| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| X Wan, Y Yokoyama, A Shinohara, Y Takahashi, T Tamay. PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway. Cell death and differentiation. vol 9. issue 4. 2002-08-22. PMID:11965494. |
pten augments staurosporine-induced apoptosis in pten-null ishikawa cells by downregulating pi3k/akt signaling pathway. |
2002-08-22 |
2023-08-12 |
Not clear |
| X Wan, Y Yokoyama, A Shinohara, Y Takahashi, T Tamay. PTEN augments staurosporine-induced apoptosis in PTEN-null Ishikawa cells by downregulating PI3K/Akt signaling pathway. Cell death and differentiation. vol 9. issue 4. 2002-08-22. PMID:11965494. |
we investigated the involvement of pten in staurosporine-induced apoptosis. |
2002-08-22 |
2023-08-12 |
Not clear |
| Joanne A Fox, Karen Ung, Sonia G Tanlimco, Frank R Jiri. Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1. Journal of immunology (Baltimore, Md. : 1950). vol 169. issue 1. 2002-08-13. PMID:12077227. |
the tumor suppressor, pten, has emerged as a critical negative regulator of phosphatidylinositol-3-kinase-dependent intracellular signaling pathways responsible for phenomena such as cellular adhesion, proliferation, and apoptosis. |
2002-08-13 |
2023-08-12 |
mouse |
| Christiane B Knobbe, Adrian Merlo, Guido Reifenberge. Pten signaling in gliomas. Neuro-oncology. vol 4. issue 3. 2002-08-12. PMID:12084351. |
this review summarizes the current state of the art concerning the involvement of aberrant pten function in the development of different biologic features of malignant gliomas, such as loss of cell-cycle control and uncontrolled cell proliferation, escape from apoptosis, brain invasion, and aberrant neoangiogenesis. |
2002-08-12 |
2023-08-12 |
human |
| Mohammad Atiqur Rahman, Ioannis D Kyriazanos, Takashi Ono, Akira Yamanoi, Hitoshi Kohno, Mikako Tsuchiya, Naofumi Nagasu. Impact of PTEN expression on the outcome of hepatitis C virus-positive cirrhotic hepatocellular carcinoma patients: possible relationship with COX II and inducible nitric oxide synthase. International journal of cancer. vol 100. issue 2. 2002-08-08. PMID:12115563. |
pten, a novel tumor suppressor, functions as a regulator of both cell cycle progression and apoptosis. |
2002-08-08 |
2023-08-12 |
human |
| Li Li, Fenghua Liu, Rebecca A Salmonsen, Tod K Turner, N Scott Litofsky, Antonio Di Cristofano, Pier Paolo Pandolfi, Stephen N Jones, Larry D Recht, Alonzo H Ros. PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Molecular and cellular neurosciences. vol 20. issue 1. 2002-08-07. PMID:12056837. |
pten in neural precursor cells: regulation of migration, apoptosis, and proliferation. |
2002-08-07 |
2023-08-12 |
mouse |
| Li Li, Fenghua Liu, Rebecca A Salmonsen, Tod K Turner, N Scott Litofsky, Antonio Di Cristofano, Pier Paolo Pandolfi, Stephen N Jones, Larry D Recht, Alonzo H Ros. PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation. Molecular and cellular neurosciences. vol 20. issue 1. 2002-08-07. PMID:12056837. |
these observations indicate that pten regulates svz precursor cell function and is particularly important for migration and apoptosis in response to oxidative stress. |
2002-08-07 |
2023-08-12 |
mouse |
| F J T Staal, R B van der Luijt, M R M Baert, J van Drunen, H van Bakel, E Peters, I de Valk, H K P van Amstel, M J B Taphoorn, G H Jansen, C W M van Veelen, B Burgering, G E J Staa. A novel germline mutation of PTEN associated with brain tumours of multiple lineages. British journal of cancer. vol 86. issue 10. 2002-08-02. PMID:12085208. |
in contrast to the wild-type molecule, the mutant pten protein is not capable of inducing apoptosis, induces increased cell proliferation and leads to high constitutive pkb/akt activation, which cannot be increased anymore by stimulation with insulin. |
2002-08-02 |
2023-08-12 |
Not clear |
| Kouji Tsugawa, Michael K Jones, Keizo Sugimachi, I James Sarfeh, Andrzej S Tarnawsk. Biological role of phosphatase PTEN in cancer and tissue injury healing. Frontiers in bioscience : a journal and virtual library. vol 7. 2002-06-28. PMID:11991859. |
pten can: 1) inhibit entry into the cell cycle by inhibiting g1 to s phase progression and arrest cell proliferation required for tissue reconstruction during injury healing; 2) increase apoptosis by blocking akt activation leading to increased bad and caspase-9 activities; 3) inhibit hypoxia-induced angiogenesis required for injury healing by blocking akt-mediated vegf gene transcription; 4) inhibit akt-mediated cell migration, i.e. |
2002-06-28 |
2023-08-12 |
Not clear |
