| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yolanda M B Marcello, Daner A Silveira, Shantanu Gupta, José Carlos M Mombac. PTEN expression can be used as a switch between senescence and apoptosis in breast cancer cells according to a logical model of the G2/M checkpoint. Bio Systems. 2023-12-08. PMID:38065398. |
we show that pics is induced by the activity of the positive feedback between akt and mtorc2, and that overexpression of pten will disrupt the feedback, abrogating senescence and only leading to arrest or apoptosis. |
2023-12-08 |
2023-12-17 |
Not clear |
| Mohammad Yasin Zamanian, Mehraveh Sadeghi Ivraghi, Reena Gupta, K D V Prasad, Hashem O Alsaab, Beneen M Hussien, Hazem Ahmed, Montather F Ramadan, Maryam Golmohammadi, Nikta Nikbakht, Tuba Oz, Małgorzata Kujawsk. miR-221 and Parkinson's disease: A biomarker with therapeutic potential. The European journal of neuroscience. 2023-12-03. PMID:38043936. |
according to the results of these studies, (1) mir-221 protects pc12 cells against oxidative stress induced by 6-hydroxydopamine; (2) mir-221 prevents bax/caspase-3 signalling activation by stopping bim; (3) mir-221 has moderate predictive power for pd; (4) mir-221 directly targets pten, and pten over-expression eliminates the protective action of mir-221 on p-akt expression in pc12 cells; and (5) mirna-221 controls cell viability and apoptosis by manipulating the akt signalling pathway in pd. |
2023-12-03 |
2023-12-10 |
Not clear |
| Chengfang Hu, Xiyu Zhao, Can Cui, Yao Zhang, Qing Zhu, Huadong Yin, Shunshun Ha. miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway. Theriogenology. vol 214. 2023-10-25. PMID:37879287. |
unlike mir-29-3p, pten appeared to foster autophagy and apoptosis in chicken granulosa cells. |
2023-10-25 |
2023-11-08 |
chicken |
| Chengfang Hu, Xiyu Zhao, Can Cui, Yao Zhang, Qing Zhu, Huadong Yin, Shunshun Ha. miRNA-29-3p targets PTEN to regulate follicular development through the PI3K/Akt/mTOR signaling pathway. Theriogenology. vol 214. 2023-10-25. PMID:37879287. |
in conclusion, the findings of this study suggest that mir-29-3p, through its targeting of pten via the akt/mtor signaling pathway, exerts inhibitory effects on autophagy and apoptosis. |
2023-10-25 |
2023-11-08 |
chicken |
| Computational And Mathematical Methods In Medicin. Retracted: lncRNA NBAT1 Inhibits Cell Metastasis and Promotes Apoptosis in Endometrial Cancer by Sponging miR-21-5p to Regulate PTEN. Computational and mathematical methods in medicine. vol 2023. 2023-10-06. PMID:37799419. |
retracted: lncrna nbat1 inhibits cell metastasis and promotes apoptosis in endometrial cancer by sponging mir-21-5p to regulate pten. |
2023-10-06 |
2023-10-07 |
Not clear |
| I V Arutyunyan, A G Soboleva, E A Kovtunov, A M Kosyreva, V V Kudelkina, A I Alekseeva, A V Elchaninov, E D Jumaniyazova, D V Goldshtein, G B Bolshakova, T Kh Fatkhudino. Gene Expression Profile of 3D Spheroids in Comparison with 2D Cell Cultures and Tissue Strains of Diffuse High-Grade Gliomas. Bulletin of experimental biology and medicine. 2023-09-28. PMID:37770789. |
using real time pcr, we evaluated the expression of gfap, cd44, pten, s100b, vegfa, hif1a, sox2, melk, gdnf, and mgmt genes playing an important role in the progression of gliomas and regulating tumor cell proliferation, adhesion, invasion, plasticity, apoptosis, dna repair, and recruitment of tumor-associated cells. |
2023-09-28 |
2023-10-07 |
Not clear |
| Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Don. Simulated weightlessness induces hippocampal insulin resistance and cognitive impairment. Life sciences. 2023-09-27. PMID:37758017. |
these data suggest that long-term simulated weightlessness induces cognitive impairment as well as neuronal apoptosis and neural degeneration, partially through hippocampal insulin resistance via pten up-regulation. |
2023-09-27 |
2023-10-07 |
rat |
