| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Swapnil Tripathi, Dharati Parmar, Samir Raval, Rajeev Mishra, Gyanendra Sing. Attenuation of chromium (VI) and arsenic (III)-induced oxidative stress and hepatic apoptosis by phloretin, biochanin-A, and coenzyme Q10 via activation of SIRT1/Nrf2/HO-1/NQO1 signaling. Journal of biochemical and molecular toxicology. vol 38. issue 9. 2024-08-23. PMID:39177155. |
by averting the triggered apoptosis in conjunction with oxidative stress, this combination increases the sirt1, nrf2, ho-1, and nqo1 signaling, thereby reassuringly maintaining the cellular equilibrium. |
2024-08-23 |
2024-08-25 |
mouse |
| Sugandh Saxena, Sumit Kumar Anand, Ankita Sharma, Poonam Kakka. Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine. Toxicology in vitro : an international journal published in association with BIBRA. 2024-08-10. PMID:39127087. |
treatment with srt-1720 (sirt1 activator) enhanced autophagy, decreased apoptosis, upregulated expression of downstream moieties (foxo3a and bnip3) and ameliorated mitochondria related anomalies while nicotinamide (sirt1 inhibitor) treatment exhibited reversal of the same. |
2024-08-10 |
2024-08-13 |
Not clear |
| Xinyan Wang, Haoyi Li, Dongchao Q. Dihydromyricetin protects sevoflurane-induced mitochondrial dysfunction in HT22 hippocampal cells. Clinical and experimental pharmacology & physiology. vol 51. issue 9. 2024-08-05. PMID:39103220. |
blocking of sirt1 counteracted the mitigatory effect of dhm on apoptosis, inflammation, oxidative stress and mitochondrial dysfunction in sev-elicited ht22 cells. |
2024-08-05 |
2024-08-08 |
Not clear |
| Maryam Owjfard, Zahra Rahimian, Farzaneh Karimi, Afshin Borhani-Haghighi, Arashk Mallahzade. A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke. Heliyon. vol 10. issue 14. 2024-07-31. PMID:39082038. |
combined, the activation of sirt1 and nrf2 pathways contributes to resveratrol's neuroprotective effects by reducing oxidative stress, inflammation, and apoptosis in is. |
2024-07-31 |
2024-08-02 |
Not clear |
| Qian Yang, Keyan Sun, Tianyu Gao, Ying Gao, Yuying Yang, Zengqiang Li, Daiying Zu. SIRT1 silencing promotes EMT and Crizotinib resistance by regulating autophagy through AMPK/mTOR/S6K signaling pathway in EML4-ALK L1196M and EML4-ALK G1202R mutant non-small cell lung cancer cells. Molecular carcinogenesis. 2024-07-30. PMID:39078281. |
sirt1 can significantly enhanced the sensitivity of mutant cells to crizotinib, improved its ability to promote apoptosis of mutant cells, and inhibited cell proliferation. |
2024-07-30 |
2024-08-02 |
Not clear |
| Areege Ibrahim Salih, Basma Talib Al-Sudani, Bahir Abdul-Razzaq Mshimes. Targeting POLD1 to suppress the proliferation and migration of breast cancer MDA-MB-231 cell lines by downregulation of SIRT1. Toxicology research. vol 13. issue 4. 2024-07-22. PMID:39036524. |
sirt1 is a class iii histone deacetylase nad + -dependent enzyme that is interlinked in tumor progression, apoptosis, metastasis, and other mechanisms of tumorigenesis, while dna polymerase delta 1 (pold1) functions as a gene coding for p125, which plays an important role in genome stability and dna replication. |
2024-07-22 |
2024-07-24 |
Not clear |
| Hui Cui, Di Sun, Sheng Meng, Tian-Ju Ma, Zi Ye, Zhao-Hui L. SIRT1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress International journal of ophthalmology. vol 17. issue 7. 2024-07-19. PMID:39026915. |
