| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shohei Shinozaki, Kyungho Chang, Michihiro Sakai, Nobuyuki Shimizu, Marina Yamada, Tomokazu Tanaka, Harumasa Nakazawa, Fumito Ichinose, Yoshitsugu Yamada, Akihito Ishigami, Hideki Ito, Yasuyoshi Ouchi, Marlene E Starr, Hiroshi Saito, Kentaro Shimokado, Jonathan S Stamler, Masao Kanek. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Science signaling. vol 7. issue 351. 2015-07-13. PMID:25389371. |
inhibition of sirt1 reduced deacetylation and promoted activation of p53 and p65, leading to apoptosis and increased expression of proinflammatory genes. |
2015-07-13 |
2023-08-13 |
Not clear |
| Juan A Godoy, Juan M Zolezzi, Nady Braidy, Nibaldo C Inestros. Role of Sirt1 during the ageing process: relevance to protection of synapses in the brain. Molecular neurobiology. vol 50. issue 3. 2015-07-08. PMID:24496572. |
sirt1 serves as a deacetylase for numerous proteins involved in several cellular pathways, including stress response and apoptosis, and plays a protective role in neurodegenerative disorders, such as ad. |
2015-07-08 |
2023-08-12 |
Not clear |
| Yi-jun Dong, Nian Liu, Zhi Xiao, Tao Sun, Shu-hui Wu, Wei-xia Sun, Zhong-gao Xu, Hang Yua. Renal protective effect of sirtuin 1. Journal of diabetes research. vol 2014. 2015-07-07. PMID:25386563. |
in the kidneys, sirt1 may inhibit renal cell apoptosis, inflammation, and fibrosis. |
2015-07-07 |
2023-08-13 |
Not clear |
| Li Lin, Xiaoxia Zheng, Chunping Qiu, Samina Dongol, Qingtao Lv, Jie Jiang, Beihua Kong, Chenguang Wan. SIRT1 promotes endometrial tumor growth by targeting SREBP1 and lipogenesis. Oncology reports. vol 32. issue 6. 2015-06-29. PMID:25270091. |
silent information regulator 1 (sirt1) is involved in a number of cellular regulatory mechanisms affecting cellular life span, stress resistance, apoptosis and cellular metabolism. |
2015-06-29 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
we examine, in vitro, the involvement of sirt1, p53 and the p65 and p50 subunits of nfκb and their interrelationships in the control of the apoptosis and proliferation of porcine ovarian granulosa cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
the accumulation of sirt1, markers of proliferation (mitogen-activated protein kinase or extracellular-signal-regulated kinases 1,2) and a marker of apoptosis (caspase 3) was detected by immunocytochemistry. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
transfection of cells with a sirt1 gene construct alone promoted the accumulation of sirt1 and decreased the accumulation of proliferation markers but did not affect the marker of apoptosis. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
thus, sirt1, p53 and nf-κb are involved in the control of both the proliferation and the apoptosis of ovarian cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Alexander V Sirotkin, Petra Dekanová, Abdel Halim Harrath, Saleh Hamad Alwasel, Dušan Vašíče. Interrelationships between sirtuin 1 and transcription factors p53 and NF-κB (p50/p65) in the control of ovarian cell apoptosis and proliferation. Cell and tissue research. vol 358. issue 2. 2015-06-25. PMID:25027053. |
these novel data on the cross-talk between the mtor/sirt1 system and the transcription factors p53 and nf-κb show both the inhibitory (proliferation) and stimulatory (apoptosis) influences of sirt1 on transcription factor action in ovarian cells. |
2015-06-25 |
2023-08-13 |
Not clear |
| Feng Zhang, Zhen-Lu Li, Xiao-Mei Xu, Yan Hu, Ji-Hong Yao, Wei Xu, Hui-Rong Jing, Shu Wang, Shi-Li Ning, Xiao-Feng Tia. Protective effects of icariin-mediated SIRT1/FOXO3 signaling pathway on intestinal ischemia/reperfusion-induced acute lung injury. Molecular medicine reports. vol 11. issue 1. 2015-06-25. PMID:25323330. |
sirtuin 1 (sirt1), a nad+-dependent deacetylase, has been reported to have an important role in apoptosis inhibition, oxidative stress resistance and cell lifespan extension through its deacetylation of forkhead box protein o3 (foxo3). |
2015-06-25 |
2023-08-13 |
rat |
| Changhe Zhang, Xiangcheng Li, Qinhong Li. Sorbitol dehydrogenase inhibitor protects the liver from ischemia/reperfusion-induced injury via elevated glycolytic flux and enhanced sirtuin 1 activity. Molecular medicine reports. vol 11. issue 1. 2015-06-25. PMID:25333577. |
next the present study further investigated the changes in liver function, histology, inflammation, apoptosis and necrosis; the cytosolic adenosine triphosphate (atp) and nictotinamide adenine dinucleotide [nad(h)] contents and the protein level of caspase 3 and sirtuin 1 (sirt1). |
2015-06-25 |
2023-08-13 |
mouse |
| Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Le. Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism. Cell stress & chaperones. vol 19. issue 5. 2015-06-11. PMID:24446069. |
