| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wallace Martins de Araujo, Bruno Kaufmann Robbs, Lilian G Bastos, Waldemir F de Souza, Flávia C B Vidal, João P B Viola, Jose A Morgado-Dia. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. Journal of cellular biochemistry. vol 117. issue 2. 2016-10-31. PMID:26224641. |
furthermore, high doses of lithium increased apoptosis, which was accompanied by decreased proteins levels of akt and pten. |
2016-10-31 |
2023-08-13 |
Not clear |
| Wallace Martins de Araujo, Bruno Kaufmann Robbs, Lilian G Bastos, Waldemir F de Souza, Flávia C B Vidal, João P B Viola, Jose A Morgado-Dia. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. Journal of cellular biochemistry. vol 117. issue 2. 2016-10-31. PMID:26224641. |
then, cells that were induced to overexpress pten were treated with lithium; we observed that low doses of lithium strongly increased apoptosis. |
2016-10-31 |
2023-08-13 |
Not clear |
| Zengjun Li, Haipeng Wang, Zhongfa Xu, Yanlai Sun, Jianjun Ha. Expression and mechanism of microRNA-181A on incidence and survival in late liver metastases of colorectal cancer. Oncology reports. vol 35. issue 3. 2016-10-28. PMID:26750720. |
upregulation of mir-181a promoted cell viability and inhibited apoptosis of sw620 cells, suppressed pten expression and activated phosphorylation of akt (p-akt) in sw620 cells. |
2016-10-28 |
2023-08-13 |
Not clear |
| Jiangyou Wang, Han Chen, You Zhou, Qiang Su, Tao Liu, Xian-tao Wang, Lang L. Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 38. issue 1. 2016-10-25. PMID:26784958. |
phosphatase and tensin homolog deleted on chromosome ten (pten) has been recognized as a promoter of apoptosis in various tissues, and revealed to be up-regulated in circumstances of coronary microembolization (cme). |
2016-10-25 |
2023-08-13 |
Not clear |
| Xinfeng Yu, Ruilian Li, Wenna Shi, Tao Jiang, Yufei Wang, Cong Li, Xianjun Q. Silencing of MicroRNA-21 confers the sensitivity to tamoxifen and fulvestrant by enhancing autophagic cell death through inhibition of the PI3K-AKT-mTOR pathway in breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 77. 2016-10-24. PMID:26796263. |
mir-21 coordinated the function of autophagy and apoptosis by targeting phosphatase and tensin homolog (pten) through inhibition of pi3k-akt-mtor pathway. |
2016-10-24 |
2023-08-13 |
Not clear |
| Ivan Verrastro, Karina Tveen-Jensen, Rudiger Woscholski, Corinne M Spickett, Andrew R Pit. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. Free radical biology & medicine. vol 90. 2016-10-21. PMID:26561776. |
phosphatase and tensin homolog (pten) is involved in a number of different cellular processes including metabolism, apoptosis, cell proliferation and survival. |
2016-10-21 |
2023-08-13 |
Not clear |
| Seung Ho Baek, Jae Hwi Lee, Jeong-Hyeon Ko, Hanwool Lee, Dongwoo Nam, Seok Geun Lee, Woong Mo Yang, Jae-Young Um, Junhee Lee, Sung-Hoon Kim, Bum Sang Shim, Kwang Seok Ah. Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases. Phytotherapy research : PTR. vol 30. issue 4. 2016-10-20. PMID:27059688. |
ginkgetin blocks constitutive stat3 activation and induces apoptosis through induction of shp-1 and pten tyrosine phosphatases. |
2016-10-20 |
2023-08-13 |
Not clear |
| Yaghoub Yazdani, Touraj Farazmandfar, Hossein Azadeh, Zeinab Zekavatia. The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: miR-21 and promoter methylation. Journal of biomedical science. vol 23. 2016-10-14. PMID:26787105. |
pten is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. |
2016-10-14 |
2023-08-13 |
human |
| L N Xu, N Lin, B N Xu, J B Li, S Q Che. Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis. Genetics and molecular research : GMR. vol 14. issue 4. 2016-10-05. PMID:26681001. |
these results suggest that ucmscs might inhibit the proliferation of human endometriotic cells in vitro and promote their apoptosis by upregulating the expression of pten. |
2016-10-05 |
2023-08-13 |
human |
| Jalil Pirayesh Islamian, Fahimeh Aghaee, Alireza Farajollahi, Behzad Baradaran, Mona Faze. Combined Treatment with 2-Deoxy-D-Glucose and Doxorubicin Enhances the in Vitro Efficiency of Breast Cancer Radiotherapy. Asian Pacific journal of cancer prevention : APJCP. vol 16. issue 18. 2016-10-05. PMID:26745097. |
we have studied the effects of 1μm dox and 500 μm 2dg on radiation induced cell death, apoptosis and also on the expression levels of p53 and pten genes in t47d and skbr3 breast cancer cells irradiated with 100, 150 and 200 cgy x-rays. |
2016-10-05 |
2023-08-13 |
Not clear |
| Manisha Ahir, Saurav Bhattacharya, Soumendu Karmakar, Ayan Mukhopadhyay, Sudeshna Mukherjee, Swatilekha Ghosh, Sreya Chattopadhyay, Prasun Patra, Arghya Adhikar. Tailored-CuO-nanowire decorated with folic acid mediated coupling of the mitochondrial-ROS generation and miR425-PTEN axis in furnishing potent anti-cancer activity in human triple negative breast carcinoma cells. Biomaterials. vol 76. 2016-09-19. PMID:26520043. |