sirt1 inhibits apoptosis of human lens epithelial cells through suppressing endoplasmic reticulum stress to explore the effect of silent information regulator factor 2-related enzyme 1 (sirt1) on modulating apoptosis of human lens epithelial cells (hlecs) and alleviating lens opacification of rats through suppressing endoplasmic reticulum (er) stress. |
2024-07-19 |
2024-07-21 |
human |
| Wei Wang, Yuanyuan Hu, Ning Ding, Jiping Wei, Cairong L. The role of SIRT1 in kidney diseases. International urology and nephrology. 2024-07-19. PMID:39030438. |
the literature reports that sirt1 regulates biological processes such as glucose metabolism, lipid metabolism, oxidative stress, inflammation, autophagy, endoplasmic reticulum stress, and apoptosis. |
2024-07-19 |
2024-07-22 |
Not clear |
| Yuling Xie, Linfeng Xie, Zhihuang Qiu, Jian He, Fei Jiang, Meiling Cai, Yanjuan Lin, Liangwan Che. miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-16. PMID:39010253. |
furthermore, by administering sirt1 agonists and inhibitors to mice, we observed that the activation of sirt1 alleviates vascular inflammation and apoptosis, subsequently reducing the incidence of ad. |
2024-07-16 |
2024-07-18 |
mouse |
| Yuling Xie, Linfeng Xie, Zhihuang Qiu, Jian He, Fei Jiang, Meiling Cai, Yanjuan Lin, Liangwan Che. miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-16. PMID:39010253. |
additionally, functional reversal experiments revealed that overexpression of sirt1 in havsmcs could reverse the cell inflammation and apoptosis mediated by mir-485-3p. |
2024-07-16 |
2024-07-18 |
mouse |
| Yuling Xie, Linfeng Xie, Zhihuang Qiu, Jian He, Fei Jiang, Meiling Cai, Yanjuan Lin, Liangwan Che. miR-485-3p targets SIRT1 in vascular smooth muscle cells mediating the occurrence of aortic dissection. Journal of cellular and molecular medicine. vol 28. issue 13. 2024-07-16. PMID:39010253. |
therefore, our research suggests that mir-485-3p can aggravate inflammation and apoptosis in vascular smooth muscle cells by suppressing the expression of sirt1, thereby promoting the progression of aortic dissection. |
2024-07-16 |
2024-07-18 |
mouse |
| Jianqiang You, Haixiang Xue, Changjiang Chao, Zhixuan Zhang, Xiaoye Tan, Xiaoye Wang, Haifeng L. Histone Methyltransferase SUV39H2 Supports Nasopharyngeal Carcinoma Cell Metastasis by Regulation of SIRT1. Environmental toxicology. 2024-07-12. PMID:38994737. |
the function of suv39h2 and sirt1 in npc cell viability, metastasis, and apoptosis was tested through cck-8, transwell, and flow cytometry experiments. |
2024-07-12 |
2024-07-14 |
Not clear |
| Jianqiang You, Haixiang Xue, Changjiang Chao, Zhixuan Zhang, Xiaoye Tan, Xiaoye Wang, Haifeng L. Histone Methyltransferase SUV39H2 Supports Nasopharyngeal Carcinoma Cell Metastasis by Regulation of SIRT1. Environmental toxicology. 2024-07-12. PMID:38994737. |
moreover, suv39h2 expedited npc cell viability, metastasis, and inhibited apoptosis, while sirt1 addition reversed these impacts. |
2024-07-12 |
2024-07-14 |
Not clear |
| Reham L Younis, Rehab M El-Gohary, Asmaa A Ghalwash, Islam Ibrahim Hegab, Maram M Ghabrial, Azza M Aboshanady, Raghad A Mostafa, Alaa H Abd El-Azeem, Eman E Farghal, Asmaa A E Belal, Haidy Khatta. Luteolin Mitigates D-Galactose-Induced Brain Ageing in Rats: SIRT1-Mediated Neuroprotection. Neurochemical research. 2024-07-10. PMID:38987448. |
additionally, luteolin treatment considerably attenuated neuronal apoptosis and upregulated hippocampal sirt1 mrna expression. |
2024-07-10 |
