| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lisa Salvatore, Maria Alessandra Calegari, Fotios Loupakis, Matteo Fassan, Brunella Di Stefano, Maria Bensi, Emilio Bria, Giampaolo Tortor. PTEN in Colorectal Cancer: Shedding Light on Its Role as Predictor and Target. Cancers. vol 11. issue 11. 2020-09-28. PMID:31717544. |
pten (phosphatase and tensin homologue), a tumor suppressor, regulating cell division and apoptosis, has been explored, and significant evidence suggests a role in cetuximab and panitumumab resistance linked to the epidermal growth factor receptor (egfr) signal transduction pathway. |
2020-09-28 |
2023-08-13 |
Not clear |
| Xi Lu, Hui-Yuan Zhang, Zhi-Yi H. MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model. Neural regeneration research. vol 15. issue 7. 2020-09-28. PMID:31960813. |
regulation of apoptosis occurred through the phosphoinositide 3 kinase (pi3k)/akt pathway by targeting of phosphatase and tensin homolog deleted on chromosome ten (pten). |
2020-09-28 |
2023-08-13 |
human |
| Yinming Wang, Junquan Gu, Linlin Hu, Liang Kong, Tinggang Wang, Meiqi Di, Chaosheng Li, Shuhua Gu. miR-130a alleviates neuronal apoptosis and changes in expression of Bcl-2/Bax and caspase-3 in cerebral infarction rats through PTEN/PI3K/Akt signaling pathway. Experimental and therapeutic medicine. vol 19. issue 3. 2020-09-28. PMID:32104274. |
effect of micro ribonucleic acid (mir)-130a on neuronal apoptosis in rats with cerebral infarction (ci) was studied to explore whether phosphatase and tensin homolog deleted on chromosome ten (pten)/phosphatidylinositol 3-hydroxy kinase (pi3k)/protein kinase b (akt) is involved in the regulation of neuronal apoptosis. |
2020-09-28 |
2023-08-13 |
rat |
| Ling Song, Yueqin Qi, Ming Li. Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis. Oncology letters. vol 19. issue 3. 2020-09-28. PMID:32194749. |
long noncoding rna plac2 regulates pten in retinoblastoma and participates in the regulation of cancer cell apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Ling Song, Yueqin Qi, Ming Li. Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis. Oncology letters. vol 19. issue 3. 2020-09-28. PMID:32194749. |
therefore, plac2 regulates pten in rb and participates in the regulation of cancer cell apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qi Gao, Yanfeng Wan. Long noncoding RNA MALAT1 regulates apoptosis in ischemic stroke by sponging miR-205-3p and modulating PTEN expression. American journal of translational research. vol 12. issue 6. 2020-09-28. PMID:32655805. |
long noncoding rna malat1 regulates apoptosis in ischemic stroke by sponging mir-205-3p and modulating pten expression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qi Gao, Yanfeng Wan. Long noncoding RNA MALAT1 regulates apoptosis in ischemic stroke by sponging miR-205-3p and modulating PTEN expression. American journal of translational research. vol 12. issue 6. 2020-09-28. PMID:32655805. |
moreover, malat1 acts as a competing endogenous rna (cerna) for mir-205-3p and further regulate pten expression protect ogd-induced apoptosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qi Gao, Yanfeng Wan. Long noncoding RNA MALAT1 regulates apoptosis in ischemic stroke by sponging miR-205-3p and modulating PTEN expression. American journal of translational research. vol 12. issue 6. 2020-09-28. PMID:32655805. |
altogether, these results suggest that malat1 may suppress the apoptosis in ischemic stroke and function as a cerna for mir-205-3p to modulate pten expression. |
2020-09-28 |
2023-08-13 |
Not clear |
| Lei Kong, Qinghua Wu, Liangchao Zhao, Jinhua Ye, Nengping Li, Huali Yan. Effect of microRNA-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31106896. |
effect of microrna-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting pten. |
2020-09-18 |
2023-08-13 |
rat |
| Lei Kong, Qinghua Wu, Liangchao Zhao, Jinhua Ye, Nengping Li, Huali Yan. Effect of microRNA-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31106896. |
quantitative real-time polymerase chain reaction was performed to measure the expression of mir-27a-5p; the mir-27a-5p mimic was transfected into cell, and the apoptosis rate of the cells was detected by flow cytometry; the levels of tnf-α, il-1, and il-6 in the culture supernatant were determined by enzyme-linked immunosorbent assay; targetscans database predicted and dual luciferase reporter gene assay verified the relationship between mir-27a-5p and the phosphatase and tensin homolog deleted on chromosome 10 (pten); the recovery experiment explored the apoptosis and the effects of inflammatory responses. |
2020-09-18 |
2023-08-13 |
rat |
| Lei Kong, Qinghua Wu, Liangchao Zhao, Jinhua Ye, Nengping Li, Huali Yan. Effect of microRNA-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31106896. |
