| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuji Saito, Began Gopalan, Abner M Mhashilkar, Jack A Roth, Sunil Chada, Louis Zumstein, Rajagopal Rames. Adenovirus-mediated PTEN treatment combined with caffeine produces a synergistic therapeutic effect in colorectal cancer cells. Cancer gene therapy. vol 10. issue 11. 2004-08-05. PMID:14605666. |
in this study, we demonstrate that treatment with a combination of adenovirus-mediated transfer of pten (ad-pten) and caffeine synergistically suppressed cell growth and induced apoptosis in colorectal cancer cells but not in normal colorectal fibroblast cells. |
2004-08-05 |
2023-08-12 |
Not clear |
| Tina Dreher, Hanswalter Zentgraf, Ulrich Abel, Alexandra Kappeler, Maurice S Michel, Uwe Bleyl, Rainer Grobhol. Reduction of PTEN and p27kip1 expression correlates with tumor grade in prostate cancer. Analysis in radical prostatectomy specimens and needle biopsies. Virchows Archiv : an international journal of pathology. vol 444. issue 6. 2004-07-27. PMID:15118854. |
pten negatively influences cell growth and induces apoptosis, while p27kip1 binds to cyclin-e-cdk2 and counteracts mitosis. |
2004-07-27 |
2023-08-12 |
human |
| Sheila M Nielsen-Preiss, Selina R Silva, Jennifer M Gillett. Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. Journal of cellular biochemistry. vol 90. issue 5. 2004-07-20. PMID:14624456. |
role of pten and akt in the regulation of growth and apoptosis in human osteoblastic cells. |
2004-07-20 |
2023-08-12 |
human |
| Sheila M Nielsen-Preiss, Selina R Silva, Jennifer M Gillett. Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. Journal of cellular biochemistry. vol 90. issue 5. 2004-07-20. PMID:14624456. |
furthermore, stimulation of cell growth or induction of apoptosis in osteosarcoma cells failed to affect pten expression or activity. |
2004-07-20 |
2023-08-12 |
human |
| Veronique Gagnon, Marie-Eve St-Germain, Sophie Parent, Eric Asseli. Akt activity in endometrial cancer cells: regulation of cell survival through cIAP-1. International journal of oncology. vol 23. issue 3. 2004-05-04. PMID:12888921. |
akt phosphorylation decreased and apoptosis was strongly increased in mutated pten human endometrial cancer cells in the presence of pi 3-k inhibitor (wortmannin) which was accompanied by a down-regulation of ciap-1 protein. |
2004-05-04 |
2023-08-12 |
human |
| Jeong Hyun Lee, Ki Young Kim, Yong-Kyu Lee, So Youn Park, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, Ki Whan Hon. Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats. The Journal of pharmacology and experimental therapeutics. vol 308. issue 3. 2004-04-06. PMID:14634032. |
we observed the signaling pathway by which cilostazol suppressed mcao-induced increased phosphorylation of phosphatase and tensin homolog deleted from chromosome 10 (pten) and apoptosis via increased phosphorylation of casein kinase 2 (ck2). |
2004-04-06 |
2023-08-12 |
rat |
| Sunghoon Kim, Claire Domon-Dell, Junghee Kang, Dai H Chung, Jean-Noel Freund, B Mark Ever. Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. The Journal of biological chemistry. vol 279. issue 6. 2004-04-01. PMID:14623898. |
similar to pten, tumor necrosis factor-alpha (tnf-alpha) affects a wide spectrum of diseases including inflammatory processes and cancer by acting as a mediator of apoptosis, inflammation, and immunity. |
2004-04-01 |
2023-08-12 |
Not clear |
| Amit Panwalkar, Srdan Verstovsek, Francis J Gile. Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer. vol 100. issue 4. 2004-03-09. PMID:14770419. |
it is known that the phosphatase and tensin homologue tumor suppressor gene (pten) plays a major role in embryonic development, cell migration, and apoptosis. |
2004-03-09 |
2023-08-12 |
Not clear |
| Amit Panwalkar, Srdan Verstovsek, Francis J Gile. Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer. vol 100. issue 4. 2004-03-09. PMID:14770419. |
malignancies with pten mutations, which are associated with constitutive activation of the pi3k/akt pathway, are relatively resistant to apoptosis and may be particularly sensitive to mtor inhibitors. |
2004-03-09 |
2023-08-12 |
Not clear |
| Hong Zhao, Joelle Dupont, Shoshana Yakar, Michael Karas, Derek LeRoit. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. vol 23. issue 3. 2004-03-03. PMID:14737113. |
