| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| T F Kovalenko, K V Morozova, L A Ozolinya, I A Lapina, L I Patrushe. The PTENP1 Pseudogene, Unlike the PTEN Gene, Is Methylated in Normal Endometrium, As Well As in Endometrial Hyperplasias and Carcinomas in Middle-Aged and Elderly Females. Acta naturae. vol 10. issue 1. 2020-09-30. PMID:29713518. |
the tumor suppressor pten controls multiple cellular functions, including cell cycle, apoptosis, senescence, transcription, and mrna translation of numerous genes. |
2020-09-30 |
2023-08-13 |
Not clear |
| Meifen Chu, Tongtong Wang, Aihua Sun, Yu Che. Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN. Experimental and therapeutic medicine. vol 16. issue 1. 2020-09-30. PMID:29896263. |
nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of pten. |
2020-09-30 |
2023-08-13 |
Not clear |
| Meifen Chu, Tongtong Wang, Aihua Sun, Yu Che. Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN. Experimental and therapeutic medicine. vol 16. issue 1. 2020-09-30. PMID:29896263. |
in summary, the results of the present study demonstrated that nimesulide could induce apoptosis and inhibit growth of panc-1 cells by enhancing the expression of pten, which indicates the potential of nimesulide to prevent tumor angiogenesis. |
2020-09-30 |
2023-08-13 |
Not clear |
| Yanxia Jiang, Hong Chang, Guoan Che. Effects of microRNA-20a on the proliferation, migration and apoptosis of multiple myeloma via the PTEN/PI3K/AKT signaling pathway. Oncology letters. vol 15. issue 6. 2020-09-30. PMID:29963125. |
cck-8 assays, transwell assays, annexin v/pi double-staining and western blotting were performed to examine the protein expressions of pten, pi3k and akt during cellullar proliferation, migration, cycling, and apoptosis. |
2020-09-30 |
2023-08-13 |
human |
| Yan-Fang Gao, Qiu-Jie Zhang, Zhuang Yu, Shi-Hai Liu, Jun Lian. miR-142 suppresses proliferation and induces apoptosis of osteosarcoma cells by upregulating Rb. Oncology letters. vol 16. issue 1. 2020-09-30. PMID:29963139. |
furthermore, an increased apoptosis rate accompanied by a statistically significant upregulation of pten, rb phosphorylation, cleaved caspase-3 and cytochrome |
2020-09-30 |
2023-08-13 |
Not clear |
| Lina Zhao, Xianyu Zhang, Shusen Cu. Matrine inhibits TPC-1 human thyroid cancer cells via the miR-21/PTEN/Akt pathway. Oncology letters. vol 16. issue 3. 2020-09-30. PMID:30127885. |
flow cytometry indicated that treatment with 10 mg/ml matrine induced up to 61.8% apoptosis of the tpc-1 cells and the cell cycle was arrested at the g0/g1 phase following treatment with matrine (2, 5 and 10 mg/ml) for 48 h. quantitative polymerase chain reaction indicated that the expression of microrna (mir)-21 was downregulated and phosphatase and tensin homolog (pten) mrna levels increased up to 1.66-fold following treatment with matrine, and rac-α serine/threonine-protein kinase (akt) mrna levels were downregulated 0.34-fold following treatment with 5 mg/ml matrine, compared with the normal control group. |
2020-09-30 |
2023-08-13 |
human |
| Li Zhao, Xue Rong Yang, Xu Ha. MicroRNA-146b induces the PI3K/Akt/NF-κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Experimental and therapeutic medicine. vol 17. issue 2. 2020-09-30. PMID:30679990. |
microrna-146b induces the pi3k/akt/nf-κb signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting pten. |
2020-09-30 |
2023-08-13 |
rat |
| Li Zhao, Xue Rong Yang, Xu Ha. MicroRNA-146b induces the PI3K/Akt/NF-κB signaling pathway to reduce vascular inflammation and apoptosis in myocardial infarction by targeting PTEN. Experimental and therapeutic medicine. vol 17. issue 2. 2020-09-30. PMID:30679990. |
an mtt assay, annexin v/propidium iodide (pi) apoptosis assay, elisa kits, western blot analysis and a caspase-3/8 activity assay were used to measure cell growth, vascular apoptosis inflammatory factors, and the b-cell lymphoma 2-associated x protein (bax), phosphatase and tensin homolog (pten), phosphoinositide 3-kinase (pi3k)/akt/nuclear factor (nf)-κb signaling pathway. |
2020-09-30 |
2023-08-13 |
rat |
| Adel H Mahmoud, Nasser M Taha, Madiha Zakhary, Marian S Tadro. PTEN gene & TNF-alpha in acute myocardial infarction. International journal of cardiology. Heart & vasculature. vol 23. 2020-09-30. PMID:31065586. |
pten gene triggers cells to undergo apoptosis and promotes myocardial dysfunction. |
2020-09-30 |
2023-08-13 |
Not clear |
