| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shi Liu, Zhong-Ling Xu, Li Sun, Ying Liu, Cheng-Chong Li, Hong-Mei Li, Wei Zhang, Cheng-Jun Li, Wei Qi. (‑)‑Epigallocatechin‑3‑gallate induces apoptosis in human pancreatic cancer cells via PTEN. Molecular medicine reports. vol 14. issue 1. 2017-04-06. PMID:27176210. |
in conclusion, the results indicated that egcg is able to reduce proliferation and induce the apoptosis of pancreatic cancer cells associated with the expression of pten. |
2017-04-06 |
2023-08-13 |
human |
| Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wan. Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:28075472. |
suppression of pten also reduced cell proliferation and induced apoptosis and caspase-3 activity in mcf-7 cells. |
2017-03-23 |
2023-08-13 |
human |
| Zhenhua Yang, Ying Liu, Changzheng Shi, Yuqin Zhang, Rongzhao Lv, Rong Zhang, Qian Wang, Yiming Wan. Suppression of PTEN/AKT signaling decreases the expression of TUBB3 and TOP2A with subsequent inhibition of cell growth and induction of apoptosis in human breast cancer MCF-7 cells via ATP and caspase-3 signaling pathways. Oncology reports. vol 37. issue 2. 2017-03-23. PMID:28075472. |
moreover, an increase in atp also reduced tubb3 and top2a protein expression, reduced cell proliferation and induced apoptosis and caspase-3 activity in the mcf-7 cells following suppression of pten. |
2017-03-23 |
2023-08-13 |
human |
| Jia He, Chongde Long, Zixin Huang, Xin Zhou, Xielan Kuang, Lanying Liu, Huijun Liu, Yan Tang, Yuting Fan, Jie Ning, Xinqi Ma, Qingjiong Zhang, Huangxuan She. PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells. BioMed research international. vol 2017. 2017-03-22. PMID:28321407. |
pten reduced uvb-mediated apoptosis in retinal pigment epithelium cells. |
2017-03-22 |
2023-08-13 |
Not clear |
| Jia He, Chongde Long, Zixin Huang, Xin Zhou, Xielan Kuang, Lanying Liu, Huijun Liu, Yan Tang, Yuting Fan, Jie Ning, Xinqi Ma, Qingjiong Zhang, Huangxuan She. PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells. BioMed research international. vol 2017. 2017-03-22. PMID:28321407. |
downregulation of the expression of pten in uvb-irradiative rpe cells triggered dna damage and increased the level of uvb-induced apoptosis by activating p53-dependent pathway. |
2017-03-22 |
2023-08-13 |
Not clear |
| Jia He, Chongde Long, Zixin Huang, Xin Zhou, Xielan Kuang, Lanying Liu, Huijun Liu, Yan Tang, Yuting Fan, Jie Ning, Xinqi Ma, Qingjiong Zhang, Huangxuan She. PTEN Reduced UVB-Mediated Apoptosis in Retinal Pigment Epithelium Cells. BioMed research international. vol 2017. 2017-03-22. PMID:28321407. |
however, overexpression of pten increased cell survival by suppressing p-h2a in response to dna damage and apoptosis. |
2017-03-22 |
2023-08-13 |
Not clear |
| M F Li, H Guan, D D Zhan. Effect of overexpression of PTEN on apoptosis of liver cancer cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-16. PMID:27173355. |
effect of overexpression of pten on apoptosis of liver cancer cells. |
2017-03-16 |
2023-08-13 |
Not clear |
| M F Li, H Guan, D D Zhan. Effect of overexpression of PTEN on apoptosis of liver cancer cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-16. PMID:27173355. |
this study aimed to investigate the effect of overexpressing the phosphatase and tensin homolog deleted on chromosome 10 (pten) gene on liver cancer cell apoptosis and provide new insight into the treatment of this disease. |
2017-03-16 |
2023-08-13 |
Not clear |
| M F Li, H Guan, D D Zhan. Effect of overexpression of PTEN on apoptosis of liver cancer cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-03-16. PMID:27173355. |
we conclude that overexpression of pten can effectively inhibit proliferation of these cells and promote their apoptosis. |
2017-03-16 |
2023-08-13 |
Not clear |
| Jing Zhang, Su-Fang Li, Hong Chen, Jun-Xian Son. MiR-106b-5p Inhibits Tumor Necrosis Factor-α-induced Apoptosis by Targeting Phosphatase and Tensin Homolog Deleted on Chromosome 10 in Vascular Endothelial Cells. Chinese medical journal. vol 129. issue 12. 2017-03-13. PMID:27270534. |
apoptosis of endothelial cells (ecs) plays a key role in the development of atherosclerosis and there are also evidence indicated that phosphatase and tensin homolog deleted on chromosome 10 (pten) is a viable target in therapeutic approaches to prevent vascular ecs apoptosis. |
2017-03-13 |
2023-08-13 |
