| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kai Tang, Yi Lin, Li-Ming L. The role of phenethyl isothiocyanate on bladder cancer ADM resistance reversal and its molecular mechanism. Anatomical record (Hoboken, N.J. : 2007). vol 296. issue 6. 2014-01-30. PMID:23495258. |
in this report, we identified the role of peitc on adm resistance reversal of human bladder carcinoma t24/adm cells, including an increased drug sensitivity to adm, cell apoptosis rates, intracellular accumulation of rhodamine-123 (rh-123), an increased expression of dna topoisomerase ii (topo-ii), and a decreased expression of multidrug resistance gene (mdr1), multidrug resistance-associated protein (mrp1), bcl-2 and glutathione s transferase π (gst-π).we also found that there was a decreased expression of nf-κb, survivin, twist, and p-akt, and an increased expression of pten and p-jnk after peitc treatment for t24/ adm cells. |
2014-01-30 |
2023-08-12 |
human |
| Caroline Morin, Samuel Fortin, André M Cantin, Marco Sirois, Chantal Sirois, Edmond Rizcallah, Éric Roussea. Anti-cancer effects of a new docosahexaenoic acid monoacylglyceride in lung adenocarcinoma. Recent patents on anti-cancer drug discovery. vol 8. issue 3. 2014-01-21. PMID:23092161. |
furthermore, mag-dha treatment increased pten expression and activation concomitant with a decrease in akt phosphorylation levels and enhanced apoptosis. |
2014-01-21 |
2023-08-12 |
mouse |
| Mohan Singh, Parvesh Chaudhry, Francois Fabi, Eric Asseli. Cisplatin-induced caspase activation mediates PTEN cleavage in ovarian cancer cells: a potential mechanism of chemoresistance. BMC cancer. vol 13. 2014-01-10. PMID:23663432. |
in the present study, we have investigated the regulation of pten during cisplatin induced apoptosis in a2780, a270-cp (cisplatin resistant), ovcar-3 and skov3 ovarian cancer cell lines. |
2014-01-10 |
2023-08-12 |
human |
| Su-Jung Kim, Hyun-Joo Jung, Chang-Jin Li. Reactive oxygen species-dependent down-regulation of tumor suppressor genes PTEN, USP28, DRAM, TIGAR, and CYLD under oxidative stress. Biochemical genetics. vol 51. issue 11-12. 2014-01-10. PMID:23832602. |
superoxide radical-generating menadione and serum deprivation diminished the steady-state mrna levels for the genes phosphatase and tensin homolog (pten), ubiquitin specific peptidase 28 (usp28), damage-regulated autophagy modulator (dram), tp53-induced glycolysis and apoptosis regulator (tigar), and cylindromatosis (cyld). |
2014-01-10 |
2023-08-12 |
human |
| Emily A Nizialek, Charissa Peterson, Jessica L Mester, Erinn Downes-Kelly, Charis En. Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest. Human molecular genetics. vol 22. issue 12. 2013-12-31. PMID:23446638. |
klln, which shares a bidirectional promoter with pten, causes cell cycle arrest and apoptosis. |
2013-12-31 |
2023-08-12 |
Not clear |
| Yu Wang, Xin He, Qi Yu, Charis En. Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas. Human molecular genetics. vol 22. issue 11. 2013-12-30. PMID:23418309. |
we demonstrate, in vitro and in murine xenograph models, that both klln and pten are ar-target genes, mediating androgen-induced growth inhibition and apoptosis in breast cancer cells. |
2013-12-30 |
2023-08-12 |
Not clear |
