| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shin-ichi Ishioka, Yoshiaki Ezaka, Kota Umemura, Takuhiro Hayashi, Toshiaki Endo, Tsuyoshi Sait. Proteomic analysis of mechanisms of hypoxia-induced apoptosis in trophoblastic cells. International journal of medical sciences. vol 4. issue 1. 2007-04-24. PMID:17299580. |
hypoxia induced apoptosis accompanied by increased expression of bcl-x, caspase-3 and -9, hsp70, pten, and bag-1. |
2007-04-24 |
2023-08-12 |
human |
| Huachuan Zheng, Koichi Tsuneyama, Hiroyuki Takahashi, Shigeharu Miwa, Kazuhiro Nomoto, Hiroshi Saito, Shinji Masuda, Yasuo Takan. Expression of PTEN and FHIT is involved in regulating the balance between apoptosis and proliferation in lung carcinomas. Anticancer research. vol 27. issue 1B. 2007-04-16. PMID:17348444. |
expression of pten and fhit is involved in regulating the balance between apoptosis and proliferation in lung carcinomas. |
2007-04-16 |
2023-08-12 |
Not clear |
| Hugo Leis, Ana Sanchis, Paloma Pére. Deletion of the N-terminus of IKKgamma induces apoptosis in keratinocytes and impairs the AKT/PTEN signaling pathway. Experimental cell research. vol 313. issue 4. 2007-04-12. PMID:17184772. |
these effects were most likely mediated through ikk since coexpression of the wild-type form of ikkgamma in keratinocytes partially reversed apoptosis and reduced pten expression. |
2007-04-12 |
2023-08-12 |
Not clear |
| Yuan Zhu, Patrick Hoell, Barbara Ahlemeyer, Ulrich Sure, Helmut Bertalanffy, Josef Krieglstei. Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease. Neurochemistry international. vol 50. issue 3. 2007-04-10. PMID:17169462. |
we have recently demonstrated an implication of phosphatase and tensin homologue deleted on chromosome 10 (pten), a tumor suppressor, in ros generation and neuronal apoptosis induced by staurosporine. |
2007-04-10 |
2023-08-12 |
human |
| Dianren Xia, Harish Srinivas, Young-Ho Ahn, Gautam Sethi, Xiaoyang Sheng, W K Alfred Yung, Qianghua Xia, Paul J Chiao, Heetae Kim, Powel H Brown, Ignacio I Wistuba, Bharat B Aggarwal, Jonathan M Kuri. Mitogen-activated protein kinase kinase-4 promotes cell survival by decreasing PTEN expression through an NF kappa B-dependent pathway. The Journal of biological chemistry. vol 282. issue 6. 2007-03-23. PMID:17158870. |
studies on a panel of nsclc cell lines revealed a subset with high mkk4/high nfkappab/low pten that was relatively resistant to apoptosis. |
2007-03-23 |
2023-08-12 |
mouse |
| Sukmi Kang-Park, Jee H Im, Je H Lee, Young I Le. PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells. Virus research. vol 122. issue 1-2. 2007-03-15. PMID:16872708. |
pten suppression of chl cell growth at g1 phase (jbc;278,4057(2003)) in cell cycle analysis, which is overcome by hbx activated akt/pkb further confirmed that same pi3k/akt pathway is involved in cell survival and apoptosis by hbx and pten. |
2007-03-15 |
2023-08-12 |
human |
| Sukmi Kang-Park, Jee H Im, Je H Lee, Young I Le. PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells. Virus research. vol 122. issue 1-2. 2007-03-15. PMID:16872708. |
pten suppression of hbx-mediated cell survival through pi3k pathway is specific, since pten does not suppress the effect of hbx on the protection from fas-mediated apoptosis. |
2007-03-15 |
2023-08-12 |
human |
| Quan-Guang Zhang, Dong-Na Wu, Dong Han, Guang-Yi Zhan. Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. FEBS letters. vol 581. issue 3. 2007-03-12. PMID:17239858. |
on the contrary, activation of the protein kinase akt, which is controlled by the opposing actions of pi3k and pten, contributes to enhanced resistance to apoptosis through multiple mechanisms. |
2007-03-12 |
2023-08-12 |
Not clear |
| Pei-Yin Lin, Susan P Fosmire, See-Hyoung Park, Jin-Young Park, Shairaz Baksh, Jaime F Modiano, Robert H Weis. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. Molecular cancer. vol 6. 2007-03-09. PMID:17300726. |
attenuation of pten increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. |
2007-03-09 |
2023-08-12 |
Not clear |
