| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Antonella Bresin, Cristina Cristofoletti, Elisabetta Caprini, Maria Cantonetti, Alessandro Monopoli, Giandomenico Russo, Maria Grazia Narducc. Preclinical Evidence for Targeting PI3K/mTOR Signaling with Dual-Inhibitors as a Therapeutic Strategy against Cutaneous T-Cell Lymphoma. The Journal of investigative dermatology. vol 140. issue 5. 2021-01-06. PMID:31682844. |
furthermore, we found an inverse correlation between pten gene expression and the ability of pf-502 to induce apoptosis in ss cells. |
2021-01-06 |
2023-08-13 |
mouse |
| Lifei Zhu, Xi Lin, Lin Zhi, Yushan Fang, Keming Lin, Kai Li, Liangcai W. Mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through PTEN pathway in vitiligo. Stem cell research & therapy. vol 11. issue 1. 2020-12-21. PMID:31941556. |
mesenchymal stem cells promote human melanocytes proliferation and resistance to apoptosis through pten pathway in vitiligo. |
2020-12-21 |
2023-08-13 |
human |
| Lijing Li, Penghua Cui, Huimin Ge, Yanjing Shi, Xiaoguang Wu, Zhang Fan R. miR-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (OGD)-induced stroke by suppressing PTEN. Experimental and molecular pathology. vol 116. 2020-12-15. PMID:32745469. |
mir-188-5p inhibits apoptosis of neuronal cells during oxygen-glucose deprivation (ogd)-induced stroke by suppressing pten. |
2020-12-15 |
2023-08-13 |
human |
| XinHong Xue, HongRu Wang, JiangLi S. Inhibition of MiR-122 Decreases Cerebral Ischemia-reperfusion Injury by Upregulating DJ-1-Phosphatase and Tensin Homologue Deleted on Chromosome 10 (PTEN)/Phosphonosinol-3 Kinase (PI3K)/AKT. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-12-11. PMID:32061171. |
flow cytometry was used to detect apoptosis and western blot was used to detect the expression of dj-1, pten, akt, and p-akt. |
2020-12-11 |
2023-08-13 |
rat |
| John Mark P Pabona, Alexander F Burnett, Dustin M Brown, Charles M Quick, Frank A Simmen, Maria Theresa E Montales, Shi J Liu, Tyler Rose, Iad Alhallak, Eric R Siegel, Rosalia Cm Simme. Metformin Promotes Anti-tumor Biomarkers in Human Endometrial Cancer Cells. Reproductive sciences (Thousand Oaks, Calif.). vol 27. issue 1. 2020-12-07. PMID:32046384. |
endometrial tumors obtained at surgery (met, n = 4; con, n = 4) were analyzed for proliferation (ki67), apoptosis (tunel), and nuclear expression of erα, pgr, pten, and klf9 proteins in tumor glandular epithelial (ge) and stromal (st) cells. |
2020-12-07 |
2023-08-13 |
human |
| Ahmad Nasimian, Parvaneh Farzaneh, Fuyuhiko Tamanoi, S Zahra Bathai. Cytosolic and mitochondrial ROS production resulted in apoptosis induction in breast cancer cells treated with Crocin: The role of FOXO3a, PTEN and AKT signaling. Biochemical pharmacology. vol 177. 2020-12-01. PMID:32353423. |
cytosolic and mitochondrial ros production resulted in apoptosis induction in breast cancer cells treated with crocin: the role of foxo3a, pten and akt signaling. |
2020-12-01 |
2023-08-13 |
human |
| Lingqi Yu, Jie Zheng, Junying Li, Yuzhen Wang, Xiaoyan Lu, Xiaohui Fa. Integrating serum exosomal microRNA and liver microRNA profiles disclose the function role of autophagy and mechanisms of Fructus Meliae Toosendan-induced hepatotoxicity in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-11-16. PMID:31855734. |
moreover, in vivo validation studies suggested that the protein expression levels of pten, p-akt, p53, and bax were indeed regulated in the mouse liver after high-dose fmt administration, indicating hepatocyte apoptosis may be mediated by these three pathways mentioned above. |
2020-11-16 |
2023-08-13 |
mouse |
| Lingqi Yu, Jie Zheng, Junying Li, Yuzhen Wang, Xiaoyan Lu, Xiaohui Fa. Integrating serum exosomal microRNA and liver microRNA profiles disclose the function role of autophagy and mechanisms of Fructus Meliae Toosendan-induced hepatotoxicity in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 123. 2020-11-16. PMID:31855734. |
in addition, serum exosomal mir-222, the most downregulated mirnas between low- and high-dose fmt treatments, might be an important event in the hepatocyte apoptosis by regulating pten and ppp2r2a. |
2020-11-16 |
2023-08-13 |
mouse |
| Jian Kang, Chenglin Zhang, Zhongzheng Zhi, Yingjie Wang, Jingdong Liu, Furong Wu, Guanghui X. Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury. Artificial cells, nanomedicine, and biotechnology. vol 48. issue 1. 2020-11-11. PMID:32054316. |
exosomes isolated from cells treated with hnesc exhibited the strongest inhibitory effect on cell apoptosis while exhibiting the highest level of mir-29b expression and the lowest levels of pten and caspase-3 expression. |
2020-11-11 |
2023-08-13 |
human |
| Shohei Miyata, Tomonori Nakamura, Susumu Kitanak. 3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation. Anticancer research. vol 40. issue 11. 2020-11-04. PMID:33109561. |
the topoisomerase 1 catalytic inhibitor 3ez, 20ac-ingenol specifically induces apoptosis through the activation of atr and the up-regulation of pten by enhancing the dna damage response (ddr) in human b lymphoma (ball-1) cells. |
