| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
preventing peroxynitrite formation by administrating nac/l: -nmma, or scavenging peroxynitrite directly by ua, attenuated cytokine-induced pten upregulation, akt inhibition, and beta-cell apoptosis. |
2010-10-20 |
2023-08-12 |
Not clear |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
these findings suggest that peroxynitrite-mediated pten upregulation plays an important role in cytokine-induced pancreatic beta-cell apoptosis. |
2010-10-20 |
2023-08-12 |
Not clear |
| Tao Tian, Ke-Jun Nan, Hui Guo, Wen-Juan Wang, Zhi-Ping Ruan, Shu-Hong Wang, Xuan Liang, Chuang-Xin L. PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway. Oncology reports. vol 23. issue 6. 2010-09-30. PMID:20428814. |
we found that overexpression of pten inhibits hepg2 cell growth via cell cycle arrest without inducing apoptosis. |
2010-09-30 |
2023-08-12 |
human |
| Yasemin Ozsürekci, Süleyman Tolga Yavuz, Yasemin Alanay, Gülen Eda Utine, Omer Kalayc. Cowden syndrome with bronchial asthma. The Turkish journal of pediatrics. vol 52. issue 3. 2010-09-21. PMID:20718196. |
mutations of tumor suppressor gene pten (phosphatase and tensin homolog) on chromosome 10p23.2, which encodes a lipid phosphatase mediating cell cycle arrest and apoptosis, were first described in cs. |
2010-09-21 |
2023-08-12 |
Not clear |
| L Su, H Cheng, A V Sampaio, T O Nielsen, T M Underhil. EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor. Oncogene. vol 29. issue 30. 2010-08-20. PMID:20514024. |
using a combination of gain- and loss-of-function approaches, we show that egr1 modulation of pten contributes to hdac inhibitor-induced apoptosis in synovial sarcoma. |
2010-08-20 |
2023-08-12 |
Not clear |
| Yong-An Zhou, Tao Zhang, Jin-Bo Zhao, Xiao-Ping Wang, Tao Jiang, Zhong-Ping Gu, Xian-Ni Wang, Xiao-Fei L. The adenovirus-mediated transfer of PTEN inhibits the growth of esophageal cancer cells in vitro and in vivo. Bioscience, biotechnology, and biochemistry. vol 74. issue 4. 2010-08-10. PMID:20378992. |
we found that compared to control cells, overexpression of pten significantly suppressed growth and induced apoptosis in esophageal cancer cell lines eca-109 and te-1 via downregulation of bcl-2 expression and changes in cell-cycle progression. |
2010-08-10 |
2023-08-12 |
human |
| Ki-Seok Jang, Young Soo Song, Si-Hyong Jang, Kyueng-Whan Min, Woong Na, Se Min Jang, Young Jin Jun, Kang Hong Lee, Dongho Choi, Seung Sam Pai. Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma. Histopathology. vol 56. issue 2. 2010-07-21. PMID:20102402. |
tumour suppressor phosphatase and tensin homologue (pten) is an important negative regulator for the pip3/akt signalling pathway that promotes cell proliferation and inhibits apoptosis. |
2010-07-21 |
2023-08-12 |
Not clear |
| Chuan-Bian Lim, Nung Ky, Hui-Min Ng, Mohamed Sabry Hamza, Yan Zha. Curcuma wenyujin extract induces apoptosis and inhibits proliferation of human cervical cancer cells in vitro and in vivo. Integrative cancer therapies. vol 9. issue 1. 2010-06-24. PMID:20150221. |
cwe-treated cells displayed reduced pten, akt, and stat3 phosphorylation and downregulation of nfkappab signaling, providing a mechanism for the g1 arrest and apoptosis observed. |
2010-06-24 |
2023-08-12 |
mouse |
| Jia-jia Ma, Bi-liang Chen, Xiang-dong Ma, Yun-xin Ca. [Effect of gestrinone on growth and apoptosis in isolated ectopic endometrium cells in vitro]. Zhonghua fu chan ke za zhi. vol 40. issue 5. 2010-06-15. PMID:15938784. |
to investigate the effects of gestrinone on growth and apoptosis, as well as the expression of phosphatase and tension homologue deleted on chromosome 10 (pten) in isolated ectopic endometrium cells in vitro and the underlying mechanisms. |
2010-06-15 |
2023-08-12 |
Not clear |
| Zhi-yong Cheng, Xiao-ling Guo, Shi-hui Li, Su-yun Wang, Xiao-yang Yang, Fang Xue, Shu-peng Wen, Ling Pa. [The role of PTEN-FAK signaling pathway in metastasis and invasive ability of leukemia cells]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. vol 30. issue 2. 2010-05-27. PMID:19563023. |
to investigate the effect of the wild type phosphatase and tensin homolog deleted on chromosome 10 (pten), a tumor-suppressor gene on the proliferation and apoptosis of human chronic myeloid leukemia (cml) cells line (k562) in vitro and explore the influence of pten-fak signaling pathway on invasion and metastasis of leukemia cells. |
2010-05-27 |
2023-08-12 |
human |
| S S Solomon, O Odunusi, D Carrigan, G Majumdar, D Kakoola, N I Lenchik, I C Gerlin. TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 42. issue 2. 2010-04-22. PMID:19960405. |
moreover, the two datasets combined generated a single molecular network that further identified pten (a phosphatase) as a unique new link between insulin signaling, ir, and apoptosis reflecting the pathophysiology of "metabolic syndrome". |
2010-04-22 |