Not clear |
| Diana Lelli, Claudio Pedone, Amirhosssein Sahebka. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-13. PMID:28167449. |
potential anti-cancer activity of curcumin and its analogues is also mediated by modulation of mirnas such as mir21, that is implicated in cell cycle regulation and apoptosis through down-regulation of pten and pdcd4 proteins. |
2017-03-13 |
2023-08-13 |
Not clear |
| Xuecheng Lv, Jinghua Li, Bingnan Yan. Clinical effects of miR-101 on prognosis of hepatocellular carcinoma and carcinogenic mechanism of anti-miR-101. Oncology reports. vol 36. issue 4. 2017-03-10. PMID:27498785. |
anti-mir-101 regulated the transcription of pten and may promote cell proliferation, differentiation and apoptosis by regulating downstream genes with pten. |
2017-03-10 |
2023-08-13 |
Not clear |
| Li Hao, Wang Ran, Li Xiang-Xin, Wang Lu-Qun, Yu Xiao-Nin. Carnosic Acid-combined Arsenic Trioxide Antileukaemia Cells in the Establishment of NB4/SCID Mouse Model. Basic & clinical pharmacology & toxicology. vol 119. issue 3. 2017-03-09. PMID:26998898. |
compared with mice treated by ca or ato alone, the mice in the combination of ca and ato group had a higher rate of apoptosis, which was linked with expressions of cleaved caspase-3, pten, p27 gene mrna and proteins. |
2017-03-09 |
2023-08-13 |
mouse |
| Yuqian Ou, Wing Shing H. Crocodile blood extract induces the apoptosis of lung cancer cells through PTEN activity. Oncology reports. vol 36. issue 3. 2017-03-09. PMID:27431918. |
crocodile blood extract induces the apoptosis of lung cancer cells through pten activity. |
2017-03-09 |
2023-08-13 |
Not clear |
| Sheng-Wei Luo, Wei-Na Wang, Ren-Chong Xie, Fu-Xing Xie, Jing-Rong Kong, Yu-Chao Xiao, Di Huang, Zuo-Ming Sun, Yuan Liu, Cong Wan. Molecular cloning and characterization of PTEN in the orange-spotted grouper (Epinephelus coioides). Fish & shellfish immunology. vol 58. 2017-03-02. PMID:27725262. |
pten is a key tumor suppressor gene that can play a regulatory role in the cellular proliferation, survival and apoptosis. |
2017-03-02 |
2023-08-13 |
Not clear |
| Xiuwu Zhang, Caroline Hadley, Isabel L Jackson, Yi Zhang, Angel Zhang, Ivan Spasojevic, Ines Batinic Haberle, Zeljko Vujaskovi. Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung. Free radical research. vol 50. issue 8. 2017-02-24. PMID:27367846. |
hypo-cpg methylation controls pten expression and cell apoptosis in irradiated lung. |
2017-02-24 |
2023-08-13 |
mouse |
| Y H Cao, D G Li, B Xu, M Q Wang, N Zhen, L X Man, Y Y Zhang, M Ch. A microRNA-152 that targets the phosphatase and tensin homolog to inhibit low oxygen induced-apoptosis in human brain microvascular endothelial cells. Genetics and molecular research : GMR. vol 15. issue 2. 2017-02-15. PMID:27323011. |
taken together, these results indicate that mir-152 induced by hypoxia suppresses cell apoptosis and acts as a protective factor during hypoxia by repressing pten. |
2017-02-15 |
2023-08-13 |
human |
| Min Wang, Xin Ge, Jitai Zheng, Dongmei Li, Xue Liu, Lin Wang, Chengfei Jiang, Zhumei Shi, Lianju Qin, Jiayin Liu, Hushan Yang, Ling-Zhi Liu, Jun He, Linlin Zhen, Bing-Hua Jian. Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth. Oncotarget. vol 7. issue 14. 2017-02-14. PMID:26909602. |
we also found that inhibition of mir-222 induced the expression of its direct targets arid1a and phosphatase and tensin homolog deleted on chromosome 10 (pten), and activated apoptosis of as-t cells in part through arid1a downregulation. |
2017-02-14 |
2023-08-13 |
human |
| Yan-Ran Wu, Hai-Jun Qi, Dan-Fang Deng, Ying-Ying Luo, Sheng-Lan Yan. MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 9. 2017-02-13. PMID:27188433. |
western blot was used for detection of pten, p13k, and akt protein expressions, mtt method for cell proliferation, transwell assay for cell migration and invasion, and flow cytometry for cell cycle and apoptosis. |
2017-02-13 |
2023-08-13 |
human |
| Xu-Dong Yang, Su-Feng Zhao, Qian Zhang, Wei Li, Yu-Xin Wang, Xiao-Wei Hong, Qin-Gang H. PTEN gene polymorphisms and susceptibility to oral squamous cell carcinoma in a Chinese Han population. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 37. issue 1. 2017-02-06. PMID:26232326. |
the tumor suppressor gene phosphatase and tensin homologue (pten) plays a significant role in regulating cell growth, proliferation, and apoptosis. |
2017-02-06 |
2023-08-13 |
Not clear |