furthermore, cuo-nw-fa mediated cytosolic retardation of nf-κb favoured inactivation of mir-425 and henceforth activated pten to induce apoptosis in tnbc cells. |
2016-09-19 |
2023-08-13 |
mouse |
| Shan Wang, Ting Wang, Tao Wang, Lintao Ji. Cell Type-Specific and Inducible PTEN Gene Silencing by a Tetracycline Transcriptional Activator-Regulated Short Hairpin RNA. Molecules and cells. vol 38. issue 11. 2016-09-14. PMID:26486163. |
the efficacy and reversibility of pten knockdown by this construct was validated in normal and neoplastic cells, in which pten deficiency resulted in accelerated cell proliferation, suppressed apoptosis, and increased invasiveness. |
2016-09-14 |
2023-08-13 |
mouse |
| Paul Toren, Soojin Kim, Fraser Johnson, Amina Zoubeid. Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer. PloS one. vol 11. issue 4. 2016-08-19. PMID:27046225. |
our data reveal that akt inhibition induces apoptosis and inhibits cell growth in pten null cell lines independently of their sensitivity to hormone therapy; however, akt inhibition had no effect on the pten positive 22rv1 cell line. |
2016-08-19 |
2023-08-13 |
Not clear |
| Zhen Zhang, Yumei Li, Chuqiao Sheng, Chunfeng Yang, Liping Chen, Jinghui Su. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. American journal of translational research. vol 8. issue 7. 2016-08-10. PMID:27508033. |
tanshinone iia inhibits apoptosis in the myocardium by inducing microrna-152-3p expression and thereby downregulating pten. |
2016-08-10 |
2023-08-13 |
human |
| Zhen Zhang, Yumei Li, Chuqiao Sheng, Chunfeng Yang, Liping Chen, Jinghui Su. Tanshinone IIA inhibits apoptosis in the myocardium by inducing microRNA-152-3p expression and thereby downregulating PTEN. American journal of translational research. vol 8. issue 7. 2016-08-10. PMID:27508033. |
treatment of h9c2 cells with tanshinone iia inhibited angiotensin ii-induced apoptosis by downregulating the expression of pten (phosphatase and tensin homolog), a tumor suppressor that plays a critical role in apoptosis. |
2016-08-10 |
2023-08-13 |
human |
| Xingwei Yang, Yanjun Qin, Suxia Shao, Yueqing Yu, Chongyang Zhang, Hua Dong, Guangwei Lv, Shimin Don. MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). International heart journal. vol 57. issue 2. 2016-08-02. PMID:26973267. |
microrna-214 inhibits left ventricular remodeling in an acute myocardial infarction rat model by suppressing cellular apoptosis via the phosphatase and tensin homolog (pten). |
2016-08-02 |
2023-08-13 |
rat |
| Xingwei Yang, Yanjun Qin, Suxia Shao, Yueqing Yu, Chongyang Zhang, Hua Dong, Guangwei Lv, Shimin Don. MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). International heart journal. vol 57. issue 2. 2016-08-02. PMID:26973267. |
the study results suggest that ad-mir-214 improves lv remodeling and decreases the apoptosis of myocardial cells through pten, suggesting a possible mechanism by which ad-mir-214 functions in protecting against ami injury. |
2016-08-02 |
2023-08-13 |
rat |
| Beata Hat, Marek Kochańczyk, Marta N Bogdał, Tomasz Lipniack. Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System. PLoS computational biology. vol 12. issue 2. 2016-07-14. PMID:26928575. |
our analysis provides an explanation why cancer cell lines known to have vastly diverse expression levels of wip1 and pten exhibit a broad spectrum of responses to dna damage: from a fast transition to a high level of p53 killer (a p53 phosphoform which promotes commitment to apoptosis) in cells characterized by high pten and low wip1 levels to long-lasting p53 level oscillations in cells having pten promoter methylated (as in, e.g., mcf-7 cell line). |
2016-07-14 |
2023-08-13 |
Not clear |
| Eun Mi Chang, Eunjin Lim, Sookyoung Yoon, Kyungah Jeong, Sijeong Bae, Dong Ryul Lee, Tae Ki Yoon, Youngsok Choi, Woo Sik Le. Cisplatin Induces Overactivation of the Dormant Primordial Follicle through PTEN/AKT/FOXO3a Pathway which Leads to Loss of Ovarian Reserve in Mice. PloS one. vol 10. issue 12. 2016-07-06. PMID:26656301. |
pten is well known as a tumor suppressor function which plays a fundamental role in the regulation of the cell cycle, apoptosis and development of cancer. |
2016-07-06 |
2023-08-13 |
mouse |
| b' Jarmila Laukov\\xc3\\xa1, Alois Kozub\\xc3\\xadk, Ji\\xc5\\x99ina Hofmanov\\xc3\\xa1, Jana Nekvindov\\xc3\\xa1, Petr Sova, Mary Pat Moyer, Ji\\xc5\\x99\\xc3\\xad Ehrmann, Alena Hyr\\xc5\\xa1lov\\xc3\\xa1 Vaculov\\xc3\\xa. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PloS one. vol 10. issue 10. 2016-06-30. PMID:26492315.' |
loss of pten facilitates rosiglitazone-mediated enhancement of platinum(iv) complex la-12-induced apoptosis in colon cancer cells. |
2016-06-30 |
2023-08-13 |
human |