pten inhibits cell proliferation and induces apoptosis by downregulating cell surface igf-ir expression in prostate cancer cells. |
2004-03-03 |
2023-08-12 |
human |
| Hong Zhao, Joelle Dupont, Shoshana Yakar, Michael Karas, Derek LeRoit. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. vol 23. issue 3. 2004-03-03. PMID:14737113. |
pten appears to play a crucial role in modulating apoptosis by reducing the levels of ptdins(3,4,5)p3, a phospholipid that activates akt, a central regulator of apoptosis. |
2004-03-03 |
2023-08-12 |
human |
| Hong Zhao, Joelle Dupont, Shoshana Yakar, Michael Karas, Derek LeRoit. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. vol 23. issue 3. 2004-03-03. PMID:14737113. |
to understand the role of pten in regulating cell proliferation and apoptosis, we stably overexpressed pten in pc3 cells, which are prostate cancer cells that lack pten. |
2004-03-03 |
2023-08-12 |
human |
| Hong Zhao, Joelle Dupont, Shoshana Yakar, Michael Karas, Derek LeRoit. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. vol 23. issue 3. 2004-03-03. PMID:14737113. |
overexpression of pten in two different clones inhibited cell proliferation and increased serum starvation-induced apoptosis, as compared to control cells. |
2004-03-03 |
2023-08-12 |
human |
| Hong Zhao, Joelle Dupont, Shoshana Yakar, Michael Karas, Derek LeRoit. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. vol 23. issue 3. 2004-03-03. PMID:14737113. |
taken together, our results show that pten can regulate cell proliferation and apoptosis through inhibition of igf-ir synthesis. |
2004-03-03 |
2023-08-12 |
human |
| Krishna Murthi Vasudevan, Sushma Gurumurthy, Vivek M Rangneka. Suppression of PTEN expression by NF-kappa B prevents apoptosis. Molecular and cellular biology. vol 24. issue 3. 2004-02-24. PMID:14729949. |
suppression of pten expression by nf-kappa b prevents apoptosis. |
2004-02-24 |
2023-08-12 |
human |
| Krishna Murthi Vasudevan, Sushma Gurumurthy, Vivek M Rangneka. Suppression of PTEN expression by NF-kappa B prevents apoptosis. Molecular and cellular biology. vol 24. issue 3. 2004-02-24. PMID:14729949. |
restoration of pten expression inhibited nf-kappa b transcriptional activity and augmented tnf-induced apoptosis, indicating a negative regulatory loop involving pten and nf-kappa b. pten is, thus, a novel target whose suppression is critical for antiapoptosis by nf-kappa b. |
2004-02-24 |
2023-08-12 |
human |
| Ki Young Kim, Hwa Kyoung Shin, Jeong Hyun Lee, Chi Dae Kim, Won Suk Lee, Byung Yong Rhim, Yung Woo Shin, Ki Whan Hon. Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. The Journal of pharmacology and experimental therapeutics. vol 308. issue 1. 2004-02-11. PMID:14569058. |
this study shows the signaling pathway by which cilostazol suppresses tumor necrosis factor-alpha (tnf-alpha)-induced the phosphatase and tensin homolog deleted from chromosome 10 (pten) phosphorylation and apoptosis via casein kinase 2 (ck2) phosphorylation in the sk-n-sh cells (neuroblastoma cells). |
2004-02-11 |
2023-08-12 |
Not clear |
| Nathalie Baeza, Michael Weller, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgak. PTEN methylation and expression in glioblastomas. Acta neuropathologica. vol 106. issue 5. 2004-01-09. PMID:12904991. |
the tumor suppressor gene pten on chromosome 10q23.3 regulates the akt signaling pathway and modulates cell growth and apoptosis. |
2004-01-09 |
2023-08-12 |
Not clear |
| Maria-Cristina Seminario, Patricia Precht, Robert P Wersto, Myriam Gorospe, Ronald L Wang. PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression. Oncogene. vol 22. issue 50. 2003-12-11. PMID:14603260. |
apoptosis played no role in the antiproliferative effect of pten, since only marginal increases in the rate of apoptosis were detected upon pten expression, and inhibitors of effector caspases did not restore proliferative capacity. |
2003-12-11 |
2023-08-12 |
Not clear |
| Y Saito, X Swanson, A M Mhashilkar, Y Oida, R Schrock, C D Branch, S Chada, L Zumstein, R Rames. Adenovirus-mediated transfer of the PTEN gene inhibits human colorectal cancer growth in vitro and in vivo. Gene therapy. vol 10. issue 23. 2003-12-04. PMID:14528320. |
in such tumor cells, enforced expression of pten decreases cell proliferation through cell-cycle arrest at g1 phase accompanied, in some cases, by induction of apoptosis. |
2003-12-04 |
2023-08-12 |
human |