| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Q-R Kong, D-M Ji, F-R Li, H-Y Sun, Q-X Wan. MicroRNA-221 promotes myocardial apoptosis caused by myocardial ischemia-reperfusion by down-regulating PTEN. European review for medical and pharmacological sciences. vol 23. issue 9. 2020-09-08. PMID:31115025. |
microrna-221 promotes myocardial apoptosis caused by myocardial ischemia-reperfusion by down-regulating pten. |
2020-09-08 |
2023-08-13 |
Not clear |
| Q-R Kong, D-M Ji, F-R Li, H-Y Sun, Q-X Wan. MicroRNA-221 promotes myocardial apoptosis caused by myocardial ischemia-reperfusion by down-regulating PTEN. European review for medical and pharmacological sciences. vol 23. issue 9. 2020-09-08. PMID:31115025. |
the aim of this study was to investigate whether microrna-221 could promote cardiomyocyte apoptosis by down-regulating the expression of pten (gene of phosphate and tension homology deleted on chromosome ten), thereby participating in the development of myocardial ischemia-reperfusion. |
2020-09-08 |
2023-08-13 |
Not clear |
| Ruofeng Yin, Jiajia Jiang, Huimin Deng, Zhaobin Wang, Rui Gu, Fei Wan. miR-140-3p aggregates osteoporosis by targeting PTEN and activating PTEN/PI3K/AKT signaling pathway. Human cell. vol 33. issue 3. 2020-09-02. PMID:32253621. |
mir-140-3p inhibitor inhibited cell proliferation, differentiation, and promoted cell apoptosis of cd14+pbmcs; while promoted cell proliferation, differentiation and inhibited cell apoptosis of c2c12 cells, by targeting pten and inactivating pten/pi3k/akt signaling pathway. |
2020-09-02 |
2023-08-13 |
human |
| Sheng Wang, Zhaoyun Cheng, Xianjie Che. Promotion of PTEN on apoptosis through PI3K/Akt signal in vascular smooth muscle cells of mice model of coronary heart disease. Journal of cellular biochemistry. vol 120. issue 9. 2020-08-28. PMID:31090947. |
promotion of pten on apoptosis through pi3k/akt signal in vascular smooth muscle cells of mice model of coronary heart disease. |
2020-08-28 |
2023-08-13 |
mouse |
| Junhui Xue, Zhengyi Cao, Yuning Cheng, Jiyin Wang, Yujuan Liu, Ruixiang Yang, Hui Li, Wei Jiang, Gang Li, Wenhui Zhao, Xiaowei Zhan. Acetylation of alpha-fetoprotein promotes hepatocellular carcinoma progression. Cancer letters. vol 471. 2020-08-27. PMID:31811908. |
afp acetylation promoted its oncogenic role by blocking binding to the phosphatase pten and the pro-apoptotic protein caspase-3, which increased signaling for proliferation, migration, and invasion and decreased apoptosis. |
2020-08-27 |
2023-08-13 |
Not clear |
| Chuntuan Li, Yahong Xu, Pengliang Xin, Yan Zheng, Xiongpeng Zh. Role and mechanism of PTEN in Burkitt's lymphoma. Oncology reports. vol 43. issue 2. 2020-08-21. PMID:31922234. |
the results revealed that pten inhibited the proliferation of ca46 and raji cells by downregulating the expression of p‑akt, it was indicated that the upregulation of proapoptotic proteins (including bad and bax) induced apoptosis, regulated cyclin (including p53, p21, cdk4, cdk6, cyclin d3 and cyclin h) to inhibit cell cycle progression, and mediated epithelial‑mesenchymal transition‑like cell markers (including e‑cadherin, n‑cadherin, β‑catenin, tcf‑8, vimentin, slug and snail) to inhibit cell migration and invasion. |
2020-08-21 |
2023-08-13 |
Not clear |
| Chuntuan Li, Yahong Xu, Pengliang Xin, Yan Zheng, Xiongpeng Zh. Role and mechanism of PTEN in Burkitt's lymphoma. Oncology reports. vol 43. issue 2. 2020-08-21. PMID:31922234. |
