| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ying Liu, Xiaoxue Wang, Daping Yang, Zhibo Xiao, Xi Che. MicroRNA-21 affects proliferation and apoptosis by regulating expression of PTEN in human keloid fibroblasts. Plastic and reconstructive surgery. vol 134. issue 4. 2014-12-29. PMID:25357050. |
microrna-21 affects proliferation and apoptosis by regulating expression of pten in human keloid fibroblasts. |
2014-12-29 |
2023-08-13 |
human |
| Zhongbing Liu, Famin Ke, Chenggang Duan, Huan Lan, Juan Li, Cen Gao, Jinwei Li, Zhirong Zhon. Mannan-conjugated adenovirus enhanced gene therapy effects on murine hepatocellular carcinoma cells in vitro and in vivo. Bioconjugate chemistry. vol 24. issue 8. 2014-12-28. PMID:23937094. |
overexpression of phosphatase and tensin homologue (pten) in cancer cells carrying deletion/mutant type of it can induce the apoptosis of cancer cells and inhibit cell proliferation. |
2014-12-28 |
2023-08-12 |
mouse |
| Rachakatla Anuradha, Mudigonda Saraswati, Kishore G Kumar, Surekha H Ran. Apoptosis of beta cells in diabetes mellitus. DNA and cell biology. vol 33. issue 11. 2014-12-18. PMID:25093391. |
the genetic alterations in apoptosis signaling machinery and the pathogenesis of diabetes include fas, fasl, akt, caspases, calpain-10, and phosphatase and tensin homolog (pten). |
2014-12-18 |
2023-08-13 |
Not clear |
| Anna Markowska, Monika Pawałowska, Jolanta Lubin, Janina Markowsk. Signalling pathways in endometrial cancer. Contemporary oncology (Poznan, Poland). vol 18. issue 3. 2014-12-18. PMID:25520571. |
pten inactivation, mutations in the pik3ca or akt result in increased transmission in the pi3k/akt pathway, apoptosis inhibition, intensive cell division, mtor excitation. |
2014-12-18 |
2023-08-13 |
Not clear |
| Chun-Hong Zhou, Xiao-Peng Zhang, Feng Liu, Wei Wan. Involvement of miR-605 and miR-34a in the DNA damage response promotes apoptosis induction. Biophysical journal. vol 106. issue 8. 2014-12-04. PMID:24739178. |
moreover, mir-605 and pten complement each other in elevating p53 levels to trigger apoptosis. |
2014-12-04 |
2023-08-13 |
Not clear |
| Rong Li, Jun-Lin He, Xue-Mei Chen, Chun-Lan Long, De-Hui Yang, Yu-Bin Ding, Hong-Bo Qi, Xue-Qing Li. MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN. Molecular biology reports. vol 41. issue 4. 2014-12-03. PMID:24413994. |
mir-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line hec-1b by targeting the tumor suppressor pten. |
2014-12-03 |
2023-08-12 |
human |
| Rong Li, Jun-Lin He, Xue-Mei Chen, Chun-Lan Long, De-Hui Yang, Yu-Bin Ding, Hong-Bo Qi, Xue-Qing Li. MiR-200a is involved in proliferation and apoptosis in the human endometrial adenocarcinoma cell line HEC-1B by targeting the tumor suppressor PTEN. Molecular biology reports. vol 41. issue 4. 2014-12-03. PMID:24413994. |
taken together, we propose that in hec-1b cells, mir-200a functions as an oncogene, affecting proliferation and apoptosis by regulating the expression of the tumor suppressor pten at the translational level. |
2014-12-03 |
2023-08-12 |
human |
| Elizabeth A Mittendorf, Anne V Philips, Funda Meric-Bernstam, Na Qiao, Yun Wu, Susan Harrington, Xiaoping Su, Ying Wang, Ana M Gonzalez-Angulo, Argun Akcakanat, Akhil Chawla, Michael Curran, Patrick Hwu, Padmanee Sharma, Jennifer K Litton, Jeffrey J Molldrem, Gheath Alatras. PD-L1 expression in triple-negative breast cancer. Cancer immunology research. vol 2. issue 4. 2014-12-03. PMID:24764583. |
increased pd-l1 cell surface expression by tumor cells induced by pten loss led to decreased t-cell proliferation and increased apoptosis. |
2014-12-03 |
2023-08-13 |
Not clear |
| Feng-Qiang Yang, Ji-Jiao Wang, Jia-Sheng Yan, Jian-Hua Huang, Wei Li, Jian-Ping Che, Guang-Chun Wang, Min Liu, Jun-Hua Zhen. Metformin inhibits cell growth by upregulating microRNA-26a in renal cancer cells. International journal of clinical and experimental medicine. vol 7. issue 10. 2014-11-24. PMID:25419360. |
mir-26a induces cell growth, cell cycle and cell apoptosis progression via direct targeting of bcl-2, clyclin d1 and pten in cancer cells. |
2014-11-24 |
2023-08-13 |
human |
| C Reynolds, J E Roderick, J L LaBelle, G Bird, R Mathieu, K Bodaar, D Colon, U Pyati, K E Stevenson, J Qi, M Harris, L B Silverman, S E Sallan, J E Bradner, D S Neuberg, A T Look, L D Walensky, M A Kelliher, A Gutierre. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. vol 28. issue 9. 2014-10-31. PMID:24552990. |
treatment resistance in t-cell acute lymphoblastic leukemia (t-all) is associated with phosphatase and tensin homolog (pten) deletions and resultant phosphatidylinositol 3'-kinase (pi3k)-akt pathway activation, as well as myc overexpression, and these pathways repress mitochondrial apoptosis in established t-lymphoblasts through poorly defined mechanisms. |
