| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kyrylenko, M Roschier, P Korhonen, A Salmine. Regulation of PTEN expression in neuronal apoptosis. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581415. |
regulation of pten expression in neuronal apoptosis. |
2000-02-14 |
2023-08-12 |
Not clear |
| S Kyrylenko, M Roschier, P Korhonen, A Salmine. Regulation of PTEN expression in neuronal apoptosis. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581415. |
on the contrary, okadaic acid and etoposide only slightly affected the expression of pten although they induce a prominent apoptosis in neuro-2a cells. |
2000-02-14 |
2023-08-12 |
Not clear |
| S Kyrylenko, M Roschier, P Korhonen, A Salmine. Regulation of PTEN expression in neuronal apoptosis. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581415. |
the early response in pten mrna expression disappeared in 5.5-kb transcripts already at 12 h and in the case of 2.5-kb transcripts it lasted up to 24 h. potassium deprivation, known to induce apoptosis in cerebellar granule cells, did not affect pten mrna expression but together with serum deprivation induced a clear decrease in the 5. |
2000-02-14 |
2023-08-12 |
Not clear |
| S Kyrylenko, M Roschier, P Korhonen, A Salmine. Regulation of PTEN expression in neuronal apoptosis. Brain research. Molecular brain research. vol 73. issue 1-2. 2000-02-14. PMID:10581415. |
it seems that the changes in pten expression level and neuronal apoptosis are not related to each other in general but the expression of pten phosphatase seems to regulate certain apoptotic signals affecting phosphoinositide 3-kinase function. |
2000-02-14 |
2023-08-12 |
Not clear |
| H Huang, C J Potter, W Tao, D M Li, W Brogiolo, E Hafen, H Sun, T X. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development (Cambridge, England). vol 126. issue 23. 2000-01-06. PMID:10556061. |
pten affects cell size, cell proliferation and apoptosis during drosophila eye development. |
2000-01-06 |
2023-08-12 |
mouse |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
in the presence of low concentrations of serum, enforced pten expression results in a marked increase in cellular apoptosis, a finding which is consistent with the capacity of pten to alter the phosphorylation, and presumably function, of the akt, bad, p70s6 kinase and gsk3 alpha apoptosis regulators. |
2000-01-04 |
2023-08-12 |
Not clear |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
under anchorage-independent conditions, pten also induces anoikis, a form of apoptosis that occurs when cells are dissociated from the extracellular matrix, which is enhanced in conjunction with low serum culture conditions. |
2000-01-04 |
2023-08-12 |
Not clear |
| Y Lu, Y Z Lin, R LaPushin, B Cuevas, X Fang, S X Yu, M A Davies, H Khan, T Furui, M Mao, R Zinner, M C Hung, P Steck, K Siminovitch, G B Mill. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. vol 18. issue 50. 2000-01-04. PMID:10597304. |
together, these data suggest that pten effects on the pi3k signaling cascade are influenced by the cell stimulatory context, and that depending on the exposure to growth factors and other exogenous stimuli such as integrin ligation, pten can induce cell cycle arrest, apoptosis or anoikis in breast cancer cells. |
2000-01-04 |
2023-08-12 |
Not clear |
| A Sakurada, H Hamada, S Fukushige, T Yokoyama, K Yoshinaga, T Furukawa, S Sato, A Yajima, M Sato, S Fujimura, A Hori. Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer. International journal of oncology. vol 15. issue 6. 1999-12-27. PMID:10568810. |
adenovirus-mediated delivery of the pten gene inhibits cell growth by induction of apoptosis in endometrial cancer. |
1999-12-27 |
2023-08-12 |
Not clear |
