| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shunlei Duan, Guohong Yuan, Xiaomeng Liu, Ruotong Ren, Jingyi Li, Weizhou Zhang, Jun Wu, Xiuling Xu, Lina Fu, Ying Li, Jiping Yang, Weiqi Zhang, Ruijun Bai, Fei Yi, Keiichiro Suzuki, Hua Gao, Concepcion Rodriguez Esteban, Chuanbao Zhang, Juan Carlos Izpisua Belmonte, Zhiguo Chen, Xiaomin Wang, Tao Jiang, Jing Qu, Fuchou Tang, Guang-Hui Li. PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype. Nature communications. vol 6. 2016-06-29. PMID:26632666. |
furthermore, we identify that mitomycin c selectively triggers apoptosis in nscs with pten deficiency. |
2016-06-29 |
2023-08-13 |
mouse |
| Barbara Herkert, Audrey Kauffmann, Sandra Mollé, Christian Schnell, Thomas Ferrat, Hans Voshol, Janina Juengert, Hélène Erasimus, Grégory Marszalek, Malika Kazic-Legueux, Eric Billy, David Ruddy, Mark Stump, Daniel Guthy, Mitko Ristov, Keith Calkins, Sauveur-Michel Maira, William R Sellers, Francesco Hofmann, Michael N Hall, Saskia M Brachman. Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition. Cancer research. vol 76. issue 2. 2016-06-28. PMID:26577700. |
combined inhibition of the mapk pathway, pi3kβ, and pi3kα or insulin-like growth factor receptor 1 (igf1r) synergistically sustained pathway blockade, induced apoptosis, and inhibited tumor growth in pten(lof)/braf(mut) melanoma models. |
2016-06-28 |
2023-08-13 |
Not clear |
| Ingiridur Skirnisdottir, Tomas Seidal, Helena Åkeru. Differences in Clinical and Biological Features Between Type I and Type II Tumors in FIGO Stages I-II Epithelial Ovarian Carcinoma. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society. vol 25. issue 7. 2016-06-23. PMID:26035126. |
the objective of this study was to compare immunohistochemical profile for the apoptosis regulators p53, c-myc, bax, puma, and pten and the cell cycle regulatory proteins p21 and p27, as well as clinical factors between types i and ii tumors. |
2016-06-23 |
2023-08-13 |
Not clear |
| Shi-Zheng Li, Shi-Feng Qiao, Jun-Hua Zhang, Kun L. Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin Via PTEN/Akt Pathway. Anti-cancer agents in medicinal chemistry. vol 15. issue 9. 2016-06-13. PMID:25612678. |
cell proliferation, cell apoptosis, cell invasion and expression of pten and phospho-akt (p-akt) were then assessed. |
2016-06-13 |
2023-08-13 |
Not clear |
| Shi-Zheng Li, Shi-Feng Qiao, Jun-Hua Zhang, Kun L. Quercetin Increase the Chemosensitivity of Breast Cancer Cells to Doxorubicin Via PTEN/Akt Pathway. Anti-cancer agents in medicinal chemistry. vol 15. issue 9. 2016-06-13. PMID:25612678. |
compared to treatment with dox alone, combined treatment with dox and que significantly inhibited cell proliferation and invasion, increased cell apoptosis, up-regulated the expression of pten and down-regulated the expression of p-akt. |
2016-06-13 |
2023-08-13 |
Not clear |
| Chong Xu, Hai Zhang, Chunxiao Liu, Yu Zhu, Xiaoxue Wang, Wei Gao, Shile Huang, Long Che. Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium. Oncotarget. vol 6. issue 25. 2016-06-10. PMID:26046303. |
inhibition of pp2a with okadaic acid or ectopic expression of dominant negative pp2a attenuated rapamycin's inhibition of cd-induced phospho-erk1/2 and apoptosis, whereas over-expression of wild-type pp2a enhanced rapamycin's effects; over-expression of wild-type pten or dominant negative akt, or inhibition of akt with akt inhibitor x strengthened rapamycin's inhibition of cd-induced phospho-erk1/2 and cell death. |
2016-06-10 |
2023-08-13 |
Not clear |
| Ling Wang, Guangyu Li, Zhi Q Yao, Jonathan P Moorman, Shunbin Nin. MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV. Reviews in medical virology. vol 25. issue 5. 2016-06-07. PMID:26258805. |
