| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xinbing Zhu, Zhengzheng Li, Tongtong Li, Fei Long, Yuesheng Lv, Lei Liu, Xuefeng Liu, Qimin Zha. Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 102. 2018-10-11. PMID:29579711. |
osthole inhibits the pi3k/akt signaling pathway via activation of pten and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma. |
2018-10-11 |
2023-08-13 |
Not clear |
| Jiaxiu Yin, Xinxin Li, Zaili Zhang, Xiaohua Luo, Li Wang, Lin Li. SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM‑1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo. International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749435. |
lentivirus-mediated knockdown of spag6 in skm‑1 cells increased phosphatase and tensin homolog (pten) expression and reduced protein kinase b (akt) phosphorylation, which in turn resulted in cell apoptosis as evidenced by induced myeloid leukaemia cell differentiation protein mcl‑1 downregulation, cytochrome c release and increased caspase‑9 expression. |
2018-10-02 |
2023-08-13 |
mouse |
| Jiaxiu Yin, Xinxin Li, Zaili Zhang, Xiaohua Luo, Li Wang, Lin Li. SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM‑1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo. International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749435. |
these results demonstrate that spag6 silencing induces pten expression to regulate apoptosis though the pi3k/akt pathway, indicating that spag6 may be a potential therapeutic target for mds. |
2018-10-02 |
2023-08-13 |
mouse |
| Shupeng Wu, Jing Wang, Fang L. Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620214. |
in addition mesangial cells were treated with scramble control, mir‑130b mimics, pten sirna and mir‑130b inhibitors to investigate the affect of mir‑130b and pten on the viability and apoptosis of mesangial cells. |
2018-09-26 |
2023-08-13 |
Not clear |
| Shupeng Wu, Jing Wang, Fang L. Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620214. |
mir‑130b accelerated apoptosis and pten inhibited apoptosis. |
2018-09-26 |
2023-08-13 |
Not clear |
| Shupeng Wu, Jing Wang, Fang L. Dysregulation of PTEN caused by the underexpression of microRNA‑130b is associated with the severity of lupus nephritis. Molecular medicine reports. vol 17. issue 6. 2018-09-26. PMID:29620214. |
mir‑130b and pten interfered with the viability and apoptosis of the mesangial cells. |
2018-09-26 |
2023-08-13 |
Not clear |
| Franziska Kässner, Tina Sauer, Melanie Penke, Sandy Richter, Kathrin Landgraf, Antje Körner, Wieland Kiess, Norman Händel, Antje Garte. Simvastatin induces apoptosis in PTEN‑haploinsufficient lipoma cells. International journal of molecular medicine. vol 41. issue 6. 2018-09-10. PMID:29568880. |
the small interfering rna‑mediated knockdown of pparγ abrogated the stimulatory effect of simvastatin on the pten protein, but did not influence apoptosis. |
2018-09-10 |
2023-08-13 |
human |
| Zhengyi Luo, Jiafeng Wang, Chenglin Li, Yumiao Qiu, Jing Huang, Yujie Huang, Hongli Gu, Bin Wu, Zhe Hu, Yan Zhe. Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436653. |
the effects of 4‑ap on cell growth and apoptosis were reversed by pten silencing. |
2018-08-30 |
2023-08-13 |
mouse |
| Zhengyi Luo, Jiafeng Wang, Chenglin Li, Yumiao Qiu, Jing Huang, Yujie Huang, Hongli Gu, Bin Wu, Zhe Hu, Yan Zhe. Upregulation of phosphatase and tensin homolog is essential for the effect of 4-aminopyridine on A549/CDDP cells. Molecular medicine reports. vol 17. issue 4. 2018-08-30. PMID:29436653. |
in conclusion, the results indicated that 4‑ap inhibited cell growth, induced apoptosis and sensitized a549/cddp cells to ddp via the upregulation of pten. |
2018-08-30 |
2023-08-13 |
mouse |
| Kenneth K W To, William K K Wu, Herbert H F Loon. PPARgamma agonists sensitize PTEN-deficient resistant lung cancer cells to EGFR tyrosine kinase inhibitors by inducing autophagy. European journal of pharmacology. vol 823. 2018-08-29. PMID:29378193. |
peroxisome proliferator-activated receptor gamma (pparγ) is a nuclear receptor, which upon activation upregulates phosphatase and tensin homolog (pten) to inhibit cell signaling downstream of pi3k to mediate apoptosis. |
