| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Li Ma, Da-Wei Wang, Xu-Dong Yu, Yan-Ling Zho. Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 81. 2017-01-31. PMID:27261630. |
tangeretin induces cell cycle arrest and apoptosis through upregulation of pten expression in glioma cells. |
2017-01-31 |
2023-08-13 |
human |
| Li-Li Ma, Da-Wei Wang, Xu-Dong Yu, Yan-Ling Zho. Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 81. 2017-01-31. PMID:27261630. |
further, tang treatment increases g2/m arrest and apoptosis by modulating pten and cell-cycle regulated genes such as cyclin-d and cdc-2 mrna and protein expressions. |
2017-01-31 |
2023-08-13 |
human |
| C-y Xie, J-r Kong, C-s Zhao, Y-c Xiao, T Peng, Y Liu, W-n Wan. Molecular characterization and function of a PTEN gene from Litopenaeus vannamei after Vibrio alginolyticus challenge. Developmental and comparative immunology. vol 59. 2017-01-06. PMID:26801100. |
pten, a tumor suppressor gene, suppresses cell survival, growth, apoptosis, cell migration and dna damage repair by inhibiting the pi3k/akt signaling pathway. |
2017-01-06 |
2023-08-13 |
Not clear |
| Anmada Nayak, Shakti Ranjan Satapathy, Dipon Das, Sumit Siddharth, Neha Tripathi, Prasad V Bharatam, ChanakyaNath Kund. Nanoquinacrine induced apoptosis in cervical cancer stem cells through the inhibition of hedgehog-GLI1 cascade: Role of GLI-1. Scientific reports. vol 6. 2017-01-04. PMID:26846872. |
nqc increased the expressions of negatively regulated hh-gli components (gsk3β, pten) and caused apoptosis in cscs. |
2017-01-04 |
2023-08-13 |
mouse |
| Baosong Xie, Guanying Zheng, Hongru Li, Xiujuan Yao, Rujun Hong, Ruihui Li, Wenxiang Yue, Yusheng Che. Effects of the tumor suppressor PTEN on the pathogenesis of idiopathic pulmonary fibrosis in Chinese patients. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26846484. |
in addition, pten overexpression enhanced apoptosis, and suppressed basal levels of proliferation and migration in fibroblasts. |
2017-01-03 |
2023-08-13 |
human |
| Xiaofang Li, Aimin Zang, Youchao Jia, Jinchao Zhang, Wufang Fan, Jia Feng, Mindan Duan, Lei Zhang, Ran Huo, Jin Jiao, Xiaowei Zh. Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26847601. |
triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through pten by targeting mir-21. |
2017-01-03 |
2023-08-13 |
human |
| Xiaofang Li, Aimin Zang, Youchao Jia, Jinchao Zhang, Wufang Fan, Jia Feng, Mindan Duan, Lei Zhang, Ran Huo, Jin Jiao, Xiaowei Zh. Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21. Molecular medicine reports. vol 13. issue 3. 2017-01-03. PMID:26847601. |
to the best of our knowledge, the present study is the first to demonstrate that triptolide reduced the proliferation and enhanced the apoptosis of human nsclc cells through pten by targeting mir-21. |
2017-01-03 |
2023-08-13 |
human |
| Shahram Teimourian, Ehsan Moghanlo. Thwarting PTEN Expression by siRNA Augments HL-60 Cell Differentiation to Neutrophil-Like Cells by DMSO and ATRA. DNA and cell biology. vol 35. issue 10. 2016-12-30. PMID:27617494. |
in this study, we inhibited pten tumor suppressor gene expression by sirna to investigate the effect of potentiating cell survival and inhibiting apoptosis on hl-60 cell differentiation by dmso and atra. |
2016-12-30 |
2023-08-13 |
Not clear |
| Xian Yu, Tingting Li, Yifan Xia, Jun Lei, Yan Wang, Lijuan Zhan. Herpes simplex virus type 1 VP22-mediated intercellular delivery of PTEN increases the antitumor activity of PTEN in esophageal squamous cell carcinoma cells in vitro and in vivo. Oncology reports. vol 35. issue 5. 2016-12-27. PMID:27004535. |
however, compared with pten alone, pten-vp22 exerted significantly higher antiproliferative effects and induced cell cycle arrest at g1 stage, apoptosis and antiangiogenic effects in eca109 cells. |
2016-12-27 |
2023-08-13 |
Not clear |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
microrna-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through pten. |
2016-12-26 |
2023-08-13 |
human |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
association of mir-29 on its downstream target, pten, in hg-induced rpe cell apoptosis was evaluated by dual-luciferase assay and qrt-pcr. |
2016-12-26 |
2023-08-13 |
human |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
