| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xi-Qian Xing, Bo Li, Shuang-Lan Xu, Chun-Fang Zhang, Jie Liu, Yi-Shu Deng, Jiao Yan. 5-Aza-2'-deoxycytidine, a DNA methylation inhibitor, attenuates hypoxic pulmonary hypertension via demethylation of the PTEN promoter. European journal of pharmacology. vol 855. 2019-12-20. PMID:31085236. |
furthermore, the demethylation of pten, which was induced by 5-aza-dc, inhibited the proliferation, migration and promoted apoptosis in pasmcs. |
2019-12-20 |
2023-08-13 |
rat |
| Maria A Dosil, Raúl Navaridas, Cristina Mirantes, Jordi Tarragona, Núria Eritja, Isidre Felip, Izaskun Urdanibia, Cristina Megino, Mónica Domingo, Maria Santacana, Sònia Gatius, Carme Piñol, Carla Barceló, Oscar Maiques, Anna Macià, Ana Velasco, Marta Vaquero, Xavier Matias-Guiu, Xavier Dolce. Tumor suppressive function of E2F-1 on PTEN-induced serrated colorectal carcinogenesis. The Journal of pathology. vol 247. issue 1. 2019-12-19. PMID:30206933. |
we found that colorectal tumors from pten/e2f-1 double knockout mice and the human colorectal carcinoma cell line ht29 with shrna-mediated downregulation of pten and e2f-1 exhibit hyperactivation of the ras-mapk pathway, accumulation of dna damage and resistance to apoptosis. |
2019-12-19 |
2023-08-13 |
mouse |
| Bin Lin, Guoyin Xiong, Wei Yan. Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa. Cell death & disease. vol 9. issue 12. 2019-12-09. PMID:30442943. |
our in vitro studies demonstrated that pten (phosphatase and tensin homolog) overexpression deactivated mtor activity and induced 661w cone cell apoptosis. |
2019-12-09 |
2023-08-13 |
mouse |
| Guangyan Yu, Chunhua Wang, Xiangfu Song, Shimeng Liu, Yixin Zhang, Lida Fan, Yixue Yang, Yulu Huang, Jiayi Son. Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway. Molecular medicine reports. vol 20. issue 1. 2019-11-26. PMID:31115571. |
phosphatase and tensin homologue deleted on chromosome 10 (pten) is a tumor‑suppressor gene and can negatively regulate the phosphoinositide 3‑kinase (pi3k)/protein kinase b (akt) signal transduction pathway, which is associated with cell proliferation, apoptosis and carcinogenesis. |
2019-11-26 |
2023-08-13 |
mouse |
| Guangyan Yu, Chunhua Wang, Xiangfu Song, Shimeng Liu, Yixin Zhang, Lida Fan, Yixue Yang, Yulu Huang, Jiayi Son. Formaldehyde induces the apoptosis of BMCs of BALB/c mice via the PTEN/PI3K/Akt signal transduction pathway. Molecular medicine reports. vol 20. issue 1. 2019-11-26. PMID:31115571. |
following treatment with fa for 24 h, cell viability, the cell cycle, apoptosis, and the expression of pten, pi3k and akt, as well as the protein expression of b‑cell lymphoma 2 (bcl‑2), bcl‑2‑associated x (bax), and caspases‑3 and ‑9 were examined. |
2019-11-26 |
2023-08-13 |
mouse |
| Hu Gao, Maoliang Ran, Hui Luo, Bo Weng, Xiangwei Tang, Yao Chen, An'qi Yang, Bin Che. miR-499 promotes immature porcine Sertoli cell growth by the PI3K/AKT pathway by targeting the PTEN gene. Reproduction (Cambridge, England). 2019-11-22. PMID:31756167. |
moreover, both mir-499 overexpression and the pten knockdown activated the pi3k/akt signaling pathway, whereas inhibition of the pi3k/akt signaling pathway caused immature porcine sertoli cell apoptosis and inhibited cell proliferation. |
2019-11-22 |
2023-08-13 |
Not clear |
| Hu Gao, Maoliang Ran, Hui Luo, Bo Weng, Xiangwei Tang, Yao Chen, An'qi Yang, Bin Che. miR-499 promotes immature porcine Sertoli cell growth by the PI3K/AKT pathway by targeting the PTEN gene. Reproduction (Cambridge, England). 2019-11-22. PMID:31756167. |
overall, mir-499 promotes proliferation and inhibits apoptosis in immature porcine sertoli cells through the pi3k/akt pathway by targeting the pten gene. |
2019-11-22 |
2023-08-13 |
Not clear |
| E Lopez-Sanchez, E Frances-Muoz, J L Menezo, M D Pinazo-Dura. Optic nerve alterations in PTEN +/- mice. European journal of ophthalmology. vol 16. issue 3. 2019-11-20. PMID:28221470. |
to study the morphologic characteristics of the optic nerve (on) by using an experimental model of knockout mice for the expression of the pten gene, mainly involved in cell cycle arrest, apoptosis control, and cell size regulation. |
2019-11-20 |
2023-08-13 |
mouse |
