| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chutima Kaewpiboon, Ratakorn Srisuttee, Waraporn Malilas, Jeong Moon, Sirichat Kaowinn, Il-Rae Cho, Randal N Johnston, Wanchai Assavalapsakul, Young-Hwa Chun. Extract of Bryophyllum laetivirens reverses etoposide resistance in human lung A549 cancer cells by downregulation of NF-κB. Oncology reports. vol 31. issue 1. 2014-09-05. PMID:24220725. |
furthermore, the combined treatment with the f14 extract, and sirt1 sirna or nam did not accelerate apoptosis, indicating that sirt1 is not involved in the regulation of p-gp levels in a549rt-eto cells. |
2014-09-05 |
2023-08-12 |
human |
| Gnanapragasam Arunachalam, Samson Mathews Samuel, Isra Marei, Hong Ding, Chris R Triggl. Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. British journal of pharmacology. vol 171. issue 2. 2014-08-26. PMID:24372553. |
metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through sirt1. |
2014-08-26 |
2023-08-12 |
mouse |
| Fei Teng, Guangxi Li, Zhangjing Liu, Liangdeng Zhang, Kuiwu Ya. The Comparative Study on Expression of SIRT1 Signal Transduction by Xuefuzhuyu Capsule. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-08-12. PMID:25114706. |
all the result showed that the target genes of sirt1 pathway including p53, nf-kb, foxo1, foxo3, and foxo4 were significantly downregulated to sirt1, suggesting that apoptosis pathway might transcriptionally be regulated to sirt1. |
2014-08-12 |
2023-08-13 |
rat |
| Blanche C Ip, Kang-Quan Hu, Chun Liu, Donald E Smith, Martin S Obin, Lynne M Ausman, Xiang-Dong Wan. Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. Cancer prevention research (Philadelphia, Pa.). vol 6. issue 12. 2014-07-31. PMID:24085778. |
this observed sirt1 induction was associated with decreased cyclin d1 protein, increased cyclin-dependent kinase inhibitor p21 protein expression, and induced apoptosis. |
2014-07-31 |
2023-08-12 |
mouse |
| Munehiro Kitada, Daisuke Koy. Renal protective effects of resveratrol. Oxidative medicine and cellular longevity. vol 2013. 2014-07-15. PMID:24379901. |
sirt1, an nad(+)-dependent deacetylase, was identified as one of the molecules through which calorie restriction extends the lifespan or delays age-related diseases, and this protein may regulate multiple cellular functions, including apoptosis, mitochondrial biogenesis, inflammation, glucose/lipid metabolism, autophagy, and adaptations to cellular stress, through the deacetylation of target proteins. |
2014-07-15 |
2023-08-12 |
Not clear |
| Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Hassen Ben Abdennebi, Joan Roselló-Catafa. Role of sirtuins in ischemia-reperfusion injury. World journal of gastroenterology. vol 19. issue 43. 2014-07-03. PMID:24616566. |
in this review, we mainly focus on sirt1 and sirt3 and examine their role in modulating pathways against energy depletion during ischemia and their involvement in oxidative stress, apoptosis, microcirculatory stress and inflammation during reperfusion. |
2014-07-03 |
2023-08-12 |
Not clear |
| Odile Gabay, Kristien J Zaal, Christelle Sanchez, Mona Dvir-Ginzberg, Viktoria Gagarina, Yingjie Song, Xiao Hong He, Michael W McBurne. Sirt1-deficient mice exhibit an altered cartilage phenotype. Joint bone spine. vol 80. issue 6. 2014-06-30. PMID:23587642. |
we previously demonstrated that sirt1 regulates apoptosis in cartilage in vitro. |
2014-06-30 |
2023-08-12 |
mouse |
| Yongkun Sun, Zhikun Guo, Shouhei Iku, Takeshi Saito, Masaaki Kurasak. Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells. Journal of applied toxicology : JAT. vol 33. issue 12. 2014-06-15. PMID:22968747. |
diethyl phthalate enhances expression of sirt1 and dnmt3a during apoptosis in pc12 cells. |
2014-06-15 |
2023-08-12 |
Not clear |
| Yongkun Sun, Zhikun Guo, Shouhei Iku, Takeshi Saito, Masaaki Kurasak. Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells. Journal of applied toxicology : JAT. vol 33. issue 12. 2014-06-15. PMID:22968747. |
here, we investigate whether dep affects sirtuins (sirt1 and sirt2) and methyltranferases (dnmt1 and dnmt3a) on the apoptosis of pc12 cells. |
