| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Todd R Mereniuk, Mohamed A M El Gendy, Ana M Mendes-Pereira, Christopher J Lord, Sunita Ghosh, Edan Foley, Alan Ashworth, Michael Weinfel. Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase. Molecular cancer therapeutics. vol 12. issue 10. 2014-05-19. PMID:23883586. |
we provide evidence that codepletion of pten and pnkp induces apoptosis. |
2014-05-19 |
2023-08-12 |
Not clear |
| Wei-Feng Pi, Xue-Jun Guo, Li-Ping Su, Wei-Guo X. Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24026200. |
troglitazone upregulates pten expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions. |
2014-05-09 |
2023-08-12 |
human |
| Wei-Feng Pi, Xue-Jun Guo, Li-Ping Su, Wei-Guo X. Troglitazone upregulates PTEN expression and induces the apoptosis of pulmonary artery smooth muscle cells under hypoxic conditions. International journal of molecular medicine. vol 32. issue 5. 2014-05-09. PMID:24026200. |
in this study, we investigated the role of troglitazone [peroxisome proliferator-activated receptor γ (pparγ) agonist] in the regulation of phosphatase and tensin homologue deleted on chromosome 10 (pten) expression and the apoptosis of pasmcs under hypoxic conditions. |
2014-05-09 |
2023-08-12 |
human |
| M Yu, P Trobridge, Y Wang, S Kanngurn, S M Morris, S Knoblaugh, W M Grad. Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo. Oncogene. vol 33. issue 12. 2014-05-07. PMID:23604118. |
inactivation of tgf-β signaling and loss of pten in the tumors led to increased cell proliferation, decreased apoptosis and decreased expression of cyclin-dependent kinase inhibitors. |
2014-05-07 |
2023-08-12 |
mouse |
| Dongliang Zhao, Yingfeng Tu, Lin Wan, Lihong Bu, Tao Huang, Xilin Sun, Kai Wang, Baozhong She. In vivo monitoring of angiogenesis inhibition via down-regulation of mir-21 in a VEGFR2-luc murine breast cancer model using bioluminescent imaging. PloS one. vol 8. issue 8. 2014-04-30. PMID:23951172. |
the results showed that knockdown of mir-21 by antagomir-21 decreased cell proliferation and induced apoptosis via targeting pten both in 4t1 cells and huvecs. |
2014-04-30 |
2023-08-12 |
mouse |
| Thomas H Beckham, Joseph C Cheng, Ping Lu, S Tucker Marrison, James S Norris, Xiang Li. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling. PloS one. vol 8. issue 10. 2014-04-29. PMID:24098536. |
to investigate whether the tumor promoting aspects of acid ceramidase in prostate cancer depend upon its ability to export pten from the nucleus, we used enforced nuclear expression of pten to study docetaxel-induced apoptosis and cell killing, proliferation, and xenoengraftment. |
2014-04-29 |
2023-08-12 |
human |
| Joo-Yun Yim, Su-Jin Yang, Jun-Mo Yim, Min-Young Song, Hye-Won Rho, Sung Kyun Yim, Yeon-Hee Han, So Yeon Jeon, Hee Sun Kim, Ho-Young Yhim, Na-Ri Lee, Eun-Kee Song, Jae-Yong Kwak, Myung-Hee Sohn, Chang-Yeol Yi. Lymphocyte-mediated macrophage apoptosis during IL-12 stimulation. Cytokine. vol 64. issue 1. 2014-04-15. PMID:23953854. |
the endogenously produced no inhibited macrophage proliferation, and induced apoptosis in concordance with the accumulation of p53, phosphatase and tensin homologue deleted on chromosome 10 (pten) and dr5, and the activation of caspase-3, processes that were inhibited by n(g)-monomethyl-l-arginine, aminoguanidine (no synthase inhibitors) and 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (an no scavenger). |
2014-04-15 |
2023-08-12 |
mouse |
| Lian-Ju Shen, Jun-Lin He, De-Hui Yang, Yu-Bin Ding, Xue-Mei Chen, Yan-Qing Geng, Shang-Jing Liu, Xue-Qing Liu, Ying-Xiong Wan. Mmu-microRNA-200a overexpression leads to implantation defect by targeting phosphatase and tensin homolog in mouse uterus. Reproductive sciences (Thousand Oaks, Calif.). vol 20. issue 12. 2014-04-10. PMID:23690337. |
in vitro gain and loss of function experiments confirm that pten, a critical gene for cell proliferation and apoptosis, is the target gene of mmu-mir-200a. |
2014-04-10 |
2023-08-12 |
mouse |
| Hui Jin, Yu Sun, Shuiying Wang, Xiaodong Chen. Matrine activates PTEN to induce growth inhibition and apoptosis in V600EBRAF harboring melanoma cells. International journal of molecular sciences. vol 14. issue 8. 2014-04-07. PMID:23912239. |
matrine activates pten to induce growth inhibition and apoptosis in v600ebraf harboring melanoma cells. |
2014-04-07 |
2023-08-12 |
Not clear |
| Ma Fátima G Klingbeil, Flávia C A Xavier, Luiz R Sardinha, Patricia Severino, Monica B Mathor, Rodrigo V Rodrigues, Décio S Pint. Cytotoxic effects of mistletoe (Viscum album L.) in head and neck squamous cell carcinoma cell lines. Oncology reports. vol 30. issue 5. 2014-04-07. PMID:24026291. |
a concentration of 0.3 mg/ml (ic50) of the drugs induced apoptosis, affecting gene expression and protein levels of akt, pten and cyclin d1. |
2014-04-07 |
2023-08-12 |
Not clear |