| Wenle Xia, Intisar Husain, Leihua Liu, Sarah Bacus, Shermini Saini, Janice Spohn, Karen Pry, Ron Westlund, Steven H Stein, Neil L Specto. Lapatinib antitumor activity is not dependent upon phosphatase and tensin homologue deleted on chromosome 10 in ErbB2-overexpressing breast cancers. Cancer research. vol 67. issue 3. 2007-03-01. PMID:17283152. |
loss of pten did not affect induction of tumor cell apoptosis by lapatinib in either cell line. |
2007-03-01 |
2023-08-12 |
Not clear |
| Yuji Hoshino, Kengo Nishimura, Bauer E Sumpi. Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain. Journal of cellular biochemistry. vol 100. issue 2. 2007-02-23. PMID:16927376. |
inhibition of pten activity had no effect on cs-mediated cell proliferation but inhibited cs-mediated suppression of apoptosis. |
2007-02-23 |
2023-08-12 |
cattle |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Shaomeng Wang, Dajun Yan. Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP). Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:16950208. |
more importantly, it has been discovered that cmep inhibits cell proliferation, and induces apoptosis in prostate cancer cells which have high-levels of akt activation and lack pten or harbor pten mutation, such as cl-1, lncap, and pc-3; only shows a minimal activity in du-145 cancer cells which do not have akt activation. |
2007-02-22 |
2023-08-12 |
mouse |
| T Ando, H Ishiguro, M Kimura, A Mitsui, H Kurehara, N Sugito, K Tomoda, R Mori, N Takashima, R Ogawa, Y Fujii, Y Kuwabar. Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 19. issue 6. 2007-02-21. PMID:17069588. |
ndrg1 (n-myc downstream regulated gene-1) was reported to be necessary for p53-mediated apoptosis and to be regulated by pten (phosphatase and tensin homolog). |
2007-02-21 |
2023-08-12 |
Not clear |
| Zhi-Xin Wu, Tian-Bao Song, Dong-Min Li, Xiao-Tian Zhang, Xiao-Lin W. Overexpression of PTEN suppresses growth and induces apoptosis by inhibiting the expression of survivin in bladder cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 28. issue 1. 2007-02-13. PMID:17108713. |
overexpression of pten suppresses growth and induces apoptosis by inhibiting the expression of survivin in bladder cancer cells. |
2007-02-13 |
2023-08-12 |
human |
| Zhi-Xin Wu, Tian-Bao Song, Dong-Min Li, Xiao-Tian Zhang, Xiao-Lin W. Overexpression of PTEN suppresses growth and induces apoptosis by inhibiting the expression of survivin in bladder cancer cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 28. issue 1. 2007-02-13. PMID:17108713. |
in the present study, we further demonstrated that overexpression of pten mediated by adenovirus suppressed bladder cancer cell growth and significantly induced apoptosis, through downregulating of survivin and activating of caspase cascades. |
2007-02-13 |
2023-08-12 |
human |
| Takeo Minaguchi, Kristin A Waite, Charis En. Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178862. |
we have recently shown in mcf-7 cells that nuclear phosphatase and tensin homologue deleted on chromosome 10 (pten) down-regulates phosphorylation of p44/42 and cyclin d1 and induces g(1) cell cycle arrest, whereas cytoplasmic pten down-regulates phosphorylation of akt, up-regulates p27, and induces apoptosis. |
2007-01-25 |
2023-08-12 |
Not clear |
| Takeo Minaguchi, Kristin A Waite, Charis En. Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Cancer research. vol 66. issue 24. 2007-01-25. PMID:17178862. |
in this manner, nucleocytoplasmic partitioning of pten seems to differentially regulate the cell cycle and apoptosis. |
2007-01-25 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
here we show that pten phosphatase becomes activated during collagen matrix contraction and is responsible for antagonizing phosphatidylinositol 3-kinase activity and promoting a decline in phosphorylated akt and fibroblast apoptosis in response to collagen contraction. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
pten null fibroblasts displayed enhanced levels of phosphorylated akt and were resistant to collagen matrix contraction-induced apoptosis. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
reconstitution of pten in pten null cells conferred susceptibility to apoptosis in response to contraction of collagen matrices. |
2006-12-11 |
2023-08-12 |
Not clear |