| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
pten regulates akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. |
2003-05-09 |
2023-08-12 |
mouse |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
the tumor suppressor phosphatase pten can promote apoptosis of mitotic cells by inhibiting activation of the cell survival kinase akt. |
2003-05-09 |
2023-08-12 |
mouse |
| Devin S Gary, Mark P Mattso. PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis. Neuromolecular medicine. vol 2. issue 3. 2003-05-09. PMID:12622404. |
these findings demonstrate a cell death function of pten in hippocampal neurons and identify pten as a potential therapeutic target for neurodegenerative disorders that involve excitotoxicity and apoptosis. |
2003-05-09 |
2023-08-12 |
mouse |
| Takayuki Kanaseki, Toshihiko Torigoe, Yoshihiko Hirohashi, Itaru Hirai, Tetsuo Himi, Noriyuki Sat. Identification of germline mutation of PTEN gene and analysis of apoptosis resistance of the lymphocytes in a patient with Cowden disease. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 70. issue 1. 2003-04-29. PMID:12415190. |
identification of germline mutation of pten gene and analysis of apoptosis resistance of the lymphocytes in a patient with cowden disease. |
2003-04-29 |
2023-08-12 |
Not clear |
| Akira Suzuki, Satoshi Itami, Minako Ohishi, Koichi Hamada, Tae Inoue, Nobuyasu Komazawa, Haruki Senoo, Takehiko Sasaki, Junji Takeda, Motomu Manabe, Tak Wah Mak, Toru Nakan. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer research. vol 63. issue 3. 2003-03-07. PMID:12566313. |
k5pten(flox/flox) keratinocytes are hyperproliferative and resistant to apoptosis and show increased activation of the pten downstream signaling mediators akt/protein kinase b (pkb) and extracellular signal-regulated kinase. |
2003-03-07 |
2023-08-12 |
mouse |
| N Omori, G Jin, F Li, W R Zhang, S J Wang, Y Hamakawa, I Nagano, Y Manabe, M Shoji, K Ab. Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Brain research. vol 954. issue 2. 2003-01-28. PMID:12414116. |
a phosphatase pten (phosphatase and tensin homologue deleted on chromosome 10) is a tumor suppressor gene that suppresses cell growth, inhibits cell migration, and induces apoptosis. |
2003-01-28 |
2023-08-12 |
rat |
| Zheng Xu, David Stokoe, Lawrence P Kane, Arthur Weis. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 13. issue 7. 2003-01-08. PMID:12133897. |
the inducible expression of the tumor suppressor gene pten promotes apoptosis and decreases cell size by inhibiting the pi3k/akt pathway in jurkat t cells. |
2003-01-08 |
2023-08-12 |
Not clear |
| Zheng Xu, David Stokoe, Lawrence P Kane, Arthur Weis. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 13. issue 7. 2003-01-08. PMID:12133897. |
pten also rendered jurkat cells more susceptible to apoptosis induced by various stimuli. |
2003-01-08 |
2023-08-12 |
Not clear |
| Zheng Xu, David Stokoe, Lawrence P Kane, Arthur Weis. The inducible expression of the tumor suppressor gene PTEN promotes apoptosis and decreases cell size by inhibiting the PI3K/Akt pathway in Jurkat T cells. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 13. issue 7. 2003-01-08. PMID:12133897. |
in summary, our results suggest that pten suppresses cell growth, promotes apoptosis, and decreases cell size by negatively regulating the phosphoinositide 3-kinase/akt pathway in jurkat t cells. |
2003-01-08 |
2023-08-12 |
Not clear |
| Magali Fernandez, Charis En. The expanding role of PTEN in neoplasia: a molecule for all seasons? Commentary re: M. A. Davies, et al., Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clin. Cancer Res., 8: 1904-1914, 2002. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 6. 2002-12-27. PMID:12060605. |
in the 5 years since the discovery of pten, encoding a dual specificity phosphatase tumor suppressor on 10q23, it has been shown to be a susceptibility gene for an inherited cancer syndrome, cowden syndrome, and for several developmental disorders; it has been shown to play a prominent role in normal murine and human development; and it has been shown to be instrumental in cell cycle arrest, apoptosis, and/or possibly cell migration and cytoskeletal affairs. |
2002-12-27 |
2023-08-12 |
human |
| Magali Fernandez, Charis En. The expanding role of PTEN in neoplasia: a molecule for all seasons? Commentary re: M. A. Davies, et al., Adenoviral-mediated expression of MMAC/PTEN inhibits proliferation and metastasis of human prostate cancer cells. Clin. Cancer Res., 8: 1904-1914, 2002. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 6. 2002-12-27. PMID:12060605. |