in conclusion, the tumor‑suppressor gene pten inhibited the phosphoinositide 3‑kinase/protein kinase b (pi3k/akt) signaling pathway and inhibited the proliferation and migration of burkitt's lymphoma cells, induced apoptosis and cell cycle arrest, thus playing a crucial role in the pathogenesis of burkitt's lymphoma. |
2020-08-21 |
2023-08-13 |
Not clear |
| Y P Shi, G L Liu, S Li, X L Li. miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN. Neoplasma. vol 67. issue 2. 2020-08-17. PMID:31973533. |
mir-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting pten. |
2020-08-17 |
2023-08-13 |
Not clear |
| Y P Shi, G L Liu, S Li, X L Li. miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN. Neoplasma. vol 67. issue 2. 2020-08-17. PMID:31973533. |
knockdown of mir-17-5p or overexpression of pten suppressed cell proliferation and autophagy but promoted apoptosis in thyroid cancer cells. |
2020-08-17 |
2023-08-13 |
Not clear |
| Y P Shi, G L Liu, S Li, X L Li. miR-17-5p knockdown inhibits proliferation, autophagy and promotes apoptosis in thyroid cancer via targeting PTEN. Neoplasma. vol 67. issue 2. 2020-08-17. PMID:31973533. |
pten was indicated as a target of mir-17-5p and its interference reversed abrogation of mir-17-5p-mediated inhibition of proliferation and autophagy and increase of apoptosis. |
2020-08-17 |
2023-08-13 |
Not clear |
| Qintao Cui, Junhua Wang, Xiaochen Liu, Xuehui Wang, Guobao S. [Knockout of PTEN improves cardiac function and inhibits NLRP3-mediated cardiomyocyte pyroptosis in rats with myocardial ischemia-reperfusion]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 3. 2020-08-13. PMID:32389167. |
conclusion knockout of pten can alleviate the pathological damage of myocardium and inhibit nlrp3-mediated apoptosis of cardiomyocytes, indicating that knockout of pten can alleviate myocardial i/r damage. |
2020-08-13 |
2023-08-13 |
rat |
| Jun Hong, Hong-Wei Ge, Jing-Quan Liu, Ren-Hua Sun, Fei-Juan Kon. Pharmacological Inhibition of PTEN Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3β SIGNALS. Shock (Augusta, Ga.). vol 52. issue 5. 2020-08-12. PMID:30499878. |
following i/r, ripc significantly attenuated postischemic infarct size, hindered cardiomyocyte apoptosis, improved cardiac systolic function, decreased phosphatase and tensin homolog deleted on chromosome ten (pten) expression, and further increased akt and gsk-3β phosphorylation in non-hypercholesterolemic, but not in hypercholesterolemic mice. |
2020-08-12 |
2023-08-13 |
mouse |
| Jun Hong, Hong-Wei Ge, Jing-Quan Liu, Ren-Hua Sun, Fei-Juan Kon. Pharmacological Inhibition of PTEN Restores Remote Ischemic Postconditioning Cardioprotection in Hypercholesterolemic Mice: Potential Role of PTEN/AKT/GSK3β SIGNALS. Shock (Augusta, Ga.). vol 52. issue 5. 2020-08-12. PMID:30499878. |
application of the pten inhibitor bisperoxovanadium (bpv) (1.0 mg/kg) reduced postischemic infarct size, attenuated cardiomyocyte apoptosis, and improved cardiac dysfunction in normal, but not in hypercholesterolemic mice. |
2020-08-12 |
2023-08-13 |
mouse |
| Alireza Pirsaraei Shabanzadeh, Philippe Matteo D'Onofrio, Mark Magharious, Kyung An Brian Choi, Philippe Patrick Monnier, Paulo Dieter Koeberl. Modifying PTEN recruitment promotes neuron survival, regeneration, and functional recovery after CNS injury. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31358730. |
