| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun Chen, Sandhya Xavier, Eliza Moskowitz-Kassai, Robert Chen, Connie Y Lu, Kyle Sanduski, Aleš Špes, Boris Turk, Michael S Goligorsk. Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. The American journal of pathology. vol 180. issue 3. 2012-04-27. PMID:22234173. |
in this study, we examined the impact of a range of cardiovascular risk factors on the expression of sirtuin 1 (sirt1), sips, and apoptosis, and we documented the role of sirt1 in reduced ec and endothelial progenitor cell (epc) viability. |
2012-04-27 |
2023-08-12 |
mouse |
| Jun Chen, Sandhya Xavier, Eliza Moskowitz-Kassai, Robert Chen, Connie Y Lu, Kyle Sanduski, Aleš Špes, Boris Turk, Michael S Goligorsk. Cathepsin cleavage of sirtuin 1 in endothelial progenitor cells mediates stress-induced premature senescence. The American journal of pathology. vol 180. issue 3. 2012-04-27. PMID:22234173. |
in conclusion, our data advance the concept of "stem cell aging" by establishing the critical role of lysosomal dysfunction in the development of sips through the cathepsin-induced proteolytic cleavage of sirt1, a mechanism linking cell stress to apoptosis and sips. |
2012-04-27 |
2023-08-12 |
mouse |
| Rong Zeng, Jing He, Jin Peng, Yan Chen, Sha Yi, Fei Zhao, Guohui Cu. The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion. Annals of hematology. vol 91. issue 3. 2012-03-30. PMID:21915620. |
the time-dependent autophagy protects against apoptosis with possible involvement of sirt1 protein in multiple myeloma under nutrient depletion. |
2012-03-30 |
2023-08-12 |
Not clear |
| Antje Menssen, Per Hydbring, Karsten Kapelle, Jörg Vervoorts, Joachim Diebold, Bernhard Lüscher, Lars-Gunnar Larsson, Heiko Hermekin. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 4. 2012-03-28. PMID:22190494. |
in primary human fibroblasts previously immortalized by introduction of c-myc, down-regulation of sirt1 induced senescence and apoptosis. |
2012-03-28 |
2023-08-12 |
human |
| Antje Menssen, Per Hydbring, Karsten Kapelle, Jörg Vervoorts, Joachim Diebold, Bernhard Lüscher, Lars-Gunnar Larsson, Heiko Hermekin. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 4. 2012-03-28. PMID:22190494. |
in various cell lines inactivation of sirt1 by rna interference, chemical inhibitors, or ectopic dbc1 enhanced c-myc-induced apoptosis. |
2012-03-28 |
2023-08-12 |
human |
| Antje Menssen, Per Hydbring, Karsten Kapelle, Jörg Vervoorts, Joachim Diebold, Bernhard Lüscher, Lars-Gunnar Larsson, Heiko Hermekin. The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 4. 2012-03-28. PMID:22190494. |
furthermore, sirt1 suppressed cellular senescence in cells with deregulated c-myc expression and also inhibited c-myc-induced apoptosis. |
2012-03-28 |
2023-08-12 |
human |
| Yi Wang, Xuemei Shi, Jian Qi, Xiaojie Li, Karen Uray, Xinfu Gua. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 2. 2012-02-16. PMID:22038824. |
sirtuin 1 (sirt1), a nad(+)-dependent histone deacetylase, is involved in a wide array of cellular processes including glucose homeostasis, energy metabolism, proliferation and apoptosis, and immune response. |
2012-02-16 |
2023-08-12 |
mouse |
| Yi Wang, Xuemei Shi, Jian Qi, Xiaojie Li, Karen Uray, Xinfu Gua. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 2. 2012-02-16. PMID:22038824. |
the sirt1 ko mice showed enhanced crypt proliferation and suppressed villous apoptosis, resulting in increased intestinal villous height. |
2012-02-16 |
2023-08-12 |
mouse |
| Yi Wang, Xuemei Shi, Jian Qi, Xiaojie Li, Karen Uray, Xinfu Gua. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 2. 2012-02-16. PMID:22038824. |
we concluded that, sirt1 plays a critical role in the control of intestinal homeostasis (by promoting apoptosis and inhibiting proliferation) and gastrointestinal motility (by reducing gastric emptying and intestinal contractile activity), implicating a novel role for sirt1. |
2012-02-16 |
2023-08-12 |
mouse |
| Peter Y Chuang, Yan Dai, Ruijie Liu, Helen He, Matthias Kretzler, Belinda Jim, Clemens D Cohen, John C H. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858169. |
sirt1 over expression in cultured murine podocytes prevents age-induced apoptosis. |
2012-02-15 |
2023-08-12 |
mouse |
| Peter Y Chuang, Yan Dai, Ruijie Liu, Helen He, Matthias Kretzler, Belinda Jim, Clemens D Cohen, John C H. Alteration of forkhead box O (foxo4) acetylation mediates apoptosis of podocytes in diabetes mellitus. PloS one. vol 6. issue 8. 2012-02-15. PMID:21858169. |
