| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ke He, Hu Qu, Li-Nan Xu, Jun Gao, Fu-Yi Cheng, Peng Xiang, Can-Quan Zho. Epigenetics changes caused by the fusion of human embryonic stem cell and ovarian cancer cells. Bioscience reports. vol 36. issue 5. 2017-11-29. PMID:27377320. |
the hescs can inhibit the growth of ovcar-3 cells in vitro by suppressing p53 and pten expression to suppress the growth of tumour that may be achieved by inducing apoptosis of ovcar-3 cells. |
2017-11-29 |
2023-08-13 |
mouse |
| Hongyan Wang, Jun Wang, Jing Zhang, Shuguang Jin, Huan L. Role of PI3K/AKT/mTOR signaling pathway in DBP-induced apoptosis of testicular sertoli cells in vitro. Environmental toxicology and pharmacology. vol 53. 2017-11-27. PMID:28578144. |
mtt results showed that dbp can significantly reduce the survival rate of sertoli cells; hoechst staining results showed that the sertoli cells treated with dbp emerged with typical morphological characteristics of apoptosis, nuclear condensation and chromatin condensation; flow cytometry results showed that dbp significantly increased the apoptotic rate of sertoli cells, and dose-dependent; western blotting showed that the expression of pten protein in sertoli cells was significantly higher than that in the control group after treated with different concentrations of dbp for 24h, while the expression of p-pi3k1, p-akt, p70s6k and 4e-bp1 protein in the pi3k/akt/mtor signal pathway were significantly decreased. |
2017-11-27 |
2023-08-13 |
rat |
| Mirjam C Boelens, Micha Nethe, Sjoerd Klarenbeek, Julian R de Ruiter, Eva Schut, Nicola Bonzanni, Amber L Zeeman, Ellen Wientjens, Eline van der Burg, Lodewyk Wessels, Renée van Amerongen, Jos Jonker. PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma. Cell reports. vol 16. issue 8. 2017-11-16. PMID:27524621. |
pten loss in e-cadherin-deficient mouse mammary epithelial cells rescues apoptosis and results in development of classical invasive lobular carcinoma. |
2017-11-16 |
2023-08-13 |
mouse |
| Mirjam C Boelens, Micha Nethe, Sjoerd Klarenbeek, Julian R de Ruiter, Eva Schut, Nicola Bonzanni, Amber L Zeeman, Ellen Wientjens, Eline van der Burg, Lodewyk Wessels, Renée van Amerongen, Jos Jonker. PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma. Cell reports. vol 16. issue 8. 2017-11-16. PMID:27524621. |
while loss of e-cadherin induced cell dissemination and apoptosis, additional pten inactivation promoted cell survival and rapid formation of invasive mammary tumors that recapitulate the histological and molecular features, estrogen receptor (er) status, growth kinetics, metastatic behavior, and tumor microenvironment of human clc. |
2017-11-16 |
2023-08-13 |
mouse |
| Arsalan Azimi, Arian Azim. Hypothesis: ROBOPHERA, a phosphatase and tensin homolog-targeted antineoplastic therapy. Anti-cancer drugs. vol 28. issue 4. 2017-11-16. PMID:28301379. |
phosphatase and tensin homolog (pten) is a protein that regulates cellular response to growth/antigrowth signals, cell survival, apoptosis, proliferation, angiogenesis, and cellular migration. |
2017-11-16 |
2023-08-13 |
Not clear |
| Jiangyou Wang, Han Chen, Qiang Su, You Zhou, Tao Liu, Lang L. The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization. Journal of cardiovascular pharmacology and therapeutics. vol 21. issue 5. 2017-11-08. PMID:26846271. |
phosphatase and the tensin homolog deleted on chromosome ten (pten) has been recognized as a promoter of apoptosis in various tissues and has been shown to be upregulated in circumstances of coronary microembolization (cme). |
