| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Mao, Xiaodong Su. Reactivation of the PI3K/Akt Signaling Pathway by the Bisperoxovanadium Compound bpV(pic) Attenuates Photoreceptor Apoptosis in Experimental Retinal Detachment. Investigative ophthalmology & visual science. vol 56. issue 9. 2015-10-27. PMID:26284558. |
this study evaluated the role of pten in photoreceptor cell apoptosis caused by retinal detachment (rd). |
2015-10-27 |
2023-08-13 |
Not clear |
| Kimberly A Foster, Esther P Jane, Daniel R Premkumar, Alejandro Morales, Ian F Pollac. Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines. Journal of neuro-oncology. vol 120. issue 3. 2015-10-15. PMID:25139025. |
these findings extend our previous observations that targeting the pi3k/akt pathway may be additionally necessary to promote apoptosis in cancers lacking pten functionality. |
2015-10-15 |
2023-08-13 |
human |
| Rohan Samarakoon, Sevann Helo, Amy D Dobberfuhl, Nidah S Khakoo, Lucas Falke, Jessica M Overstreet, Roel Goldschmeding, Paul J Higgin. Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses. The Journal of pathology. vol 236. issue 4. 2015-10-08. PMID:25810340. |
thus, pten loss initiates tubular dysfunction via smad3- and p53-mediated fibrotic gene induction, with accompanying pai-1-dependent proliferative arrest, and cooperates with tgfβ1 to induce the expression of profibrotic genes and tubular apoptosis. |
2015-10-08 |
2023-08-13 |
human |
| Valentina Grande, Giusi Manassero, Alessandro Vercell. Neuroprotective and anti-inflammatory roles of the phosphatase and tensin homolog deleted on chromosome Ten (PTEN) Inhibition in a Mouse Model of Temporal Lobe Epilepsy. PloS one. vol 9. issue 12. 2015-10-01. PMID:25501575. |
moreover, the neurotoxin administration increases significantly the scanty presence of mitochondrial pten that is significantly decreased by the administration of the inhibitor 6 hr after the injection of kainate, suggesting a role of pten in mitochondrial apoptosis. |
2015-10-01 |
2023-08-13 |
mouse |
| Chiu-Ling Chen, Yen-Wen Tseng, Jaw-Ching Wu, Guan-Yu Chen, Kuan-Chen Lin, Shiaw-Min Hwang, Yu-Chen H. Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA PTENP1 and MicroRNA regulation. Biomaterials. vol 44. 2015-09-28. PMID:25617127. |
co-transduction of hcc cells with the sb-bv vector expressing ptenp1 elevated the levels of ptenp1 and pten, which suppressed the oncogenic pi3k/akt pathway, inhibited cell proliferation, migration/invasion as well as induced autophagy and apoptosis. |
2015-09-28 |
2023-08-13 |
mouse |
| Kirti Bhatt, Qingqing Wei, Navjotsingh Pabla, Guie Dong, Qing-Sheng Mi, Mingyu Liang, Changlin Mei, Zheng Don. MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology : JASN. vol 26. issue 7. 2015-09-11. PMID:25587068. |
upon induction in vitro, mir-687 repressed the expression of phosphatase and tensin homolog (pten) and facilitated cell cycle progression and apoptosis. |
2015-09-11 |
2023-08-13 |
mouse |
| Kirti Bhatt, Qingqing Wei, Navjotsingh Pabla, Guie Dong, Qing-Sheng Mi, Mingyu Liang, Changlin Mei, Zheng Don. MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury. Journal of the American Society of Nephrology : JASN. vol 26. issue 7. 2015-09-11. PMID:25587068. |
blockade of mir-687 preserved pten expression and attenuated cell cycle activation and renal apoptosis, resulting in protection against kidney injury in mice. |
2015-09-11 |
2023-08-13 |
mouse |
| De-Yuan Li, Yi Qu, Jin-Hui Li, Li Zhang, Tao Xiong, De-Zhi M. [Changes of phosphatase PTEN in neuronal apoptosis in neonate rats with hypoxic-ischemic brain damage]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. vol 45. issue 5. 2015-09-08. PMID:25341336. |
[changes of phosphatase pten in neuronal apoptosis in neonate rats with hypoxic-ischemic brain damage]. |
2015-09-08 |
2023-08-13 |
rat |
| Wanfeng Yu, Xin He, Ying Ni, Joanne Ngeow, Charis En. Cowden syndrome-associated germline SDHD variants alter PTEN nuclear translocation through SRC-induced PTEN oxidation. Human molecular genetics. vol 24. issue 1. 2015-08-24. PMID:25149476. |
here, we show sdhd-g12s and sdhd-h50r lead to impaired pten function through alteration of its subcellular localization accompanied by resistance to apoptosis and induction of migration in both papillary and follicular thyroid carcinoma cell lines. |
2015-08-24 |
2023-08-13 |
Not clear |
| Rui Li, Xia Wang, Xiao-Hong Zhang, Hong-Hai Chen, Yan-Dong Li. Ursolic acid promotes apoptosis of SGC-7901 gastric cancer cells through ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 22. 2015-08-24. PMID:25520072. |
these findings imply that induction of apoptosis by ursolic acid stems primarily from the activation of rock1 and pten, resulting in the translocation of cofilin-1 from cytoplasm to mitochondria, release of cytochrome c, activation of caspase-3 and caspase-9, and finally inducing apoptosis of gastric cancer sgc-7901 cells. |