upregulation of mir-27a-5p significantly promoted cell apoptosis (p < 0.05) and inhibited inflammatory response (p < 0.05); the targetscans database predicted that the 3'utr of pten contains a base complementary to the mir-27a-5p seed region. |
2020-09-18 |
2023-08-13 |
rat |
| Lei Kong, Qinghua Wu, Liangchao Zhao, Jinhua Ye, Nengping Li, Huali Yan. Effect of microRNA-27a-5p on apoptosis and inflammatory response of pancreatic acinar cells in acute pancreatitis by targeting PTEN. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31106896. |
mir-27a-5p induced apoptosis and inhibited the inflammatory response of pancreatic acinar cells in ap by targeting pten. |
2020-09-18 |
2023-08-13 |
rat |
| Y-B Zhu, N Ding, H-L Yi, Z-Q L. The expression of overexpressed PTEN enhanced IR-induced apoptosis of myocardial cells. European review for medical and pharmacological sciences. vol 23. issue 10. 2020-09-17. PMID:31173315. |
the expression of overexpressed pten enhanced ir-induced apoptosis of myocardial cells. |
2020-09-17 |
2023-08-13 |
rat |
| H-Y Liu, Y-Y Zhang, B-L Zhu, F-Z Feng, H Yan, H-Y Zhang, B Zho. miR-21 regulates the proliferation and apoptosis of ovarian cancer cells through PTEN/PI3K/AKT. European review for medical and pharmacological sciences. vol 23. issue 10. 2020-09-14. PMID:31173285. |
phosphatase and tensin homologue deleted on chromosome ten (pten) regulates cell proliferation and apoptosis by inhibiting phosphatidylinositol-3 kinase (pi3k) and protein kinase (akt) signaling. |
2020-09-14 |
2023-08-13 |
Not clear |
| Liping Wu, Yafen Chen, Yuanyuan Chen, Wenbo Yang, Yanxin Han, Lin Lu, Ke Yang, Jiumei Ca. Effect of HIF-1α/miR-10b-5p/PTEN on Hypoxia-Induced Cardiomyocyte Apoptosis. Journal of the American Heart Association. vol 8. issue 18. 2020-09-14. PMID:31480879. |
a mir-10b-5p mimic was transfected into primary mouse cardiomyocytes to analyze its effects on cardiomyocyte apoptosis and pten expression. |
2020-09-14 |
2023-08-13 |
mouse |
| Liping Wu, Yafen Chen, Yuanyuan Chen, Wenbo Yang, Yanxin Han, Lin Lu, Ke Yang, Jiumei Ca. Effect of HIF-1α/miR-10b-5p/PTEN on Hypoxia-Induced Cardiomyocyte Apoptosis. Journal of the American Heart Association. vol 8. issue 18. 2020-09-14. PMID:31480879. |
overexpression of mir-10b-5p in vitro antagonized hypoxia-induced cardiomyocyte apoptosis and specifically inhibited the expression of the apoptosis-related gene pten, but overexpression of pten weakened these effects. |
2020-09-14 |
2023-08-13 |
mouse |
| Zhengping Huang, Shan Xing, Meng Liu, Weiming Deng, Yunqing Wang, Zhixiang Huang, Yukai Huang, Xuechan Huang, Chiwei Wu, Xin Guo, Xia Pan, Jiawei Jiang, Fan Feng, Tianwang L. MiR-26a-5p enhances cells proliferation, invasion, and apoptosis resistance of fibroblast-like synoviocytes in rheumatoid arthritis by regulating PTEN/PI3K/AKT pathway. Bioscience reports. vol 39. issue 7. 2020-09-11. PMID:31221815. |
our study suggested that mir-26a-5p has a complementary role in cells proliferation, invasion, and apoptosis of ra-fls, which may be attributed to its activation effect on pi3k/akt signaling pathway via targetting pten. |
2020-09-11 |
2023-08-13 |
Not clear |
| Xiaochun Jin, Hui Wang, Shuzhou Yin, Youtao Zhan. MicroRNA-19a mediates neuroprotection through the PTEN/AKT pathway in SK-N-SH cells after oxygen-glucose deprivation/reoxygenation injury. General physiology and biophysics. vol 39. issue 3. 2020-09-11. PMID:32525819. |
mir-19a mimics increased cell viability, decreased cell apoptosis of sk-n-sh cells following ogd/r, which effects was similar to pten sirna; however, mir-19a inhibitor had the opposite roles with mir-19a mimics. |
2020-09-11 |
2023-08-13 |
Not clear |
| Hanyang Liu, Jun Song, Yan Zhou, Liang Cao, Yu Gong, Yi Wei, Haojun Yang, Liming Tan. Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN. Anti-cancer drugs. vol 30. issue 4. 2020-09-09. PMID:30875347. |
methylxanthine derivatives, such as caffeine and theophylline, enhance cell apoptosis and autophagy and reportedly induce the activity of phosphatase and tensin homologue (pten) and inhibit the mammalian target of rapamycin (mtor). |
2020-09-09 |
2023-08-13 |
mouse |
| Hanyang Liu, Jun Song, Yan Zhou, Liang Cao, Yu Gong, Yi Wei, Haojun Yang, Liming Tan. Methylxanthine derivatives promote autophagy in gastric cancer cells targeting PTEN. Anti-cancer drugs. vol 30. issue 4. 2020-09-09. PMID:30875347. |
these results show that the methylxanthine derivatives (caffeine and theophylline) effectively induce gastric cancer cell apoptosis and autophagy by pten activation and pi3k/akt/mtor pathway suppression and strongly support the use of methylxanthine derivatives as potential anticancer therapeutics. |
2020-09-09 |
2023-08-13 |
mouse |