| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jianhua Wu, Jianzhe Li, Hankun Hu, Ping Liu, Yunxiang Fang, Dongfang W. Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain. Cellular and molecular neurobiology. vol 32. issue 7. 2013-07-10. PMID:22552888. |
in this study, we determined whether rock inhibitor, fasudil, inhibited ischemic neuronal apoptosis through phosphatase and tensin homolog deleted on chromosome10 (pten)/akt/signal pathway in vivo. |
2013-07-10 |
2023-08-12 |
rat |
| Yasuko Kitagishi, Satoru Matsud. Redox regulation of tumor suppressor PTEN in cancer and aging (Review). International journal of molecular medicine. vol 31. issue 3. 2013-07-10. PMID:23313933. |
accumulating evidence has revealed that pten also acts as a pivotal determinant of cell fate, regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ros) generation. |
2013-07-10 |
2023-08-12 |
Not clear |
| Furong Dai, Yi Zhang, Xin Zhu, Nianchun Shan, Yuxiang Che. Anticancer role of MUC1 aptamer-miR-29b chimera in epithelial ovarian carcinoma cells through regulation of PTEN methylation. Targeted oncology. vol 7. issue 4. 2013-06-28. PMID:23179556. |
our study indicated that chi-29b chimera can effectively exert antitumor effect through specific delivery of mir-29b into ovcar-3 tumor cells, subsequently reexpressing pten gene and inducing cell apoptosis. |
2013-06-28 |
2023-08-12 |
Not clear |
| Xia Wang, Lin Yang, Ji-jia She, Hong-mei Fan, Fu-cheng Zhang, You-ming Chen, Qi-feng Xi. [Hepatitis B virus X protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and PTEN]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 8. 2013-06-24. PMID:20813662. |
[hepatitis b virus x protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and pten]. |
2013-06-24 |
2023-08-12 |
Not clear |
| Xia Wang, Lin Yang, Ji-jia She, Hong-mei Fan, Fu-cheng Zhang, You-ming Chen, Qi-feng Xi. [Hepatitis B virus X protein suppresses adriamycin-induced apoptosis of hepatocellular carcinoma cells and expression of p53 and PTEN]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. vol 30. issue 8. 2013-06-24. PMID:20813662. |
to investigate the effect of hepatitis b virus x protein (hbx) on adriamycin-induced apoptosis of hepatocellular carcinoma cells and the expressions of p53 and pten. |
2013-06-24 |
2023-08-12 |
Not clear |
| Jayasree S Nair, Tahir Sheikh, Alan L Ho, Gary K Schwart. PTEN regulates sensitivity of melanoma cells to RO4929097, the γ-secretase inhibitor. Anticancer research. vol 33. issue 4. 2013-06-11. PMID:23564767. |
although cleaved notch-1 formation was observed in all the cell lines, ro4929097-induced senescence or apoptosis was achieved only in pten-wild-type cell lines in which gamma-secretase inhibition with an induction of pten expression and decreased akt/pkb (protein kinase b) phosphorylation in addition to transcriptional suppression at the hairy and enhancer of split-1 (hes1) gene promoter. |
2013-06-11 |
2023-08-12 |
human |
| L M Bershteĭ. [Ursolic acid as antitumor agent and inductor of PTEN and brown fat]. Voprosy onkologii. vol 58. issue 6. 2013-06-06. PMID:23600297. |
beside inhibiting tumor cell growth in vitro and in vivo and activating of apoptosis, ua (as well as some other related and not related compounds) is capable to induce pten (a tumor suppressor mutation of which is rather often discovered in human tumors including endometrial cancer type i) and amount/activity of brown fat. |
2013-06-06 |
2023-08-12 |
human |
