| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiaoyuan Wang, Zhijian Li, Jie Bai, Wuqi Song, Fengmin Zhan. miR‑17‑5p regulates the proliferation and apoptosis of human trabecular meshwork cells by targeting phosphatase and tensin homolog. Molecular medicine reports. vol 19. issue 4. 2019-07-30. PMID:30816540. |
in conclusion, mir‑17‑5p was downregulated in htmcs under oxidative conditions, and mir‑17‑5p may regulate the apoptosis of htmcs by targeting pten. |
2019-07-30 |
2023-08-13 |
human |
| Lixia Xue, Jiankang Huang, Ting Zhang, Xiuzhe Wang, Jianliang Fu, Zhi Geng, Yuwu Zhao, Hao Che. PTEN inhibition enhances angiogenesis in an in vitro model of ischemic injury by promoting Akt phosphorylation and subsequent hypoxia inducible factor-1α upregulation. Metabolic brain disease. vol 33. issue 5. 2019-07-26. PMID:29936638. |
in this present study, human umbilical vein endothelial cells (huvecs) were exposed to oxygen-glucose deprivation (ogd), cell proliferation, migration and apoptosis, in vitro tube formation and expression of pten/akt pathway and angiogenic factors were examined in huvecs after treatment with pten inhibitor bisperoxovanadium (bpv) at different doses. |
2019-07-26 |
2023-08-13 |
human |
| Larissa Kotelevets, Mark G H Scott, Eric Chastr. Targeting PTEN in Colorectal Cancers. Advances in experimental medicine and biology. vol 1110. 2019-07-22. PMID:30623366. |
pten controls an array of physiopathological processes related to cell proliferation, differentiation, dna/chromosome integrity, apoptosis and invasiveness. |
2019-07-22 |
2023-08-13 |
human |
| Larissa Kotelevets, Mark G H Scott, Eric Chastr. Targeting PTEN in Colorectal Cancers. Advances in experimental medicine and biology. vol 1110. 2019-07-22. PMID:30623366. |
strategies based on pharmacologically-induced restoration of wild-type pten function in colon cancer cells could therefore be considered, to impact cell growth, trigger apoptosis, and sensitize tumour cells to therapeutic agents.this review details current knowledge of the mechanisms regulating pten expression, activity and function. |
2019-07-22 |
2023-08-13 |
human |
| Ya-Nan Wang, Fang Xu, Pei Zhang, Pan Wang, Ya-Ning Wei, Chen Wu, Shu-Jie Chen. MicroRNA-575 regulates development of gastric cancer by targeting PTEN. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 113. 2019-07-22. PMID:30844657. |
mirna-575 serves a pivotal role in gc as a cancer promoter gene by targeting pten to regulate proliferation and apoptosis of the cancer cells. |
2019-07-22 |
2023-08-13 |
Not clear |
| Chun-Hua Dai, Yang Shu, Ping Chen, Jian-Nong Wu, Li-Haun Zhu, Rong-Xia Yuan, Wei-Guo Long, Yu-Min Zhu, Jian L. YM155 sensitizes non-small cell lung cancer cells to EGFR-tyrosine kinase inhibitors through the mechanism of autophagy induction. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 12. 2019-06-24. PMID:30315932. |
in this study, we showed that ym155 markedly enhanced the sensitivity of erlotinib to egfr-tki resistant nsclc cell lines h1650 (egfr exon 19 deletion and pten loss) and a549 (egfr wild type and kras mutation) through inducing autophagy-dependent apoptosis and autophagic cell death. |
2019-06-24 |
2023-08-13 |
Not clear |
| Xianping Dai, Feng Geng, Mengshun Li, Ming Li. Tripartite motif‑containing 11 regulates the proliferation and apoptosis of breast cancer cells. Oncology reports. vol 41. issue 4. 2019-06-24. PMID:30816511. |
