| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalie E Simpson, Volodymyr P Tryndyak, Marta Pogribna, Frederick A Beland, Igor P Pogribn. Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype. Epigenetics. vol 7. issue 12. 2013-06-06. PMID:23117580. |
further, the expression of other epigenetic regulatory genes, known to be downregulated during apoptosis (e.g., dnmt1, dnmt3b, setd1 and sirt1), was also downregulated by compound 968. |
2013-06-06 |
2023-08-12 |
human |
| G Botta, L P De Santis, R Saladin. Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins. Current medicinal chemistry. vol 19. issue 34. 2013-06-03. PMID:22998567. |
especially two sirtuin members, sirt1 and sirt2, have been found to antagonize p53-dependent transcriptional activation and apoptosis in response to dna damage by catalyzing p53 deacetylation. |
2013-06-03 |
2023-08-12 |
human |
| Jun Xie, Xiaoming Zhang, Li Zhan. Negative regulation of inflammation by SIRT1. Pharmacological research. vol 67. issue 1. 2013-05-23. PMID:23098819. |
numerous studies have demonstrated that sirt1 regulates critical metabolic and physiological processes including senescence, stress resistance, metabolism and apoptosis. |
2013-05-23 |
2023-08-12 |
Not clear |
| Raffaele Frazzi, Riccardo Valli, Ione Tamagnini, Bruno Casali, Norbert Latruffe, Francesco Merl. Resveratrol-mediated apoptosis of hodgkin lymphoma cells involves SIRT1 inhibition and FOXO3a hyperacetylation. International journal of cancer. vol 132. issue 5. 2013-05-22. PMID:22833338. |
resveratrol-mediated apoptosis of hodgkin lymphoma cells involves sirt1 inhibition and foxo3a hyperacetylation. |
2013-05-22 |
2023-08-12 |
human |
| Jenna D Lovaas, Lijia Zhu, Christine Y Chiao, Vanessa Byles, Douglas V Faller, Yan Da. SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. The Prostate. vol 73. issue 5. 2013-05-10. PMID:23038275. |
sirt1 is a nicotinamide adenine dinucleotide-dependent histone deacetylase (class iii hdac) that has recently been shown to have implications in regulating cancer cell growth and apoptosis. |
2013-05-10 |
2023-08-12 |
Not clear |
| Hong-yan Chen, Miao Geng, Ya-zhuo Hu, Jian-hua Wan. [Effects of baicalin against oxidative stress injury of SH-SY5Y cells by up-regulating SIRT1]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 46. issue 9. 2013-05-06. PMID:22121772. |
the further mechanism studies show that baicalin inhibit apoptosis via reducing caspase-3 expression and up-regulating sirt1. |
2013-05-06 |
2023-08-12 |
Not clear |
| Robert L Moore, Douglas V Falle. SIRT1 represses estrogen-signaling, ligand-independent ERα-mediated transcription, and cell proliferation in estrogen-responsive breast cells. The Journal of endocrinology. vol 216. issue 3. 2013-04-30. PMID:23169992. |
sirtuin 1 (sirt1) is a nad+-dependent class iii histone deacetylase that has been linked to gene silencing, control of the cell cycle, apoptosis, and energy homeostasis. |
2013-04-30 |
2023-08-12 |
Not clear |
| Wenjun Yan, Zongping Fang, Qianzi Yang, Hailong Dong, Yan Lu, Chong Lei, Lize Xion. SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 3. 2013-04-19. PMID:23299244. |
these results indicate that sirt1 mediates hbo-pc-induced tolerance to cerebral i/r through inhibition of apoptosis. |
2013-04-19 |
2023-08-12 |
rat |
| Wei-jun Pang, Yan Xiong, Yu Wang, Qiang Tong, Gong-she Yan. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Experimental cell research. vol 319. issue 5. 2013-04-16. PMID:23313858. |
sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. |
2013-04-16 |
2023-08-12 |
Not clear |
| Wei-jun Pang, Yan Xiong, Yu Wang, Qiang Tong, Gong-she Yan. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Experimental cell research. vol 319. issue 5. 2013-04-16. PMID:23313858. |
at present, the effect and regulatory mechanism of sirt1 and camptothecin on porcine preadipocyte apoptosis are still largely unknown. |
2013-04-16 |
2023-08-12 |
Not clear |
| Wei-jun Pang, Yan Xiong, Yu Wang, Qiang Tong, Gong-she Yan. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Experimental cell research. vol 319. issue 5. 2013-04-16. PMID:23313858. |
we also find that hyperacetylated p53 is the major effect of sirt1 knockdown by overexpression of a mutated p53, whereas sirt1 overexpression prevents camptothecin-induced apoptosis through p53 deacetylation in preadipocytes. |
2013-04-16 |
2023-08-12 |
Not clear |
| Wei-jun Pang, Yan Xiong, Yu Wang, Qiang Tong, Gong-she Yan. Sirt1 attenuates camptothecin-induced apoptosis through caspase-3 pathway in porcine preadipocytes. Experimental cell research. vol 319. issue 5. 2013-04-16. PMID:23313858. |
