| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joommo Kim, Young Han Lee, Taeg Kyu Kwon, Jong-Soo Chang, Kwang Chul Chung, Do Sik Mi. Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer research. vol 66. issue 2. 2006-02-14. PMID:16424010. |
these results show that survival signals generated by pld attenuate expression of egr-1 by activation of phosphatidylinositol 3-kinase signaling pathway and induction of pten by egr-1, which confers resistance to apoptosis. |
2006-02-14 |
2023-08-12 |
Not clear |
| Reginald Hill, Yurong Song, Robert D Cardiff, Terry Van Dyk. Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288012. |
apoptosis is dependent on pten function and not p53, unlike other epithelial cell types tested previously. |
2006-01-18 |
2023-08-12 |
mouse |
| Reginald Hill, Yurong Song, Robert D Cardiff, Terry Van Dyk. Heterogeneous tumor evolution initiated by loss of pRb function in a preclinical prostate cancer model. Cancer research. vol 65. issue 22. 2006-01-18. PMID:16288012. |
consequently, pten hemizygosity reduces apoptosis by 50%, accelerating progression to adenocarcinomas with heterogeneous composition. |
2006-01-18 |
2023-08-12 |
mouse |
| Isabel Rodríguez-Escudero, Françoise M Roelants, Jeremy Thorner, César Nombela, María Molina, Víctor J Ci. Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. The Biochemical journal. vol 390. issue Pt 2. 2006-01-12. PMID:15913452. |
the mammalian signalling pathway involving class i pi3k (phosphoinositide 3-kinase), pten (phosphatidylinositol 3-phosphatase) and pkb (protein kinase b)/c-akt has roles in multiple processes, including cell proliferation and apoptosis. |
2006-01-12 |
2023-08-12 |
Not clear |
| Randy J Levitt, Maria-Magdalena Georgescu, Michael Polla. PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2. Biochemical and biophysical research communications. vol 336. issue 4. 2005-12-12. PMID:16154532. |
using an inducible pten expression system in the pten-null glioma cell line u251, we demonstrate that pten-induction is associated with reduced proliferation, increased apoptosis, and a substantial reduction of the high levels of igfbp-2 expression. |
2005-12-12 |
2023-08-12 |
human |
| Kristin A Waite, Michelle R Sinden, Charis En. Phytoestrogen exposure elevates PTEN levels. Human molecular genetics. vol 14. issue 11. 2005-11-28. PMID:15829497. |
active pten results in decreased phosphorylation of akt and mapk, the up-regulation of p27 and down-regulation of cyclin d1 protein levels resulting in decreased proliferation and an increase in apoptosis. |
2005-11-28 |
2023-08-12 |
human |
| Anindya Goswami, Ravshan Burikhanov, Aurelie de Thonel, Naoya Fujita, Mamta Goswami, Yanming Zhao, John E Eriksson, Takashi Tsuruo, Vivek M Rangneka. Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Molecular cell. vol 20. issue 1. 2005-11-28. PMID:16209943. |
suppression of akt activation by the pi3k-inhibitor pten or ly294002, akt expression by rna-interference, or akt function by dominant-negative akt caused apoptosis in cancer cells. |
2005-11-28 |
2023-08-12 |
Not clear |
| Ji-Hyun Chung, Charis En. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer research. vol 65. issue 18. 2005-11-25. PMID:16166282. |
nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (pten) differentially regulates the cell cycle and apoptosis. |
2005-11-25 |
2023-08-12 |
Not clear |
| Ji-Hyun Chung, Charis En. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer research. vol 65. issue 18. 2005-11-25. PMID:16166282. |
additionally, we and others have shown that pten can regulate not only the cell cycle but also cellular apoptosis. |
2005-11-25 |
2023-08-12 |
Not clear |
| Ji-Hyun Chung, Charis En. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer research. vol 65. issue 18. 2005-11-25. PMID:16166282. |