2018-08-29 |
2023-08-13 |
human |
| Chun-Lin Zhao, Sheng-Na Han, Zhi-Ju Wang, Shu-Hui Wang, Guo-Qiang Zhao, Xie-Fu Zhang, Jia-Xiang Wan. Concomitant modulation of PTEN and Livin in gastric cancer treatment. International journal of molecular medicine. vol 41. issue 5. 2018-08-27. PMID:29436592. |
pten and livin are involved in the regulation of tumor cell proliferation, migration and apoptosis. |
2018-08-27 |
2023-08-13 |
mouse |
| Sarah A Altınoğlu, Ming Wang, Kathleen Q Li, Yuyang Li, Qiaobing X. Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. Biomaterials science. vol 4. issue 12. 2018-08-22. PMID:27748775. |
restoring pten activity in cancer cells through gene therapy has shown to inhibit cell growth and induce apoptosis, particularly in cells with a pten deficiency. |
2018-08-22 |
2023-08-13 |
human |
| Sarah A Altınoğlu, Ming Wang, Kathleen Q Li, Yuyang Li, Qiaobing X. Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. Biomaterials science. vol 4. issue 12. 2018-08-22. PMID:27748775. |
intracellular delivery of pten with ec16-80 to the pten deficient prostate cancer cell line pc-3 resulted in a significant decrease in activated akt and induced apoptosis. |
2018-08-22 |
2023-08-13 |
human |
| Wen-Wei Zou, Su-Ping X. Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-13. PMID:29136761. |
galangin inhibits the cell progression and induces cell apoptosis through activating pten and caspase-3 pathways in retinoblastoma. |
2018-08-13 |
2023-08-13 |
human |
| Wen-Wei Zou, Su-Ping X. Galangin inhibits the cell progression and induces cell apoptosis through activating PTEN and Caspase-3 pathways in retinoblastoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-08-13. PMID:29136761. |
furthermore, flow cytometry, hoechst 33258 staining and western blot assays indicated that galangin could induce apoptosis through promoting caspase-3 pathway, which was, at least partly, dependent on pten expression. |
2018-08-13 |
2023-08-13 |
human |
| Hong Pan, Li-Yuan Lu, Xue-Qian Wang, Bin-Xue Li, Kathleen Kelly, Hong-Sheng Li. Gambogic Acid Induces Cell Apoptosis and Inhibits MAPK Pathway in PTEN Chinese journal of integrative medicine. vol 24. issue 2. 2018-08-10. PMID:28578487. |
gambogic acid induces cell apoptosis and inhibits mapk pathway in pten to investigate the effect of gambogic acid (ga) on the growth and cell death of castrate resistant prostate cancer (pc) with phosphate and tension homology (pten) and p53 genes deleted in vitro and ex vivo, and elucidate the underlying possible molecular mechanisms. |
2018-08-10 |
2023-08-13 |
Not clear |
| Qiang Zhang, Bin Zhang, Leina Sun, Qingna Yan, Yu Zhang, Zhenfa Zhang, Yanjun Su, Changli Wan. MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β-catenin pathway. Cell biochemistry and function. vol 36. issue 4. 2018-07-10. PMID:29653464. |
these findings suggest that mir-130b targets pten to mediate chemoresistance, proliferation, and apoptosis via wnt/β-catenin pathway. |
2018-07-10 |
2023-08-13 |
mouse |
| Qiang Zhang, Bin Zhang, Leina Sun, Qingna Yan, Yu Zhang, Zhenfa Zhang, Yanjun Su, Changli Wan. MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/β-catenin pathway. Cell biochemistry and function. vol 36. issue 4. 2018-07-10. PMID:29653464. |
these findings suggest that mir-130b targets pten to mediate chemoresistance, proliferation, and apoptosis via wnt/β-catenin pathway. |
2018-07-10 |
2023-08-13 |
mouse |
| Minghui Jia, Xiaoyun Chen, Jili Liu, Jun Che. PTEN promotes apoptosis of H2O2‑injured rat nasal epithelial cells through PI3K/Akt and other pathways. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115519. |
pten promotes apoptosis of h2o2‑injured rat nasal epithelial cells through pi3k/akt and other pathways. |
2018-07-09 |
2023-08-13 |
rat |
| Minghui Jia, Xiaoyun Chen, Jili Liu, Jun Che. PTEN promotes apoptosis of H2O2‑injured rat nasal epithelial cells through PI3K/Akt and other pathways. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115519. |
in h2o2‑injured cells, oxidative stress, due to increased ros levels and apoptosis rates, was induced, and pten aggravated the injury. |
2018-07-09 |
2023-08-13 |
rat |