furthermore, repressing preadipocyte apoptosis of sirt1 is mediated by direct interaction with cleaved caspase-3 using immunoprecipitation and inhibition of caspase-3 transcriptional activity using luciferase reporter assays. |
2013-04-16 |
2023-08-12 |
Not clear |
| Ratakorn Srisuttee, Sang Seok Koh, Waraporn Malilas, Jeong Moon, Il-Rae Cho, Byung Hak Jhun, Yoshiyuki Horio, Young-Hwa Chun. SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. Biochemical and biophysical research communications. vol 429. issue 1-2. 2013-04-02. PMID:23137540. |
sirt1 sensitizes hepatocellular carcinoma cells expressing hepatitis b virus x protein to oxidative stress-induced apoptosis. |
2013-04-02 |
2023-08-12 |
Not clear |
| Ratakorn Srisuttee, Sang Seok Koh, Waraporn Malilas, Jeong Moon, Il-Rae Cho, Byung Hak Jhun, Yoshiyuki Horio, Young-Hwa Chun. SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. Biochemical and biophysical research communications. vol 429. issue 1-2. 2013-04-02. PMID:23137540. |
ectopic expression and enhanced activity of sirt1 sensitize hep3b cells stably expressing hbx to oxidative stress-induced apoptosis. |
2013-04-02 |
2023-08-12 |
Not clear |
| Ratakorn Srisuttee, Sang Seok Koh, Waraporn Malilas, Jeong Moon, Il-Rae Cho, Byung Hak Jhun, Yoshiyuki Horio, Young-Hwa Chun. SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. Biochemical and biophysical research communications. vol 429. issue 1-2. 2013-04-02. PMID:23137540. |
sirt1 mutant analysis showed that nuclear localization of sirt1 is not required for sensitization of oxidation-mediated apoptosis. |
2013-04-02 |
2023-08-12 |
Not clear |
| Ratakorn Srisuttee, Sang Seok Koh, Waraporn Malilas, Jeong Moon, Il-Rae Cho, Byung Hak Jhun, Yoshiyuki Horio, Young-Hwa Chun. SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. Biochemical and biophysical research communications. vol 429. issue 1-2. 2013-04-02. PMID:23137540. |
furthermore, ectopic expression of sirt1 and treatment with resveratrol (a sirt1 activator) attenuated jnk phosphorylation, which is a prerequisite for resistance to oxidative stress-induced apoptosis. |
2013-04-02 |
2023-08-12 |
Not clear |
| Ratakorn Srisuttee, Sang Seok Koh, Waraporn Malilas, Jeong Moon, Il-Rae Cho, Byung Hak Jhun, Yoshiyuki Horio, Young-Hwa Chun. SIRT1 sensitizes hepatocellular carcinoma cells expressing hepatitis B virus X protein to oxidative stress-induced apoptosis. Biochemical and biophysical research communications. vol 429. issue 1-2. 2013-04-02. PMID:23137540. |
conversely, suppression of sirt1 activity with nicotinamide inhibited the effect of resveratrol on jnk phosphorylation, leading to restoration of resistance to oxidation-induced apoptosis. |
2013-04-02 |
2023-08-12 |
Not clear |
| Peng Sun, Hong Yu, Wen-Qing Zhang, Ming Hu, Rui L. Lentivirus-mediated siRNA targeting VEGF inhibits gastric cancer growth in vivo. Oncology reports. vol 28. issue 5. 2013-03-14. PMID:22895814. |
furthermore, the expression of vegf, sirtuin 1 (sirt1), survivin and bcl-2 was downregulated, whereas the expression of p53 and p21 was upregulated in the tumor cells, indicating that vegf sirna induced apoptosis in gastric cancer cells by inhibiting sirt1 expression, leading to p53 transcriptional upregulation and the activation of downstream p21, while suppressing bcl-2 and survivin expression. |
2013-03-14 |
2023-08-12 |
mouse |
| Jiaoyue Zhang, Lulu Chen, Juan Zheng, Tianshu Zeng, Huiqing Li, Hu Xiao, Xiuling Deng, Xiang H. The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet. Diabetes research and clinical practice. vol 97. issue 3. 2013-02-25. PMID:22497970. |
the effect might be partly related to activated sirt1 signal pathway, improved oxidative stress induced damage and incidence of apoptosis. |
2013-02-25 |
2023-08-12 |
mouse |
| Khanapur Manjulatha, S Srinivas, Naveen Mulakayala, D Rambabu, M Prabhakar, Kalle M Arunasree, Mallika Alvala, M V Basaveswara Rao, Manojit Pa. Ethylenediamine diacetate (EDDA) mediated synthesis of aurones under ultrasound: their evaluation as inhibitors of SIRT1. Bioorganic & medicinal chemistry letters. vol 22. issue 19. 2013-02-04. PMID:22929231. |
compound 3a [(z)-2-(5-bromo-2-hydroxybenzylidene) benzofuran-3(2h)-one] was identified as a potent inhibitor of sirt1 (ic(50)=1μm) which showed a dose dependent increase in the acetylation of p53 resulting in induction of apoptosis. |
2013-02-04 |
2023-08-12 |
Not clear |