in this review, we summarize the potential roles and mechanisms of viral and cellular mirnas in the host-pathogen interactions during infection with selected tumor viruses and hiv, which include (i) repressing viral replication and facilitating latency establishment by targeting viral transcripts, (ii) evading innate and adaptive immune responses via toll-like receptors, rig-i-like receptors, t-cell receptor, and b-cell receptor pathways by targeting signaling molecules such as traf6, irak1, ikkε, and myd88, as well as downstream targets including regulatory cytokines such as tumor necrosis factor α, interferon γ, interleukin 10, and transforming growth factor β, (iii) antagonizing intrinsic and extrinsic apoptosis pathways by targeting pro-apoptotic or anti-apoptotic gene transcripts such as the bcl-2 family and caspase-3, (iv) modulating cell proliferation and survival through regulation of the wnt, pi3k/akt, erk/mapk, and jak/stat signaling pathways, as well as the signaling pathways triggered by viral oncoproteins such as epstein-barr virus lmp1, by targeting wnt-inhibiting factor 1, ship, pten, and socss, and (v) regulating cell cycle progression by targeting cell cycle inhibitors such as p21/waf1 and p27/kip1. |
2016-06-07 |
2023-08-13 |
Not clear |
| Umut Fahrioğlu, Yavuz Dodurga, Levent Elmas, Mücahit Seçm. Ferulic acid decreases cell viability and colony formation while inhibiting migration of MIA PaCa-2 human pancreatic cancer cells in vitro. Gene. vol 576. issue 1 Pt 3. 2016-06-03. PMID:26516023. |
expression profiles of certain cell cycle and apoptosis genes such as ccnd1 (cyclin d1),cdk4, cdk6, rb, p21, p16, p53, caspase-3, caspase-9, caspase-8, caspase-10, bcl-2, bcl-xl,bid, dr4,dr5,fadd,tradd,parp, apaf, bax, akt, pten, puma, noxa, mmp2, mmp9, timp1 and timp2 were determined by real-time pcr. |
2016-06-03 |
2023-08-13 |
human |
| S-J Kim, H-W Lee, J-H Baek, Y-H Cho, H G Kang, J S Jeong, J Song, H-S Park, K-H Chu. Activation of nuclear PTEN by inhibition of Notch signaling induces G2/M cell cycle arrest in gastric cancer. Oncogene. vol 35. issue 2. 2016-05-25. PMID:25823029. |
dephosphorylated nuclear pten caused prometaphase arrest by interaction with the cyclin b1-cdk1 complex, resulting in their accumulation in the nucleus and subsequent apoptosis. |
2016-05-25 |
2023-08-13 |
mouse |
| Q S-C Chu, T O Nielsen, T Alcindor, A Gupta, M Endo, A Goytain, H Xu, S Verma, R Tozer, M Knowling, V B Bramwell, J Powers, L K Seymour, E A Eisenhaue. A phase II study of SB939, a novel pan-histone deacetylase inhibitor, in patients with translocation-associated recurrent/metastatic sarcomas-NCIC-CTG IND 200†. Annals of oncology : official journal of the European Society for Medical Oncology. vol 26. issue 5. 2016-05-19. PMID:25632070. |
hdac inhibitors were shown to be effective in vitro, reversing gene repression by these complexes, restoring pten expression and apoptosis via the pi3k/akt/mtor pathway. |
2016-05-19 |
2023-08-13 |
Not clear |
| Jing Geng, Xiaoxi Huang, Ying Li, Xuefeng Xu, Shuhong Li, Dingyuan Jiang, Zheng Liu, Huaping Da. Phosphatase and tensin homolog deleted on chromosome 10 contributes to phenotype transformation of fibroblasts in idiopathic pulmonary fibrosis via multiple pathways. Experimental biology and medicine (Maywood, N.J.). vol 241. issue 2. 2016-05-18. PMID:26264443. |
furthermore, loss of pten led to the transformation of normal fibroblasts to myofibroblasts and increased proliferation, apoptosis resistance, and migration/invasion activities. |
2016-05-18 |
2023-08-13 |
Not clear |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
the activity of caspase 3 (casp3) and level changes of several apoptosis factors including b-cell lymphoma 2 (bcl2), bcl2-associated x protein (bax), phosphatase and tensin homolog (pten) and v-akt murine thymoma viral oncogene homolog 1 (akt1) were detected. |
2016-05-17 |
2023-08-13 |
rat |
| Ji Ma, Shaofeng Shui, Xinwei Han, Dong Guo, Tengfei Li, Lei Ya. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. American journal of translational research. vol 8. issue 4. 2016-05-17. PMID:27186313. |
it also caused the corresponding changes in casp3 activity and other apoptosis factors, with cleaved casp3, bax and pten inhibited and bcl2 and phosphorylated akt1 promoted, while mir-22 antagomir had the opposite effects. |
2016-05-17 |
2023-08-13 |
rat |