2024-07-13 |
rat |
| Luning Yang, Di Liu, Shide Jiang, Hengzhen Li, Lin Chen, Yuxiang Wu, Anko Elijah Essien, Michael Opoku, Shinen Naranmandakh, ShuGuang Liu, Qin Ru, Yusheng L. SIRT1 signaling pathways in sarcopenia: Novel mechanisms and potential therapeutic targets. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 177. 2024-06-22. PMID:38908209. |
sirt1 functioned as an important role in the occurrence and progression of sarcopenia through regulating key pathways related to protein homeostasis, apoptosis, mitochondrial dysfunction, insulin resistance and autophagy in skeletal muscle, including sirt1/forkhead box o (foxo), amp-activated protein kinase (ampk)/sirt1/nuclear factor κb (nf-κb), sirt1/p53, ampk/sirt1/peroxisome proliferator-activated receptor gamma coactivator-1α (pgc-1α), and sirt1/live kinase b1 (lkb1)/ampk pathways. |
2024-06-22 |
2024-06-25 |
human |
| Zhen Qiu, Biao Qi, Lu Li, Jiahui Cui, Min Liu, Zhongyuan Xi. Activation of Klotho/SIRT1 signaling pathway attenuates myocardial ischemia reperfusion injury in diabetic rats. Shock (Augusta, Ga.). 2024-06-21. PMID:38904464. |
klotho and sirt1 regulate the level of oxidative stress to participate in the regulation of many physiological functions such as cell survival, ageing, apoptosis, autophagy, mitochondrial biogenesis and inflammation. |
2024-06-21 |
2024-06-23 |
rat |
| Liheng Lin, Deliang Qiu, Fei Yang, Yu Xia, Siyuan Cai, Xiaojun Liao, Wanxin Deng, Changxue W. Hydrogen-rich saline upregulates the Sirt1/NF-κB signaling pathway and reduces vascular endothelial glycocalyx shedding in sepsis-induced acute kidney injury. Shock (Augusta, Ga.). 2024-06-18. PMID:38888497. |
compared with the clp group, hrs reduced renal apoptosis and upregulated sirt1 expression, and inhibited the nf-κb/mmp9 signalling pathway. |
2024-06-18 |
2024-06-21 |
rat |
| Shi-Shi Liao, Le-le Zhang, Yi-Guo Zhang, Jie Luo, Tulanisa Kadier, Ke Ding, Rong Chen, Qing-Tao Men. Ghrelin alleviates intestinal ischemia-reperfusion injury by activating the GHSR-1α/Sirt1/FOXO1 pathway. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 38. issue 11. 2024-05-30. PMID:38814725. |
overall, our data suggest that pretreatment with ghrelin reduces oxidative stress and apoptosis to attenuate iir/hr injury by binding with ghsr-1α to further activate sirt1. |
2024-05-30 |
2024-06-10 |
mouse |
| Manli Chen, Ji Liu, Wenwen Wu, Ting Guo, Jinjin Yuan, Zhiyun Wu, Zhijian Zheng, Zijun Zhao, Qiang Lin, Nan Liu, Hongbin Che. SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury. Cell biology and toxicology. vol 40. issue 1. 2024-05-20. PMID:38767771. |
sirt1 overexpression enhanced sirt3 activity by increasing the deacetylation of sirt3, which ameliorated ci/r-induced cerebral infarction, neuronal apoptosis, oxidative stress, neurological and motor dysfunction, and mitochondrial respiratory chain dysfunction, promoted mitochondrial biogenesis, and retained mitochondrial integrity and mitochondrial morphology. |
2024-05-20 |
2024-05-27 |
rat |
| Anatoly V Skalny, Michael Aschner, Viktor A Gritsenko, Airton C Martins, Yousef Tizabi, Tatiana V Korobeinikova, Monica M B Paoliello, Alexey A Tinko. Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity. Advances in neurotoxicology. vol 11. 2024-05-14. PMID:38741946. |
neuroprotective mechanisms of probiotics also include inhibition of apoptosis and oxidative stress, at least partially by up-regulation of sirt1 signaling. |
2024-05-14 |
2024-05-27 |
Not clear |