| A Sakurada, H Hamada, S Fukushige, T Yokoyama, K Yoshinaga, T Furukawa, S Sato, A Yajima, M Sato, S Fujimura, A Hori. Adenovirus-mediated delivery of the PTEN gene inhibits cell growth by induction of apoptosis in endometrial cancer. International journal of oncology. vol 15. issue 6. 1999-12-27. PMID:10568810. |
the pten transgene significantly suppressed cell growth in vitro through induction of apoptosis in cells lacking wild-type pten. |
1999-12-27 |
2023-08-12 |
Not clear |
| M Tamura, J Gu, H Tran, K M Yamad. PTEN gene and integrin signaling in cancer. Journal of the National Cancer Institute. vol 91. issue 21. 1999-11-30. PMID:10547389. |
in the absence of pten, this lipid signal transduction pathway can protect tumor cells from apoptosis. |
1999-11-30 |
2023-08-12 |
human |
| M Tamura, J Gu, H Tran, K M Yamad. PTEN gene and integrin signaling in cancer. Journal of the National Cancer Institute. vol 91. issue 21. 1999-11-30. PMID:10547389. |
thus, pten appears to be a unique tumor suppressor-with both lipid phosphatase and protein tyrosine phosphatase activities-that negatively regulates cell interactions with the extracellular matrix and that maintains cell sensitivity to apoptosis, e.g., after loss of cell contact with the extracellular matrix. |
1999-11-30 |
2023-08-12 |
human |
| A Di Cristofano, P Kotsi, Y F Peng, C Cordon-Cardo, K B Elkon, P P Pandolf. Impaired Fas response and autoimmunity in Pten+/- mice. Science (New York, N.Y.). vol 285. issue 5436. 1999-10-12. PMID:10497129. |
these results indicate that pten is an essential mediator of the fas response and a repressor of autoimmunity and thus implicate the pi 3-kinase/akt pathway in fas-mediated apoptosis. |
1999-10-12 |
2023-08-12 |
mouse |
| M Tamura, J Gu, E H Danen, T Takino, S Miyamoto, K M Yamad. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400703. |
pten-mutated cells were resistant to apoptosis in suspension, but most of the cells entered apoptosis after expression of exogenous pten or wortmannin treatment. |
1999-08-19 |
2023-08-12 |
Not clear |
| W Wick, F B Furnari, U Naumann, W K Cavenee, M Welle. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435616. |
pten gene transfer in human malignant glioma: sensitization to irradiation and cd95l-induced apoptosis. |
1999-08-17 |
2023-08-12 |
human |
| W Wick, F B Furnari, U Naumann, W K Cavenee, M Welle. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435616. |
in contrast, ectopic expression of wild type pten, but not the pten(g129r) mutant, in pten-mutant gliomas markedly sensitizes these cells to irradiation and to cd95-ligand (cd95l)-induced apoptosis. |
1999-08-17 |
2023-08-12 |
human |
| W Wick, F B Furnari, U Naumann, W K Cavenee, M Welle. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435616. |
thus, pten may sensitize human malignant glioma cells to cd95l-induced apoptosis in a pi 3 kinase-dependent manner that may not require pkb phosphorylation. |
1999-08-17 |
2023-08-12 |
human |
| M A Davies, D Koul, H Dhesi, R Berman, T J McDonnell, D McConkey, W K Yung, P A Stec. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer research. vol 59. issue 11. 1999-06-29. PMID:10363971. |
overexpression of bcl-2 in lncap cells blocked mmac/pten- and p53-induced apoptosis but not the growth-suppressive effects of mmac/ pten, suggesting that the growth regulatory effects of mmac/pten involve multiple pathways. |
1999-06-29 |
2023-08-12 |
Not clear |
| X X Tian, J C Pang, S S To, H K N. Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331435. |
restoration of wild-type pten expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. |
1999-05-27 |
2023-08-12 |
human |
| X X Tian, J C Pang, S S To, H K N. Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331435. |
taken together, these results suggest that pten plays an important role in regulation of cell homeostasis by maintaining a balance between proliferation, differentiation, and apoptosis. |
1999-05-27 |
2023-08-12 |
human |