| Sa-Yoon Park, Kang-Sub Kim, Won-Yung Lee, Chang-Eop Kim, Sullim Le. Integrative Approach to Identifying System-Level Mechanisms of Chung-Sang-Bo-Ha-Hwan's Influence on Respiratory Tract Diseases: A Network Pharmacological Analysis with Experimental Validation. Plants (Basel, Switzerland). vol 12. issue 17. 2023-09-09. PMID:37687271. |
experimental validation was conducted using phorbol-12-myristate-13-acetate (pma)-stimulated nci-h292 cells by analyzing the mrna expression levels of biomarkers (il-1β and tnf-α for inflammation; gstp1, gstm1, and pten for apoptosis) derived from network pharmacological analysis, in addition to the mucin genes muc5ac and muc2, to investigate the phlegm-expelling effect of csbhh. |
2023-09-09 |
2023-10-07 |
Not clear |
| El-Habib Dakir, Consuelo Gajate, Faustino Mollined. Antitumor activity of alkylphospholipid edelfosine in prostate cancer models and endoplasmic reticulum targeting. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 167. 2023-09-08. PMID:37683591. |
here, we found that edelfosine was the most potent alkylphospholipid analog in inducing apoptosis in three different human prostate cancer cell lines (lncap, pc3, and du145) with distinct androgen dependency, and differing in tumor suppressor phosphatase and tensin homolog (pten) and p53 status. |
2023-09-08 |
2023-10-07 |
mouse |
| Shrabastee Chakraborty, Subhajit Karmakar, Malini Basu, Satadeepa Kal, Mrinal K Ghos. E3 Ubiquitin Ligase CHIP Drives Monoubiquitination-mediated Nuclear Import of Tumor Suppressor PTEN. Journal of cell science. 2023-09-07. PMID:37676120. |
finally, we showed that oxidative stress enhanced chip-mediated nuclear import of pten, which resulted in increased apoptosis, and decreased cell viability and proliferation, whereas chip knockdown counteracted these effects. |
2023-09-07 |
2023-10-07 |
Not clear |
| Chunguang Sun, Lin Lia. Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity of Shikonin. Current molecular pharmacology. 2023-09-06. PMID:37670707. |
antithyroid cancer studies of shikonin discovered that it inhibited thyroid cancer cell migration and invasion by suppressing the epithelial-mesenchymal transition; induced cell cycle arrest; induced dna damage and apoptosis by producing excessive reactive oxygen species; upregulated bax; increased the stability of p53; decreased the expression of mdm2; downregulated slug and mmp-2, mmp-9, and mmp-14; repressed the phosphorylation of erk and akt; activated the p16/retinoblastoma protein pathway, leading to apoptosis; suppressed the expression of dnmt1; reduced the pten gene methylation; increased the expression of pten, leading to the inhibition of migration; increased lc3-ii to induce autophagy and apoptosis of medullary thyroid carcinoma; and upregulated βii-tubulin in the cell to produce less resistance to cisplatin and paclitaxel, without cross-resistance to other anticancer agents. |
2023-09-06 |
2023-10-07 |
mouse |
| Emanuele Fosso, Manuela Leo, Livio Muccillo, Vittorio Maria Mandrone, Maria Chiara Di Meo, Annamaria Molinario, Ettore Varricchio, Lina Sabatin. Quercetin's Dual Mode of Action to Counteract the Sp1-miR-27a Axis in Colorectal Cancer Cells. Antioxidants (Basel, Switzerland). vol 12. issue 8. 2023-08-26. PMID:37627542. |
here, we show that qc reduces cell viability and induces apoptosis in hct116 and ht-29 colon cancer cells, by upregulating negative modulators of proliferation pathways such as sprouty2, pten and sfrp1. |
2023-08-26 |
2023-09-07 |
Not clear |
| Zaid Sirhan, Rawan Alojair, Anita Thyagarajan, Ravi P Sah. Therapeutic Implications of PTEN in Non-Small Cell Lung Cancer. Pharmaceutics. vol 15. issue 8. 2023-08-26. PMID:37631304. |
among tumor suppressor genes that play critical roles in regulating cancer growth, the phosphatase and tensin homolog (pten) constitutes one of the important family members implicated in controlling various functional activities of tumor cells, including cell proliferation, apoptosis, angiogenesis, and metastasis. |