2017-11-08 |
2023-08-13 |
Not clear |
| Jiangyou Wang, Han Chen, Qiang Su, You Zhou, Tao Liu, Lang L. The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization. Journal of cardiovascular pharmacology and therapeutics. vol 21. issue 5. 2017-11-08. PMID:26846271. |
we hypothesized that the upregulation of pten correlates with cme-induced myocardial apoptosis. |
2017-11-08 |
2023-08-13 |
Not clear |
| Jose L Viñas, Dylan Burger, Joseph Zimpelmann, Randa Haneef, William Knoll, Pearl Campbell, Alex Gutsol, Anthony Carter, David S Allan, Kevin D Burn. Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury. Kidney international. vol 90. issue 6. 2017-11-03. PMID:27650731. |
exposure of hypoxic endothelial cells to conditioned medium from ecfcs pretreated with anti-mir-486-5p blocked increases in mir-486-5p and phosphorylated akt, restored expression of pten, and enhanced apoptosis. |
2017-11-03 |
2023-08-13 |
mouse |
| Jose L Viñas, Dylan Burger, Joseph Zimpelmann, Randa Haneef, William Knoll, Pearl Campbell, Alex Gutsol, Anthony Carter, David S Allan, Kevin D Burn. Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury. Kidney international. vol 90. issue 6. 2017-11-03. PMID:27650731. |
targeting of pten by mir-486-5p was observed in endothelial cells, and pten knockdown blocked apoptosis. |
2017-11-03 |
2023-08-13 |
mouse |
| María Sánchez-Del Cojo, María Rosa López-Huertas, Francisco Díez-Fuertes, Sara Rodríguez-Mora, Mercedes Bermejo, Guillermo López-Campos, Elena Mateos, Laura Jiménez-Tormo, Francisco Gómez-Esquer, Gema Díaz-Gil, José Alcamí, Mayte Coira. Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells. PloS one. vol 12. issue 10. 2017-10-31. PMID:28968466. |
specifically, the enhanced expression of hsa-mir-21 and hsa-mir-222 in jurkat-tat101 cells was associated with the reduced expression of target mrnas encoding proteins related to apoptosis and cell cycle such as pten, pdcd4 and cdkn1b. |
2017-10-31 |
2023-08-13 |
Not clear |
| Z Liu, J Jiang, Q Yang, Y Xiong, D Zou, C Yang, J Xu, H Zha. MicroRNA-682-mediated downregulation of PTEN in intestinal epithelial cells ameliorates intestinal ischemia-reperfusion injury. Cell death & disease. vol 7. 2017-10-24. PMID:27124584. |
consequently, nf-κb activation by mir-682-mediated pten downregulation prevented reactive oxygen species (ros) induction, inflammatory reaction, mitochondrial-mediated apoptosis and iec apoptosis. |
2017-10-24 |
2023-08-13 |
mouse |
| Z Liu, J Jiang, Q Yang, Y Xiong, D Zou, C Yang, J Xu, H Zha. MicroRNA-682-mediated downregulation of PTEN in intestinal epithelial cells ameliorates intestinal ischemia-reperfusion injury. Cell death & disease. vol 7. 2017-10-24. PMID:27124584. |
however, nf-κb chemical inhibitor reversed mir-682-mediated decreased pten expression, ros induction, inflammation and iec apoptosis. |
2017-10-24 |
2023-08-13 |
mouse |
| Yun Liu, Yonggang Cao, Shuyang Sun, Jinquan Zhu, Shan Gao, Jie Pang, Daling Zhu, Zengxian Su. Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways. The international journal of biochemistry & cell biology. vol 77. issue Pt A. 2017-10-10. PMID:27297622. |
transforming growth factor-beta1 (tgfβ1) and phosphatase and tensin homolog deleted on chromosome ten (pten) are involved in the regulation of proliferation, differentiation, migration and apoptosis of various cell types. |
2017-10-10 |
2023-08-13 |
rat |
