| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Li, L Liu, C Shan, Q Cheng, A Budhraja, T Zhou, H Cui, N Ga. RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo. Cell death & disease. vol 5. 2014-09-02. PMID:24434521. |
inhibiting rhoa and rock1 activation by c3 exoenzyme (c3) and y27632, respectively, attenuated the rock1 cleavage/activation, pten activity, akt inactivation, mcl-1 downregulation, bad dephosphorylation, and apoptosis mediated by at-101. |
2014-09-02 |
2023-08-12 |
mouse |
| Shankar Jayarama, Liang-Cheng Li, Lakshmy Ganesh, David Mardi, Prasad Kanteti, Nissim Hay, Peifeng Li, Bellur S Prabhaka. MADD is a downstream target of PTEN in triggering apoptosis. Journal of cellular biochemistry. vol 115. issue 2. 2014-07-23. PMID:24038283. |
madd is a downstream target of pten in triggering apoptosis. |
2014-07-23 |
2023-08-12 |
Not clear |
| Shankar Jayarama, Liang-Cheng Li, Lakshmy Ganesh, David Mardi, Prasad Kanteti, Nissim Hay, Peifeng Li, Bellur S Prabhaka. MADD is a downstream target of PTEN in triggering apoptosis. Journal of cellular biochemistry. vol 115. issue 2. 2014-07-23. PMID:24038283. |
the downstream targets of pten in triggering apoptosis have not yet been completely identified. |
2014-07-23 |
2023-08-12 |
Not clear |
| Shankar Jayarama, Liang-Cheng Li, Lakshmy Ganesh, David Mardi, Prasad Kanteti, Nissim Hay, Peifeng Li, Bellur S Prabhaka. MADD is a downstream target of PTEN in triggering apoptosis. Journal of cellular biochemistry. vol 115. issue 2. 2014-07-23. PMID:24038283. |
here, we report that madd can act as a pro-apoptotic factor to initiate trail-induced apoptosis when its phosphorylation is attenuated by pten. |
2014-07-23 |
2023-08-12 |
Not clear |
| Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Ruby Dhar, Zhixiang Fan, Zhongqiang Guo, Jing Zhang, Yuwen Ke, Lu Wang, Min Zhuang, Shengdi Hu, Xuesong Li, Liqun Zhou, Xianghong Li, Matthew F Calabrese, Edmond R Watson, Sandip M Prasad, Carrie Rinker-Schaeffer, Scott E Eggener, Thomas Stricker, Yong Tian, Brenda A Schulman, Jiang Liu, Kevin P Whit. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer cell. vol 25. issue 4. 2014-07-23. PMID:24656772. |
this tumorigenic activity occurs through the ubiquitination and degradation of multiple regulators of cellular proliferation and apoptosis, including the tumor suppressor pten, erk phosphatases, the proapoptotic molecule daxx, and the hedgehog pathway transcription factor gli2. |
2014-07-23 |
2023-08-12 |
Not clear |
| Sumit Siddharth, Purusottam Mohapatra, Ranjan Preet, Dipon Das, Shakti Ranjan Satapathy, Tathagata Choudhuri, Chanakya Nath Kund. Induction of apoptosis by 4-(3-(tert-butylamino)imidazo[1,2-α]pyridine-2-yl) benzoic acid in breast cancer cells via upregulation of PTEN. Oncology research. vol 21. issue 1. 2014-07-22. PMID:24330847. |
induction of apoptosis by 4-(3-(tert-butylamino)imidazo[1,2-α]pyridine-2-yl) benzoic acid in breast cancer cells via upregulation of pten. |
2014-07-22 |
2023-08-12 |
Not clear |
| Sumit Siddharth, Purusottam Mohapatra, Ranjan Preet, Dipon Das, Shakti Ranjan Satapathy, Tathagata Choudhuri, Chanakya Nath Kund. Induction of apoptosis by 4-(3-(tert-butylamino)imidazo[1,2-α]pyridine-2-yl) benzoic acid in breast cancer cells via upregulation of PTEN. Oncology research. vol 21. issue 1. 2014-07-22. PMID:24330847. |
bnfa-d caused apoptosis by upregulating pten leading to inhibition of wnt/tcf signaling cascade and arresting s phase in breast cancer cells. |
2014-07-22 |
2023-08-12 |
Not clear |
| Hao Li, Xiao-Peng Zhang, Feng Li. Coordination between p21 and DDB2 in the cellular response to UV radiation. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260342. |
we revealed that the downregulation of p21 is necessary for apoptosis induction and pten promotes apoptosis by amplifying p53 activation. |
2014-07-07 |
2023-08-12 |
Not clear |
| Eric C Hales, Jeffrey W Taub, Larry H Matherl. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia. Cellular signalling. vol 26. issue 1. 2014-06-25. PMID:24140475. |
loss of pten is common in primary t-alls due to mutation or posttranslational inactivation and results in chronic activation of pi3k-akt-mtor1 signaling, gsi-resistance, and repression of p53-mediated apoptosis. |
2014-06-25 |
2023-08-12 |
Not clear |
| Xin Li, Zengxia Li, Na Li, Jingjing Qi, Kun Fan, Peng Yin, Chao Zhao, Yonglei Liu, Wantong Yao, Xiumei Cai, Liying Wang, Xiliang Zh. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. International journal of molecular medicine. vol 32. issue 2. 2014-06-09. PMID:23754155. |
magi2 enhances the sensitivity of bel-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing pten stability. |
2014-06-09 |
2023-08-12 |
human |
