| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chen Wang, Zhen Bian, Da Wei, Jian-guo Zhan. miR-29b regulates migration of human breast cancer cells. Molecular and cellular biochemistry. vol 352. issue 1-2. 2011-09-30. PMID:21359530. |
inhibition of mir-29b in cultured cells increased the expression of the phosphatase and tensin homolog (pten) tumor suppressor, promoting apoptosis, decreasing migration, and decreasing invasion. |
2011-09-30 |
2023-08-12 |
human |
| Chen Wang, Zhen Bian, Da Wei, Jian-guo Zhan. miR-29b regulates migration of human breast cancer cells. Molecular and cellular biochemistry. vol 352. issue 1-2. 2011-09-30. PMID:21359530. |
in contrast, enhanced mir-29b expression by transfection with pre-mir-29b decreased the expression of pten and impaired apoptosis, increasing tumor cell migration and invasion. |
2011-09-30 |
2023-08-12 |
human |
| Matthias D Sury, Lorianne Vorlet-Fawer, Claudia Agarinis, Shida Yousefi, Denis Grandgirard, Stephen L Leib, Stephan Christe. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20875857. |
treatment with the pten inhibitor bpv(pic) restored akt activity and significantly attenuated hippocampal apoptosis. |
2011-09-27 |
2023-08-12 |
rat |
| Matthias D Sury, Lorianne Vorlet-Fawer, Claudia Agarinis, Shida Yousefi, Denis Grandgirard, Stephen L Leib, Stephan Christe. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20875857. |
these results indicate that the inhibitory effect of bpv(pic) on apoptosis was mediated by pi3k-dependent activation of akt, strongly suggesting that bpv(pic) acted on pten. |
2011-09-27 |
2023-08-12 |
rat |
| Felix Junyent, Daniel Alvira, Marc Yeste-Velasco, Aurelio Vazquez de la Torre, Carlos Beas-Zarate, Francesc X Sureda, Jaume Folch, Mercè Pallàs, Antoni Camins, Ester Verdague. Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons. Neurochemistry international. vol 57. issue 7. 2011-09-07. PMID:20817061. |
since pten is an upstream regulator of akt, its inhibition with bpv(pic) (1-30 μm) should activate akt, however, it did not attenuate cgc cell death mediated by mpp(+) but protected cgc from apoptosis mediated by s/k deprivation. |
2011-09-07 |
2023-08-12 |
Not clear |
| Lingyun Zu, Xiaoxu Zheng, Bing Wang, Nirmal Parajuli, Charles Steenbergen, Lewis C Becker, Zheqing P Ca. Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion. American journal of physiology. Heart and circulatory physiology. vol 300. issue 6. 2011-08-23. PMID:21421815. |
phosphatase and tensin homologs deleted on chromosome 10 (pten) promotes apoptosis through akt-dependent and -independent mechanisms. |
2011-08-23 |
2023-08-12 |
mouse |
| Stavroula Baritaki, Loredana Militello, Graziella Malaponte, Demetrios A Spandidos, Margarita Salcedo, Benjamin Bonavid. The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-κB/Snail/RKIP/PTEN resistance loop in B-NHL cells: role in sensitization to TRAIL apoptosis. International journal of oncology. vol 38. issue 6. 2011-08-09. PMID:21455568. |
pten silencing in ramos cells pretreated with lfb-r603 and trail inhibited trail apoptosis; thus, demonstrating that pten induction by lfb-r603 has a direct role in tumor cell sensitization to trail apoptosis. |
2011-08-09 |
2023-08-12 |
human |
| Zaina Sangale, Cynthia Prass, Amy Carlson, Eliso Tikishvili, Jorja Degrado, Jerry Lanchbury, Steven Ston. A robust immunohistochemical assay for detecting PTEN expression in human tumors. Applied immunohistochemistry & molecular morphology : AIMM. vol 19. issue 2. 2011-08-01. PMID:20930614. |
phosphatase and tensin homolog deleted on chromosome 10 (pten) is a negative regulator of the phosphoinositol-3-kinase (pi3k)/akt signaling pathway that controls cell cycle progression, growth and inhibition of apoptosis. |
2011-08-01 |
2023-08-12 |
human |
| Hui-Fang Li, Adam Keeton, Michele Vitolo, Clinton Maddox, Lynn Rasmussen, Judith Hobrath, E Lucille White, Ben Ho Park, Gary A Piazza, Jung-Sik Kim, Todd Waldma. A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. Journal of biomolecular screening. vol 16. issue 4. 2011-08-01. PMID:21335596. |
a high-throughput screen with isogenic pten+/+ and pten-/- cells identifies cid1340132 as a novel compound that induces apoptosis in pten and pik3ca mutant human cancer cells. |
2011-08-01 |
2023-08-12 |
human |
