| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rasmi Rekha Mishra, Jitendra Kumar Chaudhary, Pramod C Rat. Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells. Molecular biology reports. vol 39. issue 7. 2012-11-23. PMID:22311048. |
overexpression of tpip-c2 cdna in human embryonic kidney (hek-293) cells caused cell cycle arrest, inhibition of cell proliferation and induced apoptosis in an activated caspase 3 and parp-dependent manner in comparison to overexpression of the full length human pten cdna. |
2012-11-23 |
2023-08-12 |
human |
| P Villagrasa, V M Díaz, R Viñas-Castells, S Peiró, B Del Valle-Pérez, N Dave, A Rodríguez-Asiain, J I Casal, J M Lizcano, M Duñach, A García de Herrero. Akt2 interacts with Snail1 in the E-cadherin promoter. Oncogene. vol 31. issue 36. 2012-11-21. PMID:22158034. |
moreover, snail1 promotes resistance to apoptosis, an effect associated to pten gene repression and akt stimulation. |
2012-11-21 |
2023-08-12 |
Not clear |
| Rachid Seqqat, Xinji Guo, Khadija Rafiq, Mikhail A Kolpakov, Jianfen Guo, Walter J Koch, Steven R Houser, Louis J Dell'italia, Abdelkarim Sabr. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22609523. |
β(1)-ar blockade (extended-release of metoprolol succinate, 100mg qd) markedly attenuated pten activation, restored fa signaling and reduced myocyte apoptosis induced by acf at 2days, but failed to reduce interstitial collagen loss and left ventricular dilatation. |
2012-10-31 |
2023-08-12 |
rat |
| Rachid Seqqat, Xinji Guo, Khadija Rafiq, Mikhail A Kolpakov, Jianfen Guo, Walter J Koch, Steven R Houser, Louis J Dell'italia, Abdelkarim Sabr. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22609523. |
treating cultured myocytes with β(1)-ar agonists or adenoviral expression of β(1)-ars caused pten activation and interaction with fa proteins, thus leading to fa signaling downregulation and myocyte apoptosis. |
2012-10-31 |
2023-08-12 |
rat |
| Rachid Seqqat, Xinji Guo, Khadija Rafiq, Mikhail A Kolpakov, Jianfen Guo, Walter J Koch, Steven R Houser, Louis J Dell'italia, Abdelkarim Sabr. Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload. Journal of molecular and cellular cardiology. vol 53. issue 2. 2012-10-31. PMID:22609523. |
adenoviral-mediated expression of a catalytically inactive pten mutant or wild-type fak restored fa signaling downregulation and attenuated myocyte apoptosis induced by β(1)-ars. |
2012-10-31 |
2023-08-12 |
rat |
| Zhiyong Cheng, Ning Yang, Wentong Liang, Xiaoyan Yan, Lin Li, Ling Pa. Effect of phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene transfection on reversal of multidrug resistance in K562/ADM cells. Leukemia & lymphoma. vol 53. issue 7. 2012-10-30. PMID:22185283. |
pten, nuclear factor-κb (nf-κb), i-κb, p53, multidrug resistance genes mdr1 and mrp, and apoptosis related genes bcl-2, bcl-xl and bax mrna levels were detected by real-time fluorescence relative-quantification reverse transcription polymerase chain reaction (fq-pcr). |
2012-10-30 |
2023-08-12 |
human |
| Wei-Tian Wei, Hui Chen, Zhao-Hong Wang, Zhong-Lin Ni, Hai-Bin Liu, Hong-Fei Tong, Hong-Chun Guo, Dian-Lei Liu, Sheng-Zhang Li. Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway. International journal of biological sciences. vol 8. issue 1. 2012-10-09. PMID:22211100. |
in vitro application of the combination therapy triggered significantly higher frequency of pancreatic cancer cells apoptosis, inhibited the activities of pi3k, akt, pka, mtor and pten, and decreased the activation of nf-κb and expression of nf-κb-regulated products. |
2012-10-09 |
2023-08-12 |
Not clear |
| Wei-Tian Wei, Hui Chen, Zhao-Hong Wang, Zhong-Lin Ni, Hai-Bin Liu, Hong-Fei Tong, Hong-Chun Guo, Dian-Lei Liu, Sheng-Zhang Li. Enhanced antitumor efficacy of gemcitabine by evodiamine on pancreatic cancer via regulating PI3K/Akt pathway. International journal of biological sciences. vol 8. issue 1. 2012-10-09. PMID:22211100. |
in vivo application of the combination therapy induced significant enhancement of tumor cell apoptosis, reductions in tumor volume, and inhibited activation of mtor and pten. |
2012-10-09 |
2023-08-12 |
Not clear |
| Sncvl Pushpavalli, M Janaki Ramaiah, Ch Srinivas, Debasmita Mukhopadhya, J L Aditya, Ravindra M Kumbhare, Utpal Bhadra, Manika Pal Bhadr. Effect of Benzothiazole based conjugates in causing apoptosis by Regulating p53, PTEN and MAP Kinase proteins affecting miR-195a and miR-101-1. Cancer cell international. vol 11. 2012-10-02. PMID:22035408. |
effect of benzothiazole based conjugates in causing apoptosis by regulating p53, pten and map kinase proteins affecting mir-195a and mir-101-1. |
2012-10-02 |
2023-08-12 |
Not clear |
| Dong Wook Kim, Li Zhao, John Hanover, Mark Willingham, Sheue-Yann Chen. Thyroid hormone receptor β suppresses SV40-mediated tumorigenesis via novel nongenomic actions. American journal of cancer research. vol 2. issue 5. 2012-10-02. PMID:22957312. |