| Libo Zheng, Xiuli Chen, Jinbo Guo, Huicong Sun, Lei Liu, David Q Shih, Xiaolan Zhan. Differential expression of PTEN in hepatic tissue and hepatic stellate cells during rat liver fibrosis and its reversal. International journal of molecular medicine. vol 30. issue 6. 2013-05-28. PMID:23041795. |
to evaluate the change in phosphatase and tensin homology deleted on chromosome ten (pten) expression in liver fibrogenesis, particularly the reversal of fibrogenic liver tissues, and to investigate the relation with the proliferation and apoptosis of hepatic stellate cells (hscs) in vivo, a rat model of hepatic fibrosis was established by hypodermic injection of carbon tetrachloride (ccl4) mixed with olive oil at the concentration of 40% for 5 weeks (2 ml/kg, twice a week). |
2013-05-28 |
2023-08-12 |
rat |
| Dong Wang, Yuren Wei, Melinda Frye, Christopher L Gentile, Michael J Pagliassott. Saturated Fatty Acid-induced cytotoxicity in liver cells does not involve phosphatase and tensin homologue deleted on chromosome 10. Journal of nutrition and metabolism. vol 2013. 2013-05-22. PMID:23691291. |
sirna-mediated knockdown of pten did not increase liver cell triglyceride stores or reduce palmitate- or stearate-mediated er stress or apoptosis. |
2013-05-22 |
2023-08-12 |
Not clear |
| Carmen Formisano, Daniela Rigano, Alessandra Russo, Venera Cardile, Silvia Caggia, Nelly Apostolides Arnold, Angela Mari, Sonia Piacente, Sergio Rosselli, Felice Senatore, Maurizio Brun. Phytochemical profile and apoptotic activity of Onopordum cynarocephalum. Planta medica. vol 78. issue 15. 2013-04-22. PMID:22965548. |
furthermore, apoptosis appears to be mediated, at least in part, via pten activity and the inhibition of hsp70 expression. |
2013-04-22 |
2023-08-12 |
human |
| Wei Li, Wu Di, Lijuan Hua, Bingrong Zhou, Ze Guo, Dan Lu. UVB suppresses PTEN expression by upregulating miR-141 in HaCaT cells. Journal of biomedical research. vol 25. issue 2. 2013-04-05. PMID:23554681. |
furthermore, mir-141 expression increased apoptosis, while anti-mir-141 partly restored pten expression and reversed the pro-apoptosis effect of uvb. |
2013-04-05 |
2023-08-12 |
Not clear |
| Mohammed S Orloff, Xin He, Charissa Peterson, Fusong Chen, Jin-Lian Chen, Jessica L Mester, Charis En. Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. American journal of human genetics. vol 92. issue 1. 2013-03-12. PMID:23246288. |
pten antagonizes the akt1/pi3k signaling pathway and has roles in cell cycle, migration, cell polarity, and apoptosis. |
2013-03-12 |
2023-08-12 |
Not clear |
| D Lu, J Qian, X Yin, Qin Xiao, C Wang, Y Zen. Expression of PTEN and survivin in cervical cancer: promising biological markers for early diagnosis and prognostic evaluation. British journal of biomedical science. vol 69. issue 4. 2013-01-31. PMID:23310986. |
this study aims to evaluate the expression of the antioncogene phosphatase and tensin (pten) homologue and survivin, a protein encoded by the anti-apoptotic gene baculoviral inhibitor of apoptosis repeat containing 5 (birc5), in the progression of cervical neoplasia and to elucidate the relationship between pten and survivin expression based on clinicopathological features in squamous cell carcinoma of the uterine cervix. |
2013-01-31 |
2023-08-12 |
Not clear |
| Zhongbing Liu, Jinwei Li, Juan Li, Juan Huang, Famin Ke, Qiaona Qi, Xing Jiang, Zhirong Zhon. Mannan-modified Ad5-PTEN treatment combined with docetaxel improves the therapeutic effect in H22 tumor-bearing mice. International journal of nanomedicine. vol 7. 2013-01-17. PMID:23055722. |