2015-08-24 |
2023-08-13 |
Not clear |
| Hesheng Ou, Yumei Li, Min Kan. Activation of miR-21 by STAT3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting PTEN gene. PloS one. vol 9. issue 11. 2015-08-18. PMID:25365510. |
activation of mir-21 by stat3 induces proliferation and suppresses apoptosis in nasopharyngeal carcinoma by targeting pten gene. |
2015-08-18 |
2023-08-13 |
human |
| Guizhi Dong, Xiaoling Liang, Deguang Wang, Huiquan Gao, Ling Wang, Lili Wang, Jingjun Liu, Zhaohui D. High expression of miR-21 in triple-negative breast cancers was correlated with a poor prognosis and promoted tumor cell in vitro proliferation. Medical oncology (Northwood, London, England). vol 31. issue 7. 2015-07-24. PMID:24930006. |
in present study, we determined the mir-21 levels in tnbc specimens, and tnbc cell levels in vitro, and then identified the role of mir-21 on tumor cell proliferation, apoptosis, and then identified pten as the possible target of the microrna. |
2015-07-24 |
2023-08-13 |
Not clear |
| Mukund Patel, Nicholas C Gomez, Andrew W McFadden, Billie M Moats-Staats, Sam Wu, Andres Rojas, Travis Sapp, Jeremy M Simon, Scott V Smith, Kathleen Kaiser-Rogers, Ian J Davi. PTEN deficiency mediates a reciprocal response to IGFI and mTOR inhibition. Molecular cancer research : MCR. vol 12. issue 11. 2015-07-22. PMID:24994750. |
pten rescue led to decreased proliferation, inhibition of colony formation, and increased apoptosis. |
2015-07-22 |
2023-08-13 |
Not clear |
| Ida Aronchik, Aishwarya Kundu, Jeanne G Quirit, Gary L Fireston. The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation. Molecular cancer research : MCR. vol 12. issue 11. 2015-07-22. PMID:25009292. |
i3c induced a g1-phase cell-cycle arrest and apoptosis by stabilization of pten in human melanoma cells that express wild-type pten, but not in cells with mutant or null pten genotypes. |
2015-07-22 |
2023-08-13 |
mouse |
| Wenting Xu, Zhen Yang, Shu-Feng Zhou, Nonghua L. Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors. Drug design, development and therapy. vol 8. 2015-07-13. PMID:25336918. |
pten is a tumor suppressor gene that occupies a key position in regulating cell growth, proliferation, apoptosis, mobility, signal transduction, and other crucial cellular processes. |
2015-07-13 |
2023-08-13 |
human |
| Wenting Xu, Zhen Yang, Shu-Feng Zhou, Nonghua L. Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors. Drug design, development and therapy. vol 8. 2015-07-13. PMID:25336918. |
deficiency in the posttranslational regulation of pten leads to abnormal cell proliferation, apoptosis, migration, and adhesion, which are associated with cancer initiation, progression, and metastasis. |
2015-07-13 |
2023-08-13 |
human |
| Chen Shao, Jianqiu Gu, Xin Meng, Hongzhi Zheng, Difei Wan. Systematic investigation into the role of intermittent high glucose in pancreatic beta-cells. International journal of clinical and experimental medicine. vol 8. issue 4. 2015-07-01. PMID:26131124. |
to determine how it induces beta-cell dysfunction, we systematically evaluated the effects of intermittent high glucose (ihg) in ins-1 rat pancreatic beta-cells on their proliferation activity, apoptosis, insulin secretion, reactive oxygen species (ros), intracellular concentration of ca(2+) ([ca(2+)]i), and the pten expression as well as akt phosphorylation. |
2015-07-01 |
2023-08-13 |
rat |
| Xiaoyu Wang, Chen Li, Qiaoqun Da. Down-regulation of microRNA-26b rescued hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes by regulating PTEN. International journal of clinical and experimental medicine. vol 8. issue 3. 2015-06-11. PMID:26064312. |
down-regulation of microrna-26b rescued hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes by regulating pten. |
2015-06-11 |
2023-08-13 |
rat |
| Qiang Xie, Yongrong Yan, Zuoping Huang, Xueyun Zhong, Lei Huan. MicroRNA-221 targeting PI3-K/Akt signaling axis induces cell proliferation and BCNU resistance in human glioblastoma. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 34. issue 5. 2015-06-10. PMID:24780067. |
overexpression of pten lacking 3'utr or pi3-k/akt specific inhibitor wortmannin attenuated mir-221-mediated bcnu resistance and prompted cell apoptosis. |
2015-06-10 |
2023-08-13 |
human |
| Gang Zhang, Maidong Li, Shuwen Han, Dongyun Chen, Ying Wang, Wencai Ye, Zhaoning J. Induction of human chronic myeloid leukemia K562 cell apoptosis by virosecurinine and its molecular mechanism. Molecular medicine reports. vol 10. issue 5. 2015-06-09. PMID:25189629. |
virosecurinine inhibited the growth and proliferation of the k562 cell lines and induced apoptosis in k562 cells by affecting the expression of mtor, ship2, bcr/abl and pten. |
2015-06-09 |
2023-08-13 |
human |