trβ- sv40tag interaction also resulted in reactivating p53 to increase the expression of pten, thus attenuating pi3k-akt signaling to decrease cell proliferation and to induce apoptosis. |
2012-10-02 |
2023-08-12 |
mouse |
| Daniel R Premkumar, Esther P Jane, Joseph D DiDomenico, Natalie A Vukmer, Naomi R Agostino, Ian F Pollac. ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22393246. |
this study demonstrates that interference with multiple apoptosis-resistance signaling nodes, including nf-κb, akt, and bcl-2, may be required to induce apoptosis in highly resistant glioma cells, and therapeutic strategies that target the pi3k/akt pathway may have a selective role for cancers lacking pten function. |
2012-09-24 |
2023-08-12 |
human |
| Jixiao Niu, Yuling Shi, Guangyun Tan, Chuan He Yang, Meiyun Fan, Lawrence M Pfeffer, Zhao-Hui W. DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22547075. |
induction of mir-21 may enable cancer cells to elude dna damage-induced apoptosis and enhance the metastatic potential of breast cancer cells through repressing expression of pten and pdcd4. |
2012-09-20 |
2023-08-12 |
human |
| Cheng Zhiyong, Liang Wentong, Yang Xiaoyang, Pan Lin. PTEN's regulation of VEGF and VEGFR1 expression and its clinical significance in myeloid leukemia. Medical oncology (Northwood, London, England). vol 29. issue 2. 2012-09-18. PMID:21360018. |
pten protein plays an important role in regulating proliferation, apoptosis, invasion, and migration of many cancer cells. |
2012-09-18 |
2023-08-12 |
Not clear |
| Changju Qu, Zhihui Liang, JiaLing Huang, Ruiying Zhao, Chunhui Su, Sumei Wang, Xudan Wang, Rong Zhang, Mong-Hong Lee, Huiling Yan. MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22374676. |
introducing mir-205 into cne-2 cells suppresses pten protein expression, followed by activation of akt, increased number of foci formation and reduction of cell apoptosis postirradiation. |
2012-09-14 |
2023-08-12 |
human |
| Changju Qu, Zhihui Liang, JiaLing Huang, Ruiying Zhao, Chunhui Su, Sumei Wang, Xudan Wang, Rong Zhang, Mong-Hong Lee, Huiling Yan. MiR-205 determines the radioresistance of human nasopharyngeal carcinoma by directly targeting PTEN. Cell cycle (Georgetown, Tex.). vol 11. issue 4. 2012-09-14. PMID:22374676. |
on the other hand, knocking down mir-205 in cne-2r cells compromises the inhibition of pten and increases cell apoptosis. |
2012-09-14 |
2023-08-12 |
human |
| Weifeng Pi, Xuejun Guo, Liping Su, Weiguo X. BMP-2 up-regulates PTEN expression and induces apoptosis of pulmonary artery smooth muscle cells under hypoxia. PloS one. vol 7. issue 5. 2012-09-14. PMID:22615735. |
bmp-2 up-regulates pten expression and induces apoptosis of pulmonary artery smooth muscle cells under hypoxia. |
2012-09-14 |
2023-08-12 |
Not clear |
| Weifeng Pi, Xuejun Guo, Liping Su, Weiguo X. BMP-2 up-regulates PTEN expression and induces apoptosis of pulmonary artery smooth muscle cells under hypoxia. PloS one. vol 7. issue 5. 2012-09-14. PMID:22615735. |
to investigate the role of bone morphogenetic protein 2 (bmp-2) in regulation of phosphatase and tensin homologue deleted on chromosome ten (pten) and apoptosis of pulmonary artery smooth muscle cells (pasmcs) under hypoxia. |
2012-09-14 |
2023-08-12 |
Not clear |
| N Hayashi, J W Peacock, E Beraldi, A Zoubeidi, M E Gleave, C J On. Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch. Cell death and differentiation. vol 19. issue 6. 2012-09-10. PMID:22179576. |
these data identify a dual coordinated role of hsp27 in cell proliferation and fas-induced apoptosis via akt and pea-15, and indicate that improved clinical responses to hsp27-targeted therapy may be achieved by stratifying patient populations based on tumor pten expression. |
2012-09-10 |
2023-08-12 |
Not clear |
| Xin-Li Li, Jiu-Hong Xu, Ji-Hua Nie, Sai-Jun Fa. Exogenous expression of UHRF1 promotes proliferation and metastasis of breast cancer cells. Oncology reports. vol 28. issue 1. 2012-09-04. PMID:22552622. |
in conclusion, uhrf1 promoted the proliferation of breast cancer cells by apoptosis inhibition, g1 phase shortage and promotion of tumor vessel formation, and pro-invasion and pro-migration activity was also observed by interacting with pten and maspin. |
2012-09-04 |
2023-08-12 |
Not clear |
| Zhi-yong Cheng, Jian-she Wan, Ya-li Wang, Li-qing Liang, Wen-tong Liang, Jing Mu, Xi Lu, Ling Pa. [Regulation of wild type PTEN gene on Survivin, Xiap and Smac in chronic leukemia cells]. Zhonghua yi xue za zhi. vol 91. issue 40. 2012-08-02. PMID:22333553. |
to explore the effects of tumor-suppressing gene wild type pten on the cell proliferation, apoptosis and the possible regulations of apoptosis-related molecules survivin, xiap and smac gene in human chronic myeloid leukemia (cml) and cell line k562 cells. |
2012-08-02 |
2023-08-12 |
human |