additionally, whereas we observe that nuclear pten is required for cell cycle arrest, we found that cytoplasmic pten is required for apoptosis. |
2005-11-25 |
2023-08-12 |
Not clear |
| Ji-Hyun Chung, Charis En. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer research. vol 65. issue 18. 2005-11-25. PMID:16166282. |
our observations show that nuclear-cytoplasmic partitioning differentially regulates the cell cycle and apoptosis and, in this manner, provide further evidence that nuclear import of pten should play a role in carcinogenesis. |
2005-11-25 |
2023-08-12 |
Not clear |
| Qing-Yong Chen, Chun-You Wang, He-Shui Wu, Dao-da Che. [Exogenous PTEN gene induces apoptosis in breast cancer cells]. Zhonghua yi xue za zhi. vol 85. issue 1. 2005-11-22. PMID:15808072. |
[exogenous pten gene induces apoptosis in breast cancer cells]. |
2005-11-22 |
2023-08-12 |
Not clear |
| Qing-Yong Chen, Chun-You Wang, He-Shui Wu, Dao-da Che. [Exogenous PTEN gene induces apoptosis in breast cancer cells]. Zhonghua yi xue za zhi. vol 85. issue 1. 2005-11-22. PMID:15808072. |
to investigate the effects of exogenous pten gene on apoptosis of breast cancer cells. |
2005-11-22 |
2023-08-12 |
Not clear |
| Qing-Bai She, David B Solit, Qing Ye, Kathryn E O'Reilly, Jose Lobo, Neal Rose. The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer cell. vol 8. issue 4. 2005-11-15. PMID:16226704. |
induction of pten sensitizes cells to egfr inhibition, and the combination causes synergistic apoptosis. |
2005-11-15 |
2023-08-12 |
Not clear |
| Bhuvanesh Dave, Renea R Eason, S Renée Till, Yan Geng, Michael C Velarde, Thomas M Badger, Rosalia C M Simme. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905199. |
the soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor pten. |
2005-11-08 |
2023-08-12 |
rat |
| Bhuvanesh Dave, Renea R Eason, S Renée Till, Yan Geng, Michael C Velarde, Thomas M Badger, Rosalia C M Simme. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905199. |
gen-induced apoptosis in mcf-7 cells was concomitant with increased pten expression, and this was abrogated by pten sirna. |
2005-11-08 |
2023-08-12 |
rat |
| Bhuvanesh Dave, Renea R Eason, S Renée Till, Yan Geng, Michael C Velarde, Thomas M Badger, Rosalia C M Simme. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905199. |
mcf-7 cells treated with serum from gen- or spi(+)-fed rats had increased apoptosis as well as increased levels of the pten transcript. |
2005-11-08 |
2023-08-12 |
rat |
| Bhuvanesh Dave, Renea R Eason, S Renée Till, Yan Geng, Michael C Velarde, Thomas M Badger, Rosalia C M Simme. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905199. |
decreased p21 and bok gene expression accompanied the inhibition of apoptosis by pten sirna. |
2005-11-08 |
2023-08-12 |
rat |
| Bhuvanesh Dave, Renea R Eason, S Renée Till, Yan Geng, Michael C Velarde, Thomas M Badger, Rosalia C M Simme. The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN. Carcinogenesis. vol 26. issue 10. 2005-11-08. PMID:15905199. |
data implicate pten in the induction of apoptosis by gen and suggest that the promotion of apoptosis leading to inhibition of tumorigenesis in vivo by diets containing gen may also involve the distinct activities of yet unknown gen metabolite(s) and/or other systemic factors induced by gen. |
2005-11-08 |
2023-08-12 |
rat |
| Li Xie, Wen-Xin Qin, Jin-Jun Li, Xiang-Huo He, Hui-Qun Shu, Gen-Fu Yao, Da-Fang Wan, Jian-Ren G. cDNA expression array analysis of gene expression in human hepatocarcinoma Hep3B cells induced by BNIPL-1. Acta biochimica et biophysica Sinica. vol 37. issue 9. 2005-10-14. PMID:16143817. |
among these differentially expressed genes, p16ink4, il-12, trail and the lymphotoxin beta gene involved in growth suppression or cell apoptosis were up-regulated, and pten involved in cell proliferation was down-regulated by bnipl-1. |
2005-10-14 |
2023-08-12 |
human |