(clin cancer res., 8: 1904-1914, 2002) sheds light on all of these issues when they report on data that derive from a "triple threat" strategy, i.e., in vitro, in vivo, and ex vivo, to demonstrate that adenoviral infection of pten into pten-null pc3 prostate cancer cell lines results in decreased metastatic potential without significantly altering tumor size via the predominant mechanism of g(1) cell cycle arrest but not apoptosis. |
2002-12-27 |
2023-08-12 |
human |
| O Davi. Akt and PTEN: new diagnostic markers of non-small cell lung cancer? Journal of cellular and molecular medicine. vol 5. issue 4. 2002-12-03. PMID:12067477. |
we are particularly interested in testing the principles of cell proliferation and apoptosis in the microenvironment of human lung cancers with respect to the cell survival protein akt 1 and pten 2. |
2002-12-03 |
2023-08-12 |
human |
| Xiufen Lei, Abhik Bandyopadhyay, Thy Le, LuZhe Su. Autocrine TGFbeta supports growth and survival of human breast cancer MDA-MB-231 cells. Oncogene. vol 21. issue 49. 2002-11-14. PMID:12386814. |
treatment with tgfbeta(1) decreased pten and inhibited apoptosis in sriii cells to a level similar to that in the control cells. |
2002-11-14 |
2023-08-12 |
human |
| Joëlle Dupont, Jean Pierre Renou, Moshe Shani, Lothar Hennighausen, Derek LeRoit. PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. The Journal of clinical investigation. vol 110. issue 6. 2002-10-23. PMID:12235113. |
pten overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. |
2002-10-23 |
2023-08-12 |
mouse |
| Joëlle Dupont, Jean Pierre Renou, Moshe Shani, Lothar Hennighausen, Derek LeRoit. PTEN overexpression suppresses proliferation and differentiation and enhances apoptosis of the mouse mammary epithelium. The Journal of clinical investigation. vol 110. issue 6. 2002-10-23. PMID:12235113. |
the phosphatase pten regulates growth, adhesion, and apoptosis, among many other cell processes. |
2002-10-23 |
2023-08-12 |
mouse |
| Gang Li, Gertraud W Robinson, Ralf Lesche, Hilda Martinez-Diaz, Zhaorong Jiang, Nora Rozengurt, Kay-Uwe Wagner, De-Chang Wu, Timothy F Lane, Xin Liu, Lothar Hennighausen, Hong W. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development (Cambridge, England). vol 129. issue 17. 2002-09-23. PMID:12163417. |
similar phenotypes were observed in pten-null mammary epithelia that had been transplanted into wild-type stroma, suggesting that pten plays an essential and cell-autonomous role in controlling the proliferation, differentiation and apoptosis of mammary epithelial cells. |
2002-09-23 |
2023-08-12 |
mouse |
| Silvia Marino, Paul Krimpenfort, Carly Leung, Hetty A G M van der Korput, Jan Trapman, Isabelle Camenisch, Anton Berns, Sebastian Brandne. PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development (Cambridge, England). vol 129. issue 14. 2002-09-13. PMID:12091320. |
pten is a tumour suppressor gene involved in cell cycle control, apoptosis and mediation of adhesion and migration signalling. |
2002-09-13 |
2023-08-12 |
mouse |
| Yong Choi, Jie Zhang, Cristina Murga, Hong Yu, Erich Koller, Brett P Monia, J Silvio Gutkind, Weiqun L. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene. vol 21. issue 34. 2002-08-30. PMID:12149650. |
pten, but not ship and ship2, suppresses the pi3k/akt pathway and induces growth inhibition and apoptosis of myeloma cells. |
2002-08-30 |
2023-08-12 |
mouse |
| Yong Choi, Jie Zhang, Cristina Murga, Hong Yu, Erich Koller, Brett P Monia, J Silvio Gutkind, Weiqun L. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells. Oncogene. vol 21. issue 34. 2002-08-30. PMID:12149650. |
biologically, expression of only pten, but not ship and ship2, resulted in growth inhibition and increased apoptosis in opm2 myeloma line. |
2002-08-30 |
2023-08-12 |
mouse |
| Xiao-Ping Zhou, Anu Loukola, Reijo Salovaara, Minna Nystrom-Lahti, Päivi Peltomäki, Albert de la Chapelle, Lauri A Aaltonen, Charis En. PTEN mutational spectra, expression levels, and subcellular localization in microsatellite stable and unstable colorectal cancers. The American journal of pathology. vol 161. issue 2. 2002-08-28. PMID:12163369. |
pten on 10q23.3 encodes a dual-specificity phosphatase that negatively regulates the phosphoinositol-3-kinase/akt pathway and mediates cell-cycle arrest and apoptosis. |
2002-08-28 |
2023-08-12 |
Not clear |