the tunel assay consistently showed that exendin-4 reversed hepatocyte apoptosis induced by treatment with pa. inhibition of sirt1 by nicotinamide and sirna significantly increased the expression of er stress marker genes in cells treated with both pa and exendin-4. |
2015-06-11 |
2023-08-12 |
Not clear |
| Ayako Sakurabashi, Osamu Wada-Hiraike, Mana Hirano, Houju Fu, Wataru Isono, Tomohiko Fukuda, Yoshihiro Morita, Michihiro Tanikawa, Yuichiro Miyamoto, Katsutoshi Oda, Kei Kawana, Yutaka Osuga, Tomoyuki Fuji. CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase. The Journal of steroid biochemistry and molecular biology. vol 149. 2015-06-05. PMID:25661920. |
cell cycle and apoptosis regulator 2 (ccar2), previously known as dbc1/kiaa1967, is a transcriptional regulator that regulates cellular proliferation and energy metabolism by inhibiting sirtuin 1 (sirt1) deacetylase. |
2015-06-05 |
2023-08-13 |
Not clear |
| Chiara Botti, Botti Chiara, Ilaria Caiafa, Caiafa Ilaria, Antonietta Coppola, Coppola Antonietta, Francesca Cuomo, Cuomo Francesca, Marco Miceli, Miceli Marco, Lucia Altucci, Altucci Lucia, Gilda Cobellis, Cobellis Gild. SIRT1 inhibition affects angiogenic properties of human MSCs. BioMed research international. vol 2014. 2015-06-04. PMID:25243179. |
inhibition of sirt1 by sirtinol, a cell-permeable inhibitor, or by specific sh-rna resulted in an increase of premature-senescence phenotype, a reduction of proliferation rate with increased apoptosis. |
2015-06-04 |
2023-08-13 |
human |
| Yi Cai, Li Zhao, Yuan Qin, Yanhuan H. High dose of epigallocatechin-3-gallate inhibits proliferation and induces apoptosis of H9C2 cardiomyocytes through down-regulation of SIRT1. Die Pharmazie. vol 70. issue 1. 2015-06-02. PMID:25975092. |
high dose of epigallocatechin-3-gallate inhibits proliferation and induces apoptosis of h9c2 cardiomyocytes through down-regulation of sirt1. |
2015-06-02 |
2023-08-13 |
Not clear |
| Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Hye Gwang Jeon. Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. Free radical biology & medicine. vol 74. 2015-06-01. PMID:24970682. |
furthermore, upregulation of death receptor 5 by metformin-mediated sirt1 downregulation enhanced the sensitivity of wild-type p53 cancer cells to trail-induced apoptosis. |
2015-06-01 |
2023-08-13 |
human |
| Yasar Colak, Atakan Yesil, Hasan Huseyin Mutlu, Ozge Telci Caklili, Celal Ulasoglu, Ebubekir Senates, Mumtaz Takir, Osman Kostek, Yusuf Yilmaz, Feruze Yilmaz Enc, Guralp Tasan, Ilyas Tunce. A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators. Journal of gastrointestinal and liver diseases : JGLD. vol 23. issue 3. 2015-05-29. PMID:25267960. |
among the effects of sirt1 are: its healing activity on insulin sensitivity, thereby ameliorating glycemic regulation; its mimetic activity on calorie restriction; its antihyperlipidemic activity on lipid homeostasis via the liver, adipose tissues and skeletal muscles; its anti-inflammatory activities; its protective effects against cardiovascular events and endothelial dysfunction; its positive influence on autophagy, apoptosis and cancer; and finally, its anti-aging activity. |
2015-05-29 |
2023-08-13 |
Not clear |
| Ki Hwan Kweon, Cho Rok Lee, Soo Jung Jung, Eun Jeong Ban, Sang-Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Young Suk Jo, Jandee Lee, Woong Youn Chun. Sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. International journal of oncology. vol 45. issue 5. 2015-05-25. PMID:25109285. |
sirt1 induction confers resistance to etoposide-induced genotoxic apoptosis in thyroid cancers. |
2015-05-25 |
2023-08-13 |
human |
| Lijia Zhu, Ji Qi, Christine Ya-Chi Chiao, Qiang Zhang, John A Porco, Douglas V Faller, Yan Da. Identification of a novel polyprenylated acylphloroglucinol‑derived SIRT1 inhibitor with cancer‑specific anti-proliferative and invasion-suppressing activities. International journal of oncology. vol 45. issue 5. 2015-05-25. PMID:25189993. |
in summary, we have identified jq-101 as a new sirt1 inhibitor which may have potential application in cancer treatment through its ability to induce tumor cell apoptosis and senescence and suppress cancer cell invasion. |
2015-05-25 |
2023-08-13 |
human |
| WenLi Mu, QingJun Zhang, XiaoQiang Tang, WenYan Fu, Wei Zheng, YunBiao Lu, HongLiang Li, YuSheng Wei, Li Li, ZhiGang She, HouZao Chen, DePei Li. Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. Science China. Life sciences. vol 57. issue 9. 2015-05-15. PMID:25104317. |
overexpression of a dominant-negative mutant of sirt1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure. |
2015-05-15 |
2023-08-13 |
mouse |