2014-10-31 |
2023-08-12 |
human |
| Yanrong Lv, Shanshan Song, Kai Zhang, Haidong Gao, Rong M. CHIP regulates AKT/FoxO/Bim signaling in MCF7 and MCF10A cells. PloS one. vol 8. issue 12. 2014-10-06. PMID:24376685. |
in general, the chip-modulated akt/foxo/bim signaling pathway was shown to induce apoptosis resistance by decreasing the protein level of the tumor suppressor pten in both transcriptional and post-translational regulations. |
2014-10-06 |
2023-08-12 |
human |
| Jianmei Chen, Weining Wang, Yangde Zhang, Tiehui Hu, Yuxiang Che. The roles of miR-200c in colon cancer and associated molecular mechanisms. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24682933. |
in conclusion, mir-200c functions as an oncogene in colon cancer cells through regulating tumor cell apoptosis, survival, invasion, and metastasis as well as xenograft tumor growth through inhibition of pten expression and p53 phosphorylation. |
2014-10-06 |
2023-08-12 |
Not clear |
| Kai-Chun Cheng, Akihiro Asakawa, Ying-Xiao Li, Hsien-Hui Chung, Haruka Amitani, Takatoshi Ueki, Juei-Tang Cheng, Akio Inu. Silymarin induces insulin resistance through an increase of phosphatase and tensin homolog in Wistar rats. PloS one. vol 9. issue 1. 2014-09-16. PMID:24404172. |
phosphatase and tensin homolog (pten) is a phosphoinositide phosphatase that regulates crucial cellular functions, including insulin signaling, lipid and glucose metabolism, as well as survival and apoptosis. |
2014-09-16 |
2023-08-12 |
rat |
| Min Shi, Xiumin Zhou, Zubin Zhang, Man Wang, Guodong Chen, Kunkun Han, Biyin Cao, Zhaopeng Liu, Xinliang Ma. A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3. Toxicology letters. vol 228. issue 3. 2014-09-12. PMID:24831963. |
notably, pten restoration attenuated benc-511 induced apoptosis. |
2014-09-12 |
2023-08-13 |
mouse |
| Shevali Kansal, Archana Bhatnagar, Navneet Agnihotr. Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-κB signaling in colorectal cancer. PloS one. vol 9. issue 1. 2014-09-10. PMID:24416253. |
the tumor suppressor pten (phosphatase and tensin homolog deleted on chromosome 10), a dual-specificity phosphatase, plays a functional role in cell cycle arrest and apoptosis. |
2014-09-10 |
2023-08-12 |
rat |
| Shevali Kansal, Archana Bhatnagar, Navneet Agnihotr. Fish oil suppresses cell growth and metastatic potential by regulating PTEN and NF-κB signaling in colorectal cancer. PloS one. vol 9. issue 1. 2014-09-10. PMID:24416253. |
in the initiation phase, animals receiving dmh have shown increased % of apoptotic cells, pten, parp, nf-κbp50, nf-κbp65 and vegf however in post-initiation phase no significant alteration in apoptosis with decreased pten and increased parp, nf-κbp50, nf-κbp65 and vegf were observed as compared to control animals. |
2014-09-10 |
2023-08-12 |
rat |
| Wen-Wen Jia, Miao Miao, Jia Li, Bin Wu, Zhuo-Gang Li. [Inducing effects of ursolic acid on Jurkat cell apoptosis and its mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 2. 2014-09-04. PMID:24762997. |
the study was aimed to investigate the inducing effect of ursolic acid (ua) on the apoptosis of human t-cell leukemia/lymphoma (jurkat), and whether the regulation of pten involved in the effect of ua on jurkat cells. |
2014-09-04 |
2023-08-13 |
human |
| Wen-Wen Jia, Miao Miao, Jia Li, Bin Wu, Zhuo-Gang Li. [Inducing effects of ursolic acid on Jurkat cell apoptosis and its mechanisms]. Zhongguo shi yan xue ye xue za zhi. vol 22. issue 2. 2014-09-04. PMID:24762997. |
it is concluded that ua may induce jurkat cell apoptosis by up-regulating the pten mrna expression. |
2014-09-04 |
2023-08-13 |
human |
| Ranjita Das, Kaushik Bhattacharya, Sayantani Sarkar, Suman Kumar Samanta, Bikas C Pal, Chitra Manda. Mahanine synergistically enhances cytotoxicity of 5-fluorouracil through ROS-mediated activation of PTEN and p53/p73 in colon carcinoma. Apoptosis : an international journal on programmed cell death. vol 19. issue 1. 2014-09-02. PMID:24052409. |
we demonstrated that mahanine-induced apoptosis involved reactive oxygen species (ros)-mediated nuclear accumulation of pten and its interaction with p53/p73. |
2014-09-02 |
2023-08-12 |
Not clear |
| Ying Wang, Zhongdong Hu, Zhibo Liu, Rongrong Chen, Haiyong Peng, Jing Guo, Xinxin Chen, Hongbing Zhan. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy. vol 9. issue 12. 2014-09-02. PMID:24189100. |
here, we show that loss of tsc2 or pten enhanced etoposide-induced dna damage and apoptosis, which was blunted by suppression of mtor with either rapamycin or rna interference. |
2014-09-02 |
2023-08-12 |
mouse |