| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhao Zhang, Yang Yang, Weijun Pang, Chao Sun, Gongshe Yan. [Effect and underlying mechanism of resveratol on porcine primary preadipocyte apoptosis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 26. issue 8. 2011-12-05. PMID:21090107. |
taken together, our data established resveratrol as new regulator in porcine primary preadipocyte apoptosis via activating the expression of sirt1, modulating activity of apoptotic-associated factor. |
2011-12-05 |
2023-08-12 |
Not clear |
| Narendra P Singh, Udai P Singh, Venkatesh L Hegde, Hongbing Guan, Lorne Hofseth, Mitzi Nagarkatti, Prakash S Nagarkatt. Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB. Molecular nutrition & food research. vol 55. issue 8. 2011-11-28. PMID:21520490. |
resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses el4 tumor growth by induction of apoptosis involving reciprocal regulation of sirt1 and nf-κb. |
2011-11-28 |
2023-08-12 |
Not clear |
| Dante Rotili, Vincenzo Carafa, Domenico Tarantino, Giorgia Botta, Angela Nebbioso, Lucia Altucci, Antonello Ma. Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile. Bioorganic & medicinal chemistry. vol 19. issue 12. 2011-11-22. PMID:21306905. |
such compounds, differently from the unselective prototype, are endowed with a selective inhibition of sirt1 over sirt2, and, in some cases (6j, 6k, and 6q), are more efficient than 3 to induce apoptosis in u937 cells. |
2011-11-22 |
2023-08-12 |
human |
| Jinling Hou, Shaohui Wang, Yan Chen Shang, Zhao Zhong Chong, Kenneth Maies. Erythropoietin employs cell longevity pathways of SIRT1 to foster endothelial vascular integrity during oxidant stress. Current neurovascular research. vol 8. issue 3. 2011-11-21. PMID:21722091. |
epo through sirt1 averts apoptosis through activation of protein kinase b (akt1) and the phosphorylation and cytoplasmic retention of the forkhead transcription factor foxo3a. |
2011-11-21 |
2023-08-12 |
Not clear |
| Fabienne Niederer, Caroline Ospelt, Fabia Brentano, Michael O Hottiger, Renate E Gay, Steffen Gay, Michael Detmar, Diego Kybur. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Annals of the rheumatic diseases. vol 70. issue 10. 2011-11-09. PMID:21742641. |
sirt1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. |
2011-11-09 |
2023-08-12 |
Not clear |
| Fabienne Niederer, Caroline Ospelt, Fabia Brentano, Michael O Hottiger, Renate E Gay, Steffen Gay, Michael Detmar, Diego Kybur. SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance. Annals of the rheumatic diseases. vol 70. issue 10. 2011-11-09. PMID:21742641. |
to analyse the expression of sirt1 in synovial tissues and cells of patients with rheumatoid arthritis (ra) and to study the function of sirt1 in inflammation and apoptosis in ra. |
2011-11-09 |
2023-08-12 |
Not clear |
| Hee-Don Chae, Hal E Broxmeye. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem cells and development. vol 20. issue 7. 2011-10-20. PMID:21083429. |
sirt1 deficiency downregulates pten/jnk/foxo1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. |
2011-10-20 |
2023-08-12 |
mouse |
| Hee-Don Chae, Hal E Broxmeye. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem cells and development. vol 20. issue 7. 2011-10-20. PMID:21083429. |
silent mating type information regulation 2 homolog 1 (sirt1) plays a critical role in reactive oxygen species-triggered apoptosis in mouse embryonic stem (mes) cells. |
2011-10-20 |
2023-08-12 |
mouse |
| Hee-Don Chae, Hal E Broxmeye. SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem cells and development. vol 20. issue 7. 2011-10-20. PMID:21083429. |
since pten is a negative regulator of akt and its activity can be modulated by acetylation, we investigated if sirt1 deacetylated pten to downregulate akt to trigger apoptosis in anti-oxidant-free culture conditions. |
2011-10-20 |
2023-08-12 |
mouse |
| Duk Hoon Kim, Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Myung Kwan Han, Sang Yong Lee, Kunga Mohan Ramkumar, Mi Jeong Sung, Won Ki. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. American journal of physiology. Renal physiology. vol 301. issue 2. 2011-10-03. PMID:21593185. |
the nicotinamide adenine dinucleotide-dependent protein deacetylase sirt1 decreases apoptosis through deacetylating of p53, and resveratrol is known as an activator of sirt1. |
2011-10-03 |
2023-08-12 |
mouse |
| Duk Hoon Kim, Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Myung Kwan Han, Sang Yong Lee, Kunga Mohan Ramkumar, Mi Jeong Sung, Won Ki. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. American journal of physiology. Renal physiology. vol 301. issue 2. 2011-10-03. PMID:21593185. |
