| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Soon Young Shin, Yeonjoong Yong, Chang Gun Kim, Young Han Lee, Yoongho Li. Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells. Cancer letters. vol 287. issue 2. 2010-03-02. PMID:19616373. |
together, these data suggest that dppt induces g(2)/m cell-cycle arrest followed by apoptosis through multiple cellular processes, involving the activation of atm, upregulation of p53 and bax, activation of caspase-3 and -7, and accumulation of pten resulting in the inhibition of the akt pathway. |
2010-03-02 |
2023-08-12 |
Not clear |
| Venkatabalasubramanian Sivaramakrishnan, Sivasitambaram Niranjali Devara. Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. Chemico-biological interactions. vol 183. issue 2. 2010-02-25. PMID:19931519. |
further, morin caused the up-regulation of tumor suppressor pten, an important negative regulator of akt, thus initiating apoptosis. |
2010-02-25 |
2023-08-12 |
Not clear |
| M Ming, W Han, J Maddox, K Soltani, C R Shea, D M Freeman, Y-Y H. UVB-induced ERK/AKT-dependent PTEN suppression promotes survival of epidermal keratinocytes. Oncogene. vol 29. issue 4. 2010-02-05. PMID:19881543. |
increasing pten expression enhances apoptosis of keratinocytes in response to uvb irradiation. |
2010-02-05 |
2023-08-12 |
mouse |
| Seunggu J Han, Brian J Ahn, James S Waldron, Isaac Yang, Shanna Fang, Courtney A Crane, Russell O Pieper, Andrew T Pars. Gamma interferon-mediated superinduction of B7-H1 in PTEN-deficient glioblastoma: a paradoxical mechanism of immune evasion. Neuroreport. vol 20. issue 18. 2010-02-01. PMID:19875977. |
the combination of pten loss and gamma-interferon exposure in glioblastoma patients results in an exceptionally immunoresistant phenotype that may negate adaptive immunity through induction of t-cell apoptosis. |
2010-02-01 |
2023-08-12 |
Not clear |
| Deyuan Li, Yi Qu, Meng Mao, Xiaolan Zhang, Jinhui Li, Donna Ferriero, Dezhi M. Involvement of the PTEN-AKT-FOXO3a pathway in neuronal apoptosis in developing rat brain after hypoxia-ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 29. issue 12. 2010-01-26. PMID:19623194. |
moreover, the downregulation of bim caused by pten inhibition attenuated cellular apoptosis in developing rat brain. |
2010-01-26 |
2023-08-12 |
rat |
| Joshua A Smith, Ran Zhang, Abhay K Varma, Arabinda Das, Swapan K Ray, Naren L Bani. Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma. Brain research. vol 1301. 2010-01-05. PMID:19748493. |
estrogen partially down-regulates pten to prevent apoptosis in vsc4.1 motoneurons following exposure to ifn-gamma. |
2010-01-05 |
2023-08-12 |
human |
| Joshua A Smith, Ran Zhang, Abhay K Varma, Arabinda Das, Swapan K Ray, Naren L Bani. Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-gamma. Brain research. vol 1301. 2010-01-05. PMID:19748493. |
up-regulation of pten following ifn-gamma exposure was associated with decreased overall cell viability due to increased apoptosis, as assessed by wright staining and analysis of cell death markers including bax, bcl-2, calpain activity, and caspase-3 activity, indicating a prominent role for pten in suppression of the pi3k/akt survival pathway to promote motoneuron death. |
2010-01-05 |
2023-08-12 |
human |
| Bozena Kaminska, Aleksandra Ellert-Miklaszewska, Agata Oberbek, Pawel Wisniewski, Beata Kaza, Malgorzata Makowska, Maria Bretner, Zygmunt Kazimierczu. Efficacy and mechanism of anti-tumor action of new potential CK2 inhibitors toward glioblastoma cells. International journal of oncology. vol 35. issue 5. 2009-12-16. PMID:19787263. |
tbi, dmat and zkk1-induced apoptosis associated with caspase cascade activation in human malignant glioblastoma cells with mutated pt53 and pten genes. |
2009-12-16 |
2023-08-12 |
human |
| Cong Liu, Sheng Zhou, Chang-Shu Ke, Na-Ping Li, Ren-Liang W. [Activation and prognostic significance of AKT, NF-kappaB and STAT3 in breast cancer with lymph node metastasis and estrogen receptor expression]. Ai zheng = Aizheng = Chinese journal of cancer. vol 26. issue 9. 2009-12-03. PMID:17927847. |
being downstream targets of the phosphatase and tensin homolog deleted on chromosome ten (pten) and epidermal growth factor receptor (egfr) pathways, serine/threonine kinase akt, nuclear factor-kappab (nf-kappab) and signal transducer and activator of transcription-3 (stat3), play important roles in cell proliferation, apoptosis and oncogenesis. |
2009-12-03 |
2023-08-12 |
Not clear |
| Amith Panner, Courtney A Crane, Changjiang Weng, Alberto Feletti, Andrew T Parsa, Russell O Piepe. A novel PTEN-dependent link to ubiquitination controls FLIPS stability and TRAIL sensitivity in glioblastoma multiforme. Cancer research. vol 69. issue 20. 2009-11-24. PMID:19808964. |
phosphatase and tensin homologue (pten) loss and activation of the akt-mammalian target of rapamycin (mtor) pathway increases mrna translation, increases levels of the antiapoptotic protein flip(s), and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand (trail)-induced apoptosis in glioblastoma multiforme (gbm). |
