| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Liza D Morales, Edgar A Casillas Pavón, Jun Wan Shin, Alexander Garcia, Mario Capetillo, Dae Joon Kim, Jonathan H Liema. Protein tyrosine phosphatases PTP-1B, SHP-2, and PTEN facilitate Rb/E2F-associated apoptotic signaling. PloS one. vol 9. issue 5. 2015-06-08. PMID:24809452. |
we also demonstrate that ptp-1b, shp-2, and pten play a functional role in rb/e2f-associated apoptosis. |
2015-06-08 |
2023-08-13 |
Not clear |
| Hongyu Li, Jianjun Li, Xu Liu, Jiang Chen, Chunyan Wu, Xiaozhong Gu. Effect of PTEN and KAI1 gene overexpression on the proliferation, metastasis and radiosensitivity of ASPC‑1 pancreatic cancer cells under hypoxic conditions. Molecular medicine reports. vol 10. issue 4. 2015-05-22. PMID:25051346. |
in conclusion, double overexpression of pten and kai1 inhibited the proliferation and metastatic activity, and enhanced apoptosis induced by x‑ray in aspc‑1 cells under hypoxic conditions, which indicates that pten and kai1 double-expression may have valuable application in pancreatic cancer gene therapy. |
2015-05-22 |
2023-08-13 |
Not clear |
| Xiao-Ling Chen, Hai-Lan Ma, Yi Xie, Rong Yang, Sha-Li We. Expression of phosphatase and tensin homolog deleted on chromosome ten in mouse endometrium and its effect during blastocyst implantation. Sheng li xue bao : [Acta physiologica Sinica]. vol 60. issue 1. 2015-05-16. PMID:18288367. |
the results suggest that pten might associate with apoptosis of luminal epithelial and decidual cells, coordinating decidualization of endometrium and invasion of trophoblastic cells. |
2015-05-16 |
2023-08-12 |
mouse |
| Long-Feng Xu, Zhi-Ping Wu, Yan Chen, Qi-Shun Zhu, Shoeleh Hamidi, Roya Nava. MicroRNA-21 (miR-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting PTEN, RECK and Bcl-2 in lung squamous carcinoma, Gejiu City, China. PloS one. vol 9. issue 8. 2015-04-23. PMID:25084400. |
microrna-21 (mir-21) regulates cellular proliferation, invasion, migration, and apoptosis by targeting pten, reck and bcl-2 in lung squamous carcinoma, gejiu city, china. |
2015-04-23 |
2023-08-13 |
Not clear |
| Kun Yao, Hai-Xia Zhu, Rong Zhang, Ai-Jun Liao, Wei Yang, Zhuo-Gang Li. [Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2/BAX, PTEN]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338572. |
[effects of tieg1 on k562 cell apoptosis and expression of bcl-2/bax, pten]. |
2015-03-30 |
2023-08-13 |
Not clear |
| Kun Yao, Hai-Xia Zhu, Rong Zhang, Ai-Jun Liao, Wei Yang, Zhuo-Gang Li. [Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2/BAX, PTEN]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338572. |
the aim of this study was to investigate the effect of tieg1 on k562 cell apoptosis and expression of bcl-2/bax, pten. |
2015-03-30 |
2023-08-13 |
Not clear |
| Kun Yao, Hai-Xia Zhu, Rong Zhang, Ai-Jun Liao, Wei Yang, Zhuo-Gang Li. [Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2/BAX, PTEN]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338572. |
in process of k562 cell apoptosis, the expression level of bcl-2 gradually decreased (r = 0.48, p < 0.05), meanwhile the expression levels of bax (r = 0.69, p < 0.05) and pten (r = 0.57, p < 0.05) gradually increased. |
2015-03-30 |
2023-08-13 |
Not clear |
| Kun Yao, Hai-Xia Zhu, Rong Zhang, Ai-Jun Liao, Wei Yang, Zhuo-Gang Li. [Effects of TIEG1 on K562 cell apoptosis and expression of BCL-2/BAX, PTEN]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 5. 2015-03-30. PMID:25338572. |