| Changlei Cui, Gong Xu, Jinpeng Qiu, Xiushuang Fa. Up-regulation of miR-26a promotes neurite outgrowth and ameliorates apoptosis by inhibiting PTEN in bupivacaine injured mouse dorsal root ganglia. Cell biology international. vol 39. issue 8. 2016-05-10. PMID:25808510. |
up-regulation of mir-26a promotes neurite outgrowth and ameliorates apoptosis by inhibiting pten in bupivacaine injured mouse dorsal root ganglia. |
2016-05-10 |
2023-08-13 |
mouse |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
the up-regulation of mir-200a down-regulated the expression of the following targets in vitro and in vivo models: (i) growth factor receptor-bound protein 2 (grb2), an adaptor protein involved in epidermal growth factor receptor (egfr)/grb2/ras/mek/erk1/c-jun signaling pathway, which negatively regulates the expression of myelin basic protein (mbp), a marker of mature oligodendrocyte; (ii) errfi-1/mig-6, an endogenous potent kinase inhibitor of egfr, which resulted in activation/phosphorylation of egfr; (iii) friend of gata 2, and phosphatase and tensin homolog deleted in chromosome 10 (pten), which are potent inhibitors of the phosphatidylinositol-3-kinase (pi3k)/akt signaling pathway, and resulted in marked activation of akt; and (iv) transcription factor, p53, which induces pro-apoptotic genes, and possibly reduced apoptosis of the progenitor cells subjected to oxygen glucose deprivation (ogd). |
2016-04-25 |
2023-08-13 |
rat |
| Manoranjan Santra, Michael Chopp, Sutapa Santra, Ankita Nallani, Shivam Vyas, Zheng Gang Zhang, Daniel C Morri. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. Journal of neurochemistry. vol 136. issue 1. 2016-04-25. PMID:26466330. |
tβ4-induced micro-rna-200a (mir-200a) regulates egfr signaling pathways for mbp synthesis and apoptosis: up-regulation of mir-200a after tβ4 treatment, increases mbp synthesis after targeting grb2 and thereby inactivating c-jun from inhibition of mbp synthesis; and also inhibits ogd-mediated apoptosis after targeting egfr inhibitor (mig-6), pi3k inhibitors (fog2 and pten) and an inducer (p53) of pro-apoptotic genes, for akt activation and down-regulation of p53. |
2016-04-25 |
2023-08-13 |
rat |
| Zhi-Lu Li, Chen Chen, Yuan Yang, Cheng Wang, Ting Yang, Xin Yang, Sheng-Chun Li. Gamma secretase inhibitor enhances sensitivity to doxorubicin in MDA-MB-231 cells. International journal of clinical and experimental pathology. vol 8. issue 5. 2016-04-15. PMID:26191129. |
gsi-induced proliferation inhibition and apoptosis was achieved with an induction of pten and pro-apoptotic protein bax expression and suppression of notch-1, hes-1, cyclind1 and anti-apoptotic protein bcl-2. |
2016-04-15 |
2023-08-13 |
Not clear |
| Raktim Biswas, Arindam Mondal, Jin-Chul Ah. Deregulation of EGFR/PI3K and activation of PTEN by photodynamic therapy combined with carboplatin in human anaplastic thyroid cancer cells and xenograft tumors in nude mice. Journal of photochemistry and photobiology. B, Biology. vol 148. 2016-04-05. PMID:25910816. |
this suggests a combination of cbdca and pdt modulates egfr and pi3k as well as activates pten to inhibit tumor growth and induce apoptosis with an enhanced efficacy in anaplastic thyroid cancer. |
2016-04-05 |
2023-08-13 |
mouse |
| Katsuya Ohta, Hiromitsu Hoshino, Jinhua Wang, Shigeshi Ono, Yuuki Iida, Keisuke Hata, Sharon K Huang, Steven Colquhoun, Dave S B Hoo. MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A. Oncotarget. vol 6. issue 5. 2016-03-28. PMID:25633810. |
we concluded that mir-93 stimulated cell proliferation, migration, and invasion through the oncogenic c-met/pi3k/akt pathway and also inhibited apoptosis by directly inhibiting pten and cdkn1a expression in human hcc. |
2016-03-28 |
2023-08-13 |
human |
| H Wu, K Wang, W Liu, Q Ha. Recombinant adenovirus-mediated overexpression of PTEN and KRT10 improves cisplatin resistance of ovarian cancer in vitro and in vivo. Genetics and molecular research : GMR. vol 14. issue 2. 2016-03-25. PMID:26125866. |
recombinant adenovirus-mediated overexpression of krt10 and pten also increased the cisplatin-induced apoptosis rate of c13k cells. |
2016-03-25 |
2023-08-13 |
mouse |