| Y Xu, P H Wierni. Systemic lupus erythematosus and B-cell hematologic neoplasm. Lupus. vol 10. issue 12. 2002-06-21. PMID:11787873. |
a tumor suppressor gene pten may link the two disorders via a defective apoptosis pathway to eliminate hyperactive b and t cells in sle. |
2002-06-21 |
2023-08-12 |
Not clear |
| Jianhua Huang, Christopher D Konto. Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN. Arteriosclerosis, thrombosis, and vascular biology. vol 22. issue 5. 2002-06-19. PMID:12006385. |
moreover, pten overexpression induced cleavage of caspase-3 and significantly increased apoptosis compared with control cells. |
2002-06-19 |
2023-08-12 |
rabbit |
| Imran Mohiuddin, Xiaobo Cao, Mustafa K Ozvaran, Lou Zumstein, Sunil Chada, W Roy Smyth. Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation. Annals of surgical oncology. vol 9. issue 3. 2002-06-04. PMID:11923140. |
a downstream target of pten is akt, a serine-threonine kinase that when activated inhibits apoptosis. |
2002-06-04 |
2023-08-12 |
human |
| Imran Mohiuddin, Xiaobo Cao, Mustafa K Ozvaran, Lou Zumstein, Sunil Chada, W Roy Smyth. Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation. Annals of surgical oncology. vol 9. issue 3. 2002-06-04. PMID:11923140. |
we sought to determine whether pten overexpression in mesothelioma cells would engender hypophosphorylation of akt and apoptosis. |
2002-06-04 |
2023-08-12 |
human |
| Bhuvanesh Singh, Pabbathi G Reddy, Andy Goberdhan, Christine Walsh, Su Dao, Ivan Ngai, Ting Chao Chou, Pornchai O-Charoenrat, Arnold J Levine, Pulivarthi H Rao, Archontoula Stoffe. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes & development. vol 16. issue 8. 2002-05-13. PMID:11959846. |
in benign cells these pathways are interrelated through the transcriptional regulation of pten by p53, which is required for p53-mediated apoptosis. |
2002-05-13 |
2023-08-12 |
Not clear |
| Bhuvanesh Singh, Pabbathi G Reddy, Andy Goberdhan, Christine Walsh, Su Dao, Ivan Ngai, Ting Chao Chou, Pornchai O-Charoenrat, Arnold J Levine, Pulivarthi H Rao, Archontoula Stoffe. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas. Genes & development. vol 16. issue 8. 2002-05-13. PMID:11959846. |
conversely, constitutive activation of pik3ca results in resistance to p53-related apoptosis in pten deficient cells. |
2002-05-13 |
2023-08-12 |
Not clear |
| Jianhua Huang, Christopher D Konto. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11784722. |
inhibition of endogenous pten in cultured endothelial cells by adenovirus-mediated overexpression of a dominant negative pten mutant (pten-c/s) enhanced vegf-mediated akt phosphorylation, and this effect correlated with decreases in caspase-3 cleavage, caspase-3 activity, and dna degradation after induction of apoptosis with tumor necrosis factor-alpha. |
2002-05-10 |
2023-08-12 |
rat |
| Marty W Mayo, Lee V Madrid, Sandy D Westerheide, David R Jones, Xiu-Juan Yuan, Albert S Baldwin, Young E Whan. PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit. The Journal of biological chemistry. vol 277. issue 13. 2002-05-10. PMID:11799112. |
the ability of pten to inhibit the tnf-induced transactivation function of p65 is important, because expression of pten blocked tnf-stimulated nf-kappab-dependent gene expression, thus sensitizing cells to tnf-induced apoptosis. |
2002-05-10 |
2023-08-12 |
Not clear |
| Walburgis Brenner, Gloria Färber, Thomas Herget, Hans-Anton Lehr, Jan G Hengstler, Joachim W Thürof. Loss of tumor suppressor protein PTEN during renal carcinogenesis. International journal of cancer. vol 99. issue 1. 2002-05-01. PMID:11948491. |
the tumor suppressor gene pten (phosphatase and tensin homologue deleted from chromosome 10) encodes a dual specific protein and phospholipid phosphatase that affects cell proliferation, apoptosis and migration. |
2002-05-01 |
2023-08-12 |
Not clear |
| Nick R Leslie, C Peter Downe. PTEN: The down side of PI 3-kinase signalling. Cellular signalling. vol 14. issue 4. 2002-04-10. PMID:11858936. |
early studies of pten showed that its activity was able to promote cell cycle arrest and apoptosis and inhibit cell motility, but more recent data have identified other functional consequences of pten action, such as effects on the regulation of angiogenesis. |
2002-04-10 |
2023-08-12 |
Not clear |
| Eleanor Latta, William B Chapma. PTEN mutations and evolving concepts in endometrial neoplasia. Current opinion in obstetrics & gynecology. vol 14. issue 1. 2002-04-02. PMID:11801878. |
pten has been shown to play several roles in tumour suppression, including cell cycle arrest and promotion of apoptosis. |
2002-04-02 |
2023-08-12 |
Not clear |