in apoptosis process of k562 cells induced by tieg1, the expression changes of bcl-2/bax and pten associate with the k562 cell apoptosis. |
2015-03-30 |
2023-08-13 |
Not clear |
| C Girardi, C De Pittà, S Casara, E Calura, C Romualdi, L Celotti, M Mognat. Integration analysis of microRNA and mRNA expression profiles in human peripheral blood lymphocytes cultured in modeled microgravity. BioMed research international. vol 2014. 2015-03-12. PMID:25045661. |
we identified the correlation of mir-9-3p, mir-155-5p, mir-150-3p, and mir-378-3p expression with that of genes involved in immune/inflammatory response (e.g., ifng and il17f), apoptosis (e.g., pdcd4 and pten), and cell proliferation (e.g., nkx3-1 and gadd45a). |
2015-03-12 |
2023-08-13 |
human |
| Kostyantyn Krysan, Rebecca Kusko, Tristan Grogan, James O'Hearn, Karen L Reckamp, Tonya C Walser, Edward B Garon, Marc E Lenburg, Sherven Sharma, Avrum E Spira, David Elashoff, Steven M Dubinet. PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC. Molecular cancer research : MCR. vol 12. issue 5. 2015-02-27. PMID:24469837. |
here, prostaglandin e2 (pge2) exposure rapidly upregulates the expression of the myc gene followed by the elevation of mir-17-92 levels, which in turn suppresses pten expression, thus enhancing apoptosis resistance in non-small cell lung cancer (nsclc) cells. |
2015-02-27 |
2023-08-12 |
human |
| Ji Wang, Min Zhou, Xiaobin Wang, Xiaoling Yang, Maohua Wang, Chunxiang Zhang, Shuzhi Zhou, Ni Tan. Impact of ketamine on learning and memory function, neuronal apoptosis and its potential association with miR-214 and PTEN in adolescent rats. PloS one. vol 9. issue 6. 2015-01-29. PMID:24914689. |
impact of ketamine on learning and memory function, neuronal apoptosis and its potential association with mir-214 and pten in adolescent rats. |
2015-01-29 |
2023-08-13 |
rat |
| Ji Wang, Min Zhou, Xiaobin Wang, Xiaoling Yang, Maohua Wang, Chunxiang Zhang, Shuzhi Zhou, Ni Tan. Impact of ketamine on learning and memory function, neuronal apoptosis and its potential association with miR-214 and PTEN in adolescent rats. PloS one. vol 9. issue 6. 2015-01-29. PMID:24914689. |
the rats were then decapitated, and the brains were isolated for detection of neuronal apoptosis and protein pten expression by tunel and immunohistochemistry respectively. |
2015-01-29 |
2023-08-13 |
rat |
| Hyung Jin Kim, Jihee Ryu, Hae-Mi Woo, Samuel Sunghwan Cho, Min Kyung Sung, Sang Cheol Kim, Mi-Hyun Park, Taesung Park, Soo Kyung Ko. Patterns of gene expression associated with Pten deficiency in the developing inner ear. PloS one. vol 9. issue 6. 2015-01-20. PMID:24893171. |
we previously reported that pten conditional knockout (cko) mice exhibited disorganized fasciculus with neuronal apoptosis in spiral ganglion neurons (sgns). |
2015-01-20 |
2023-08-13 |
mouse |
| Hyung Jin Kim, Jihee Ryu, Hae-Mi Woo, Samuel Sunghwan Cho, Min Kyung Sung, Sang Cheol Kim, Mi-Hyun Park, Taesung Park, Soo Kyung Ko. Patterns of gene expression associated with Pten deficiency in the developing inner ear. PloS one. vol 9. issue 6. 2015-01-20. PMID:24893171. |
this result was consistent with the phenotypic defects of sgns in pten cko mice (e.g., neuronal apoptosis, abnormal migration, and irregular nerve fiber patterns of sgns). |
2015-01-20 |
2023-08-13 |
mouse |