phosphatase and tensin homolog (pten) regulates apoptosis and axonal growth in the developing and adult central nervous system (cns). |
2020-08-03 |
2023-08-13 |
human |
| Alireza Pirsaraei Shabanzadeh, Philippe Matteo D'Onofrio, Mark Magharious, Kyung An Brian Choi, Philippe Patrick Monnier, Paulo Dieter Koeberl. Modifying PTEN recruitment promotes neuron survival, regeneration, and functional recovery after CNS injury. Cell death & disease. vol 10. issue 8. 2020-08-03. PMID:31358730. |
here, we show that human pten c-terminal pdz interactions play a critical role in neuronal apoptosis and axon regeneration after traumatic cns injury and stroke, highlighted by the findings that antagonizing the pdz-motif interactions of pten has therapeutic applicability for these indications. |
2020-08-03 |
2023-08-13 |
human |
| Sang-Gyun Kim, Seung-Hwan Seo, Ji-Hun Shin, Jung-Pyo Yang, Sang Hyung Lee, Eun-Hee Shi. Increase in the nuclear localization of PTEN by the Toxoplasma GRA16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect. Journal of cellular and molecular medicine. vol 23. issue 5. 2020-07-24. PMID:30834688. |
increase in the nuclear localization of pten by the toxoplasma gra16 protein and subsequent induction of p53-dependent apoptosis and anticancer effect. |
2020-07-24 |
2023-08-13 |
mouse |
| Jian-Min Lu, Zhen-Zhen Zhang, Xiang Ma, Shi-Feng Fang, Xiu-Hong Qi. Repression of microRNA-21 inhibits retinal vascular endothelial cell growth and angiogenesis via PTEN dependent-PI3K/Akt/VEGF signaling pathway in diabetic retinopathy. Experimental eye research. vol 190. 2020-07-17. PMID:31759996. |
in order to assess the contributory role of mir-21 in dr, the rvecs were transfected with mimic or inhibitor of mir-21, or sirna-pten, followed by the detection of expression of pten and pi3k/akt/vegf-related genes, as well as the measurement of cell viability, cell cycle and apoptosis. |
2020-07-17 |
2023-08-13 |
rat |
| Zi-Yuan Nie, Lin Yang, Xiao-Jun Liu, Zhan Yang, Gao-Shan Yang, Jing Zhou, Yan Qin, Jing Yu, Ling-Ling Jiang, Jin-Kun Wen, Jian-Min Lu. Morin Inhibits Proliferation and Induces Apoptosis by Modulating the miR-188-5p/PTEN/AKT Regulatory Pathway in CML Cells. Molecular cancer therapeutics. vol 18. issue 12. 2020-07-07. PMID:31515296. |
knockdown of pten by its sirna completely abrogated morin-induced cell apoptosis, indicating that pten mediates the inductive effect of morin on cml cell apoptosis. |
2020-07-07 |
2023-08-13 |
mouse |
| Zi-Yuan Nie, Lin Yang, Xiao-Jun Liu, Zhan Yang, Gao-Shan Yang, Jing Zhou, Yan Qin, Jing Yu, Ling-Ling Jiang, Jin-Kun Wen, Jian-Min Lu. Morin Inhibits Proliferation and Induces Apoptosis by Modulating the miR-188-5p/PTEN/AKT Regulatory Pathway in CML Cells. Molecular cancer therapeutics. vol 18. issue 12. 2020-07-07. PMID:31515296. |
mir-188-5p downregulation induced by morin enhanced cml cell apoptosis by relieving mir-188-5p repression of pten expression. |
2020-07-07 |
2023-08-13 |
mouse |
| Young-Eun Seo, Hee-Won Suh, Raman Bahal, Alexander Josowitz, Junwei Zhang, Eric Song, Jiajia Cui, Seth Noorbakhsh, Christopher Jackson, Tom Bu, Alexandra Piotrowski-Daspit, Ranjit Bindra, W Mark Saltzma. Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma. Biomaterials. vol 201. 2020-07-06. PMID:30802686. |
we show that both nanoparticle products facilitate efficient intracellular delivery and mir-21 suppression that leads to pten upregulation and apoptosis of human gbm cells. |
2020-07-06 |
2023-08-13 |
human |