| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meng Lian, Boxuan Han, Jiaming Chen, Xixi Shen, Yanming Zhao, Qian Shi, Ling Feng, Shizhi He, Hongzhi Ma, Lizhen Hou, Qi Zhong, Hongbao Cao, Jugao Fan. Investigating the impact of clinical and genetic factors on the post-surgery prognosis of sinonasal squamous cell carcinoma. Scientific reports. vol 14. issue 1. 2024-09-27. PMID:39333222. |
these genes, including egfr, pik3ca, erbb2, pten, bcl2, braf, kras, and prl, form a complex snscc-prognosis pathway and were significantly enriched in 42 kegg pathways and gene ontology (go) terms (fdr-corrected p-value < 0.001), influencing cell growth, apoptosis, and oncogenic signaling pathways. |
2024-09-27 |
2024-10-01 |
Not clear |
| Huaijuan Liu, Peijun Zhang, Jingwen Yu, Jiwei Wang, Jiezhong Yu, Minfang Gu. [Fasudil improves cognitive function in APP/PS1 transgenic mice by promoting mitophagy and inhibiting NLRP3 inflammasome activation]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 40. issue 8. 2024-08-31. PMID:39215667. |
terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling assay (tunel) staining was used to detect neuronal apoptosis; the expression of p62 and nlrp3 was detected by immunofluorescence histochemical staining; real time fluorescence quantitative pcr was used to detect the mrna expression levels of phosphatase and tensin homolog deleted on chromosome ten (pten) -induced putative kinase 1 (pink1), parkin and nlrp3; western blot analysis was used to detect the expression of pink1, parkin, p62, microtubule-associated protein 1 light chain 3 (lc3), nlrp3, adapter protein apoptosis-associated speck-like protein (asc) and interleukin-18 (il-18). |
2024-08-31 |
2024-09-04 |
mouse |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
set8 inhibition preserves pten to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
here we showed that set8 and h4k20me1 were upregulated in the murine kidney with aki induced by cisplatin, along with increased renal tubular cell injury and apoptosis and decreased expression of e-cadherin and phosphatase and tensin homolog (pten). |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
consistently, inhibition of set8 with either unc0379 or sirna mitigated apoptosis and ddr, and restored autophagy, along with pten preservation in cultured renal proximal tubular epithelial cell (tkpts) exposed to cisplatin. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
further studies showed that inhibition of pten with bpv or sirna potentiated cisplatin-induced apoptosis, ddr, and hindered autophagy, and conversely, alleviated by overexpression of pten in tkpts. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
finally, blocking pten largely abolished the inhibitory effect of unc0379 on apoptosis. |
2024-08-26 |
2024-08-28 |
Not clear |
| Shougang Zhuang, Xu Yang, Yingjie Guan, George Bayliss, Ting C Zha. SET8 inhibition preserves PTEN to attenuate kidney cell apoptosis in cisplatin nephrotoxicity. Research square. 2024-08-26. PMID:39184108. |
taken together, these results suggest that set8 inhibition protects against cisplatin-induced aki and renal cell apoptosis through a mechanism associated with the preservation of pten, which in turn inhibits ddr and restores autophagy. |
2024-08-26 |
2024-08-28 |
Not clear |
| Ziqiang Lin, Suo Wang, Yu Cao, Jialing Lin, Ailing Sun, Wei Huang, Jun Zhou, Qingxiong Hon. Bioinformatics and Validation Reveal the Potential Target of Curcumin in the Treatment of Diabetic Peripheral Neuropathy. Neuropharmacology. 2024-08-23. PMID:39179172. |
subsequently, qrt-pcr, mtt assay, flow cytometry, caspase-3 activity detection and westernblot showed that curcumin treatment increased rsc96 cell viability, reduced cell apoptosis, increased hmox1, pten, vegfa and myc expression, and up-regulated akt phosphorylation level under high glucose environment. |
2024-08-23 |
2024-08-27 |
rat |
| Le Sun, Jishang Sun, Cuiyao Li, Keying Wu, Zhiyang Gu, Lan Guo, Yi Zhou, Baoqin Han, Jing Chan. STAT3-specific nanocarrier for shRNA/drug dual delivery and tumor synergistic therapy. Bioactive materials. vol 41. 2024-08-12. PMID:39131627. |
the co-delivery and synergistic effect of dox and pdna could up-regulate the expression of pten (phosphatase and tensin homolog), down-regulate the expression of cd31, and induce apoptosis of tumor cells. |
2024-08-12 |
2024-08-14 |
Not clear |
| Yuan Tian, Yi-Fan Liu, Yan-Yue Wang, Yong-Zhen Li, Wen-Yan Ding, Chi Zhan. Molecular mechanisms of PTEN in atherosclerosis: A comprehensive review. European journal of pharmacology. 2024-08-02. PMID:39094923. |
this article reviews the role of pten in atherosclerosis from the perspectives of autophagy, apoptosis, inflammation, proliferation, and angiogenesis. |
2024-08-02 |
2024-08-06 |
Not clear |
