| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Munekazu Yamakuch. MicroRNA Regulation of SIRT1. Frontiers in physiology. vol 3. 2012-10-02. PMID:22479251. |
mir-34a induces colon cancer apoptosis through sirt1, and mir-34a also promotes senescence in endothelial cells via sirt1. |
2012-10-02 |
2023-08-12 |
Not clear |
| Sankarathi Balaiya, Lee R Ferguson, Kakarla V Chala. Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia. Investigative ophthalmology & visual science. vol 53. issue 7. 2012-09-18. PMID:22669716. |
this investigation demonstrated sirt1 importance in forestalling the effects of hypoxia-induced apoptosis. |
2012-09-18 |
2023-08-12 |
Not clear |
| Hanning Wang, Hao Liu, Kaiyun Chen, Jinfeng Xiao, Ke He, Jinqian Zhang, Guoan Xian. SIRT1 promotes tumorigenesis of hepatocellular carcinoma through PI3K/PTEN/AKT signaling. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552445. |
our study demonstrated that overexpression of sirt1 promoted mitotic entry of liver cells, cell growth and proliferation and inhibited apoptosis. |
2012-09-04 |
2023-08-12 |
human |
| Ratakorn Srisuttee, Sang Seok Koh, Su Jin Kim, Waraporn Malilas, Wassamon Boonying, Il-Rae Cho, Byung Hak Jhun, Masafumi Ito, Yoshiyuki Horio, Edward Seto, Sangtaek Oh, Young-Hwa Chun. Hepatitis B virus X (HBX) protein upregulates β-catenin in a human hepatic cell line by sequestering SIRT1 deacetylase. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22562294. |
furthermore, in hep3b cells stably expressing hbx, overexpression of sirt1 or treatment with resveratrol enhanced sensitivity to doxorubicin-induced apoptosis, indicating that upregulation of sirt1 could be a therapeutic strategy for hbv-related hepatocellular carcinoma. |
2012-09-04 |
2023-08-12 |
human |
| Hak-Bong Kim, Mi-Ju Kim, Su-Hoon Lee, Jae-Won Lee, Jae-Ho Bae, Dong-Wan Kim, Trong Tuan Dao, Won Keun Oh, Chi-Dug Kang, Sun-Hee Ki. Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. Biochemical pharmacology. vol 84. issue 3. 2012-08-14. PMID:22483777. |
amurensin g, a novel sirt1 inhibitor, sensitizes trail-resistant human leukemic k562 cells to trail-induced apoptosis. |
2012-08-14 |
2023-08-12 |
human |
| Hak-Bong Kim, Mi-Ju Kim, Su-Hoon Lee, Jae-Won Lee, Jae-Ho Bae, Dong-Wan Kim, Trong Tuan Dao, Won Keun Oh, Chi-Dug Kang, Sun-Hee Ki. Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis. Biochemical pharmacology. vol 84. issue 3. 2012-08-14. PMID:22483777. |
these findings suggest that the suppression of sirt1 with sirna or amurensin g sensitize the trail-resistant k562 cell to trail-induced apoptosis, possibly by the up-regulation of c-myc and dr5 surface expression and the down-regulations of c-flip and mcl-1. |
2012-08-14 |
2023-08-12 |
human |
| Amarjit Saini, Nasser Al-Shanti, Adam P Sharples, Claire E Stewar. Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Experimental physiology. vol 97. issue 3. 2012-08-02. PMID:22125309. |
treatment with 10 ng ml(-1) tnf-α or co-incubation with 1.25 ng ml(-1) tnf-α and 1.5 ng ml(-1) igf-i resulted in apoptosis (20.33 ± 2.08 and 19 ± 2.65%, respectively), which was increased when myoblasts were pretreated with sirt1 small interfering rna (31 ± 2.65 and 27.33 ± 2.52%, respectively; p < 0.05) and was reduced (14.33 ± 3.05%, p < 0.05 and 12.78 ± 4.52%, p = 0.054) by resveratrol, which also significantly rescued the block on differentiation. |
2012-08-02 |
2023-08-12 |
Not clear |
| Qi Zhang, Shelya X Zeng, Yu Zhang, Yiwei Zhang, Derong Ding, Qizhuang Ye, Samy O Meroueh, Hua L. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO molecular medicine. vol 4. issue 4. 2012-07-30. PMID:22331558. |
here, we report a novel small molecule inauhzin (inz) that effectively reactivates p53 by inhibiting sirt1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. |
2012-07-30 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
usp22 antagonizes p53 transcriptional activation by deubiquitinating sirt1 to suppress cell apoptosis and is required for mouse embryonic development. |
2012-07-27 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
the nad-dependent histone deacetylase sirt1 antagonizes p53 transcriptional activity to regulate cell-cycle progression and apoptosis. |
