| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karuppaiyah Selvendiran, Liyue Tong, Shilpa Vishwanath, Anna Bratasz, Nancy J Trigg, Vijay K Kutala, Kalman Hideg, Periannan Kuppusam. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17684018. |
suppression of pten expression with sirna significantly reduced the p53 and p21 levels and activated akt phosphorylation at ser(473) and thr(308), resulting in decreased apoptosis and increased cell survival. |
2007-11-08 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Liyue Tong, Shilpa Vishwanath, Anna Bratasz, Nancy J Trigg, Vijay K Kutala, Kalman Hideg, Periannan Kuppusam. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17684018. |
on the other hand, overexpression of pten markedly induced apoptosis. |
2007-11-08 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, Liyue Tong, Shilpa Vishwanath, Anna Bratasz, Nancy J Trigg, Vijay K Kutala, Kalman Hideg, Periannan Kuppusam. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. The Journal of biological chemistry. vol 282. issue 39. 2007-11-08. PMID:17684018. |
the up-regulation of pten inhibited akt and mdm2, which enhanced the level of p53, thereby inducing g(2)/m arrest and apoptosis. |
2007-11-08 |
2023-08-12 |
human |
| Nan-Hyung Kim, Songhee Jeon, Hyun-Joo Lee, Ai-Young Le. Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes. The Journal of investigative dermatology. vol 127. issue 11. 2007-10-29. PMID:17522703. |
moreover, pten, which could inhibit the phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) signaling pathway, was significantly higher in depigmented epidermis, implying that vitiliginous keratinocytes may be more susceptible to tnf-alpha-mediated apoptosis through impaired akt and nf-kappab activation. |
2007-10-29 |
2023-08-12 |
human |
| Preetha Rajaraman, Sophia S Wang, Nathaniel Rothman, Merideth M Brown, Peter M Black, Howard A Fine, Jay S Loeffler, Robert G Selker, William R Shapiro, Stephen J Chanock, Peter D Inski. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 16. issue 8. 2007-10-11. PMID:17684142. |
using data from a hospital-based case-control study conducted by the national cancer institute between 1994 and 1998, we evaluated risk of glioma (n = 388), meningioma (n = 162), and acoustic neuroma (n = 73) with respect to 12 single nucleotide polymorphisms from 10 genes involved in apoptosis and cell cycle control: casp8, ccnd1, ccnh, cdkn1a, cdkn2a, chek1, chek2, mdm2, pten, and tp53. |
2007-10-11 |
2023-08-12 |
Not clear |
| Carmen Blanco-Aparicio, Oliver Renner, Juan F M Leal, Amancio Carner. PTEN, more than the AKT pathway. Carcinogenesis. vol 28. issue 7. 2007-10-04. PMID:17341655. |
phosphatase and tensin homolog deleted on chromosome 10 (pten)/phosphatidylinositol 3-kinase (pi3k)/akt constitute an important pathway regulating the signaling of multiple biological processes such as apoptosis, metabolism, cell proliferation and cell growth. |
2007-10-04 |
2023-08-12 |
mouse |
| Xiao-yun Wan, Yu-yan Mao, Yasuhiro Yokoyam. [Sensitivity of PTEN gene-transfected endometrial carcinoma cell line to doxorubicin-induced apoptosis]. Zhonghua zhong liu za zhi [Chinese journal of oncology]. vol 27. issue 9. 2007-10-02. PMID:16438844. |
[sensitivity of pten gene-transfected endometrial carcinoma cell line to doxorubicin-induced apoptosis]. |
2007-10-02 |
2023-08-12 |
Not clear |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Ribo Guo, Xiaojin Wu, Bihua Li, Feng Zhu, Yan Ling, Brian N Griffith, Shaomeng Wang, Dajun Yan. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer letters. vol 252. issue 2. 2007-10-01. PMID:17293030. |
cmep inhibits growth and induces apoptosis in breast cancer cells which have high-levels of akt activation and lack functional pten; however, cmep only shows a minimal activity in nih3t3 cells which do not have akt activation. |
2007-10-01 |
2023-08-12 |
human |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Ribo Guo, Xiaojin Wu, Bihua Li, Feng Zhu, Yan Ling, Brian N Griffith, Shaomeng Wang, Dajun Yan. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer letters. vol 252. issue 2. 2007-10-01. PMID:17293030. |
cmep inhibits growth and induces apoptosis in cancer cells which have high-levels of akt activation and lack pten or harbor pten mutation. |
2007-10-01 |
2023-08-12 |
human |
| James A McCubrey, Linda S Steelman, William H Chappell, Stephen L Abrams, Ellis W T Wong, Fumin Chang, Brian Lehmann, David M Terrian, Michele Milella, Agostino Tafuri, Franca Stivala, Massimo Libra, Jorg Basecke, Camilla Evangelisti, Alberto M Martelli, Richard A Frankli. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochimica et biophysica acta. vol 1773. issue 8. 2007-09-26. PMID:17126425. |
