| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James W Peacock, Jodie Palmer, Dieter Fink, Stephen Ip, Eric M Pietras, Alice L-F Mui, Stephen W Chung, Martin E Gleave, Michael E Cox, Ramon Parsons, Marcus E Peter, Christopher J On. PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103758. |
we further show that pten influences fas signaling, at least in part, by regulating pea-15 phosphorylation and activity that, in turn, regulate the ability of bcl-2 to suppress fas-induced apoptosis. |
2009-03-10 |
2023-08-12 |
mouse |
| C J Guigon, L Zhao, M C Willingham, S-Y Chen. PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer. Oncogene. vol 28. issue 4. 2009-02-17. PMID:18997818. |
apoptosis was decreased as indicated by increased expression of nuclear factor-kappab (nf-kappab) and decreased caspase-3 activity in the thyroids of trbeta(pv/pv)pten(+/-) mice. |
2009-02-17 |
2023-08-12 |
mouse |
| M A Scheper, R Chaisuparat, N G Nikitakis, J J Sau. Expression and alterations of the PTEN / AKT / mTOR pathway in ameloblastomas. Oral diseases. vol 14. issue 6. 2009-01-26. PMID:18826385. |
in carcinogenesis, loss of pten allows for overactivity of the phosphatidylinositol-3-kinase/protein kinase b (pi3k / akt) pathway inducing an upregulation of mammalian-target of rapamycin (mtor) and its downstream effector ribosomal-subunit-6 kinase (s6k); allowing for uncontrolled cell proliferation, apoptosis inhibition and cell cycle deregulation. |
2009-01-26 |
2023-08-12 |
Not clear |
| E M Schaeffer, L Marchionni, Z Huang, B Simons, A Blackman, W Yu, G Parmigiani, D M Berma. Androgen-induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer. Oncogene. vol 27. issue 57. 2009-01-22. PMID:18794802. |
here, we show that androgen exposure regulates genes previously implicated in prostate carcinogenesis comprising pathways for the phosphatase and tensin homolog (pten), fibroblast growth factor (fgf)/mitogen-activated protein kinase (mapk), and wnt signaling along with cellular programs regulating such 'hallmarks' of cancer as angiogenesis, apoptosis, migration and proliferation. |
2009-01-22 |
2023-08-12 |
human |
| Dai-Wu Seo. Up-regulation of IAPs by PI-3K: a cell survival signal-mediated anti-apoptotic mechanism. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18929542. |
human prostate cancer lncap cells, known to contain constitutively activated akt as a result of a frame-shift mutation in pten, an inhibitor of pi-3k/akt pathway, were observed to be completely resistant to trail-induced apoptosis. |
2008-12-05 |
2023-08-12 |
human |
| Gregory D Ford, Byron D Ford, Ernest C Steele, Alicia Gates, Darryl Hood, Mika A B Matthews, Sophia Mirza, Peter R MacLeis. Analysis of transcriptional profiles and functional clustering of global cerebellar gene expression in PCD3J mice. Biochemical and biophysical research communications. vol 377. issue 2. 2008-12-05. PMID:18930027. |
ipa analysis indicated that mutant pcd3j mice showed dysregulation of specific processes that may lead to purkinje cell death, including several molecules known to control neuronal apoptosis such as bad, cdk5 and pten. |
2008-12-05 |
2023-08-12 |
mouse |
| Shuang-ping Guo, Li Wang, Wen-liang Wang, Qin-long Li, Wen-yong Wang, Jing Zhan. [Mutations of tumor suppressor gene PTEN mutations in hepatocellular carcinoma and its implications in tumor proliferation and apoptosis]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 35. issue 8. 2008-12-03. PMID:17069699. |
[mutations of tumor suppressor gene pten mutations in hepatocellular carcinoma and its implications in tumor proliferation and apoptosis]. |
2008-12-03 |
2023-08-12 |
human |
| Shuang-ping Guo, Li Wang, Wen-liang Wang, Qin-long Li, Wen-yong Wang, Jing Zhan. [Mutations of tumor suppressor gene PTEN mutations in hepatocellular carcinoma and its implications in tumor proliferation and apoptosis]. Zhonghua bing li xue za zhi = Chinese journal of pathology. vol 35. issue 8. 2008-12-03. PMID:17069699. |
to study mutations of tumor suppressor gene pten in human hepatocellular carcinomas and its effects on the proliferation and apoptosis of hepatocellular carcinoma cell line hhcc. |
2008-12-03 |
2023-08-12 |
human |
| Francis Dida, Yufeng Li, Atsushi Iwao, Takao Deguchi, Eiichi Azuma, Yoshihiro Komad. Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells. Experimental hematology. vol 36. issue 10. 2008-12-03. PMID:18599181. |
resistance to trail-induced apoptosis caused by constitutional phosphorylation of akt and pten in acute lymphoblastic leukemia cells. |
2008-12-03 |
2023-08-12 |
Not clear |
| Marie-Noëlle Laguë, Marilène Paquet, Heng-Yu Fan, M Johanna Kaartinen, Simon Chu, Soazik P Jamin, Richard R Behringer, Peter J Fuller, Andrew Mitchell, Monique Doré, Louis M Huneault, Joanne S Richards, Derek Boerboo. Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. Carcinogenesis. vol 29. issue 11. 2008-11-24. PMID:18687666. |