2012-07-27 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
in contrast, depletion of endogenous usp22 by rna interference destabilizes sirt1, inhibits sirt1-mediated deacetylation of p53 and elevates p53-dependent apoptosis. |
2012-07-27 |
2023-08-12 |
mouse |
| Zhenghong Lin, Heeyoung Yang, Qingfei Kong, Jinping Li, Sang-Myeong Lee, Beixue Gao, Hongxin Dong, Jianjun Wei, Jianxun Song, Donna D Zhang, Deyu Fan. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Molecular cell. vol 46. issue 4. 2012-07-27. PMID:22542455. |
our study elucidates a molecular mechanism in suppression of cell apoptosis by stabilizing sirt1 in response to dna damage and reveals a critical physiological function of usp22 in mouse embryonic development. |
2012-07-27 |
2023-08-12 |
mouse |
| D Dixit, V Sharma, S Ghosh, V S Mehta, E Se. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell death & disease. vol 3. 2012-07-24. PMID:22318540. |
inhibition of casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (tnfα)-induced apoptosis through sirt1 inhibition. |
2012-07-24 |
2023-08-12 |
Not clear |
| D Dixit, V Sharma, S Ghosh, V S Mehta, E Se. Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition. Cell death & disease. vol 3. 2012-07-24. PMID:22318540. |
interestingly, ck2-is downregulated sirt1 activity and over-expression of sirt1 decreased p53 transcriptional activity and rescued cells from ck2-i-induced apoptosis. |
2012-07-24 |
2023-08-12 |
Not clear |
| Kyung-Soo Hong, Jun-Ik Park, Mi-Ju Kim, Hak-Bong Kim, Jae-Won Lee, Trong Tuan Dao, Won Keun Oh, Chi-Dug Kang, Sun-Hee Ki. Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols. Toxicology and applied pharmacology. vol 259. issue 2. 2012-06-28. PMID:22245592. |
sirt1 has been found to function as a class iii deacetylase that affects the acetylation status of histones and other important cellular nonhistone proteins involved in various cellular pathways including stress responses and apoptosis. |
2012-06-28 |
2023-08-12 |
Not clear |
| Rong Zeng, Yan Chen, Shuai Zhao, Guo-hui Cu. Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. Acta pharmacologica Sinica. vol 33. issue 1. 2012-06-04. PMID:22158107. |
autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ros and sirt1. |
2012-06-04 |
2023-08-12 |
human |
| Wenting Du, Sichong Ren, Qifeng Suo, Mingming Yang, Dan He, Ji Li. [Construction of Sirtl shRNA interfering vector and its effects on cell proliferation and apoptosis]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 28. issue 5. 2012-05-24. PMID:22097266. |
this study was aimed to construct sirt1 shrna interfering vector and to analyze the effects of sirtl on cell proliferation and apoptosis in hepg2, a549 and 293t cell lines. |
2012-05-24 |
2023-08-12 |
Not clear |
| Wenting Du, Sichong Ren, Qifeng Suo, Mingming Yang, Dan He, Ji Li. [Construction of Sirtl shRNA interfering vector and its effects on cell proliferation and apoptosis]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 28. issue 5. 2012-05-24. PMID:22097266. |
sirt1 took an important role in maintaining cell proliferation and resisting cell apoptosis caused by dna damage, and this result also provided theoretical information for the further research. |
2012-05-24 |
2023-08-12 |
Not clear |
| Hongfeng Yuan, Zhiqiang Wang, Ling Li, Hao Zhang, Hardik Modi, David Horne, Ravi Bhatia, WenYong Che. Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood. vol 119. issue 8. 2012-05-21. PMID:22207735. |
imatinib-mediated inhibition of bcr-abl kinase activity partially reduces sirt1 expression and sirt1 inhibition further sensitizes cml cells to imatinib-induced apoptosis. |
2012-05-21 |
2023-08-12 |
mouse |
| Ling Li, Lisheng Wang, Liang Li, Zhiqiang Wang, Yinwei Ho, Tinisha McDonald, Tessa L Holyoake, WenYong Chen, Ravi Bhati. Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib. Cancer cell. vol 21. issue 2. 2012-05-04. PMID:22340598. |
pharmacological inhibition of sirt1 or sirt1 knockdown increased apoptosis in lsc of chronic phase and blast crisis cml and reduced their growth in vitro and in vivo. |
2012-05-04 |
2023-08-12 |
human |