| Nicole Oatman, Mruniya V Gawali, Sunny Congrove, Roman Caceres, Abitha Sukumaran, Nishtha Gupta, Narmadha Murugesan, Priyanka Arora, Sri Vidhya Subramanian, Kwangmin Choi, Zalfa Abdel-Malek, Julie A Reisz, Daniel Stephenson, Ravi Amaravadi, Pankaj Desai, Angelo D'Alessandro, Kakajan Komurov, Biplab Dasgupt. A multimodal drug-diet-immunotherapy combination restrains melanoma progression and metastasis. Cancer research. 2024-06-17. PMID:38885087. |
the combination reduced monounsaturated fatty acids and increased saturated fatty acids, inducing robust apoptosis and growth suppression and inhibiting lung metastasis with minimal toxicity in preclinical mouse models of pten wildtype melanoma. |
2024-06-17 |
2024-06-21 |
mouse |
| Peng Sun, Kang Huo, Fude Liu, Yawen Cheng, Chen Chen, Jianfeng Han, Jia Y. Regulation and molecular mechanism of adiponectin on the proliferation, apoptosis, autophagy, and chemosensitivity of LN18 Glioma cell line. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836664. |
moreover, adiponectin inhibits the proliferation rate of the pten wild-type glioma cell line ln18, enhances the expression of cleaved caspase3 and bax, and significantly elevates the apoptosis rate, as evidenced by annexinv/pi flow cytometry. |
2024-06-05 |
2024-06-07 |
Not clear |
| Fatemeh Sadat Hosseini, Abdolreza Ahmadi, Prashant Kesharwani, Hossein Hosseini, Amirhossein Sahebka. Regulatory effects of statins on Akt signaling for prevention of cancers. Cellular signalling. vol 120. 2024-05-11. PMID:38729324. |
akt signaling plays a crucial role in key cancer cell features like proliferation, invasion, and apoptosis by activating multiple effectors in downstream pathways such as foxo, pten, nf-κb, gsk3β, and mtor. |
2024-05-11 |
2024-05-27 |
Not clear |
| Guoxin Liang, Chang Guo, Hongyue Tang, Mingming Zhan. miR-30a-5p attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by regulating PTEN protein expression and activating PI3K/Akt signaling pathway. BMC cardiovascular disorders. vol 24. issue 1. 2024-05-05. PMID:38705985. |
mir-30a-5p attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by regulating pten protein expression and activating pi3k/akt signaling pathway. |
2024-05-05 |
2024-05-08 |
Not clear |
| Pan Zhou, Xingwen Meng, Zhimin Nie, Hua Wang, Kaijun Wang, Aihua Du, Yu Le. PTEN: an emerging target in rheumatoid arthritis? Cell communication and signaling : CCS. vol 22. issue 1. 2024-04-27. PMID:38671436. |
phosphatase and tensin homolog deleted on chromosome 10 (pten) is a critical tumor suppressor protein that regulates various biological processes such as cell proliferation, apoptosis, and inflammatory responses by controlling the phosphatidylinositol 3-kinase (pi3k)/protein kinase b (pi3k/akt) signaling pathway. |
2024-04-27 |
2024-04-29 |
Not clear |
| Lin Ding, Ruo-Yu Wang, Fan Zhang, Meng-Si Wu, Bin Chen, Ke-Wei Su. [Bupleuri Radix-Paeoniae Radix Alba medicated plasma exerts effects on HepG2 hepatoma cells by regulating miR-1297/PTEN signaling axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 49. issue 4. 2024-04-15. PMID:38621914. |
in conclusion, bupleuri radix-paeoniae radix alba medicated plasma can inhibit the expression of mir-1297 in hepg2 hepatoma cells, promote the expression of pten, and negatively regulate pi3k/akt signaling pathway, thereby inhibiting the proliferation and inducing the apoptosis of hepg2 cells. |
2024-04-15 |
2024-04-18 |
Not clear |
| Jia-Yuan Zhang, Szu-Kai Fu, Hsia-Ling Tai, Kuo-Wei Tseng, Chia-Yu Tang, Chia-Hsien Yu, Chang-Chi La. A Comparative Study: Cardioprotective Effects of High-Intensity Interval Training Versus Ischaemic Preconditioning in Rat Myocardial Ischaemia-Reperfusion. Life (Basel, Switzerland). vol 14. issue 3. 2024-03-28. PMID:38541636. |
furthermore, the expression of pro-apoptotic proteins pten, caspase-3, tnf-α, and bax in the myocardium was reduced, and the expression of anti-apoptotic b-cell lymphoma 2 (bcl-2) was increased, ultimately reducing cellular apoptosis in the myocardium. |
2024-03-28 |
2024-03-30 |
rat |
| Fang Fang, Xiaoyan Zhang, Yun Fan. Diosgenin inhibits proliferation and migration of ovarian cancer cells and induce apoptosis via upregulation of PTEN. Chemical biology & drug design. vol 103. issue 3. 2024-03-27. PMID:38538058. |
diosgenin inhibits proliferation and migration of ovarian cancer cells and induce apoptosis via upregulation of pten. |
2024-03-27 |
2024-03-30 |
Not clear |
| Kai Zhu, Yan Zhang, DongDong Li, MingZhong Xie, HuaCai Jiang, KaiQuan Zhang, Yang Lei, GuangYou Che. MiR-29a-3p mediates phosphatase and tensin homolog and inhibits osteoarthritis progression. Functional & integrative genomics. vol 24. issue 2. 2024-03-12. PMID:38467932. |
mir-29a-3p can stimulate chondrocyte proliferation and inhibit apoptosis by inhibiting pten expression. |
2024-03-12 |
2024-03-14 |
human |