| Yun Liu, Yonggang Cao, Shuyang Sun, Jinquan Zhu, Shan Gao, Jie Pang, Daling Zhu, Zengxian Su. Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT pathways. The international journal of biochemistry & cell biology. vol 77. issue Pt A. 2017-10-10. PMID:27297622. |
in conclusion, tgfβ1 mediated pten inactivation and resistance to apoptosis seems to be key mediators of lung vascular remodeling associated with pah. |
2017-10-10 |
2023-08-13 |
rat |
| Jia Song, Qing Shao, Chunhong Li, Hui Liu, Jing Li, Yihao Wang, Wenjing Song, Lijuan Li, Guojin Wang, Zonghong Shao, Rong F. Effects of microRNA-21 on apoptosis by regulating the expression of PTEN in diffuse large B-cell lymphoma. Medicine. vol 96. issue 39. 2017-10-04. PMID:28953617. |
effects of microrna-21 on apoptosis by regulating the expression of pten in diffuse large b-cell lymphoma. |
2017-10-04 |
2023-08-13 |
Not clear |
| Jia Song, Qing Shao, Chunhong Li, Hui Liu, Jing Li, Yihao Wang, Wenjing Song, Lijuan Li, Guojin Wang, Zonghong Shao, Rong F. Effects of microRNA-21 on apoptosis by regulating the expression of PTEN in diffuse large B-cell lymphoma. Medicine. vol 96. issue 39. 2017-10-04. PMID:28953617. |
after down-regulating the mir-21 expression, apoptosis of dlbcl cells increased and pten protein was up-regulated in aso-21-treated cells compared with sco-21-treated cells by western blot.these results suggested that mir-21 affects apoptosis of lymphoma cells by regulating the expression of pten in dlbcl, which may be associated with increased poor prognosis for dlbcl patients and represents a useful approach for dlbcl treatment. |
2017-10-04 |
2023-08-13 |
Not clear |
| Duy Luong, Samaresh Sau, Prashant Kesharwani, Arun K Iye. Polyvalent Folate-Dendrimer-Coated Iron Oxide Theranostic Nanoparticles for Simultaneous Magnetic Resonance Imaging and Precise Cancer Cell Targeting. Biomacromolecules. vol 18. issue 4. 2017-09-28. PMID:28245646. |
the results were corroborated by observation of a larger population of cells undergoing apoptosis due to upregulation of tumor suppressor phosphatase and tensis homologue (pten), caspase 3, and inhibition of nf-κb in groups treated with the targeted formulations, which further confirmed the ability of the multivalent theranostic nanoparticles for simultaneous imaging and therapy of cancers. |
2017-09-28 |
2023-08-13 |
Not clear |
| Xiao Fu, Hongqing Wen, Li Jing, Yujuan Yang, Wenjuan Wang, Xuan Liang, Kejun Nan, Yu Yao, Tao Tia. MicroRNA-155-5p promotes hepatocellular carcinoma progression by suppressing PTEN through the PI3K/Akt pathway. Cancer science. vol 108. issue 4. 2017-09-26. PMID:28132399. |
through in vitro experiments, we found that mir-155-5p promoted proliferation, invasion and migration, but inhibited apoptosis in hcc by directly targeting the 3'-utr of pten. |
2017-09-26 |
2023-08-13 |
human |
| Dominika E Butler, Christopher Marlein, Hannah F Walker, Fiona M Frame, Vincent M Mann, Matthew S Simms, Barry R Davies, Anne T Collins, Norman J Maitlan. Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer. Oncotarget. vol 8. issue 34. 2017-09-25. PMID:28915623. |
although apoptosis was not induced, a g1 growth arrest was observed in pten null lncap cells, but not in bph1 or pc3 cells. |
2017-09-25 |
2023-08-13 |
Not clear |
| Tasneem Bawa-Khalfe, Feng-Ming Yang, Joan Ritho, Hui-Kuan Lin, Jinke Cheng, Edward T H Ye. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. vol 8. issue 11. 2017-09-20. PMID:27852060. |
we now show that tumor suppressive pten signaling is induced in senp1-tg to enhance prostate epithelial cell apoptosis. |
2017-09-20 |
2023-08-13 |
mouse |