| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marion Peyrou, Lucie Bourgoin, Michelangelo Fot. PTEN in liver diseases and cancer. World journal of gastroenterology. vol 16. issue 37. 2011-01-28. PMID:20872961. |
the phosphoinositide 3-kinase (pi3k)/phosphatase and tensin homolog (pten)/akt axis is a key signal transduction node that regulates crucial cellular functions, including insulin and other growth factors signaling, lipid and glucose metabolism, as well as cell survival and apoptosis. |
2011-01-28 |
2023-08-12 |
Not clear |
| Yan Cao, Shi-Liang Yu, Yan Wang, Gui-Ying Guo, Qiang Ding, Rui-Hua A. MicroRNA-dependent regulation of PTEN after arsenic trioxide treatment in bladder cancer cell line T24. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 32. issue 1. 2011-01-25. PMID:20857258. |
among them, knockdown of mirna-19a by anti-mirna-19a transfection showed a positive therapeutic effect in bladder cancer cells by inhibiting cell growth and inducing cell apoptosis targeting pten through the pten/akt pathway. |
2011-01-25 |
2023-08-12 |
human |
| Stephen Hyter, Gaurav Bajaj, Xiaobo Liang, Mariano Barbacid, Gitali Ganguli-Indra, Arup Kumar Indr. Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment cell & melanoma research. vol 23. issue 5. 2011-01-24. PMID:20629968. |
expression of several keratinocyte-derived mitogenic growth factors (et-1, hgf, scf, α-msh and fgf 2 ) was elevated in skin of bigenic mice, whereas fas, e-cadherin and pten, implicated in apoptosis, cellular invasion and melanomagenesis, respectively, were downregulated within the microdissected melanocytic tumors. |
2011-01-24 |
2023-08-12 |
mouse |
| Huiping Yuan, Yonggang Lu, Xiuqing Huang, Qinghua He, Yong Man, Yingsheng Zhou, Shu Wang, Jian L. Suppression of NADPH oxidase 2 substantially restores glucose-induced dysfunction of pancreatic NIT-1 cells. The FEBS journal. vol 277. issue 24. 2011-01-13. PMID:21073655. |
furthermore, high glucose concentrations led to apoptosis of β-cells by activation of p38mapk and p53, and dysfunction of β-cells through phosphatase and tensih homolog (pten)-dependent jun n-terminal kinase (jnk) activation and protein kinase b (akt/pkb) inhibition, which induced the translocation of forkhead box o1 and pancreatic duodenal homeobox-1, followed by reduced insulin expression and secretion. |
2011-01-13 |
2023-08-12 |
rat |
| Xue-qiong Fu, Jie-ping Yu, He-sheng Luo, Hong-gang Y. [The expression and role of PTEN in doxorubicin induced gastric cancer cell apoptosis]. Zhonghua nei ke za zhi. vol 49. issue 5. 2011-01-11. PMID:20646419. |
[the expression and role of pten in doxorubicin induced gastric cancer cell apoptosis]. |
2011-01-11 |
2023-08-12 |
Not clear |
| Lei Han, An-ling Zhang, Peng Xu, Xiao Yue, Yang Yang, Guang-xiu Wang, Zhi-fan Jia, Pei-yu Pu, Chun-sheng Kan. Combination gene therapy with PTEN and EGFR siRNA suppresses U251 malignant glioma cell growth in vitro and in vivo. Medical oncology (Northwood, London, England). vol 27. issue 3. 2010-12-30. PMID:19728186. |
it was found that down-regulation of egfr expression and up-regulation of pten expression resulted in the suppression of cell proliferation, arrest of cell cycle, reduction in cell invasion and promotion of cell apoptosis in vitro. |
2010-12-30 |
2023-08-12 |
mouse |
| Zafer Cetin, Gulay Ozbilim, Abdullah Erdogan, Guven Luleci, Sibel Berker Karauzu. Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR. Medical oncology (Northwood, London, England). vol 27. issue 3. 2010-12-30. PMID:19763916. |
