| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kimberly R Holloway, Tara N Calhoun, Madhurima Saxena, Cheynita F Metoyer, Ethan F Kandler, Chantal A Rivera, Kevin Pruit. SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 20. 2010-07-22. PMID:20439735. |
because sirt1 regulates very diverse responses such as apoptosis, insulin sensitivity, autophagy, differentiation, and stem cell pluripotency, it has been a challenge to reconcile how it orchestrates such pleiotropic effects. |
2010-07-22 |
2023-08-12 |
Not clear |
| Isabelle Mader, Martin Wabitsch, Klaus-Michael Debatin, Pamela Fischer-Posovszky, Simone Fuld. Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 6. 2010-07-21. PMID:20097879. |
the synergistic interaction of resveratrol and trail depends on the intrinsic apoptosis pathway and caspases, since bcl-2 overexpression and the caspase inhibitor zvad.fmk inhibit apoptosis, whereas knockdown of sirt1 by rna interference has no effect. |
2010-07-21 |
2023-08-12 |
human |
| Ting Zhao, Jian Li, Alex F Che. MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. American journal of physiology. Endocrinology and metabolism. vol 299. issue 1. 2010-07-14. PMID:20424141. |
mir-34a, recently reported as a tumor suppressor, has been found to target silent information regulator 1 (sirt1), leading to cell cycle arrest or apoptosis. |
2010-07-14 |
2023-08-12 |
rat |
| Euan W Baxter, Jo Milne. p53 Regulates LIF expression in human medulloblastoma cells. Journal of neuro-oncology. vol 97. issue 3. 2010-07-12. PMID:19907922. |
interestingly, sirna against wip1 or sirt1 also induced increased apoptosis in the medulloblastoma line d283med and, over a longer time period, in daoy cells. |
2010-07-12 |
2023-08-12 |
human |
| Miriam Uhl, Andreea Csernok, Sevtap Aydin, Rolf Kreienberg, Lisa Wiesmüller, Susanne Andrea Gat. Role of SIRT1 in homologous recombination. DNA repair. vol 9. issue 4. 2010-06-29. PMID:20097625. |
the class iii histone deacetylase (hdac) sirt1 plays a role in the metabolism, aging, and carcinogenesis of organisms and regulates senescence and apoptosis in cells. |
2010-06-29 |
2023-08-12 |
human |
| Viktoria Gagarina, Odile Gabay, Mona Dvir-Ginzberg, Eun Jin Lee, Jillian K Brady, Michael J Quon, David J Hal. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis and rheumatism. vol 62. issue 5. 2010-06-14. PMID:20131294. |
the protein deacetylase sirt1 inhibits apoptosis in a variety of cell systems by distinct mechanisms, yet its role in chondrocyte death has not been explored. |
2010-06-14 |
2023-08-12 |
human |
| Christian-Lars Dransfeld, Hamed Alborzinia, Stefan Wölfl, Ulrich Mahlknech. SIRT3 SNPs validation in 640 individuals, functional analyses and new insights into SIRT3 stability. International journal of oncology. vol 36. issue 4. 2010-06-04. PMID:20198340. |
from within the 7 known human sirtuins, sirt3 recently stepped out of the shadow of sirt1 showing strong effects on stress response, apoptosis, cell cycle and energy metabolism, mimicking effects of caloric restriction. |
2010-06-04 |
2023-08-12 |
human |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Keiko Sueyasu, Naoki Washida, Hirobumi Tokuyama, Maty Tzukerman, Karl Skorecki, Koichi Hayashi, Hiroshi Ito. Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20139070. |
sirt1, a nad-dependent protein deacetylase, is reported to regulate intracellular metabolism and attenuate reactive oxidative species (ros)-induced apoptosis leading to longevity and acute stress resistance. |
2010-05-20 |
2023-08-12 |
mouse |
| Kazuhiro Hasegawa, Shu Wakino, Kyoko Yoshioka, Satoru Tatematsu, Yoshikazu Hara, Hitoshi Minakuchi, Keiko Sueyasu, Naoki Washida, Hirobumi Tokuyama, Maty Tzukerman, Karl Skorecki, Koichi Hayashi, Hiroshi Ito. Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20139070. |
in hk-2 cells, a cultured proximal tubule cell line, overexpression of sirt1 rescued the cisplatin-induced cell apoptosis through the restoration of peroxisome number, although the mitochondria number was not restored. |
2010-05-20 |
2023-08-12 |
mouse |
| Xiumei Guo, Jason G Williams, Thaddeus T Schug, Xiaoling L. DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. The Journal of biological chemistry. vol 285. issue 17. 2010-05-20. PMID:20167603. |
a sirt1 phosphorylation mimetic (sirt1 t522d) displays elevated deacetylase activity, thus inhibiting cell apoptosis. |
2010-05-20 |
2023-08-12 |
human |