2014-06-15 |
2023-08-12 |
Not clear |
| Yongkun Sun, Zhikun Guo, Shouhei Iku, Takeshi Saito, Masaaki Kurasak. Diethyl phthalate enhances expression of SIRT1 and DNMT3a during apoptosis in PC12 cells. Journal of applied toxicology : JAT. vol 33. issue 12. 2014-06-15. PMID:22968747. |
however, dnmt3a, dnmt3b and sirt1 were significantly increased under the enhancement of apoptosis induced by serum deprivation. |
2014-06-15 |
2023-08-12 |
Not clear |
| Yusuke S Hori, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Hori. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PloS one. vol 8. issue 9. 2014-06-15. PMID:24040102. |
sirt1 modulates the transcription factors p53, a tumor suppressor and inducer of apoptosis, and the forkhead o (foxo) family, both of which play roles for cell survival and cell death. |
2014-06-15 |
2023-08-12 |
Not clear |
| Yusuke S Hori, Atsushi Kuno, Ryusuke Hosoda, Yoshiyuki Hori. Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PloS one. vol 8. issue 9. 2014-06-15. PMID:24040102. |
the antimycin a-induced increase in ros levels and apoptosis was enhanced by sirt1 inhibitors nicotinamide and splitomicin, whereas it was suppressed by a sirt1 activator, resveratrol, and a sirt1 cofactor, nad+. |
2014-06-15 |
2023-08-12 |
Not clear |
| Jun-Gang Zhang, De-Fei Hong, Cheng-Wu Zhang, Xiao-Dong Sun, Zhi-Fei Wang, Ying Shi, Jun-Wei Liu, Guo-Liang Shen, Yuan-Biao Zhang, Jian Cheng, Chun-You Wang, Gang Zha. Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress. Cancer science. vol 105. issue 4. 2014-06-02. PMID:24484175. |
moreover, the decrease in sirt1 activity with special inhibitor ex527 had a synergic effect on chemotherapy with gemcitabine in panc-1 and aspc-1 cell lines, which significantly promoted apoptosis, senescence, and g0 /g1 cycle arrest. |
2014-06-02 |
2023-08-12 |
Not clear |
| Cosmin A Tegla, Philippe Azimzadeh, Maria Andrian-Albescu, Alvaro Martin, Cornelia D Cudrici, Richard Trippe, Adam Sugarman, Hegang Chen, Dallas Boodhoo, Sonia I Vlaicu, Walter Royal, Christopher Bever, Violeta Rus, Horea Ru. SIRT1 is decreased during relapses in patients with multiple sclerosis. Experimental and molecular pathology. vol 96. issue 2. 2014-05-28. PMID:24397908. |
furthermore, we investigated the role of sirt1 in the expression of fasl and found a significant increase in fasl expression and apoptosis after inhibition of sirt1 expression. |
2014-05-28 |
2023-08-12 |
Not clear |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
sirt1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of akt pathway. |
2014-05-20 |
2023-08-12 |
human |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
many studies have demonstrated that sirt1, an nad(+)-dependent deacetylase, reduces apoptosis in several different cells. |
2014-05-20 |
2023-08-12 |
human |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
however, the role of sirt1 in apoptosis of disc nucleus pulposus (np) cells remains unclear. |
2014-05-20 |
2023-08-12 |
human |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
the present study was performed to determine whether degenerative human np would express sirt1, and to investigate the role of sirt1 in np cells apoptosis. |
2014-05-20 |
2023-08-12 |
human |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
degenerative human np cells were treated in culture with activator or inhibitor of sirt1, resveratrol or nicotinamide, or sirt1 small interfering rna (sirna), and cell apoptosis was quantified via flow cytometry. |
2014-05-20 |
2023-08-12 |
human |
| DaWu Wang, ZhenMing Hu, Jie Hao, Bin He, Qiang Gan, XiaoMing Zhong, XiaoJun Zhang, JieLiang Shen, Ji Fang, Wei Jian. SIRT1 inhibits apoptosis of degenerative human disc nucleus pulposus cells through activation of Akt pathway. Age (Dordrecht, Netherlands). vol 35. issue 5. 2014-05-20. PMID:22990594. |
the rate of apoptosis was far fewer in resveratrol-treated np cells than in sirt1 sirna-transfected or nicotinamide-treated np cells. |
2014-05-20 |
2023-08-12 |
human |