our results indicate that, in addition to lack of pten expression, elevated levels of the mcl-1 protein might be one of the important intrinsic mechanisms protecting non-small-cell-lung cancer cells from apoptosis induced by several compounds. |
2010-12-30 |
2023-08-12 |
Not clear |
| Marie-Noëlle Laguë, Jacqui Detmar, Marilène Paquet, Alexandre Boyer, Joanne S Richards, S Lee Adamson, Derek Boerboo. Decidual PTEN expression is required for trophoblast invasion in the mouse. American journal of physiology. Endocrinology and metabolism. vol 299. issue 6. 2010-12-28. PMID:20858757. |
terminal deoxynucleotidyl transferase-mediated nick end labeling and bromodeoxyuridine incorporation analyses attributed to the lack of decidual regression mainly to decreased apoptosis in pten(tm1hwu/tm1hwu);amhr2(tm3(cre)bhr/+) decidual cells, rather than to increased proliferation. |
2010-12-28 |
2023-08-12 |
mouse |
| Qin Wang, Yang Wei, Madhusoodanan Mottamal, Mary F Roberts, Goran Krilo. Understanding the stereospecific interactions of 3-deoxyphosphatidylinositol derivatives with the PTEN phosphatase domain. Journal of molecular graphics & modelling. vol 29. issue 1. 2010-12-27. PMID:20538496. |
pten is an important control element of pi3k/akt signaling involved in controlling the processes of embryonic development, cell migration and apoptosis. |
2010-12-27 |
2023-08-12 |
Not clear |
| Suyun Wang, Zhiyong Cheng, Xiaoyang Yang, Kai Deng, Yan Cao, Hao Chen, Ling Pa. Effect of wild type PTEN gene on proliferation and invasion of multiple myeloma. International journal of hematology. vol 92. issue 1. 2010-12-23. PMID:20582577. |
we explored the effect of the wild type pten gene on the proliferation, apoptosis and invasive ability of multiple myeloma (mm) cells from mm patients and rpmi 8226 cells (a human myeloma cell line), and the effect of the pten/focal adhesion kinase (fak)/mmp signaling pathway on the invasion activity of rpmi 8226 cells. |
2010-12-23 |
2023-08-12 |
human |
| Wenyu Song, Marta Volosin, Andrea B Cragnolini, Barbara L Hempstead, Wilma J Friedma. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 46. 2010-12-23. PMID:21084616. |
apoptosis induced by p75(ntr) required suppression of trkb-induced phosphoinositide-3 kinase signaling, mediated by induction of pten, for apoptosis to proceed. |
2010-12-23 |
2023-08-12 |
rat |
| Lixin Hong, Maoyi Lai, Michelle Chen, Changchuan Xie, Rong Liao, Young Jun Kang, Changchun Xiao, Wen-Yuan Hu, Jiahuai Han, Peiqing Su. The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence. Cancer research. vol 70. issue 21. 2010-12-21. PMID:20851997. |
taken together with previous reports that mir-17-92 inhibits apoptosis by suppressing pten via the mir-19 components, our results indicate that this mirna cluster promotes tumorigenesis by antagonizing both tumor-suppressing mechanisms, apoptosis, and senescence, through the activities of different mirna components encoded in this cluster. |
2010-12-21 |
2023-08-12 |
human |
| Hui-Juan Zhang, Michelle Kwan-Yee Siu, Li-Li Jiang, Victor Chun-Yin Mak, Hextan Yuen-Sheung Ngan, Annie Nga-Yin Cheun. Overexpression of the Parkinson disease protein DJ-1 and its regulator PTEN in gestational trophoblastic disease. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 29. issue 5. 2010-12-10. PMID:20736773. |
a significant negative correlation was found between dj-1 and the apoptosis resistant gene bcl-2 (p=0.031), whereas a positive correlation was shown between pten and wild-type p53 (p=0.019). |
2010-12-10 |
2023-08-12 |
human |
