. 2009-04-07. PMID:19047049. |
together, these findings suggest that the interactions between ha/cd44-stimulated p300 (acetyltransferase) and resveratrol-activated sirt1 (deacetylase) play pivotal roles in regulating the balance between cell survival versus apoptosis, and multidrug resistance versus sensitivity in breast tumor cells. |
2009-04-07 |
2023-08-12 |
human |
| Charn-Jung Chang, Chuan-Chih Hsu, Ming-Chi Yung, Kai-Yun Chen, Ching Tzao, Wei-Fong Wu, Hsiang-Yun Chou, Yi-Yen Lee, Kai-Hsi Lu, Shih-Hwa Chiou, Hsin-I M. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. Biochemical and biophysical research communications. vol 380. issue 2. 2009-04-01. PMID:19166820. |
enhanced radiosensitivity and radiation-induced apoptosis in glioma cd133-positive cells by knockdown of sirt1 expression. |
2009-04-01 |
2023-08-12 |
mouse |
| Charn-Jung Chang, Chuan-Chih Hsu, Ming-Chi Yung, Kai-Yun Chen, Ching Tzao, Wei-Fong Wu, Hsiang-Yun Chou, Yi-Yen Lee, Kai-Hsi Lu, Shih-Hwa Chiou, Hsin-I M. Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. Biochemical and biophysical research communications. vol 380. issue 2. 2009-04-01. PMID:19166820. |
silencing of sirt1 significantly enhanced the sensitivity of gbm-cd133(+) to radiation and increased the level of radiation-mediated apoptosis. |
2009-04-01 |
2023-08-12 |
mouse |
| E Lara, A Mai, V Calvanese, L Altucci, P Lopez-Nieva, M L Martinez-Chantar, M Varela-Rey, D Rotili, A Nebbioso, S Ropero, G Montoya, J Oyarzabal, S Velasco, M Serrano, M Witt, A Villar-Garea, A Imhof, A Inhof, J M Mato, M Esteller, M F Frag. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. vol 28. issue 6. 2009-03-30. PMID:19060927. |
consistently with this, rna interference-mediated knockdown of sirt1, but not sirt2, induced apoptosis in cancer cells. |
2009-03-30 |
2023-08-12 |
mouse |
| Tao Liu, Pei Y Liu, Glenn M Marshal. The critical role of the class III histone deacetylase SIRT1 in cancer. Cancer research. vol 69. issue 5. 2009-03-20. PMID:19244112. |
sirt1 may play a critical role in tumor initiation, progression, and drug resistance by blocking senescence and apoptosis, and promoting cell growth and angiogenesis. |
2009-03-20 |
2023-08-12 |
Not clear |
| Takeshi Yoshizaki, Jill C Milne, Takeshi Imamura, Simon Schenk, Noriyuki Sonoda, Jennie L Babendure, Juu-Chin Lu, Jesse J Smith, Michael R Jirousek, Jerrold M Olefsk. SIRT1 exerts anti-inflammatory effects and improves insulin sensitivity in adipocytes. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103747. |
sirt1 is a prominent member of a family of nad(+)-dependent enzymes and affects a variety of cellular functions ranging from gene silencing, regulation of the cell cycle and apoptosis, to energy homeostasis. |
2009-03-10 |
2023-08-12 |
Not clear |
| Barbara Zschoernig, Ulrich Mahlknech. SIRTUIN 1: regulating the regulator. Biochemical and biophysical research communications. vol 376. issue 2. 2008-11-07. PMID:18774777. |
earlier analyses on the sirtuin family of histone deacetylases and its well-known member sirt1 had their primary focus mostly on the identification of cellular targets exploring molecular mechanisms and functional networks in the control of metabolic homeostasis, differentiation, apoptosis and cell survival. |
2008-11-07 |
2023-08-12 |
Not clear |