| Xiaoxin Mu, Shu Lin, Junhua Yang, Chen Chen, Yun Chen, Maryanne C Herzig, Kenneth Washburn, Glenn A Halff, Christi A Walter, Beicheng Sun, Lu-Zhe Su. TGF-β signaling is often attenuated during hepatotumorigenesis, but is retained for the malignancy of hepatocellular carcinoma cells. PloS one. vol 8. issue 5. 2013-12-30. PMID:23704908. |
furthermore, knockdown of smad4 also led to a significant inhibition of growth on plastic and in soft agar with concomitant increase of apoptosis, pten expression, and reduced nuclear accumulation of linker region-phosphorylated smad3. |
2013-12-30 |
2023-08-12 |
human |
| Meng Zhang, Bao-En Shan, Nai-Fen Yuan, Wei Li. Effect of topotecan on retinocytoma cell apoptosis and expression of Livin and PTEN. Chinese medical journal. vol 126. issue 2. 2013-12-27. PMID:23324287. |
effect of topotecan on retinocytoma cell apoptosis and expression of livin and pten. |
2013-12-27 |
2023-08-12 |
Not clear |
| Pan Chen, Xiaofang Guo, Houde Zhou, Wenling Zhang, Zhaoyang Zeng, Qianjin Liao, Xiayu Li, Bo Xiang, Jianbo Yang, Jian Ma, Ming Zhou, Shuping Peng, Juanjuan Xiang, Xiaoling Li, Colvin Wanshura L E, Wei Xiong, James B McCarthy, Guiyuan L. SPLUNC1 regulates cell progression and apoptosis through the miR-141-PTEN/p27 pathway, but is hindered by LMP1. PloS one. vol 8. issue 3. 2013-12-03. PMID:23472073. |
splunc1 regulates npc cell proliferation, differentiation and apoptosis through mir-141, which in turn regulates pten and p27 expression. |
2013-12-03 |
2023-08-12 |
Not clear |
| F M Berglund, N R Weerasinghe, L Davidson, J C Lim, B J Eickholt, N R Lesli. Disruption of epithelial architecture caused by loss of PTEN or by oncogenic mutant p110α/PIK3CA but not by HER2 or mutant AKT1. Oncogene. vol 32. issue 37. 2013-11-08. PMID:23085752. |
changes in her2, pten, pik3ca and akt have all been reported to lead to both enhanced proliferation and failures in hollow lumen formation in three dimensional epithelial culture models, but it is not clear whether these failures in lumen formation are caused by any failure in the spatial coordination of lumen formation (hollowing) or purely a failure in the apoptosis and clearance of luminal cells (cavitation). |
2013-11-08 |
2023-08-12 |
Not clear |
| Shi Liu, Xiao-Jie Wang, Ying Liu, Yun-Fu Cu. PI3K/AKT/mTOR signaling is involved in (-)-epigallocatechin-3-gallate-induced apoptosis of human pancreatic carcinoma cells. The American journal of Chinese medicine. vol 41. issue 3. 2013-10-17. PMID:23711146. |
in conclusion, these results suggest that egcg can suppress proliferation and induce apoptosis of panc-1 cells in a time- and dose-dependent manner; moreover, egcg also can upregulate pten expression and downregulate the expression of pakt and p-mtor to modulate the pi3k/akt/mtor signaling pathway. |
2013-10-17 |
2023-08-12 |
human |
| M M Sun, M Z Zhang, Y Chen, S L Li, W Zhang, G W Ya, K S Che. Effect of PTEN antisense oligonucleotide on oesophageal squamous cell carcinoma cell lines. The Journal of international medical research. vol 40. issue 6. 2013-09-30. PMID:23321166. |
to investigate the effects of a phosphatase and tensin homologue (pten) antisense oligonucleotide on pten and mammalian target of rapamycin (mtor) mrna and protein, cell proliferation and apoptosis in oesophageal squamous cell carcinoma (ocss) cell lines. |
2013-09-30 |
2023-08-12 |
Not clear |
| James T Lee, Jing Shan, Jiayun Zhong, Muyang Li, Brenda Zhou, Amanda Zhou, Ramon Parsons, Wei G. RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation. Cell research. vol 23. issue 4. 2013-09-13. PMID:23419514. |