2020-11-04 |
2023-08-13 |
human |
| Jiandong Sun, Yilin Wang, Lirong Su. INNO-406 inhibits the growth of chronic myeloid leukemia and promotes its apoptosis via targeting PTEN. Human cell. vol 33. issue 4. 2020-10-27. PMID:32862368. |
inno-406 inhibits the growth of chronic myeloid leukemia and promotes its apoptosis via targeting pten. |
2020-10-27 |
2023-08-13 |
Not clear |
| Yingrui Fan, Weiwei Sheng, Yi Meng, Yundi Cao, Rong L. LncRNA PTENP1 inhibits cervical cancer progression by suppressing miR-106b. Artificial cells, nanomedicine, and biotechnology. vol 48. issue 1. 2020-10-23. PMID:31913710. |
our results suggest that lncrna ptenp1 inhibits cervical cancer progression by competitively binding to mir-106b, leading to promote pten expression, inhibit cell proliferation and emt and induce cell apoptosis in cervical cancer cells. |
2020-10-23 |
2023-08-13 |
Not clear |
| Qinglin Li, Yunpeng Bai, L Tiffany Lyle, Guimei Yu, Ovini Amarasinghe, Frederick Nguele Meke, Colin Carlock, Zhong-Yin Zhan. Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 34. 2020-10-22. PMID:32788364. |
prl2 deficiency elevates pten and attenuates akt signaling, leading to decreased proliferation and increased apoptosis in tumors. |
2020-10-22 |
2023-08-13 |
human |
| Kenneth Anthony R Roquid, Krizelle Mae M Alcantara, Reynaldo L Garci. Identification and validation of mRNA 3'untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN. International journal of oncology. vol 56. issue 2. 2020-10-15. PMID:31894272. |
overexpression of dnmt3b or tet3 3'utr promoted apoptosis and decreased migratory capacity, potentially because of shared mirna sequestration and subsequent activation of pten expression. |
2020-10-15 |
2023-08-13 |
Not clear |
| Jianli Qin, Minglei Fu, Juan Wang, Fengxiang Huang, Haiping Liu, Mengjie Huangfu, Dan Yu, Haowei Liu, Xumei Li, Xiao Guan, Xu Che. PTEN/AKT/mTOR signaling mediates anticancer effects of epigallocatechin‑3‑gallate in ovarian cancer. Oncology reports. vol 43. issue 6. 2020-10-15. PMID:32236585. |
in the present study, egcg exerted stronger proliferation inhibition on skov3 cells compared with a549 cells and induced apoptosis in skov3 cells, as well as upregulated pten expression and downregulated the expression of phosphoinositide‑dependent kinase‑1 (pdk1), phosphor (p)‑akt and p‑mtor. |
2020-10-15 |
2023-08-13 |
mouse |
| Retraction of: Reactive Nitrogen Species Induced by Hyperglycemia Suppresses Akt Signaling and Triggers Apoptosis by Upregulating Phosphatase PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) in an LKB1-Dependent Manner. Circulation. vol 142. issue 15. 2020-10-13. PMID:32975449. |
retraction of: reactive nitrogen species induced by hyperglycemia suppresses akt signaling and triggers apoptosis by upregulating phosphatase pten (phosphatase and tensin homologue deleted on chromosome 10) in an lkb1-dependent manner. |
2020-10-13 |
2023-08-13 |
Not clear |
| Xuefeng Gu, Guoqing Wan, Yue Yang, Yihao Liu, Xintong Yang, Yanjun Zheng, Liying Jiang, Peng Zhang, Dingsheng Liu, Weiming Zhao, Gang Huang, Changlian L. SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer. American journal of cancer research. vol 10. issue 9. 2020-10-13. PMID:33042620. |
slfn5 influences proliferation and apoptosis by upregulating pten transcription via zeb1 and inhibits the purine metabolic pathway in breast cancer. |
2020-10-13 |
2023-08-13 |
mouse |
| Xuefeng Gu, Guoqing Wan, Yue Yang, Yihao Liu, Xintong Yang, Yanjun Zheng, Liying Jiang, Peng Zhang, Dingsheng Liu, Weiming Zhao, Gang Huang, Changlian L. SLFN5 influences proliferation and apoptosis by upregulating PTEN transcription via ZEB1 and inhibits the purine metabolic pathway in breast cancer. American journal of cancer research. vol 10. issue 9. 2020-10-13. PMID:33042620. |
knockdown and overexpression of slfn5 in brca cell lines proved that slfn5 can inhibit cell proliferation and colony formation and promote apoptosis by upregulating the transcription of a known cancer suppressor gene (the phosphatase and tensin homologue on chromosome 10, pten), resulting in molecular changes in the downstream akt pathway and in proliferation/apoptosis. |
2020-10-13 |
2023-08-13 |
mouse |
| Ping Jiang, Xin Yang, Yuanli Li, Juan Che. miRNA-216 knockdown has effects to suppress osteosarcoma via stimulating PTEN. Food science & nutrition. vol 8. issue 9. 2020-10-02. PMID:32994932. |
mirna-216 knockdown had effects to suppress cancer cell proliferation, invasion and migration and improve cell apoptosis by keeping in g1 phase via pten. |
2020-10-02 |
2023-08-13 |
Not clear |
| Lijie Zhou, Fangfang Jiang, Xijuan Chen, Zifeng Liu, Ying Ouyang, Wei Zhao, Dongsheng Y. Downregulation of miR-221/222 by a microRNA sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of PTEN. Oncology letters. vol 12. issue 6. 2020-10-01. PMID:28101204. |
downregulation of mir-221/222 by a microrna sponge promotes apoptosis in oral squamous cell carcinoma cells through upregulation of pten. |
2020-10-01 |
2023-08-13 |
Not clear |