| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karuppaiyah Selvendiran, M Lakshmi Kuppusamy, Anna Bratasz, Liyue Tong, Brian K Rivera, Cameron Rink, Chandan K Sen, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19276401. |
suppression of pten expression by pten-small interfering rna transfection reduced p53 and p21 levels and increased extracellular signal-regulated kinase 1/2 phosphorylation, resulting in decreased apoptosis. |
2009-06-23 |
2023-08-12 |
human |
| Karuppaiyah Selvendiran, M Lakshmi Kuppusamy, Anna Bratasz, Liyue Tong, Brian K Rivera, Cameron Rink, Chandan K Sen, Tamás Kálai, Kálmán Hideg, Periannan Kuppusam. Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression. The Journal of pharmacology and experimental therapeutics. vol 329. issue 3. 2009-06-23. PMID:19276401. |
conversely, overexpression of pten by cdna transfection activated caspase-3 and increased apoptosis. |
2009-06-23 |
2023-08-12 |
human |
| Yitang Li, Yonghui Jia, Muriel Pichavant, Fabien Loison, Bara Sarraj, Anongnard Kasorn, Jian You, Bryanne E Robson, Dale T Umetsu, Joseph P Mizgerd, Keqiang Ye, Hongbo R Lu. Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood. vol 113. issue 20. 2009-06-09. PMID:19286998. |
depleting pten also significantly delayed apoptosis and enhanced the bacteria-killing capability of the recruited neutrophils. |
2009-06-09 |
2023-08-12 |
mouse |
| Zhi Y Cheng, Xiao L Guo, Xiao Y Yang, Zhi Y Niu, Shi H Li, Su Y Wang, Hao Chen, Ling Pa. PTEN and rapamycin inhibiting the growth of K562 cells through regulating mTOR signaling pathway. Journal of experimental & clinical cancer research : CR. vol 27. 2009-06-08. PMID:19115995. |
to investigate, in vitro, the regulatory effects of tumor-suppressing gene pten on mtor (mammalian target of rapamycin) signaling pathway, the effects of transfected pten and rapamycin on the growth inhibition, and apoptosis induction for human leukemia cell line k562 cells. |
2009-06-08 |
2023-08-12 |
human |
| Nageatte Ibrahim, Frank G Halusk. Molecular pathogenesis of cutaneous melanocytic neoplasms. Annual review of pathology. vol 4. 2009-05-28. PMID:19400696. |
this review explores the major genes involved in familial and sporadic cutaneous melanoma with an emphasis on cdkn2a, cdk4, mc1r, and mapk pathway targets (e.g., ras and braf), apoptosis regulators (e.g., bcl-2, akt, and apaf-1), and the tumor-suppressor genes tp53 and pten. |
2009-05-28 |
2023-08-12 |
Not clear |
| Sanae Bouali, Anne-Sophie Chrétien, Carole Ramacci, Marie Rouyer, Philippe Becuwe, Jean-Louis Merli. PTEN expression controls cellular response to cetuximab by mediating PI3K/AKT and RAS/RAF/MAPK downstream signaling in KRAS wild-type, hormone refractory prostate cancer cells. Oncology reports. vol 21. issue 3. 2009-05-07. PMID:19212633. |
reintroduction of pten significantly reduced the constitutive overexpression of phosphorylated-akt (p-akt) and downstream kinases (p-gsk3beta and p-p70s6 kinase) as well as phosphorylated-erk1/2 (p-erk1/2) and consequently significantly restored cetuximab-induced cell growth inhibition and apoptosis induction. |
2009-05-07 |
2023-08-12 |
human |
| Xiao-Jing Yue, Wei-Dong Song, Xue-Jun Jian. [The mitochondrial localization of tumor suppressor PTEN promotes apoptosis in A431 cells]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 6. 2009-05-05. PMID:18271247. |
[the mitochondrial localization of tumor suppressor pten promotes apoptosis in a431 cells]. |
2009-05-05 |
2023-08-12 |
Not clear |
| Xiao-Jing Yue, Wei-Dong Song, Xue-Jun Jian. [The mitochondrial localization of tumor suppressor PTEN promotes apoptosis in A431 cells]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 6. 2009-05-05. PMID:18271247. |
to study the function of mitochondrial pten in mediation of cellular apoptosis, the adenoviral recombinant of mito-pten, which contains coxvii (subunit vii of cytochrome c oxidase) gene in n-terminus, were generated. |
2009-05-05 |
2023-08-12 |
Not clear |
| Xiao-Jing Yue, Wei-Dong Song, Xue-Jun Jian. [The mitochondrial localization of tumor suppressor PTEN promotes apoptosis in A431 cells]. Wei sheng wu xue bao = Acta microbiologica Sinica. vol 47. issue 6. 2009-05-05. PMID:18271247. |
take together, the successful generation of adenoviral recombinant of mito-pten, which could induce apoptosis in a431 cells, sets up a basis for further functional studies of mitochondrial pten and provides us a potential tool for cancer treatment in future. |
2009-05-05 |
2023-08-12 |
Not clear |
| Hongmei Ruan, Jian Li, Shuxun Ren, Jing Gao, Guangping Li, Rachel Kim, Hong Wu, Yibin Wan. Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury. Journal of molecular and cellular cardiology. vol 46. issue 2. 2009-05-05. PMID:19038262. |
