| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei Zheng, Yun-Biao Lu, Shu-Ting Liang, Qing-Jun Zhang, Jing Xu, Zhi-Gang She, Zhu-Qin Zhang, Rui-Feng Yang, Bei-Bei Mao, Zhen Xu, Li Li, De-Long Hao, Jie Lu, Yu-Sheng Wei, Hou-Zao Chen, De-Pei Li. SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes. Basic research in cardiology. vol 108. issue 4. 2013-11-19. PMID:23744058. |
furthermore, the cardiac-specific overexpression of sirt1 decreased the dox-induced apoptosis of cardiomyocytes in sirt1 transgenic mouse hearts compared with the hearts of their wild-type littermates. |
2013-11-19 |
2023-08-12 |
mouse |
| Martine Müller Kloster, Elin Hallan Naderi, Ingvild Haaland, Bjørn Tore Gjertsen, Heidi Kiil Blomhoff, Soheil Nader. cAMP signalling inhibits p53 acetylation and apoptosis via HDAC and SIRT deacetylases. International journal of oncology. vol 42. issue 5. 2013-11-01. PMID:23483263. |
importantly, diminishing the activity of hdacs and sirt1 was also found to reverse the inhibitory effect of camp on the dna damage-induced p53 stabilization and apoptosis, suggesting the involvement of the p53 acetylation pathway in the anti-apoptotic effect of camp signalling. |
2013-11-01 |
2023-08-12 |
Not clear |
| Heping Yang, Yuhua Zheng, Tony W H Li, Hui Peng, David Fernandez-Ramos, María L Martínez-Chantar, Adriana L Rojas, José M Mato, Shelly C L. Methionine adenosyltransferase 2B, HuR, and sirtuin 1 protein cross-talk impacts on the effect of resveratrol on apoptosis and growth in liver cancer cells. The Journal of biological chemistry. vol 288. issue 32. 2013-11-01. PMID:23814050. |
in conclusion, resveratrol induces hur, sirt1, and mat2b expression; the last may represent a compensatory response against apoptosis and growth inhibition. |
2013-11-01 |
2023-08-12 |
Not clear |
| Mi-Ju Kim, Kyung-Soo Hong, Hak-Bong Kim, Su-Hoon Lee, Jae-Ho Bae, Dong-Wan Kim, Trong Tuan Dao, Won Keun Oh, Chi-Dug Kang, Sun-Hee Ki. Ku70 acetylation and modulation of c-Myc/ATF4/CHOP signaling axis by SIRT1 inhibition lead to sensitization of HepG2 cells to TRAIL through induction of DR5 and down-regulation of c-FLIP. The international journal of biochemistry & cell biology. vol 45. issue 3. 2013-09-11. PMID:23247197. |
these findings reveal for the first time that sirt1 inhibition increases ku70 acetylation, and the acetylated ku70 with a decreased function mediates the induction of dr5 and the down-regulation of c-flip by up-regulating c-myc/atf4/chop pathway, and consequently promotes the trail-induced apoptosis of hepg2 cells. |
2013-09-11 |
2023-08-12 |
human |
| M Nikbakht Dastjerdi, M R Salahshoor, M Mardani, M Rabbani, B Hashemibeni, M Gharagozloo, M Kazemi, N Esmaeil, Sh Roshankhah, R Golmohammadi, M Mobarakia. The apoptotic effects of sirtuin1 inhibitor on the MCF-7 and MRC-5 cell lines. Research in pharmaceutical sciences. vol 8. issue 2. 2013-09-10. PMID:24019817. |
hereby, this study describes the potency of salermide as a sirt1 inhibitor to induce apoptosis in the mcf-7 and mrc-5 cell lines. |
2013-09-10 |
2023-08-12 |
Not clear |
| Xiaoli Liu, Kuiqing Shao, Tieying Su. SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 1. 2013-09-05. PMID:23363613. |
sirt1 regulates the human alveolar epithelial a549 cell apoptosis induced by pseudomonas aeruginosa lipopolysaccharide. |
2013-09-05 |
2023-08-12 |
human |
| Xiaoli Liu, Kuiqing Shao, Tieying Su. SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 1. 2013-09-05. PMID:23363613. |
sirtuin1 (sirt1) is an nad(+)-dependent deacetylase that plays an inhibitory role in cell apoptosis, which is associated with p53 deacetylation. |
2013-09-05 |
2023-08-12 |
human |
| Xiaoli Liu, Kuiqing Shao, Tieying Su. SIRT1 regulates the human alveolar epithelial A549 cell apoptosis induced by Pseudomonas aeruginosa lipopolysaccharide. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 31. issue 1. 2013-09-05. PMID:23363613. |
however, the effect of sirt1 in the regulation of lps-induced human alveolar epithelial a549 cells apoptosis is unknown. |
2013-09-05 |
2023-08-12 |
human |
| Hong Fan, Hai-Chun Yang, Li You, Ying-Ying Wang, Wen-Juan He, Chuan-Ming Ha. The histone deacetylase, SIRT1, contributes to the resistance of young mice to ischemia/reperfusion-induced acute kidney injury. Kidney international. vol 83. issue 3. 2013-08-20. PMID:23302720. |