downregulation of trim11 in mcf‑7 and mda‑mb‑231 cells inhibited cell proliferation and promoted cell apoptosis, accompanied by increased phosphatase and tensin homolog deleted on chromosome 10 (pten), p53 and bcl‑2‑associated x protein, and decreased b‑cell lymphoma 2, phosphorylated c‑jun n‑terminal kinase 1/2 (p‑jnk1/2) and phosphorylated extracellular signal‑regulated kinases 1/2 (p‑erk1/2), whereas the overexpression of trim11 completely reversed these effects. |
2019-06-24 |
2023-08-13 |
Not clear |
| Małgorzata Dawidowska, Roman Jaksik, Monika Drobna, Bronisława Szarzyńska-Zawadzka, Maria Kosmalska, Łukasz Sędek, Ludomiła Machowska, Anna Lalik, Monika Lejman, Marek Ussowicz, Krzysztof Kałwak, Jerzy R Kowalczyk, Tomasz Szczepański, Michał Wit. Comprehensive Investigation of miRNome Identifies Novel Candidate miRNA-mRNA Interactions Implicated in T-Cell Acute Lymphoblastic Leukemia. Neoplasia (New York, N.Y.). vol 21. issue 3. 2019-06-11. PMID:30763910. |
we finally focused on hsa-mir-106a-363 cluster and functionally validated direct interactions of hsa-mir-20b-5p and hsa-mir-363-3p with 3' untranslated regions of their predicted targets (pten, sos1, lats2), overrepresented in regulation of apoptosis. |
2019-06-11 |
2023-08-13 |
Not clear |
| Yuehua Wang, Jie Lin, Jinlong Tian, Xu Si, Xinyao Jiao, Weijia Zhang, Ersheng Gong, Bin L. Blueberry Malvidin-3-galactoside Suppresses Hepatocellular Carcinoma by Regulating Apoptosis, Proliferation, and Metastasis Pathways In Vivo and In Vitro. Journal of agricultural and food chemistry. vol 67. issue 2. 2019-05-06. PMID:30586992. |
in vivo, m3g promoted the apoptosis of liver tumor cells, as determined by immunohistochemistry (cleaved caspase-3, ki-67, pten, and p-akt), a terminal deoxynucleotidyl transferase dutp nick end labeling assay, and hematoxylin-eosin staining. |
2019-05-06 |
2023-08-13 |
Not clear |
| Jun Zhou, Li Jia, Zhaoyong Hu, Yanlin Wan. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Scientific reports. vol 7. issue 1. 2019-04-16. PMID:28842716. |
pten inhibition enhanced tubular cell apoptosis in kidneys with iri, which was associated with excessive caspase-3 activation. |
2019-04-16 |
2023-08-13 |
mouse |
| Jun Zhou, Li Jia, Zhaoyong Hu, Yanlin Wan. Pharmacological Inhibition of PTEN Aggravates Acute Kidney Injury. Scientific reports. vol 7. issue 1. 2019-04-16. PMID:28842716. |
these results have demonstrated that pten plays a crucial role in the pathogenesis of ischemic acute kidney injury through regulating tubular cell apoptosis and inflammation suggesting pten could be a potential therapeutic target for acute kidney injury. |
2019-04-16 |
2023-08-13 |
mouse |
| Lei Zhang, Xiaorui Liu, Junze Liu, Xingna Ma, Zhanqin Zhou, Yuxuan Song, Binyun Ca. miR-26a promoted endometrial epithelium cells (EECs) proliferation and induced stromal cells (ESCs) apoptosis via the PTEN-PI3K/AKT pathway in dairy goats. Journal of cellular physiology. vol 233. issue 6. 2019-04-15. PMID:29115668. |
furthermore, mir-26a played a role in the regulation of cells proliferation and apoptosis by directly regulating pten and indirectly regulating the pi3k/akt pathway in eecs but not in escs of dairy goats in vitro. |
2019-04-15 |
2023-08-13 |
Not clear |
| Mingli Hu, Shixuan Zhu, Shengwei Xiong, Xingxing Xue, Xiaodong Zho. MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review). Oncology reports. vol 41. issue 3. 2019-03-05. PMID:30628706. |
recently, results of previous studies regarding mechanisms underlying mirnas generally converged on pathways critical in cellular processes, including cell proliferation, apoptosis and invasion, among which phosphatase and tensin homolog (pten)/phosphatidylinositol 3‑kinase (pi3k)/protein kinase b (akt) signaling is a fundamental one, with frequent oncogenic alterations in gc. |