the expression of the pi3k/akt downstream effector foxo1 was abrogated in pten(flox/flox);amhr2(cre/+) gct, indicating a mechanism by which gct cells may increase proliferation and evade apoptosis. |
2008-11-24 |
2023-08-12 |
mouse |
| Heng-Yu Fan, Zhilin Liu, Nicola Cahill, JoAnne S Richard. Targeted disruption of Pten in ovarian granulosa cells enhances ovulation and extends the life span of luteal cells. Molecular endocrinology (Baltimore, Md.). vol 22. issue 9. 2008-11-13. PMID:18606860. |
these physiological differences in the pten mutant mice were associated with hyperactivation of the pi3k/acute transforming retrovirus thymoma protein kinase pathway, decreased susceptibility to apoptosis, and increased proliferation of mutant granulosa cells. |
2008-11-13 |
2023-08-12 |
mouse |
| Qingyong Chen, Chunyou Wang, Chunfang Jiang, Daoda Che. Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 1. 2008-10-14. PMID:17393112. |
exogenous pten gene induces apoptosis in breast carcinoma cell line mda468. |
2008-10-14 |
2023-08-12 |
Not clear |
| Qingyong Chen, Chunyou Wang, Chunfang Jiang, Daoda Che. Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 1. 2008-10-14. PMID:17393112. |
the effects and mechanisms of exogenous phosphatase and tensin homolog deleted from chromosome ten (pten) gene on phosphatase activity-dependent apoptosis of breast cancer cell line mda468 were investigated. |
2008-10-14 |
2023-08-12 |
Not clear |
| Qingyong Chen, Chunyou Wang, Chunfang Jiang, Daoda Che. Exogenous PTEN gene induces apoptosis in breast carcinoma cell line MDA468. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 27. issue 1. 2008-10-14. PMID:17393112. |
pten induced breast cancer apoptosis phosphatase activity-dependently. |
2008-10-14 |
2023-08-12 |
Not clear |
| M Keniry, R Parson. The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene. vol 27. issue 41. 2008-10-08. PMID:18794882. |
since then, pten has been shown to be a non-redundant, evolutionarily conserved phosphatase whose function affects diverse cellular progresses such as cell cycle progression, cell proliferation, chemotaxis, apoptosis, aging, muscle contractility, dna damage response, angiogenesis and cell polarity. |
2008-10-08 |
2023-08-12 |
Not clear |
| L O Almeida, A C Custódio, J J Araújo, J A Rey, J R W Almeida, M J Santos, C A Clara, C Casartell. Mutational analysis of genes p14ARF, p15INK4b, p16INK4a, and PTEN in human nervous system tumors. Genetics and molecular research : GMR. vol 7. issue 2. 2008-10-06. PMID:18551412. |
the pten gene is related to the induction of growth suppression through cell cycle arrest, to apoptosis and to the inhibition of cell adhesion and migration. |
2008-10-06 |
2023-08-12 |
human |
| R Wang, H Li, G Guo, X Li, X Yu, H Li, J Wang, F Liu, X Che. Augmentation by carnosic acid of apoptosis in human leukaemia cells induced by arsenic trioxide via upregulation of the tumour suppressor PTEN. The Journal of international medical research. vol 36. issue 4. 2008-09-18. PMID:18652763. |
augmentation by carnosic acid of apoptosis in human leukaemia cells induced by arsenic trioxide via upregulation of the tumour suppressor pten. |
2008-09-18 |
2023-08-12 |
human |
| R Wang, H Li, G Guo, X Li, X Yu, H Li, J Wang, F Liu, X Che. Augmentation by carnosic acid of apoptosis in human leukaemia cells induced by arsenic trioxide via upregulation of the tumour suppressor PTEN. The Journal of international medical research. vol 36. issue 4. 2008-09-18. PMID:18652763. |
these findings indicate that pten plays an important role in the coordinated induction of apoptosis and g(1) arrest by carnosic acid and arsenic trioxide. |
2008-09-18 |
2023-08-12 |
human |
| Daniela Opel, Mike-Andrew Westhoff, Ariane Bender, Veit Braun, Klaus-Michael Debatin, Simone Fuld. Phosphatidylinositol 3-kinase inhibition broadly sensitizes glioblastoma cells to death receptor- and drug-induced apoptosis. Cancer research. vol 68. issue 15. 2008-09-08. PMID:18676851. |
here, we report that inhibition of pi3k by ly294002 broadly sensitizes wild-type and mutant pten glioblastoma cells to both death receptor- and chemotherapy-induced apoptosis, whereas mammalian target of rapamycin (mtor) inhibition is not sufficient to restore apoptosis sensitivity. |
2008-09-08 |
2023-08-12 |
human |
| Ningxi Zhu, Lubing Gu, Fengzhi Li, Muxiang Zho. Inhibition of the Akt/survivin pathway synergizes the antileukemia effect of nutlin-3 in acute lymphoblastic leukemia cells. Molecular cancer therapeutics. vol 7. issue 5. 2008-08-22. PMID:18483299. |
we report that inhibition of pi3k/akt, either by the pi3k inhibitor ly294002 or by expression of pten, synergized the ability of the mdm2 antagonist nutlin-3 to induce apoptosis in acute lymphoblastic leukemia (all). |
2008-08-22 |
2023-08-12 |
Not clear |