| Wenjuan He, Yingying Wang, Ming-Zhi Zhang, Li You, Linda S Davis, Hong Fan, Hai-Chun Yang, Agnes B Fogo, Roy Zent, Raymond C Harris, Matthew D Breyer, Chuan-Ming Ha. Sirt1 activation protects the mouse renal medulla from oxidative injury. The Journal of clinical investigation. vol 120. issue 4. 2010-04-21. PMID:20335659. |
the unilateral ureteral obstruction (uuo) model of kidney injury induced markedly more renal apoptosis and fibrosis in sirt1+/- mice than in wild-type controls, while pharmacologic sirt1 activation substantially attenuated apoptosis and fibrosis in wild-type mice. |
2010-04-21 |
2023-08-12 |
mouse |
| H Hiraike, O Wada-Hiraike, S Nakagawa, S Koyama, Y Miyamoto, K Sone, M Tanikawa, T Tsuruga, K Nagasaka, Y Matsumoto, K Oda, K Shoji, H Fukuhara, S Saji, K Nakagawa, S Kato, T Yano, Y Taketan. Identification of DBC1 as a transcriptional repressor for BRCA1. British journal of cancer. vol 102. issue 6. 2010-04-16. PMID:20160719. |
caspase-dependent processing of dbc1 promotes apoptosis, and depletion of endogenous dbc1 negatively regulates p53-dependent apoptosis through its specific inhibition of sirt1. |
2010-04-16 |
2023-08-12 |
Not clear |
| Satoshi Koyama, Osamu Wada-Hiraike, Shunsuke Nakagawa, Michihiro Tanikawa, Haruko Hiraike, Yuichiro Miyamoto, Kenbun Sone, Katsutoshi Oda, Hiroshi Fukuhara, Keiichi Nakagawa, Shigeaki Kato, Tetsu Yano, Yuji Taketan. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochemical and biophysical research communications. vol 392. issue 3. 2010-03-23. PMID:20074560. |
caspase-dependent processing of dbc1 promotes apoptosis, and depletion of the endogenous dbc1 negatively regulates p53-dependent apoptosis through its specific inhibition of sirt1. |
2010-03-23 |
2023-08-12 |
Not clear |
| Işin Cakir, Mario Perello, Omar Lansari, Norma J Messier, Charles A Vaslet, Eduardo A Nilln. Hypothalamic Sirt1 regulates food intake in a rodent model system. PloS one. vol 4. issue 12. 2010-03-17. PMID:20020036. |
sirt1 is an evolutionarily conserved nad(+) dependent deacetylase involved in a wide range of processes including cellular differentiation, apoptosis, as well as metabolism, and aging. |
2010-03-17 |
2023-08-12 |
Not clear |
| Wei Yu, Yu-Cai Fu, Chun-Juan Chen, Xin Wang, Wei Wan. SIRT1: a novel target to prevent atherosclerosis. Journal of cellular biochemistry. vol 108. issue 1. 2010-02-12. PMID:19562740. |
the recent studies have demonstrated that endothelial sirt1 is an anti-atherosclerosis factor and the possible mechanism may be related to inhibit oxidized low-density lipoprotein (oxldl)-induced apoptosis, upregulate endothelial nitric oxide synthase (enos) expression, and improve endothelium relaxation function. |
2010-02-12 |
2023-08-12 |
Not clear |
| Danian Chen, Marek Pacal, Pamela Wenzel, Paul S Knoepfler, Gustavo Leone, Rod Bremne. Division and apoptosis of E2f-deficient retinal progenitors. Nature. vol 462. issue 7275. 2010-02-01. PMID:20016601. |
however, loss of activating e2fs caused downregulation of the p53 deacetylase sirt1, p53 hyperacetylation and elevated apoptosis, establishing a novel e2f-sirt1-p53 survival axis in vivo. |
2010-02-01 |
2023-08-12 |
mouse |
| Hyeog Kang, Jae-Won Jung, Myung K Kim, Jay H Chun. CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PloS one. vol 4. issue 8. 2010-01-19. PMID:19680552. |
sirt1, an nad(+) (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells from stress-induced apoptosis, and its orthologues delay aging in lower eukaryotes. |
2010-01-19 |
2023-08-12 |
mouse |
| Hyeog Kang, Jae-Won Jung, Myung K Kim, Jay H Chun. CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PloS one. vol 4. issue 8. 2010-01-19. PMID:19680552. |
ck2-mediated phosphorylation increases the ability of sirt1 to deacetylate p53 and protect cells from apoptosis after dna damage. |
2010-01-19 |
2023-08-12 |
mouse |
| Hyeog Kang, Jae-Won Jung, Myung K Kim, Jay H Chun. CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage. PloS one. vol 4. issue 8. 2010-01-19. PMID:19680552. |
based on these findings, we propose that ck2 protects against ir-induced apoptosis partly by phosphorylating and activating sirt1. |
2010-01-19 |
2023-08-12 |
mouse |
| Yong Li, Rong Xu, Xiu-min Zhang, Dian-dong Li, Qi-yang H. [Mechanism of apoptosis induced by SIRT1 deacetylase inhibitors in human breast cancer MCF-7 drug-resistant cells]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 43. issue 10. 2010-01-13. PMID:19127863. |
[mechanism of apoptosis induced by sirt1 deacetylase inhibitors in human breast cancer mcf-7 drug-resistant cells]. |
2010-01-13 |
2023-08-12 |
human |