moreover, rfp-mediated ubiquitination of pten inhibits pten-dependent activation of trail expression and also suppresses its ability to induce apoptosis. |
2013-09-13 |
2023-08-12 |
Not clear |
| Daniel G Sedding, Rebecca Widmer-Teske, Andreas Mueller, Philipp Stieger, Jan-Marcus Daniel, Dursun Gündüz, Soni Pullamsetti, Holger Nef, Helge Moellmann, Christian Troidl, Christian Hamm, Rüdiger Braun-Dullaeu. Role of the phosphatase PTEN in early vascular remodeling. PloS one. vol 8. issue 3. 2013-09-11. PMID:23533567. |
in the present study we sought to determine pten's effect on vascular smooth muscle cell (vsmc) apoptosis following acute injury in vivo and in vitro. |
2013-09-11 |
2023-08-12 |
Not clear |
| Andrea Lunardi, Ugo Ala, Mirjam T Epping, Leonardo Salmena, John G Clohessy, Kaitlyn A Webster, Guocan Wang, Roberta Mazzucchelli, Maristella Bianconi, Edward C Stack, Rosina Lis, Akash Patnaik, Lewis C Cantley, Glenn Bubley, Carlos Cordon-Cardo, William L Gerald, Rodolfo Montironi, Sabina Signoretti, Massimo Loda, Caterina Nardella, Pier Paolo Pandolf. A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nature genetics. vol 45. issue 7. 2013-09-10. PMID:23727860. |
we show that castration counteracts tumor progression in a pten loss-driven mouse model of prostate cancer through the induction of apoptosis and proliferation block. |
2013-09-10 |
2023-08-12 |
mouse |
| Xiaodong Ma, Saibyasachi N Choudhury, Xiang Hua, Zhongping Dai, Yong L. Interaction of the oncogenic miR-21 microRNA and the p53 tumor suppressor pathway. Carcinogenesis. vol 34. issue 6. 2013-08-01. PMID:23385064. |
in addition, loss of mir-21 sensitizes transformed trp53 (-/-) cells to dna damage-induced apoptosis through elevation of pten expression. |
2013-08-01 |
2023-08-12 |
mouse |
| Liang Luo, Yuan Qi Gong, Xiefei Qi, Wenyan Lai, Haibing Lan, Yaling Lu. Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells. Molecular and cellular biochemistry. vol 375. issue 1-2. 2013-07-26. PMID:23275086. |
effect of tumor suppressor pten gene on apoptosis and cell cycle of human airway smooth muscle cells. |
2013-07-26 |
2023-08-12 |
human |
| Liang Luo, Yuan Qi Gong, Xiefei Qi, Wenyan Lai, Haibing Lan, Yaling Lu. Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells. Molecular and cellular biochemistry. vol 375. issue 1-2. 2013-07-26. PMID:23275086. |
tumor suppressor pten gene with phosphatase activity plays an important regulatory role in embryonic development, cell proliferation, and apoptosis, cell cycle regulation, migration (invasion) of the cytoskeleton. |
2013-07-26 |
2023-08-12 |
human |
| Liang Luo, Yuan Qi Gong, Xiefei Qi, Wenyan Lai, Haibing Lan, Yaling Lu. Effect of tumor suppressor PTEN gene on apoptosis and cell cycle of human airway smooth muscle cells. Molecular and cellular biochemistry. vol 375. issue 1-2. 2013-07-26. PMID:23275086. |
our study revealed that overexpression of pten gene did not induce apoptosis of human asmcs cultured in vitro. |
2013-07-26 |
2023-08-12 |
human |
| Jianhua Wu, Jianzhe Li, Hankun Hu, Ping Liu, Yunxiang Fang, Dongfang W. Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain. Cellular and molecular neurobiology. vol 32. issue 7. 2013-07-10. PMID:22552888. |
rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the akt activation and pten inactivation in the ischemic penumbra of rat brain. |
2013-07-10 |
2023-08-12 |
rat |