together, our data provide evidence that alteration of foxo4 acetylation and down regulation of sirt1 expression in diabetes promote podocyte apoptosis. |
2012-02-15 |
2023-08-12 |
mouse |
| Huaqing Zhu, Yixin Yang, Yanpeng Wang, Jianmin Li, Peter W Schiller, Tianqing Pen. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. Cardiovascular research. vol 92. issue 1. 2012-01-23. PMID:21622680. |
microrna-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating sirt1. |
2012-01-23 |
2023-08-12 |
Not clear |
| Huaqing Zhu, Yixin Yang, Yanpeng Wang, Jianmin Li, Peter W Schiller, Tianqing Pen. MicroRNA-195 promotes palmitate-induced apoptosis in cardiomyocytes by down-regulating Sirt1. Cardiovascular research. vol 92. issue 1. 2012-01-23. PMID:21622680. |
this study was to examine whether mir-195 regulates palmitate-induced cardiomyocyte apoptosis by targeting sirt1, a known anti-apoptotic protein. |
2012-01-23 |
2023-08-12 |
Not clear |
| Jing Wang, Yun Zhang, Lu Tang, Nan Zhang, Dongsheng Fa. Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis. Neuroscience letters. vol 503. issue 3. 2012-01-20. PMID:21896316. |
further investigation revealed that a 24-h treatment with 0.5-20μm resveratrol had a dose-dependent protective effect on this als cell model, and the effects of resveratrol on increasing cell viability, preventing cell apoptosis and elevating cellular atp levels through promoting mitochondria biogenesis were blocked by sirt1 inhibition. |
2012-01-20 |
2023-08-12 |
Not clear |
| Yuncheng Wu, Xinqun Li, Julie Xiaohong Zhu, Wenjie Xie, Weidong Le, Zhen Fan, Joseph Jankovic, Tianhong Pa. Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease. Neuro-Signals. vol 19. issue 3. 2012-01-10. PMID:21778691. |
moreover, suppression of ampk caused inhibition of sirt1 activity and attenuated protective effects of resveratrol on rotenone-induced apoptosis, further suggesting that ampk-sirt1-autophagy pathway plays an important role in the neuroprotection by resveratrol on pd cellular models. |
2012-01-10 |
2023-08-12 |
Not clear |
| G Zhao, J Cui, J-G Zhang, Q Qin, Q Chen, T Yin, S-C Deng, Y Liu, L Liu, B Wang, K Tian, G-B Wang, C-Y Wan. SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. Gene therapy. vol 18. issue 9. 2012-01-09. PMID:21677689. |
sirt1 rnai knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells. |
2012-01-09 |
2023-08-12 |
Not clear |
| Selvakumar Elangovan, Sabarish Ramachandran, Narayanan Venkatesan, Sudha Ananth, Jaya P Gnana-Prakasam, Pamela M Martin, Darren D Browning, Patricia V Schoenlein, Puttur D Prasad, Vadivel Ganapathy, Muthusamy Thangaraj. SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. Cancer research. vol 71. issue 21. 2012-01-09. PMID:21920899. |
moreover, sirt1 inactivation eliminated estrogen/erα-induced cell growth and tumor development, triggering apoptosis. |
2012-01-09 |
2023-08-12 |
human |
| Nagalingam R Sundaresan, Vinodkumar B Pillai, Mahesh P Gupt. Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. Journal of molecular and cellular cardiology. vol 51. issue 4. 2012-01-06. PMID:21276800. |
the founding member of this family, sirt1, is shown to protect cardiomyocytes from apoptosis and age-dependent degeneration in a dose dependent manner-protecting cells at low doses but showing detrimental effects at high doses. |
2012-01-06 |
2023-08-12 |
Not clear |
| Cong Cao, Shan Lu, Rebecca Kivlin, Brittany Wallin, Elizabeth Card, Andrew Bagdasarian, Tyrone Tamakloe, Wen-jun Wang, Xiuzu Song, Wen-ming Chu, Nicola Kouttab, Aie Xu, Yinsheng Wa. SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:18681908. |
sirt1 has been found to function as a deacetylase for numerous protein targets involved in various cellular pathways, including stress responses, apoptosis and axonal degeneration. |
2011-12-23 |
2023-08-12 |
human |
| Zhao Zhang, Yang Yang, Weijun Pang, Chao Sun, Gongshe Yan. [Effect and underlying mechanism of resveratol on porcine primary preadipocyte apoptosis]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 26. issue 8. 2011-12-05. PMID:21090107. |
we used optical microscope and fluorescence microscope to observe morphological changes during apoptosis after hoechst 33258 fluorescent dyes staining; and rt-pcr and western blotting to measure the expression of apoptosis-associated gene sirt1, caspase-3, bcl-2, bax, p53, nf-kappab. |
2011-12-05 |
2023-08-12 |
Not clear |