| Yiwei Lin, Tiebang Kang, Binhua P Zho. Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner. Cell cycle (Georgetown, Tex.). vol 13. issue 11. 2015-01-12. PMID:24675890. |
while previous studies have showed that snail protects tumor cells from apoptosis through transcriptional repression of pten, the specific mechanism remains unclear. |
2015-01-12 |
2023-08-12 |
human |
| Young Min Kim, Konstantin Tsoyi, Hwa Jin Jang, Eun Jung Park, Sang Won Park, Hye Jung Kim, Jeong Seok Hwa, Ki Churl Chan. CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN. Life sciences. vol 112. issue 1-2. 2015-01-06. PMID:25058922. |
it has been reported that in human glioblastoma cells, phosphotase and tensin homolog (pten) positive cells are more prone to paclitaxel-induced apoptosis than pten-negative cells. |
2015-01-06 |
2023-08-13 |
human |
| Young Min Kim, Konstantin Tsoyi, Hwa Jin Jang, Eun Jung Park, Sang Won Park, Hye Jung Kim, Jeong Seok Hwa, Ki Churl Chan. CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN. Life sciences. vol 112. issue 1-2. 2015-01-06. PMID:25058922. |
we investigated whether (s)-1-(α-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ckd712) enhances the therapeutic effects of paclitaxel (including effects on cellular proliferation, invasion and apoptosis) in mda-mb-231 cells through pten and nf-κb activity. |
2015-01-06 |
2023-08-13 |
human |
| Qiong Yang, Kan Yang, Anying L. microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24676391. |
during i/r and h/r, forced expression of mir-21 upregulated the akt signaling activity via suppressing the expression of phosphatase and tensin homolog (pten) and the increased activity of akt signaling further inhibited apoptosis partially by increasing the ratio of b-cell lymphoma 2(bcl-2)/bcl-2-associated x protein, which further suppressed the expression of caspase-3. |
2015-01-05 |
2023-08-12 |
Not clear |
| Shintaro Hara, Reiko Morita, Takashi Ogawa, Risa Segawa, Norifumi Takimoto, Kazuhiko Suzuki, Naobumi Hamadate, Shim-Mo Hayashi, Ayano Odachi, Isao Ogiwara, Sakae Shibusawa, Toshinori Yoshida, Makoto Shibutan. Tumor suppression effects of bilberry extracts and enzymatically modified isoquercitrin in early preneoplastic liver cell lesions induced by piperonyl butoxide promotion in a two-stage rat hepatocarcinogenesis model. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. vol 66. issue 5-6. 2014-12-30. PMID:24680176. |
we examined the modifying effect of co-administration with bbe or emiq on the liver tissue environment including oxidative stress responses, cell proliferation and apoptosis, and phosphatase and tensin homolog (pten)/akt and transforming growth factor (tgf)-β/smad signalings on the induction mechanism of preneoplastic lesions during early stages of hepatocellular tumor promotion. |
2014-12-30 |
2023-08-12 |
rat |
| Mohamad Farid, Elizabeth G Demicco, Roberto Garcia, Linda Ahn, Pamela R Merola, Angela Cioffi, Robert G Mak. Malignant peripheral nerve sheath tumors. The oncologist. vol 19. issue 2. 2014-12-29. PMID:24470531. |
these include classical cancer-driving genetic aberrations such as tp53 and phosphatase and tensin homolog (pten) loss of function, and upregulation of mitogen-activated protein kinase (mapk) and (mechanistic) target of rapamycin (tor) pathways, as well as less ubiquitous molecular abnormalities involving inhibitors of apoptosis proteins, aurora kinases, and the wingless/int (wnt) signaling pathway. |
2014-12-29 |
2023-08-12 |
Not clear |