2023-08-12 |
rat |
| Xuan Zhou, Yu Ren, Lynette Moore, Mei Mei, Yongping You, Peng Xu, Baoli Wang, Guangxiu Wang, Zhifan Jia, Peiyu Pu, Wei Zhang, Chunsheng Kan. Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Laboratory investigation; a journal of technical methods and pathology. vol 90. issue 2. 2010-04-09. PMID:20048743. |
to explore whether mir-21 can serve as a therapeutic target for glioblastoma, we downregulated mir-21 with a specific antisense oligonucleotide and found that apoptosis was induced and cell-cycle progression was inhibited in vitro in u251 (pten mutant) and ln229 (pten wild-type) gbm cells; xenograft tumors from antisense-treated u251 cells were suppressed in vivo. |
2010-04-09 |
2023-08-12 |
human |
| Zhi-Yong Cheng, Wen-Tong Liang, Zhi-Yun Niu, Fang Xue, Li Yao, Ling Pa. [Effects of wild type PTEN gene on proliferation, apoptosis and the influence on apoptosis key factor Bcl-2 and Caspase family on K562 cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 40. issue 4. 2010-03-30. PMID:19764572. |
[effects of wild type pten gene on proliferation, apoptosis and the influence on apoptosis key factor bcl-2 and caspase family on k562 cells]. |
2010-03-30 |
2023-08-12 |
human |
| Zhi-Yong Cheng, Wen-Tong Liang, Zhi-Yun Niu, Fang Xue, Li Yao, Ling Pa. [Effects of wild type PTEN gene on proliferation, apoptosis and the influence on apoptosis key factor Bcl-2 and Caspase family on K562 cells]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 40. issue 4. 2010-03-30. PMID:19764572. |
to investigate the effect of tumor-suppressing gene,wild type pten gene, mediated by adenovirus vector on the cell proliferation, apoptosis and the influence on apoptosis key factor bcl-2 and caspase family on human chronic myeloid leukemia (cml) cell line k562 in vitro. |
2010-03-30 |
2023-08-12 |
human |
| Li-sen Hao, Xiao-lan Zhang, Jun-yan An, Dong-mei Yao, Justin Karlin, Shu-ming Fang, Hui-qing Jiang, Wen-yuan Bai, Shuang Che. Adenoviral transduction of PTEN induces apoptosis of cultured hepatic stellate cells. Chinese medical journal. vol 122. issue 23. 2010-03-30. PMID:20092800. |
adenoviral transduction of pten induces apoptosis of cultured hepatic stellate cells. |
2010-03-30 |
2023-08-12 |
Not clear |
| Lina Pan, Ammar F Matloob, Juan Du, Hong Pan, Zhixiong Dong, Jing Zhao, Yu Feng, Yun Zhong, Baiqu Huang, Jun L. Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. The FEBS journal. vol 277. issue 4. 2010-03-08. PMID:20089040. |
vitamin d stimulates apoptosis in gastric cancer cells in synergy with trichostatin a /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced pten upregulation. |
2010-03-08 |
2023-08-12 |
Not clear |
| Lina Pan, Ammar F Matloob, Juan Du, Hong Pan, Zhixiong Dong, Jing Zhao, Yu Feng, Yun Zhong, Baiqu Huang, Jun L. Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. The FEBS journal. vol 277. issue 4. 2010-03-08. PMID:20089040. |
here we show that 1,25-dihydroxyvitamin d3 (vd3, the active form of vitamin d) significantly promoted apoptosis in the undifferentiated gastric cancer cell line hgc-27, and this was accompanied by a concurrent increase in phosphatase and tensin homolog deleted on chromosome 10 (pten) expression on vd3 treatment. |
2010-03-08 |
2023-08-12 |
Not clear |
| Lina Pan, Ammar F Matloob, Juan Du, Hong Pan, Zhixiong Dong, Jing Zhao, Yu Feng, Yun Zhong, Baiqu Huang, Jun L. Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. The FEBS journal. vol 277. issue 4. 2010-03-08. PMID:20089040. |
in contrast, knockdown of pten expression by stable transfection of pten small interfering rna greatly decreased the apoptosis rate. |
2010-03-08 |
2023-08-12 |
Not clear |
| Lina Pan, Ammar F Matloob, Juan Du, Hong Pan, Zhixiong Dong, Jing Zhao, Yu Feng, Yun Zhong, Baiqu Huang, Jun L. Vitamin D stimulates apoptosis in gastric cancer cells in synergy with trichostatin A /sodium butyrate-induced and 5-aza-2'-deoxycytidine-induced PTEN upregulation. The FEBS journal. vol 277. issue 4. 2010-03-08. PMID:20089040. |
furthermore, we found that the histone deacetylase inhibitors trichostatin a and sodium butyrate and the methylation inhibitor 5-aza-2'-deoxycytidine played important roles in vitamin d-induced apoptosis through pten upregulation. |
2010-03-08 |
2023-08-12 |
Not clear |
| Hyunsoo Kim, Wei Huang, Xiuli Jiang, Brenton Pennicooke, Peter J Park, Mark D Johnso. Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proceedings of the National Academy of Sciences of the United States of America. vol 107. issue 5. 2010-03-05. PMID:20080666. |
we demonstrate that mir-26a alone can transform cells and it promotes glioblastoma cell growth in vitro and in the mouse brain by decreasing pten, rb1, and map3k2/mekk2 protein expression, thereby increasing akt activation, promoting proliferation, and decreasing c-jun n-terminal kinase-dependent apoptosis. |
2010-03-05 |
2023-08-12 |
mouse |