resveratrol, a sirt1 activator, ameliorated cisplatin-induced acetylation of p53, apoptosis, and cytotoxicity in mpt cells. |
2011-10-03 |
2023-08-12 |
mouse |
| Duk Hoon Kim, Yu Jin Jung, Jung Eun Lee, Ae Sin Lee, Kyung Pyo Kang, Sik Lee, Sung Kwang Park, Myung Kwan Han, Sang Yong Lee, Kunga Mohan Ramkumar, Mi Jeong Sung, Won Ki. SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. American journal of physiology. Renal physiology. vol 301. issue 2. 2011-10-03. PMID:21593185. |
sirt1 activation by resveratrol decreased cisplatin-induced apoptosis while improving the glomerular filtration rate. |
2011-10-03 |
2023-08-12 |
mouse |
| Tetsuo Ogawa, Chizu Wakai, Tomomi Saito, Aya Murayama, Yuuichi Mimura, Sachiko Youfu, Tomoya Nakamachi, Makiko Kuwagata, Kazue Satoh, Seiji Shiod. Distribution of the longevity gene product, SIRT1, in developing mouse organs. Congenital anomalies. vol 51. issue 2. 2011-09-13. PMID:21054562. |
the mammalian homolog of sir2, sirt1(sirtuin 1), has been shown to play important roles related to anti-aging effects (regulating apoptosis, stress tolerance, insulin resistance, and fat metabolism). |
2011-09-13 |
2023-08-12 |
mouse |
| Juan Chen, Bin Zhang, Nathalie Wong, Anthony W I Lo, Ka-Fai To, Anthony W H Chan, Margaret H L Ng, Cecilia Y S Ho, Suk-Hang Cheng, Paul B S Lai, Jun Yu, Ho-Keung Ng, Ming-Tat Ling, Ai-Long Huang, Xue-Fei Cai, Ben C B K. Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth. Cancer research. vol 71. issue 12. 2011-08-18. PMID:21527554. |
downregulation of sirt1 consistently suppressed the proliferation of hcc cells via the induction of cellular senescence or apoptosis. |
2011-08-18 |
2023-08-12 |
human |
| Jung Ho Back, Hamid Reza Rezvani, Yucui Zhu, Véronique Guyonnet-Duperat, Mohammad Athar, Desiree Ratner, Arianna L Ki. Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1. The Journal of biological chemistry. vol 286. issue 21. 2011-07-28. PMID:21471201. |
the pharmacologic and genetic inhibition of mtor, unphosphorylatable s47a, or f474a tos mutants restored sirt1 deacetylase activity, blocked bfl-1/a1 induction, and sensitized prematurely senescent scc cells for apoptosis. |
2011-07-28 |
2023-08-12 |
mouse |
| Byung-Wan Lee, Sung Wan Chun, Soo Hyun Kim, Yongho Lee, Eun Seok Kang, Bong-Soo Cha, Hyun Chul Le. Lithospermic acid B protects β-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of Nrf2-HO-1 and Sirt1. Toxicology and applied pharmacology. vol 252. issue 1. 2011-05-16. PMID:21295052. |
lithospermic acid b protects β-cells from cytokine-induced apoptosis by alleviating apoptotic pathways and activating anti-apoptotic pathways of nrf2-ho-1 and sirt1. |
2011-05-16 |
2023-08-12 |
rat |
| Katherine J Hughes, Gordon P Meares, Polly A Hansen, John A Corbet. FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide. The Journal of biological chemistry. vol 286. issue 10. 2011-05-11. PMID:21196578. |
in response to sirt1 inhibitors, the foxo1-dependent protective actions of nitric oxide (gadd45α expression and dna repair) are attenuated, and foxo1 activates a proapoptotic program that includes puma (p53-up-regulated mediator of apoptosis) mrna accumulation and caspase-3 cleavage. |
2011-05-11 |
2023-08-12 |
Not clear |
| Fang Yuan, Qi Xie, Junbing Wu, Yujie Bai, Beibei Mao, Yongli Dong, Wenzhi Bi, Guangju Ji, Wufan Tao, Yan Wang, Zengqiang Yua. MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21212262. |
collectively, these findings define a novel regulatory mechanism involving the phosphorylation of sirt1 by mst1 kinase which leads to p53 activation, with implications for our understanding of signaling mechanisms during dna damage-induced apoptosis. |
2011-05-04 |
2023-08-12 |
Not clear |
| Javier G Pizarro, Ester Verdaguer, Virginie Ancrenaz, Felix Junyent, Francesc Sureda, Mercè Pallàs, Jaume Folch, Antoni Camin. Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:20972827. |
here we evaluated the cell-cycle inhibition and apoptosis of resveratrol in b65 neuroblastoma cells, and we also studied the effects of resveratrol on the mammalian silent information regulator 2 (sirt1). |
2011-04-29 |
2023-08-12 |
Not clear |
| Javier G Pizarro, Ester Verdaguer, Virginie Ancrenaz, Felix Junyent, Francesc Sureda, Mercè Pallàs, Jaume Folch, Antoni Camin. Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1. Neurochemical research. vol 36. issue 2. 2011-04-29. PMID:20972827. |
our results show that a decrease in sirt1 content, caused by exposure to resveratrol, does not appear to be involved in cell-cycle arrest or activation of apoptosis. |
2011-04-29 |
2023-08-12 |
Not clear |