thus the raf/mek/erk pathway has different effects on growth, prevention of apoptosis, cell cycle arrest and induction of drug resistance in cells of various lineages which may be due to the presence of functional p53 and pten and the expression of lineage specific factors. |
2007-09-26 |
2023-08-12 |
human |
| H Lue, M Thiele, J Franz, E Dahl, S Speckgens, L Leng, G Fingerle-Rowson, R Bucala, B Lüscher, J Bernhage. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene. vol 26. issue 35. 2007-09-24. PMID:17310986. |
apoptosis inhibition by mif was functionally associated with akt activation as it was abolished by overexpression of the akt pathway inhibitor pten and occurred independently of p53. |
2007-09-24 |
2023-08-12 |
Not clear |
| Doyeob Kim, Gregory R Dressle. PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney. Developmental biology. vol 307. issue 2. 2007-09-05. PMID:17540362. |
the pten tumor suppressor gene encodes a protein and lipid phosphatase that regulates cell growth, apoptosis and many other cellular processes. |
2007-09-05 |
2023-08-12 |
mouse |
| Hiroo Nakajima, Koichi Sakaguchi, Ikuya Fujiwara, Mitsuhiko Mizuta, Mie Tsuruga, Junji Magae, Naruhiko Mizut. Apoptosis and inactivation of the PI3-kinase pathway by tetrocarcin A in breast cancers. Biochemical and biophysical research communications. vol 356. issue 1. 2007-06-20. PMID:17350598. |
the apoptosis is accompanied by the activation of a proteolytic cascade of caspases including caspase-3 and -9, and concomitantly decreases phosphorylation of akt, pdk1, and pten, a tumor suppressor that regulates the activity of akt through the dephosphorylation of polyphosphoinositides. |
2007-06-20 |
2023-08-12 |
human |
| Lina Pan, Jun Lu, Xiuli Wang, Liping Han, Yu Zhang, Songyan Han, Baiqu Huan. Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer. vol 109. issue 8. 2007-06-13. PMID:17330857. |
histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating pten expression. |
2007-06-13 |
2023-08-12 |
Not clear |
| Lina Pan, Jun Lu, Xiuli Wang, Liping Han, Yu Zhang, Songyan Han, Baiqu Huan. Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer. vol 109. issue 8. 2007-06-13. PMID:17330857. |
overexpression of pten by adenoviral transfection increases doxorubicin-induced apoptosis. |
2007-06-13 |
2023-08-12 |
Not clear |
| Lina Pan, Jun Lu, Xiuli Wang, Liping Han, Yu Zhang, Songyan Han, Baiqu Huan. Histone deacetylase inhibitor trichostatin a potentiates doxorubicin-induced apoptosis by up-regulating PTEN expression. Cancer. vol 109. issue 8. 2007-06-13. PMID:17330857. |
the aim of this work was to investigate whether changes in pten expression are involved in tsa/doxorubicin-induced apoptosis. |
2007-06-13 |
2023-08-12 |
Not clear |
| A Avivi, O Ashur-Fabian, A Joel, L Trakhtenbrot, K Adamsky, I Goldstein, N Amariglio, G Rechavi, E Nev. P53 in blind subterranean mole rats--loss-of-function versus gain-of-function activities on newly cloned Spalax target genes. Oncogene. vol 26. issue 17. 2007-05-31. PMID:17043642. |
this substitution reduces the p53 effect on the transcription of apoptosis genes (apaf1, puma, pten and noxa) and enhances it on human cell cycle arrest and p53 stabilization/homeostasis genes (mdm2, pten, p21 and cycg). |
2007-05-31 |
2023-08-12 |
mouse |
| Ximeng Liu, Katia J Bruxvoort, Cassandra R Zylstra, Jiarong Liu, Rachel Cichowski, Marie-Claude Faugere, Mary L Bouxsein, Chao Wan, Bart O Williams, Thomas L Clemen. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 7. 2007-05-17. PMID:17287359. |
in vitro osteoblasts lacking pten differentiated more rapidly than controls and exhibited greatly reduced apoptosis in association with markedly increased levels of phosphorylated akt and activation of signaling pathways downstream of activated akt. |
2007-05-17 |
2023-08-12 |
mouse |
| b' Nilgun Kapucuoglu, Fatma Aktepe, Hakan Kaya, Sema Bircan, Nermin Karahan, Metin Ciri\\xc5\\x9. Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index. Pathology, research and practice. vol 203. issue 3. 2007-05-04. PMID:17317031.' |
pten is a tumor suppressor gene that is frequently mutated in type i endometrioid endometrial carcinomas (eecs), and is involved in the control of cell proliferation, differentiation, and apoptosis. |
2007-05-04 |
2023-08-12 |
Not clear |
| Sharmila Shankar, Rakesh K Srivastav. Involvement of Bcl-2 family members, phosphatidylinositol 3'-kinase/AKT and mitochondrial p53 in curcumin (diferulolylmethane)-induced apoptosis in prostate cancer. International journal of oncology. vol 30. issue 4. 2007-05-04. PMID:17332930. |
similarly, wild-type phosphatase and tensin homolog deleted from chromosome 10 (pten) enhanced curcumin-induced apoptosis and, in contrast, inactive pten (g129e and g129r) inhibited curcumin-induced apoptosis. |
2007-05-04 |
2023-08-12 |
human |