it has been reported that the tumor suppressor gene, pten, which is inactivated in many malignant tumors, plays an important role in apoptosis, cell cycle arrest, cell migration, and cell spread. |
2013-01-17 |
2023-08-12 |
mouse |
| Vivek Vaish, Sankar Nath Sanya. Role of Sulindac and Celecoxib in the regulation of angiogenesis during the early neoplasm of colon: exploring PI3-K/PTEN/Akt pathway to the canonical Wnt/β-catenin signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 66. issue 5. 2013-01-04. PMID:22397759. |
nsaids can overcome these carcinogenic effects by controlling various key check points including higher pten and glycogen synthase kinase-3β (gsk-3β) expression and repressing akt, mmps and inos activation while inducing apoptosis among the cancer cells. |
2013-01-04 |
2023-08-12 |
Not clear |
| John Mark P Pabona, Bhuvanesh Dave, Ying Su, Maria Theresa E Montales, Ben O de Lumen, Elvira G de Mejia, Omar M Rahal, Rosalia C M Simme. The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein. Genes & nutrition. vol 8. issue 1. 2013-01-04. PMID:22864686. |
the soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor pten: similarities and distinct actions from soy isoflavone genistein. |
2013-01-04 |
2023-08-12 |
mouse |
| John Mark P Pabona, Bhuvanesh Dave, Ying Su, Maria Theresa E Montales, Ben O de Lumen, Elvira G de Mejia, Omar M Rahal, Rosalia C M Simme. The soybean peptide lunasin promotes apoptosis of mammary epithelial cells via induction of tumor suppressor PTEN: similarities and distinct actions from soy isoflavone genistein. Genes & nutrition. vol 8. issue 1. 2013-01-04. PMID:22864686. |
lun-induced cellular apoptosis, akin to gen, was mediated by pten, but unlike that for gen, was p53-independent. |
2013-01-04 |
2023-08-12 |
mouse |
| Lorna W Harries, Alexander D Fellows, Luke C Pilling, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack Guralnik, Jonathan Powell, Luigi Ferrucci, David Melze. Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations. Mechanisms of ageing and development. vol 133. issue 8. 2012-12-31. PMID:22813852. |
genes involved in insulin signaling (pten, pi3k, pdk1), ribosomal biogenesis (s6k), lipid metabolism (srebf1), cellular apoptosis (sgk1), angiogenesis (vegfb), insulin production and sensitivity (foxo), cellular stress response (hif1a) and cytoskeletal remodeling (pkc) were inversely correlated with age, whereas genes relating to inhibition of ribosomal components (4ebp1) and inflammatory mediators (stat3) were positively associated with age in one or both datasets. |
2012-12-31 |
2023-08-12 |
human |
| Zhi-Ping Ruan, Rui Xu, Yi Lv, Tao Tian, Wen-Juan Wang, Hui Guo, Ke-Jun Na. PTEN enhances the sensitivity of human hepatocellular carcinoma cells to sorafenib. Oncology research. vol 20. issue 2-3. 2012-12-11. PMID:23193917. |
in addition, hepg2 cells transfected with pten were more sensitive to sorafenib in terms of its ability to inhibit proliferation and to induce apoptosis. |
2012-12-11 |
2023-08-12 |
human |
| Jianhe Chen, Jing Li, Qin Han, Zhao Sun, Jing Wang, Shihua Wang, Robert C H Zha. Enhancer of zeste homolog 2 is overexpressed and contributes to epigenetic inactivation of p21 and phosphatase and tensin homolog in B-cell acute lymphoblastic leukemia. Experimental biology and medicine (Maywood, N.J.). vol 237. issue 9. 2012-11-29. PMID:22956625. |
functional analysis showed that sirna-mediated ezh2 knockdown led to decreased proliferation and increased apoptosis of nalm-6 cells, accompanied by the reactivation of pten and p21 expression. |
2012-11-29 |
2023-08-12 |
Not clear |