| Medhat Shehata, Susanne Schnabl, Dita Demirtas, Martin Hilgarth, Rainer Hubmann, Elena Ponath, Sigrun Badrnya, Claudia Lehner, Andrea Hoelbl, Markus Duechler, Alexander Gaiger, Christoph Zielinski, Josef D Schwarzmeier, Ulrich Jaege. Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood. vol 116. issue 14. 2010-11-23. PMID:20576813. |
induction of apoptosis was associated with a decrease in phosphatidylinositol-3,4,5-triphosphate, pi3-k-p85, and dephosphorylation of phosphatidylinositol-dependent kinase-1 (pdk-1), akt1, and pten. |
2010-11-23 |
2023-08-12 |
human |
| Medhat Shehata, Susanne Schnabl, Dita Demirtas, Martin Hilgarth, Rainer Hubmann, Elena Ponath, Sigrun Badrnya, Claudia Lehner, Andrea Hoelbl, Markus Duechler, Alexander Gaiger, Christoph Zielinski, Josef D Schwarzmeier, Ulrich Jaege. Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia. Blood. vol 116. issue 14. 2010-11-23. PMID:20576813. |
ck2 inhibitors (4,5,6,7-tetrabromo-1h-benzotriazole, apigenin, and 5,6-dichloro-1-β-d-ribofuranosylbenzimidazol) decreased phosphorylation of pten and akt, induced apoptosis in cll cells, and enhanced the response to fludarabine. |
2010-11-23 |
2023-08-12 |
human |
| Jung Mook Kang, Nayoung Kim, Joo-Hyon Kim, Euichaul Oh, Bong-Yong Lee, Byoung Hwan Lee, Cheol Min Shin, Ji Hyun Park, Mi Kyoung Lee, Ryoung Hee Nam, Hee Eun Lee, Hye Seung Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Son. Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 5. 2010-11-12. PMID:20724528. |
we also evaluated the expression of early growth response-1 (egr-1), phosphatase and tension homologue deleted on chromosome 10 (pten), caspase-9 (index of apoptosis), vegf (index of angiogenesis), calcitonin gene-related peptide (cgrp, index of sensory neurons), and neuronal nitric oxide synthase (nnos). |
2010-11-12 |
2023-08-12 |
rat |
| Jung Mook Kang, Nayoung Kim, Joo-Hyon Kim, Euichaul Oh, Bong-Yong Lee, Byoung Hwan Lee, Cheol Min Shin, Ji Hyun Park, Mi Kyoung Lee, Ryoung Hee Nam, Hee Eun Lee, Hye Seung Lee, Joo Sung Kim, Hyun Chae Jung, In Sung Son. Effect of aging on gastric mucosal defense mechanisms: ROS, apoptosis, angiogenesis, and sensory neurons. American journal of physiology. Gastrointestinal and liver physiology. vol 299. issue 5. 2010-11-12. PMID:20724528. |
in addition, impairment of apoptosis, angiogenesis, and sensory neuron activity via the activation of egr-1 and pten might increase the susceptibility of gastric mucosa to injury during aging. |
2010-11-12 |
2023-08-12 |
rat |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
upregulation of pten by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. |
2010-10-20 |
2023-08-12 |
Not clear |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
phosphatase and tensin homolog (pten), a tumor suppressor gene, by negatively regulating the pi3k-akt signaling pathway, participates in multiple biological processes such as cell proliferation, apoptosis, differentiation, and migration. |
2010-10-20 |
2023-08-12 |
Not clear |
| Rongrong Hou, Jing Zhang, Tao Yin, Hongwei Cao, Nanyan Zhang, Xiaomiao Li, Li Wang, Ying Xing, Deqiang Li, Qiuhe J. Upregulation of PTEN by peroxynitrite contributes to cytokine-induced apoptosis in pancreatic beta-cells. Apoptosis : an international journal on programmed cell death. vol 15. issue 8. 2010-10-20. PMID:20464496. |
the present study investigated the role of pten in cytokine-induced beta-cell apoptosis, and further explored whether oxidative stress, particularly peroxynitrite formation, could regulate pten-akt pathway. |
2010-10-20 |
2023-08-12 |
Not clear |