| Xin Li, Zengxia Li, Na Li, Jingjing Qi, Kun Fan, Peng Yin, Chao Zhao, Yonglei Liu, Wantong Yao, Xiumei Cai, Liying Wang, Xiliang Zh. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. International journal of molecular medicine. vol 32. issue 2. 2014-06-09. PMID:23754155. |
our results demonstrated that magi2 enhanced sts-induced apoptosis by increasing the protein expression of cytoplasmic phosphatase and tensin homologue deleted on chromosome 10 (pten) and decreasing its protein degradation. |
2014-06-09 |
2023-08-12 |
human |
| Xin Li, Zengxia Li, Na Li, Jingjing Qi, Kun Fan, Peng Yin, Chao Zhao, Yonglei Liu, Wantong Yao, Xiumei Cai, Liying Wang, Xiliang Zh. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. International journal of molecular medicine. vol 32. issue 2. 2014-06-09. PMID:23754155. |
the apoptotic sensitivity of the cells caused by the overexpression of myc-magi2 was reversed by the silencing of pten expression by pten sirna, thus revealing a momentous role of pten in the enhancement of the sensitivity of cancer cells to sts-induced apoptosis by magi2. |
2014-06-09 |
2023-08-12 |
human |
| Xin Li, Zengxia Li, Na Li, Jingjing Qi, Kun Fan, Peng Yin, Chao Zhao, Yonglei Liu, Wantong Yao, Xiumei Cai, Liying Wang, Xiliang Zh. MAGI2 enhances the sensitivity of BEL-7404 human hepatocellular carcinoma cells to staurosporine-induced apoptosis by increasing PTEN stability. International journal of molecular medicine. vol 32. issue 2. 2014-06-09. PMID:23754155. |
these results suggest that magi2 overexpression enhances the sensitivity of cancer cells harboring ectopic pten to sts-induced apoptosis. |
2014-06-09 |
2023-08-12 |
human |
| A Bononi, M Bonora, S Marchi, S Missiroli, F Poletti, C Giorgi, P P Pandolfi, P Pinto. Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell death and differentiation. vol 20. issue 12. 2014-06-05. PMID:23811847. |
identification of pten at the er and mams and its regulation of ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. |
2014-06-05 |
2023-08-12 |
Not clear |
| A Bononi, M Bonora, S Marchi, S Missiroli, F Poletti, C Giorgi, P P Pandolfi, P Pinto. Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell death and differentiation. vol 20. issue 12. 2014-06-05. PMID:23811847. |
we show here that a fraction of pten protein localizes to the endoplasmic reticulum (er) and mitochondria-associated membranes (mams), signaling domains involved in calcium ((2+)) transfer from the er to mitochondria and apoptosis induction. |
2014-06-05 |
2023-08-12 |
Not clear |
| A Bononi, M Bonora, S Marchi, S Missiroli, F Poletti, C Giorgi, P P Pandolfi, P Pinto. Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell death and differentiation. vol 20. issue 12. 2014-06-05. PMID:23811847. |
specific targeting of pten to the er is sufficient to enhance er-to-mitochondria ca(2+) transfer and sensitivity to apoptosis. |
2014-06-05 |
2023-08-12 |
Not clear |
| A Bononi, M Bonora, S Marchi, S Missiroli, F Poletti, C Giorgi, P P Pandolfi, P Pinto. Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner. Cell death and differentiation. vol 20. issue 12. 2014-06-05. PMID:23811847. |
pten localization at the er is further increased during ca(2+)-dependent apoptosis induction. |
2014-06-05 |
2023-08-12 |
Not clear |
| Feng Xie, Ming Su, Wei Qiu, Min Zhang, Zhongqiang Guo, Boxing Su, Jie Liu, Xuesong Li, Liqun Zho. Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. International journal of molecular sciences. vol 14. issue 11. 2014-06-03. PMID:24284390. |
kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, pten. |
2014-06-03 |
2023-08-12 |
human |
| Feng Xie, Ming Su, Wei Qiu, Min Zhang, Zhongqiang Guo, Boxing Su, Jie Liu, Xuesong Li, Liqun Zho. Kaempferol promotes apoptosis in human bladder cancer cells by inducing the tumor suppressor, PTEN. International journal of molecular sciences. vol 14. issue 11. 2014-06-03. PMID:24284390. |
furthermore, we found kae-induced apoptosis in ej cells to be associated with phosphatase and the tensin homolog deleted on the chromosome 10 (pten)/pi3k/akt pathway. |
2014-06-03 |
2023-08-12 |
human |
| Vijayalakshmi Sridharan, Nukhet Aykin-Burns, Preeti Tripathi, Kimberly J Krager, Sunil K Sharma, Eduardo G Moros, Peter M Corry, Grazyna Nowak, Martin Hauer-Jensen, Marjan Boerm. Radiation-induced alterations in mitochondria of the rat heart. Radiation research. vol 181. issue 3. 2014-06-02. PMID:24568130. |
at time points from 6 h to 9 months after a cardiac dose of 21 gy, the following analyses were performed: left ventricular bax and bcl-2 protein levels; apoptosis; mitochondrial inner membrane potential and mptp opening; mitochondrial mass and expression of mitophagy mediators parkin and pten induced putative kinase-1 (pink-1); mitochondrial respiration and protein levels of succinate dehydrogenase a (sdha); and the 70 kda subunit of complex ii. |
2014-06-02 |
2023-08-12 |
rat |