| Weibin Wang, Yifan Chen, Shuya Wang, Ningguang Hu, Zhengyi Cao, Wengong Wang, Tanjun Tong, Xiaowei Zhan. PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase. The Journal of biological chemistry. vol 289. issue 6. 2014-04-07. PMID:24344134. |
the tumor suppressor pten plays a critical role in the regulation of multiple cellular processes that include survival, cell cycle, proliferation, and apoptosis. |
2014-04-07 |
2023-08-12 |
human |
| Yuanshu Dong, Lujuan Zhang, Yunpeng Bai, Hong-Ming Zhou, Amanda M Campbell, Hanying Chen, Weidong Yong, Wenjun Zhang, Qi Zeng, Weinian Shou, Zhong-Yin Zhan. Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis. The Journal of biological chemistry. vol 289. issue 6. 2014-04-07. PMID:24371141. |
mechanistically, prl2 deficiency results in elevated pten level in the testis, which attenuates the kit-pi3k-akt pathway, resulting in increased germ cell apoptosis. |
2014-04-07 |
2023-08-12 |
mouse |
| Katsuhiro Takeda, Pouneh Kermani, Agustin Anastasia, Yusuke Obinata, Barbara L Hempstead, Hidemi Kurihar. BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. Biochemistry and cell biology = Biochimie et biologie cellulaire. vol 91. issue 5. 2014-04-03. PMID:24032685. |
terminal deoxynucleotidyl transferase (tdt) dutp nick end labeling (tunel) assay showed that the pten inhibitor bpv(pic) rescues hmvecs from tnfα-induced apoptosis. |
2014-04-03 |
2023-08-12 |
human |
| Aldo Germani, Antonio Matrone, Valentina Grossi, Alessia Peserico, Paola Sanese, Micaela Liuzzi, Rocco Palermo, Stefania Murzilli, Antonio Francesco Campese, Giuseppe Ingravallo, Gianluca Canettieri, Tugsan Tezil, Cristiano Simon. Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A. Cancer letters. vol 344. issue 1. 2014-03-25. PMID:24215867. |
our results indicate that foxo3a activation up-regulates transcription of its target genes (p21, pten, bim and gadd45), which forces both chemosensitive and chemoresistant crc cells to undergo apoptosis. |
2014-03-25 |
2023-08-12 |
Not clear |
| Chin-Hui Su, Li-Jen Chen, Jyh Fei Liao, Juei-Tang Chen. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer. Journal of medicinal food. vol 16. issue 9. 2014-03-21. PMID:23909904. |
the short interfering rna (sirna) is used to confirm the role of phosphatase and tensin homolog (pten) in silymarin-induced apoptosis. |
2014-03-21 |
2023-08-12 |
human |
| Choo-Peng Goh, Ulrich Putz, Jason Howitt, Ley-Hian Low, Jenny Gunnersen, Nicole Bye, Cristina Morganti-Kossmann, Seong-Seng Ta. Nuclear trafficking of Pten after brain injury leads to neuron survival not death. Experimental neurology. vol 252. 2014-03-10. PMID:24275527. |
a number of in vitro studies have reported enhanced apoptosis in neurons possessing nuclear pten, with the interpretation that its nuclear phosphatase activity leads to reduction of the survival protein phospho-akt. |
2014-03-10 |
2023-08-12 |
mouse |
| Jianjian Zheng, Cunzao Wu, Zhuo Lin, Yong Guo, Liang Shi, Peihong Dong, Zhongqiu Lu, Shenmeng Gao, Yi Liao, Bicheng Chen, Fujun Y. Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis. The FEBS journal. vol 281. issue 1. 2014-03-04. PMID:24138392. |
in the present study, curcumin treatment significantly resulted in the inhibition of cell proliferation and an increase in the apoptosis rate through the up-regulation of pten associated with a decreased dna methylation level. |
2014-03-04 |
2023-08-12 |
Not clear |
| Chuan He Yang, Junming Yue, Michelle Sims, Lawrence M Pfeffe. The curcumin analog EF24 targets NF-κB and miRNA-21, and has potent anticancer activity in vitro and in vivo. PloS one. vol 8. issue 8. 2014-03-03. PMID:23940701. |
ef24 induces apoptosis in these cells apparently by inhibiting mir-21 expression, and also enhances the expression of several mir-21 target genes, pten and pdcd4. |
2014-03-03 |
2023-08-12 |
mouse |
| Jennifer E Kim, Mira Patel, Jacob Ruzevick, Christopher M Jackson, Michael Li. STAT3 Activation in Glioblastoma: Biochemical and Therapeutic Implications. Cancers. vol 6. issue 1. 2014-02-12. PMID:24518612. |
nevertheless, some studies show that stat3 also participates in terminal differentiation and apoptosis of various cell lines and in glioma with phosphatase and tensin homolog (pten)-deficient genetic backgrounds. |
2014-02-12 |
2023-08-12 |
Not clear |
| Erich Piovan, Jiyang Yu, Valeria Tosello, Daniel Herranz, Alberto Ambesi-Impiombato, Ana Carolina Da Silva, Marta Sanchez-Martin, Arianne Perez-Garcia, Isaura Rigo, Mireia Castillo, Stefano Indraccolo, Justin R Cross, Elisa de Stanchina, Elisabeth Paietta, Janis Racevskis, Jacob M Rowe, Martin S Tallman, Giuseppe Basso, Jules P Meijerink, Carlos Cordon-Cardo, Andrea Califano, Adolfo A Ferrand. Direct reversal of glucocorticoid resistance by AKT inhibition in acute lymphoblastic leukemia. Cancer cell. vol 24. issue 6. 2014-02-11. PMID:24291004. |
moreover, we demonstrate that loss of pten and consequent akt1 activation can effectively block glucocorticoid-induced apoptosis and induce resistance to glucocorticoid therapy. |
2014-02-11 |
2023-08-12 |
Not clear |