2019-03-05 |
2023-08-13 |
human |
| Yongjian Xiong, Juanjuan Qiu, Changyi Li, Yang Qiu, Li Guo, Yuejian Liu, Jiajia Wan, Yuchun Li, Guokai Wu, Liang Wang, Zijuan Zhou, Jianyi Dong, Chunhua Du, Dapeng Chen, Huishu Gu. Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis. Frontiers in immunology. vol 9. 2019-02-28. PMID:29472916. |
activation of phosphatase and tensin homolog (pten) is known to induce cell apoptosis. |
2019-02-28 |
2023-08-13 |
human |
| Yongjian Xiong, Juanjuan Qiu, Changyi Li, Yang Qiu, Li Guo, Yuejian Liu, Jiajia Wan, Yuchun Li, Guokai Wu, Liang Wang, Zijuan Zhou, Jianyi Dong, Chunhua Du, Dapeng Chen, Huishu Gu. Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis. Frontiers in immunology. vol 9. 2019-02-28. PMID:29472916. |
fortunellin decreased epithelial cell apoptosis through inhibiting pten expression in colitis. |
2019-02-28 |
2023-08-13 |
human |
| Yifan Lian, Yetao Xu, Chuanxing Xiao, Rui Xia, Huangbo Gong, Peng Yang, Tao Chen, Dongdong Wu, Zeling Cai, Jianping Zhang, Keming Wan. The pseudogene derived from long non-coding RNA DUXAP10 promotes colorectal cancer cell growth through epigenetically silencing of p21 and PTEN. Scientific reports. vol 7. issue 1. 2019-02-21. PMID:28779166. |
further mechanism study showed that, by binding to histone demethylase lysine-specific demethylase 1 (lsd1), duxap10 promote crc cell growth and reduced cell apoptosis through silencing the expression of p21 and phosphatase and tensin homolog (pten) tumor suppressor. |
2019-02-21 |
2023-08-13 |
Not clear |
| Juelan Wang, Wenqian Xu, Yangke He, Qi Xia, Siwei Li. LncRNA MEG3 impacts proliferation, invasion, and migration of ovarian cancer cells through regulating PTEN. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. vol 67. issue 11-12. 2019-02-20. PMID:30310931. |
we investigated the expressions of lncrna meg3 and pten in ovarian cancer tissues and their effects on cell proliferation, cycle and apoptosis of ovarian cancer. |
2019-02-20 |
2023-08-13 |
Not clear |
| Hongwei Li, Xuchang Hu, Bing Ma, Haihong Zhan. [Effect of Parkinson's disease-relevant protein DJ-1 on cell proliferation, apoptosis, invasion and migration in human osteosarcoma cells]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 10. 2019-02-14. PMID:30523224. |
moreover, dj-1 down-regulation of dj-1 could promote cell apoptosis, suppress the ability of cell invasion and migration, and increase the pten protein expression level (all p<0.05). |
2019-02-14 |
2023-08-13 |
human |
| Hongwei Li, Xuchang Hu, Bing Ma, Haihong Zhan. [Effect of Parkinson's disease-relevant protein DJ-1 on cell proliferation, apoptosis, invasion and migration in human osteosarcoma cells]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 43. issue 10. 2019-02-14. PMID:30523224. |
conclusion: dj-1 can promote the cell proliferation, inhibit cell apoptosis, and decrease the ability of cell invasion and migration, and the potential underlying mechanisms may be associated with the up-regulation of pten protein expression. |
2019-02-14 |
2023-08-13 |
human |
| Xiaofei Cheng, Guoying Zhang, Liang Zhang, Ying Hu, Kai Zhang, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zha. Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration. Journal of cellular and molecular medicine. vol 22. issue 1. 2019-02-08. PMID:28805297. |
the exosomal mir-21 could be transferred into npcs and alleviated tnf-α induced npc apoptosis by targeting phosphatase and tensin homolog (pten) through phosphatidylinositol 3-kinase (pi3k)-akt pathway. |
2019-02-08 |
2023-08-13 |
rat |