pten(cko) hearts had significantly fewer apoptosis positive cardiomyocytes after i/r injury as identified by tunel staining. |
2009-05-05 |
2023-08-12 |
mouse |
| H Ge, Y Y Cao, L Q Chen, Y M Wang, Z F Chen, D G Wen, X F Zhang, W Guo, N Wang, Y Li, J H Zhan. PTEN polymorphisms and the risk of esophageal carcinoma and gastric cardiac carcinoma in a high incidence region of China. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 21. issue 5. 2009-04-21. PMID:19125794. |
pten, as a tumor suppressor gene, plays an important role in regulating cell growth, proliferation, and apoptosis. |
2009-04-21 |
2023-08-12 |
human |
| Liang-Qi Cao, Xi-Lin Chen, Qian Wang, Xiao-Hui Huang, Mao-Chuan Zhen, Long-Juan Zhang, Wen Li, Jiong B. Upregulation of PTEN involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. Acta pharmacologica Sinica. vol 28. issue 6. 2009-04-20. PMID:17506947. |
upregulation of pten involved in rosiglitazone-induced apoptosis in human hepatocellular carcinoma cells. |
2009-04-20 |
2023-08-12 |
human |
| Fredrika Gauffin, Eva Diffner, Bertil Gustafsson, Ann Nordgren, Anette Gjörloff Wingren, Birgitta Sander, Jenny Liao Persson, Britt Gustafsso. Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia. Pediatric hematology and oncology. vol 26. issue 1. 2009-04-13. PMID:19206008. |
pten and shp1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. |
2009-04-13 |
2023-08-12 |
Not clear |
| Anna Radziszewska, Diana Choi, Kinh-Tung T Nguyen, Stephanie A Schroer, Panteha Tajmir, Linyuan Wang, Akira Suzuki, Tak W Mak, Gerard I Evan, Minna Wo. PTEN deletion and concomitant c-Myc activation do not lead to tumor formation in pancreatic beta cells. The Journal of biological chemistry. vol 284. issue 5. 2009-04-07. PMID:19056726. |
surprisingly, we found that pten loss did not confer protection from the overwhelming apoptosis and diabetes development seen with c-myc activation. |
2009-04-07 |
2023-08-12 |
mouse |
| Shuhua Cheng, Constance Yu Hsia, Biao Feng, Mei-Ling Liou, Xiaoying Fang, Pier Paolo Pandolfi, Hsiou-Chi Lio. BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten. Cell research. vol 19. issue 2. 2009-03-30. PMID:18781138. |
bcr-mediated apoptosis associated with negative selection of immature b cells is selectively dependent on pten. |
2009-03-30 |
2023-08-12 |
Not clear |
| Shuhua Cheng, Constance Yu Hsia, Biao Feng, Mei-Ling Liou, Xiaoying Fang, Pier Paolo Pandolfi, Hsiou-Chi Lio. BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten. Cell research. vol 19. issue 2. 2009-03-30. PMID:18781138. |
we use transitional immature b cells that are highly susceptible to bcr-induced apoptosis to show that pten is selectively required for bcr-mediated initiation of the mitochondrial death pathway. |
2009-03-30 |
2023-08-12 |
Not clear |
| Shuhua Cheng, Constance Yu Hsia, Biao Feng, Mei-Ling Liou, Xiaoying Fang, Pier Paolo Pandolfi, Hsiou-Chi Lio. BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten. Cell research. vol 19. issue 2. 2009-03-30. PMID:18781138. |
specifically, deleting pten, but not other pro-apoptotic molecules, abrogates bcr-elicited apoptosis and improves viability in wild-type immature b cells. |
2009-03-30 |
2023-08-12 |
Not clear |
| Shuhua Cheng, Constance Yu Hsia, Biao Feng, Mei-Ling Liou, Xiaoying Fang, Pier Paolo Pandolfi, Hsiou-Chi Lio. BCR-mediated apoptosis associated with negative selection of immature B cells is selectively dependent on Pten. Cell research. vol 19. issue 2. 2009-03-30. PMID:18781138. |
restoration of akt activity using a constitutive form of akt or reduction of pten to a level comparable with that seen in mature b cells rescues immature b cells from bcr-induced apoptosis. |
2009-03-30 |
2023-08-12 |
Not clear |
| James W Peacock, Jodie Palmer, Dieter Fink, Stephen Ip, Eric M Pietras, Alice L-F Mui, Stephen W Chung, Martin E Gleave, Michael E Cox, Ramon Parsons, Marcus E Peter, Christopher J On. PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103758. |
pten loss promotes mitochondrially dependent type ii fas-induced apoptosis via pea-15. |
2009-03-10 |
2023-08-12 |
mouse |
| James W Peacock, Jodie Palmer, Dieter Fink, Stephen Ip, Eric M Pietras, Alice L-F Mui, Stephen W Chung, Martin E Gleave, Michael E Cox, Ramon Parsons, Marcus E Peter, Christopher J On. PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15. Molecular and cellular biology. vol 29. issue 5. 2009-03-10. PMID:19103758. |
importantly, from analyses of bcl-2 transgenic pten(+/-) mice, pten haploinsufficiency converts fas-induced apoptosis from a bcl-2-independent to a bcl-2-sensitive response in primary thymocytes and activated t lymphocytes. |
2009-03-10 |
2023-08-12 |
mouse |