| Weidong Shen, Zhonghai Jin, Xiuping Tong, Haiying Wang, Lilei Zhuang, Xiaofeng Lu, Shenbao W. TRIM14 promotes cell proliferation and inhibits apoptosis by suppressing PTEN in colorectal cancer. Cancer management and research. vol 11. 2020-09-30. PMID:31296997. |
trim14 promotes cell proliferation and inhibits apoptosis by suppressing pten in colorectal cancer. |
2020-09-30 |
2023-08-13 |
Not clear |
| Q-Y Yue, W Zhao, Y Tan, X-L Deng, Y-H Zhan. PLCE1 inhibits apoptosis of non-small cell lung cancer via promoting PTEN methylation. European review for medical and pharmacological sciences. vol 23. issue 14. 2020-09-30. PMID:31364122. |
plce1 inhibits apoptosis of non-small cell lung cancer via promoting pten methylation. |
2020-09-30 |
2023-08-13 |
Not clear |
| Takatoshi Tokudome, Akiko Sasaki, Mayumi Tsuji, Yuko Udaka, Hideto Oyamada, Hiromichi Tsuchiya, Katsuji Oguch. Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation. Oncology letters. vol 10. issue 4. 2020-09-29. PMID:26622832. |
phosphatase and tensin homolog deleted on chromosome 10 (pten) is a tumor suppressor gene that induces cell apoptosis by inhibiting the pi3k/akt signaling pathway. |
2020-09-29 |
2023-08-13 |
human |
| Takatoshi Tokudome, Akiko Sasaki, Mayumi Tsuji, Yuko Udaka, Hideto Oyamada, Hiromichi Tsuchiya, Katsuji Oguch. Reduced PTEN expression and overexpression of miR-17-5p, -19a-3p, -19b-3p, -21-5p, -130b-3p, -221-3p and -222-3p by glioblastoma stem-like cells following irradiation. Oncology letters. vol 10. issue 4. 2020-09-29. PMID:26622832. |
the objective of the present study was to identify mirnas that target pten, which induces apoptosis, in irradiation-resistant gscs. |
2020-09-29 |
2023-08-13 |
human |
| Yingwei Zhu, Hong Tang, Lili Zhang, Lei Gong, Gaojue Wu, Jingbin Ni, Xuejun Tan. Suppression of miR-21-3p enhances TRAIL-mediated apoptosis in liver cancer stem cells by suppressing the PI3K/Akt/Bad cascade via regulating PTEN. Cancer management and research. vol 11. 2020-09-29. PMID:30774424. |
suppression of mir-21-3p enhances trail-mediated apoptosis in liver cancer stem cells by suppressing the pi3k/akt/bad cascade via regulating pten. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yongming Xi, Jinfeng Ma, Yan Che. PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors. Cell biology international. vol 44. issue 2. 2020-09-29. PMID:31663655. |
using the pten knockdown approach by lentivirus-mediated short interfering rna gene transfer technique, we report that pten decreases survival but induces apoptosis and senescence of np cells. |
2020-09-29 |
2023-08-13 |
Not clear |
| He Qin, Chong Qi. Downregulation of long non-coding RNA NR2F2-AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN. Oncology letters. vol 19. issue 2. 2020-09-29. PMID:31966043. |
downregulation of long non-coding rna nr2f2-as1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of pten. |
2020-09-29 |
2023-08-13 |
Not clear |
| He Qin, Chong Qi. Downregulation of long non-coding RNA NR2F2-AS1 inhibits proliferation and induces apoptosis of nasopharyngeal carcinoma cells by upregulating the expression of PTEN. Oncology letters. vol 19. issue 2. 2020-09-29. PMID:31966043. |
in conclusion, nr2f2-as1 downregulation decreased proliferation and increased apoptosis of npc cells via upregulation of pten. |
2020-09-29 |
2023-08-13 |
Not clear |
| Yi Yu, Yuyan Xiong, Diogo Ladeiras, Zhihong Yang, Xiu-Fen Min. Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus. iScience. vol 19. 2020-09-28. PMID:31349190. |
moreover, the elevated nuclear pten upon silencing myo1b promotes apoptosis of mefs and melanoma b16f10 cells. |
2020-09-28 |
2023-08-13 |
mouse |
| Yi Yu, Yuyan Xiong, Diogo Ladeiras, Zhihong Yang, Xiu-Fen Min. Myosin 1b Regulates Nuclear AKT Activation by Preventing Localization of PTEN in the Nucleus. iScience. vol 19. 2020-09-28. PMID:31349190. |
taken together, we demonstrate that myo1b, by interacting with pten, prevents nuclear localization of pten contributing to nuclear akt activation and suppression of cell apoptosis. |
2020-09-28 |
2023-08-13 |
mouse |
| Jiande Wu, Tarun Karthik Kumar Mamidi, Lu Zhang, Chindo Hick. Deconvolution of the Genomic and Epigenomic Interaction Landscape of Triple-Negative Breast Cancer. Cancers. vol 11. issue 11. 2020-09-28. PMID:31683572. |
network and pathway analysis revealed molecule networks and signaling pathways enriched for germline, somatic and epigenomic variation, among them: role of brca1 in dna damage response, hereditary breast cancer signaling, molecular mechanisms of cancer, estrogen-dependent breast cancer, p53, myc mediated apoptosis, and pten signaling pathways. |
2020-09-28 |
2023-08-13 |
Not clear |