2009-11-24 |
2023-08-12 |
Not clear |
| Emanuela D'Angelo, Luigi G Spagnoli, Jaime Pra. Comparative clinicopathologic and immunohistochemical analysis of uterine sarcomas diagnosed using the World Health Organization classification system. Human pathology. vol 40. issue 11. 2009-11-10. PMID:19540555. |
a tissue microarray was prepared and immunostaining performed for 10 selected oncoproteins involved in cell proliferation (ki-67, p53, p16, and phosphatase and tensin homolog [pten]), cell differentiation (cd10, h-caldesmon, estrogen receptor, and progesterone receptor), and apoptosis (bcl-2 and twist). |
2009-11-10 |
2023-08-12 |
Not clear |
| Xiao-Han Li, Hua-Chuan Zheng, Hiroyuki Takahashi, Shinji Masuda, Xiang-Hong Yang, Yasuo Takan. PTEN expression and mutation in colorectal carcinomas. Oncology reports. vol 22. issue 4. 2009-11-09. PMID:19724853. |
these results suggested that down-regulated pten expression was involved in the pathogenesis, invasion and metastasis of colorectal carcinomas possibly by regulating the balance between apoptosis and proliferation. |
2009-11-09 |
2023-08-12 |
Not clear |
| Céline Van Themsche, Valérie Leblanc, Sophie Parent, Eric Asseli. X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization. The Journal of biological chemistry. vol 284. issue 31. 2009-10-14. PMID:19473982. |
x-linked inhibitor of apoptosis protein (xiap) regulates pten ubiquitination, content, and compartmentalization. |
2009-10-14 |
2023-08-12 |
mouse |
| Cristina Cellai, Anna Laurenzana, Elisa Bianchi, Sara Sdelci, Rossella Manfredini, Alessandro M Vannucchi, Roberto Caporale, Manjola Balliu, Francesco Mannelli, Sergio Ferrari, Alberto Bosi, Debora Miniati, Pier L Cocco, Steeve Veronneau, Jana Stankova, Francesco Paolett. Mechanistic insight into WEB-2170-induced apoptosis in human acute myelogenous leukemia cells: the crucial role of PTEN. Experimental hematology. vol 37. issue 10. 2009-10-07. PMID:19615424. |
mechanistic insight into web-2170-induced apoptosis in human acute myelogenous leukemia cells: the crucial role of pten. |
2009-10-07 |
2023-08-12 |
human |
| Johanna Heering, Patrik Erlmann, Monilola A Olayioy. Simultaneous loss of the DLC1 and PTEN tumor suppressors enhances breast cancer cell migration. Experimental cell research. vol 315. issue 15. 2009-09-28. PMID:19482022. |
pten loss confers a growth advantage to cells, protects from apoptosis and favors cell migration. |
2009-09-28 |
2023-08-12 |
Not clear |
| Fang Gao, Hao Li, Ya-Dong Chen, Xiao-Ning Yu, Ran Wang, Xue-Liang Che. Upregulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line. Leukemia & lymphoma. vol 50. issue 4. 2009-09-25. PMID:19373662. |
upregulation of pten involved in scorpion venom-induced apoptosis in a lymphoma cell line. |
2009-09-25 |
2023-08-12 |
human |
| Fang Gao, Hao Li, Ya-Dong Chen, Xiao-Ning Yu, Ran Wang, Xue-Liang Che. Upregulation of PTEN involved in scorpion venom-induced apoptosis in a lymphoma cell line. Leukemia & lymphoma. vol 50. issue 4. 2009-09-25. PMID:19373662. |
the results indicate that key regulators in bmk venom-induced apoptosis are pten, acting through downregulation of the pi3k/akt signal pathway, in raji cells and p27 in jurkat cells. |
2009-09-25 |
2023-08-12 |
human |
| Brock C Christensen, Carmen J Marsit, E Andres Houseman, John J Godleski, Jennifer L Longacker, Shichun Zheng, Ru-Fang Yeh, Margaret R Wrensch, Joseph L Wiemels, Margaret R Karagas, Raphael Bueno, David J Sugarbaker, Heather H Nelson, John K Wiencke, Karl T Kelse. Differentiation of lung adenocarcinoma, pleural mesothelioma, and nonmalignant pulmonary tissues using DNA methylation profiles. Cancer research. vol 69. issue 15. 2009-09-11. PMID:19638575. |
using the cpg loci with significant differential methylation in a pathway analysis revealed significant enrichment of methylated gene-loci in cell cycle regulation, dna damage response, pten signaling, and apoptosis signaling pathways in lung adenocarcinoma when compared with mesothelioma. |
2009-09-11 |
2023-08-12 |
Not clear |
| S Bouali, A-S Chrétien, C Ramacci, M Rouyer, S Marchal, T Galenne, P Juin, P Becuwe, J-L Merli. P53 and PTEN expression contribute to the inhibition of EGFR downstream signaling pathway by cetuximab. Cancer gene therapy. vol 16. issue 6. 2009-08-05. PMID:19165235. |
the results presented show that p53 and pten gene transfer additionally mediated cell growth inhibition and apoptosis induction by restoral of signaling functionality, which enabled the control of pi3k/akt and mapkinase signaling pathways by cetuximab in pc3 cells. |
2009-08-05 |
2023-08-12 |
Not clear |
| Minakshi Guha, Janet Plescia, Irwin Leav, Jing Li, Lucia R Languino, Dario C Altier. Endogenous tumor suppression mediated by PTEN involves survivin gene silencing. Cancer research. vol 69. issue 12. 2009-07-06. PMID:19470765. |
here, we show that the dual specificity phosphatase pten, a gene almost universally altered in human tumors, silences the expression of survivin, an essential regulator of cell division and apoptosis in cancer. |
2009-07-06 |
2023-08-12 |
mouse |