| Zohreh Jahanafrooz, Nasrin Motamed, Behnaz Bakhshande. Effects of miR-21 downregulation and silibinin treatment in breast cancer cell lines. Cytotechnology. vol 69. issue 4. 2019-11-20. PMID:28321778. |
compared to silibinin, mir-21 mimic transfection in combination with silibinin caused a slight modulation in some of the examined silibinin effects including apoptosis, bcl2 mrna and pten mrna and protein levels. |
2019-11-20 |
2023-08-13 |
Not clear |
| Jun Zhou, Youling Fan, Simin Tang, Huiping Wu, Jiying Zhong, Zhengxing Huang, Chengxiang Yang, Hongtao Che. Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury. Oncotarget. vol 8. issue 61. 2019-11-20. PMID:29262553. |
furthermore, inhibition of pten activity increased cell apoptosis in the kidneys of mice induced by cisplatin. |
2019-11-20 |
2023-08-13 |
mouse |
| Jun Zhou, Youling Fan, Simin Tang, Huiping Wu, Jiying Zhong, Zhengxing Huang, Chengxiang Yang, Hongtao Che. Inhibition of PTEN activity aggravates cisplatin-induced acute kidney injury. Oncotarget. vol 8. issue 61. 2019-11-20. PMID:29262553. |
in summary, our study has demonstrated that inhibiting pten activity aggravates cisplatin-induced aki via apoptosis, inflammatory reaction, and p53 signaling pathway. |
2019-11-20 |
2023-08-13 |
mouse |
| Youliang Shen, Jingjing Zhang, Tengbo Yu, Chao Q. Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR/Cas9-mediated genome editing. Cytotechnology. vol 70. issue 2. 2019-11-20. PMID:29387984. |
the tumor suppressor pten is involved in the regulation of cell proliferation, lineage determination, motility, adhesion and apoptosis. |
2019-11-20 |
2023-08-13 |
Not clear |
| Francesca Punzo, Iolanda Manzo, Chiara Tortora, Elvira Pota, Velia D' Angelo, Giulia Bellini, Alessandra Di Paola, Federica Verace, Fiorina Casale, Francesca Ross. Effects of CB2 and TRPV1 receptors' stimulation in pediatric acute T-lymphoblastic leukemia. Oncotarget. vol 9. issue 30. 2019-11-20. PMID:29765535. |
we analyzed the effect on apoptosis and cell cycle progression by a cytofluorimetric assays and evaluated the expression level of several target genes (caspase 3, bax, bcl-2, akt, erk, pten, notch-1, cdk2, p53) involved in cell survival and apoptosis, by real-time pcr and western blotting. |
2019-11-20 |
2023-08-13 |
Not clear |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
aberrant pten expression in response to progesterone reduces endometriotic stromal cell apoptosis in some human cancer cells, pten (phosphatase and tensin homolog deleted on chromosome 10) is known to regulate autophagy induction positively through the inhibition of pi3k/akt pathway, leading to the activation of mtor, a major negative regulator of autophagy. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
in endometriosis, abnormal pten expression may contribute to the alteration of endometrial cell autophagy, which may affect apoptosis because endometrial cell autophagy is directly involved in the regulation of apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
in addition, we sought to determine whether aberrant pten expression in endometriotic cyst stromal cells (ecscs) is associated with autophagy dysregulation, and a subsequent decrease in apoptosis. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
this progesterone-induced increase in apoptosis was reversed by the inhibition of autophagy induction using either mifepristone (progesterone receptor modulator) or pten inhibitor. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
in contrast, progesterone had no significant effects on pten expression, akt, mtor activity, autophagy or apoptosis in ecscs. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
furthermore, in contrast to normal eutopic endometrium, endometriotic tissues have constant pten expression, autophagy and apoptosis throughout the menstrual cycle. |
2019-11-20 |
2023-08-13 |
human |
| JongYeob Choi, MinWha Jo, EunYoung Lee, Seongsoo Hwang, DooSeok Cho. Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis Reproduction (Cambridge, England). vol 153. issue 1. 2019-11-20. PMID:30390418. |
in conclusion, our results suggest abnormal pten expression in response to progesterone was observed in ecscs, which led to the dysregulation of autophagy induction via akt/mtor signalling and a subsequent decrease in apoptosis. |
2019-11-20 |
2023-08-13 |
human |