| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
the roles of circ_pola2 and pten in regulating gbm cell apoptosis were explored using cell apoptosis assay. |
2023-02-02 |
2023-08-14 |
Not clear |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
moreover, pten reduced the inhibitory effects of circ_pola2 on gbm cell apoptosis. |
2023-02-02 |
2023-08-14 |
Not clear |
| Fangmin Xie, Yuanyuan Cheng, Xin Gao, Sixin Song, Xu Zhao, Xianbing Meng, Zhende Shang, Mingfeng Yan. CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma. Anti-cancer drugs. 2023-02-02. PMID:36730613. |
circ_pola2 is overexpressed in mcl and might promote gbm cell apoptosis through downregulating pten. |
2023-02-02 |
2023-08-14 |
Not clear |
| Hui Wang, HaiTang Re. Circular RNA SMARCA5 Modulates Epithelial-Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA-582-3p/Phosphatase and Tensin Homolog Axis. Evidence-based complementary and alternative medicine : eCAM. vol 2023. 2023-01-23. PMID:36686977. |
the action mechanism in which circular rna (circ) smarca5 targeted nasopharyngeal carcinoma (npc) cell proliferation, migration, invasion, and apoptosis via microrna (mir)-582-3p/phosphatase and tensin homolog (pten) axis was explored. |
2023-01-23 |
2023-08-14 |
Not clear |
| Peyman Amini, Reza Moazamiyanfar, Mohammad Sedigh Dakkali, Emad Jafarzadeh, Maryam Ganjizadeh, Nima Rastegar-Pouyani, Kave Mouludi, Ehsan Khodamoradi, Shahram Taeb, Masoud Najaf. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. Mini reviews in medicinal chemistry. 2023-01-20. PMID:36658710. |
it seems that apigenin enhances apoptosis by inducing anticancer immunity and tumor suppressor genes, like p53 and pten, and also by inhibiting stat3 and nf-κb signaling pathways. |
2023-01-20 |
2023-08-14 |
Not clear |
| Buket Altinok Gunes, Yalda Hekmatshoar, Tulin Ozkan, Sureyya Bozkurt, O Sena Erdogan Aydos, Yahya Buyukasik, Elifcan Aladag, Asuman Sungurogl. Downregulation of Stearoyl-CoA Desaturase 1 (SCD-1) Promotes Resistance to Imatinib in Chronic Myeloid Leukemia. Mediterranean journal of hematology and infectious diseases. vol 15. issue 1. 2023-01-20. PMID:36660357. |
moreover, we analyzed the mrna expression levels of genes responsible for apoptosis, such as bcl-2, p53, and other genes (scd-1, pten). |
2023-01-20 |
2023-08-14 |
Not clear |
| Yueli Zhang, Xinchun Wang, Shuyun Wang, Jia Liu, Ruijia Li, Xiaoxia Li, Rui Zhan. Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway. Journal of biochemical and molecular toxicology. 2023-01-14. PMID:36639866. |
in addition, phosphatase and tensin homolog (pten) was verified as mir-181a-5p's downstream target, circ-erbb2 activates the akt pathway and inhibits cell apoptosis through modulating mir-181a-5p/pten. |
2023-01-14 |
2023-08-14 |
Not clear |
| b' H Gbelcov\\xc3\\xa1, L Gergely, V \\xc5\\xa0i\\xc5\\xa1ovsk\\xc3\\xbd, \\xc4\\xbd Straka, D B\\xc3\\xb6hmer, A Pastor\\xc3\\xa1kov\\xc3\\xa1, K Su\\xc5\\xa1ienkov\\xc3\\xa1, V Repisk\\xc3\\xa1, M Korbe\\xc4\\xbe, \\xc4\\xbd Danihel, P Pri\\xc5\\xa1\\xc4\\x8d\\xc3\\xa1kov\\xc3\\xa. PTEN mutations as predictive marker for the high-grade endometrial cancer development in slovak women. Physiological research. vol 71. issue Suppl 1. 2023-01-02. PMID:36592448.' |
pten encodes a phosphatase, a key regulatory enzyme involved in a signal transduction pathway that regulates cell growth, migration and apoptosis. |
2023-01-02 |
2023-08-14 |
human |
| Bei Yu, Yuan Huang, Yue Yang, Haifeng Hu, Jin Yan. Effect of CTP-mediated PTEN on 5637 bladder cancer cells and the underlying molecular mechanism. BMC urology. vol 22. issue 1. 2022-12-10. PMID:36496361. |
the aim of the present study was to explore the effect of cytoplasmic transduction peptide (ctp)-phosphatase and tensin homolog (pten) on the proliferation, cell cycle, apoptosis, migration and invasion of bladder cancer cells and the underlying molecular mechanism. |
2022-12-10 |
2023-08-14 |
Not clear |
| Fatemeh Yarmohammadi, Zainab Ebrahimian, Gholamreza Karim. MicroRNAs target the PI3K/Akt/p53 and the Sirt1/Nrf2 signaling pathways in doxorubicin-induced cardiotoxicity. Journal of biochemical and molecular toxicology. 2022-11-23. PMID:36416353. |
studies have demonstrated that mirnas by modifying the expression of proteins such as pten, akt, and survivin can affect dox-induced cardiac apoptosis. |
2022-11-23 |
2023-08-14 |
Not clear |
| Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Su. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN. The Kaohsiung journal of medical sciences. 2022-11-11. PMID:36367154. |
alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the m1/m2 polarization of tumor-associated macrophages by upregulating pten. |
2022-11-11 |
2023-08-14 |
mouse |
| Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Su. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN. The Kaohsiung journal of medical sciences. 2022-11-11. PMID:36367154. |
downregulation of pten reversed the effects of alkannin on apoptosis of cscc cells and m1/m2 polarization of macrophages. |
2022-11-11 |
2023-08-14 |
mouse |
| Zhong-Zhao Zhang, Chang-Hui Wen, Min Jia, Hong-Qiang Zhang, Shao-Qin Su. Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor-associated macrophages by upregulating PTEN. The Kaohsiung journal of medical sciences. 2022-11-11. PMID:36367154. |
in conclusion, alkannin curbed the advancement of cscc by expediting apoptosis and facilitating m1 polarization of macrophages by upregulating pten. |
2022-11-11 |
2023-08-14 |
mouse |
| Mahtab Yadollahi-Farsani, Zeinab Amini-Farsani, Fatemeh Moayedi, Niusha Khazaei, Hajar Yaghoob. MiR-548k suppresses apoptosis in breast cancer cells by affecting PTEN/PI3K/AKT signaling pathway. IUBMB life. 2022-10-30. PMID:36309967. |
in brief, suppression of pten partly mediated by mir-548k diminished apoptosis and promoted cell proliferation through pi3k/akt pathway in breast cancer, suggesting a novel therapeutic axis, mir-548k/pten/ pi3k/akt, for treatment of breast cancer in the future. |
2022-10-30 |
2023-08-14 |
Not clear |
| Yuan Cheng, Qing He, Na Li, Mengdi Lu. Activation of PTEN/P13K/AKT Signaling Pathway by miRNA-124-3p-Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury. Oxidative medicine and cellular longevity. vol 2022. 2022-10-21. PMID:36267811. |
the expression of cleaved caspase 3 and the apoptosis rate in the nano-mir-124-3p and pten cotransfection group was also significantly increased. |
2022-10-21 |
2023-08-14 |
rat |
| Xiaohong Li, Peng An, Fang Han, Meihong Yu, Zhenfei Yu, Ying L. Silencing of YTHDF1 Attenuates Cerebral Stroke by Inducing PTEN Degradation and Activating the PTEN/AKT/mTOR Pathway. Molecular biotechnology. 2022-10-19. PMID:36261761. |
overexpressing pten rescued the effects of ythdf1 depletion on cell viability and apoptosis. |
2022-10-19 |
2023-08-14 |
mouse |
| Maheshkumar Kannan, Sridharan Jayamohan, Rajesh Kannan Moorthy, Siva Chander Chabattula, Mathan Ganeshan, Antony Joseph Velanganni Arockia. Dysregulation of miRISC Regulatory Network Promotes Hepatocellular Carcinoma by Targeting PI3K/Akt Signaling Pathway. International journal of molecular sciences. vol 23. issue 19. 2022-10-14. PMID:36232606. |
the mir-221/aeg-1 axis silencing induces apoptosis and g2/m phase arrest and inhibits cellular proliferation and angiogenesis by upregulating p57, p53, rb, and pten and downregulating lsf, lc3a, bcl-2, opn, mmp9, pi3k, and akt in hcc cells. |
2022-10-14 |
2023-08-14 |
Not clear |
| Sara Julietta Lozano-Herrera, Gabriel Luna-Bárcenas, Ramón Gerardo Guevara-González, Rocio Campos-Vega, Juan Carlos Solís-Sáinz, Ana Gabriela Hernández-Puga, Haydé Azeneth Vergara-Castañed. Fermentation Extract of Naringenin Increases the Expression of Estrogenic Receptor β and Modulates Genes Related to the p53 Signalling Pathway, miR-200c and miR-141 in Human Colon Cancer Cells Exposed to BPA. Molecules (Basel, Switzerland). vol 27. issue 19. 2022-10-14. PMID:36235125. |
as an important result, naringenin (ic50 250 µm) and fen (ic50 37%) promoted intrinsic pathways of apoptosis through phosphatase and tensin homolog (pten) (+2.70, +1.72-fold, respectively) and casp9 (+3.99, +2.03-fold, respectively) expression. |
2022-10-14 |
2023-08-14 |
human |
| Chengpeng Yu, Dean Rao, Tiantian Wang, Jia Song, Lei Zhang, Wenjie Huan. Emerging roles of TRIM27 in cancer and other human diseases. Frontiers in cell and developmental biology. vol 10. 2022-10-06. PMID:36200036. |
its ubiquitination targets include pten, iκbα and p53, which allows it to regulate many signaling pathways to exert its functions under both physiological and pathological conditions, such as cell proliferation, differentiation and apoptosis. |
2022-10-06 |
2023-08-14 |
human |
| Junbin Wang, Xinyi Lai, Xuxing Pen. CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression. Biochemical genetics. 2022-09-14. PMID:36104590. |
importantly, overexpression of circlifr impeded cell proliferation, migration, invasion, and inactivated protein kinase b (akt)/phosphatase and tensin homolog (pten)-signaling pathways while enhanced apoptosis and cell-cycle arrest in nsclc cells, which was overturned by upregulation of mir-429 or silencing of celf2. |
2022-09-14 |
2023-08-14 |
human |