| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Tamura, J Gu, H Tran, K M Yamad. PTEN gene and integrin signaling in cancer. Journal of the National Cancer Institute. vol 91. issue 21. 1999-11-30. PMID:10547389. |
in the absence of pten, this lipid signal transduction pathway can protect tumor cells from apoptosis. |
1999-11-30 |
2023-08-12 |
human |
| M Tamura, J Gu, H Tran, K M Yamad. PTEN gene and integrin signaling in cancer. Journal of the National Cancer Institute. vol 91. issue 21. 1999-11-30. PMID:10547389. |
thus, pten appears to be a unique tumor suppressor-with both lipid phosphatase and protein tyrosine phosphatase activities-that negatively regulates cell interactions with the extracellular matrix and that maintains cell sensitivity to apoptosis, e.g., after loss of cell contact with the extracellular matrix. |
1999-11-30 |
2023-08-12 |
human |
| A Di Cristofano, P Kotsi, Y F Peng, C Cordon-Cardo, K B Elkon, P P Pandolf. Impaired Fas response and autoimmunity in Pten+/- mice. Science (New York, N.Y.). vol 285. issue 5436. 1999-10-12. PMID:10497129. |
these results indicate that pten is an essential mediator of the fas response and a repressor of autoimmunity and thus implicate the pi 3-kinase/akt pathway in fas-mediated apoptosis. |
1999-10-12 |
2023-08-12 |
mouse |
| M Tamura, J Gu, E H Danen, T Takino, S Miyamoto, K M Yamad. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway. The Journal of biological chemistry. vol 274. issue 29. 1999-08-19. PMID:10400703. |
pten-mutated cells were resistant to apoptosis in suspension, but most of the cells entered apoptosis after expression of exogenous pten or wortmannin treatment. |
1999-08-19 |
2023-08-12 |
Not clear |
| W Wick, F B Furnari, U Naumann, W K Cavenee, M Welle. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435616. |
pten gene transfer in human malignant glioma: sensitization to irradiation and cd95l-induced apoptosis. |
1999-08-17 |
2023-08-12 |
human |
| W Wick, F B Furnari, U Naumann, W K Cavenee, M Welle. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435616. |
in contrast, ectopic expression of wild type pten, but not the pten(g129r) mutant, in pten-mutant gliomas markedly sensitizes these cells to irradiation and to cd95-ligand (cd95l)-induced apoptosis. |
1999-08-17 |
2023-08-12 |
human |
| W Wick, F B Furnari, U Naumann, W K Cavenee, M Welle. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis. Oncogene. vol 18. issue 27. 1999-08-17. PMID:10435616. |
thus, pten may sensitize human malignant glioma cells to cd95l-induced apoptosis in a pi 3 kinase-dependent manner that may not require pkb phosphorylation. |
1999-08-17 |
2023-08-12 |
human |
| M A Davies, D Koul, H Dhesi, R Berman, T J McDonnell, D McConkey, W K Yung, P A Stec. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer research. vol 59. issue 11. 1999-06-29. PMID:10363971. |
overexpression of bcl-2 in lncap cells blocked mmac/pten- and p53-induced apoptosis but not the growth-suppressive effects of mmac/ pten, suggesting that the growth regulatory effects of mmac/pten involve multiple pathways. |
1999-06-29 |
2023-08-12 |
Not clear |
| X X Tian, J C Pang, S S To, H K N. Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331435. |
restoration of wild-type pten expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. |
1999-05-27 |
2023-08-12 |
human |
| X X Tian, J C Pang, S S To, H K N. Restoration of wild-type PTEN expression leads to apoptosis, induces differentiation, and reduces telomerase activity in human glioma cells. Journal of neuropathology and experimental neurology. vol 58. issue 5. 1999-05-27. PMID:10331435. |
taken together, these results suggest that pten plays an important role in regulation of cell homeostasis by maintaining a balance between proliferation, differentiation, and apoptosis. |
1999-05-27 |
2023-08-12 |
human |
| J P Carson, G Kulik, M J Webe. Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3'-kinase and Akt/protein kinase B. Cancer research. vol 59. issue 7. 1999-04-21. PMID:10197612. |
in lncap prostate cancer cells, the pten phosphoinositide phosphatase is inactivated, leading to constitutive activation of akt/pkb and resistance to apoptosis. |
1999-04-21 |
2023-08-12 |
Not clear |
| K Podsypanina, L H Ellenson, A Nemes, J Gu, M Tamura, K M Yamada, C Cordon-Cardo, G Catoretti, P E Fisher, R Parson. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 4. 1999-03-25. PMID:9990064. |
taken together, these data suggest that pten is a regulator of apoptosis and proliferation that behaves as a "landscaper" tumor suppressor in the gut and a "gatekeeper" tumor suppressor in other organs. |
1999-03-25 |
2023-08-12 |
mouse |
| P L Dahia, R C Aguiar, J Alberta, J B Kum, S Caron, H Sill, D J Marsh, J Ritz, A Freedman, C Stiles, C En. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Human molecular genetics. vol 8. issue 2. 1999-03-18. PMID:9931326. |
the finding that pten levels inversely correlate with phosphorylated akt supports the hypothesis that pten regulates ptdins(3,4,5)p3and suggests a role for pten in apoptosis. |
1999-03-18 |
2023-08-12 |
human |
| V Stambolic, A Suzuki, J L de la Pompa, G M Brothers, C Mirtsos, T Sasaki, J Ruland, J M Penninger, D P Siderovski, T W Ma. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell. vol 95. issue 1. 1998-11-02. PMID:9778245. |
expression of exogenous pten in mutant cells restores both their sensitivity to agonist-induced apoptosis and normal pattern of pkb/akt phosphorylation. |
1998-11-02 |
2023-08-12 |
mouse |