2023-08-26 |
2023-09-07 |
human |
| Zhongkang Li, Yibin Liu, Yanpeng Tian, Qian Li, Wenxin Shi, Jingkun Zhang, Huihui Zhang, Yi Tan, Shuangshuang Yang, Tao Yang, Xianghua Huang, Yanfang D. Human umbilical cord mesenchymal stem cell‑derived exosomes improve ovarian function in natural aging by inhibiting apoptosis. International journal of molecular medicine. vol 52. issue 4. 2023-08-24. PMID:37615174. |
these exosomes were found to exhibit the ability to inhibit pten expression and suppress apoptosis both |
2023-08-24 |
2023-09-07 |
mouse |
| Hongnan Li, Weidong Lin, Guangzhi Zhang, Runsheng Liu, Minghai Qu, Jiayang Zhang, Xuekun Xin. BMSC-exosomes miR-25-3p Regulates the p53 Signaling Pathway Through PTEN to Inhibit Cell Apoptosis and Ameliorate Liver Ischemia‒reperfusion Injury. Stem cell reviews and reports. 2023-08-18. PMID:37594613. |
bmsc-exosomes mir-25-3p regulates the p53 signaling pathway through pten to inhibit cell apoptosis and ameliorate liver ischemia‒reperfusion injury. |
2023-08-18 |
2023-09-07 |
Not clear |
| Haixin He, Cuibo Lin, Yongwei Lu, Hongqing W. Knockdown of miR-24 Suppressed the Tumor Growth of Cervical Carcinoma Through Regulating PTEN/PI3K/AKT Signaling Pathway. Biochemical genetics. 2023-08-17. PMID:37589947. |
knockdown of pten significantly reversed the effects of mir-24 inhibitor on cell proliferation, invasion, migration, and apoptosis of cc cells. |
2023-08-17 |
2023-09-07 |
mouse |
| Brian J Engel, Vincenzo Paolillo, Md Nasir Uddin, Kristyn A Gonzales, Kathryn M McGinnis, Margie N Sutton, Madhavi Patnana, Brian J Grindel, Gregory J Gores, David Piwnica-Worms, Laura Beretta, Federica Pisaneschi, Seth T Gammon, Steven W Millwar. Gender Differences in a Mouse Model of Hepatocellular Carcinoma Revealed Using Multi-Modal Imaging. Cancers. vol 15. issue 15. 2023-08-12. PMID:37568603. |
we have carried out longitudinal imaging studies on the liver-specific pten knockout mouse model using ct, mri, and multi-tracer pet to interrogate liver size, steatosis, inflammation, and apoptosis. |
2023-08-12 |
2023-08-16 |
mouse |
| You-Cheng Liao, Tzu-Chun Cheng, Shih-Hsin Tu, Jungshan Chang, Peixuan Guo, Li-Ching Chen, Yuan-Soon H. Tumor targeting and therapeutic assessments of RNA nanoparticles carrying α9-nAChR aptamer and anti-miR-21 in triple-negative breast cancers. Molecular therapy. Nucleic acids. vol 33. 2023-08-07. PMID:37547295. |
moreover, 3wj-b-α9-nachr-aptamer rna nanoparticles carrying anti-mir-21 (3wj-b-α9-apt-anti-mir-21) significantly suppressed tnbc-pdx tumor growth and induced cell apoptosis because of reduced mir-21 gene expression and upregulated the phosphatase and tensin homolog (pten) and programmed cell death 4 (pdcd4) proteins. |
2023-08-07 |
2023-08-14 |
mouse |
| Delong Meng, Xin Zhao, Yu Chi Yang, Albertas Navickas, Ciara Helland, Hani Goodarzi, Mallika Singh, Sourav Bandyopadhya. A bi-steric mTORC1-selective inhibitor overcomes drug resistance in breast cancer. Oncogene. 2023-06-01. PMID:37264081. |
complete suppression of mtorc1 by rmc-6272 causes apoptosis in er+/her2- breast cancer cell lines, particularly in those that harbor mutations in pik3ca or pten, due to inhibition of the rapamycin resistant, mtorc1 substrate 4ebp1 and reduction of the pro-survival protein mcl1. |
2023-06-01 |
2023-08-14 |
Not clear |
| Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fa. USP22 knockdown protects against cerebral ischemia/reperfusion injury via destabilizing PTEN protein and activating the mTOR/TFEB pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023-05-16. PMID:37191727. |
pten overexpression reversed the promoting effect of usp22 knockdown on cell viability and the inhibitory effects of usp22 knockdown on apoptosis, oxidative stress, and ldh release rate in pc12 cells subjected to ogd/r. |
2023-05-16 |
2023-08-14 |
mouse |