| Hui-Fang Li, Adam Keeton, Michele Vitolo, Clinton Maddox, Lynn Rasmussen, Judith Hobrath, E Lucille White, Ben Ho Park, Gary A Piazza, Jung-Sik Kim, Todd Waldma. A high-throughput screen with isogenic PTEN+/+ and PTEN-/- cells identifies CID1340132 as a novel compound that induces apoptosis in PTEN and PIK3CA mutant human cancer cells. Journal of biomolecular screening. vol 16. issue 4. 2011-08-01. PMID:21335596. |
preferential killing of pten and pik3ca mutant cells was accompanied by dna damage, inhibition of dna synthesis, and apoptosis. |
2011-08-01 |
2023-08-12 |
human |
| Rosemary E Teresi, Kristin A Wait. PPARgamma, PTEN, and the Fight against Cancer. PPAR research. vol 2008. 2011-07-14. PMID:19096712. |
activation of ppargamma through agonists increases functional pten protein levels that subsequently induces apoptosis and inhibits cellular growth, which suggests that ppargamma may be a tumor suppressor. |
2011-07-14 |
2023-08-12 |
Not clear |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
pten status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. |
2011-07-11 |
2023-08-12 |
human |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
these cells exhibited different cellular responses, senescence or apoptosis, depending on the pten status. |
2011-07-11 |
2023-08-12 |
human |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
furthermore, transfection with wild-type (wt) pten or akt small interfering rna induced a change from premature senescence to apoptosis and depletion of p53 or p21 prevented ir-induced premature senescence in u87 cells. |
2011-07-11 |
2023-08-12 |
human |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
our data indicate that pten acts as a pivotal determinant of cell fate, regarding senescence and apoptosis in ir-exposed glioma cells. |
2011-07-11 |
2023-08-12 |
human |
| J-J Lee, B C Kim, M-J Park, Y-S Lee, Y-N Kim, B L Lee, J-S Le. PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21072054. |
we conclude that premature senescence could have a compensatory role for apoptosis in the absence of the tumor suppressor pten through the akt/ros/p53/p21 signaling pathway. |
2011-07-11 |
2023-08-12 |
human |
| Kim H T Paraiso, Yun Xiang, Vito W Rebecca, Ethan V Abel, Y Ann Chen, A Cecilia Munko, Elizabeth Wood, Inna V Fedorenko, Vernon K Sondak, Alexander R A Anderson, Antoni Ribas, Maurizia Dalla Palma, Katherine L Nathanson, John M Koomen, Jane L Messina, Keiran S M Smalle. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21317224. |
although pten expression status did not predict for sensitivity to the growth inhibitory effects of plx4720, it was predictive for apoptosis, with only limited cell death observed in melanomas lacking pten expression (pten-). |
2011-07-11 |
2023-08-12 |
Not clear |
| Kim H T Paraiso, Yun Xiang, Vito W Rebecca, Ethan V Abel, Y Ann Chen, A Cecilia Munko, Elizabeth Wood, Inna V Fedorenko, Vernon K Sondak, Alexander R A Anderson, Antoni Ribas, Maurizia Dalla Palma, Katherine L Nathanson, John M Koomen, Jane L Messina, Keiran S M Smalle. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer research. vol 71. issue 7. 2011-07-11. PMID:21317224. |
in conclusion, we have shown for the first time that loss of pten contributes to intrinsic braf inhibitor resistance via the suppression of bim-mediated apoptosis. |
2011-07-11 |
2023-08-12 |
Not clear |
| Hao-ling Liu, Hai-yan Yang, Lian-xin Liu, Yue Chen, Hong-yu Kuang, Hui-juan Zhang, Hui-qing Yi. Relationship between down-regulation of HIC1 and PTEN genes and dysfunction of pancreatic islet cells in diabetic rats. Acta histochemica. vol 113. issue 3. 2011-06-24. PMID:20129651. |
from this study we conclude that hic1, pten and mtor cannot be recognized as the key influencing factors promoting pancreatic islet cells apoptosis of diabetic rats; however, lower expressions of hic1 and pten and higher expression of mtor may affect the function of the pancreatic islet cells in diabetic rats. |
2011-06-24 |
2023-08-12 |
rat |
| Jing Xu, Jun-Ying Zhou, Wei-Zen Wei, Gen Sheng W. Activation of the Akt survival pathway contributes to TRAIL resistance in cancer cells. PloS one. vol 5. issue 4. 2011-06-16. PMID:20419107. |
taken together, our data indicate that inactivation of functional pten and the consequent activation of the akt pathway prevents trail-induced apoptosis, leading to trail resistance. |
2011-06-16 |
2023-08-12 |
mouse |