the mechanisms underlying the protective effect of sirt1 included the suppression of cell apoptosis. |
2013-08-20 |
2023-08-12 |
mouse |
| Judith Katto, Nicole Engel, Wasim Abbas, Georges Herbein, Ulrich Mahlknech. Transcription factor NFκB regulates the expression of the histone deacetylase SIRT1. Clinical epigenetics. vol 5. issue 1. 2013-07-31. PMID:23870485. |
sirt1 is therefore involved in the regulation of many different and fundamental cellular processes such as apoptosis, metabolism, differentiation and cell cycle arrest. |
2013-07-31 |
2023-08-12 |
Not clear |
| Jing-Xin Ma, Hong Li, Xiao-Ming Chen, Xiang-Hong Yang, Qian Wang, Mo-Li Wu, Qing-You Kong, Zai-Xia Li, Jia Li. Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 33. issue 1. 2013-07-26. PMID:22537175. |
inhibition of sirt1 expression by sirna arrested 64.96% of uw228-3 medulloblastoma cells in the gap 1 (g1) phase and induced 14.53% of cells to apoptosis at the 48-h time point. |
2013-07-26 |
2023-08-12 |
human |
| Jing-Xin Ma, Hong Li, Xiao-Ming Chen, Xiang-Hong Yang, Qian Wang, Mo-Li Wu, Qing-You Kong, Zai-Xia Li, Jia Li. Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 33. issue 1. 2013-07-26. PMID:22537175. |
similarly, inhibition of sirt1 enzymatic activity with nicotinamide brought about g1 arrest and apoptosis in a dose-related fashion. |
2013-07-26 |
2023-08-12 |
human |
| Xiaofei Zhu, Xiaofang Guo, Genxiang Mao, Zhitao Gao, Hui Wang, Qiyang He, Diandong L. Hepatoprotection of berberine against hydrogen peroxide-induced apoptosis by upregulation of Sirtuin 1. Phytotherapy research : PTR. vol 27. issue 3. 2013-06-27. PMID:22628222. |
this study demonstrated that the protective effect of bbr against h2 o2 -induced apoptosis was associated with regulation of sirt1 in hepatic cell line l02, which provided a possible explanation for its antioxidant activity, and implied an application of bbr for the therapeutic relevance in oxidative-stress-related liver diseases. |
2013-06-27 |
2023-08-12 |
Not clear |
| Laura Zannini, Giacomo Buscemi, Ja-Eun Kim, Enrico Fontanella, Domenico Deli. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22735644. |
dbc1 depletion in human cells increases sirt1 activity, resulting in the deacetylation of p53 and protection from apoptosis. |
2013-06-21 |
2023-08-12 |
human |
| Wei-Jun Pang, Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-She Yan. Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23065251. |
lentivirus-mediated sirt1 shrna and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. |
2013-06-14 |
2023-08-12 |
Not clear |
| Wei-Jun Pang, Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-She Yan. Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23065251. |
the effects of sirt1 gene and resveratrol on porcine preadipocyte apoptosis have not been characterized. |
2013-06-14 |
2023-08-12 |
Not clear |
| Wei-Jun Pang, Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-She Yan. Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23065251. |
here, we investigated the apoptotic effects of sirt1 and resveratrol on porcine preadipocytes, finding that resveratrol-induced preadipocyte apoptosis and up-regulated protein levels of sirt1. |
2013-06-14 |
2023-08-12 |
Not clear |
| Wei-Jun Pang, Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-She Yan. Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23065251. |
intriguingly, sirt1 knockdown by rnai also resulted in preadipocyte apoptosis. |
2013-06-14 |
2023-08-12 |
Not clear |
| Wei-Jun Pang, Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-She Yan. Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23065251. |
these data indicate that although resveratrol treatment up-regulates sirt1 expression, it augments porcine preadipocyte apoptosis in a sirt1-independent manner. |
2013-06-14 |
2023-08-12 |
Not clear |
| Wei-Jun Pang, Yan Xiong, Zhao Zhang, Ning Wei, Ni Chen, Gong-She Yan. Lentivirus-mediated Sirt1 shRNA and resveratrol independently induce porcine preadipocyte apoptosis by canonical apoptotic pathway. Molecular biology reports. vol 40. issue 1. 2013-06-14. PMID:23065251. |
the regulation of apoptosis by resveratrol and sirt1 may provide a novel insight to control preadipocyte number through cellular apoptosis. |
2013-06-14 |
2023-08-12 |
Not clear |