the effects of pten downregulation on mir-29-mediated hg-induced rpe cell apoptosis were also examined by tunel and western blot assays. |
2016-12-26 |
2023-08-13 |
human |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
small interfering rna (sirna)-mediated pten downregulation reversed the protective effect of mir-29 downregulation on hg-induced rpe cell apoptosis. |
2016-12-26 |
2023-08-13 |
human |
| Xiaohui Lin, Xiyuan Zhou, Danning Liu, Lixia Yun, Lina Zhang, Xiaohai Chen, Qinghe Chai, Langen L. MicroRNA-29 regulates high-glucose-induced apoptosis in human retinal pigment epithelial cells through PTEN. In vitro cellular & developmental biology. Animal. vol 52. issue 4. 2016-12-26. PMID:26822433. |
this study demonstrates that mir-29, through inverse association of pten, plays an important role in the process of hg-induced apoptosis in rpe cells. |
2016-12-26 |
2023-08-13 |
human |
| Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki, Hiroshi Tsumur. MicroRNA-301a promotes cell proliferation via PTEN targeting in Ewing's sarcoma cells. International journal of oncology. vol 48. issue 4. 2016-12-26. PMID:26846737. |
given that pten is a pivotal phosphatase factor that regulates cell cycle progression, apoptosis, and proliferation, these results might lead to development of new es-related therapeutic targets. |
2016-12-26 |
2023-08-13 |
human |
| Fang Wang, Lin Li, Zhuo Chen, Mingzhi Zhu, Yuanting G. MicroRNA-214 acts as a potential oncogene in breast cancer by targeting the PTEN-PI3K/Akt signaling pathway. International journal of molecular medicine. vol 37. issue 5. 2016-12-26. PMID:26951965. |
importantly, the introduction of pten cdna lacking the 3' untranslated region (3'utr) significantly inhibited the mir‑214‑induced activation of the pi3k/akt signaling pathway, and abrogated the protetive effects of mir‑214 on cell survival and resistance to apoptosis. |
2016-12-26 |
2023-08-13 |
human |
| Mingming Zhu, Cong Huang, Xiao Ma, Rui Wu, Weiwei Zhu, Xiaoting Li, Zhaofeng Liang, Feifei Deng, Jianyun Zhu, Wei Xie, Xue Yang, Ye Jiang, Shijia Wang, Jieshu Wu, Shanshan Geng, Chunfeng Xie, Caiyun Zhon. Modulation of miR-19 in Aluminum-Induced Neural Cell Apoptosis. Journal of Alzheimer's disease : JAD. vol 50. issue 4. 2016-12-13. PMID:26836165. |
in the present study, we showed that aluminum maltolate (al-malt), a lipophilic al complex which is a common component of human diet with the ability to facilitate the entry of al into the brain, induced apoptosis in human neuroblastoma sh-sy5y cells, along with downregulation of mir-19a/mir-19b, upregulation of mir-19-targeted pten, and alterations of its downstream apoptosis related proteins including akt, p53, bax, and bcl-2. |
2016-12-13 |
2023-08-13 |
human |
| b' Zsuzs\\xc3\\xa1nna Pap, Izabella \\xc3\\x81gota Ily\\xc3\\xa9s, Simona Liliana Mocan, L\\xc3\\xb3r\\xc3\\xa1nd D\\xc3\\xa9nes, Monica Cristina Muic\\xc4\\x83 Nagy-Bota, Zolt\\xc3\\xa1n P\\xc3\\xa1vai, Annam\\xc3\\xa1ria Sz\\xc3\\xa1nt\\xc3\\xb. Changes in immunoexpression of p53, Ki-67, Ets-1, APAF-1 and PTEN in serrated and conventional colon adenomas. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 56. issue 4. 2016-11-07. PMID:26743285.' |
according to literature data, proteins like p53, ki-67, apaf-1, ets-1, pten contribute to inhibition of apoptosis and stimulation of proliferation. |
2016-11-07 |
2023-08-13 |
Not clear |
| Chen Lv, Yuehan Hao, Yaxin Han, Wei Zhang, Lin Cong, Yao Shi, Guanjun T. Role and mechanism of microRNA-21 in H2O2-induced apoptosis in bone marrow mesenchymal stem cells. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 27. 2016-11-07. PMID:26810470. |
these results suggest that mir-21 contributes to inhibition of apoptosis in bmsc by down-regulating pten, potentially via the pi3k/akt pathway. |
2016-11-07 |
2023-08-13 |
Not clear |
| Wallace Martins de Araujo, Bruno Kaufmann Robbs, Lilian G Bastos, Waldemir F de Souza, Flávia C B Vidal, João P B Viola, Jose A Morgado-Dia. PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells. Journal of cellular biochemistry. vol 117. issue 2. 2016-10-31. PMID:26224641. |
pten overexpression cooperates with lithium to reduce the malignancy and to increase cell death by apoptosis via pi3k/akt suppression in colorectal cancer cells. |
2016-10-31 |
2023-08-13 |
Not clear |