| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tiejun Liu, Xiaoliu Dong, Bin Wang, Shubo Zhang, Jing Bai, Wei Ma, Xiaojing Zhao, Xiaotao Wan. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). vol 19. issue 6. 2021-02-23. PMID:32089060. |
phosphatase and tensin homolog (pten) is a suppressive player in tumor but its concrete role in oxidative stress (os) damage and cell apoptosis remains much exploration. |
2021-02-23 |
2023-08-13 |
rat |
| Tiejun Liu, Xiaoliu Dong, Bin Wang, Shubo Zhang, Jing Bai, Wei Ma, Xiaojing Zhao, Xiaotao Wan. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). vol 19. issue 6. 2021-02-23. PMID:32089060. |
thus, this study is conducted to explore the participation of pten and its mechanisms in os damage and cell apoptosis in hippocampal cells.infant rats were grouped into normal, sevo, sevo + si-negative control (nc), sevo + si-pten and sevo + si-pten + pd (mek1/erk signaling pathway inhibitor) groups. |
2021-02-23 |
2023-08-13 |
rat |
| Tiejun Liu, Xiaoliu Dong, Bin Wang, Shubo Zhang, Jing Bai, Wei Ma, Xiaojing Zhao, Xiaotao Wan. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). vol 19. issue 6. 2021-02-23. PMID:32089060. |
cell apoptosis was detected by flow cytometry.sevoflurane up-regulated pten expression and silencing of pten activates mek1/erk signaling pathway in hippocampal tissues and cells of infant rats. |
2021-02-23 |
2023-08-13 |
rat |
| Tiejun Liu, Xiaoliu Dong, Bin Wang, Shubo Zhang, Jing Bai, Wei Ma, Xiaojing Zhao, Xiaotao Wan. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). vol 19. issue 6. 2021-02-23. PMID:32089060. |
silencing of pten alleviated hippocampal tissue pathological status and inhibited sevoflurane-induced cell apoptosis in hippocampal tissues of infant rats. |
2021-02-23 |
2023-08-13 |
rat |
| Tiejun Liu, Xiaoliu Dong, Bin Wang, Shubo Zhang, Jing Bai, Wei Ma, Xiaojing Zhao, Xiaotao Wan. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). vol 19. issue 6. 2021-02-23. PMID:32089060. |
silencing of pten inhibited sevoflurane-induced apoptosis after os damage in hippocampal cells of infant rats. |
2021-02-23 |
2023-08-13 |
rat |
| Tiejun Liu, Xiaoliu Dong, Bin Wang, Shubo Zhang, Jing Bai, Wei Ma, Xiaojing Zhao, Xiaotao Wan. Silencing of PTEN inhibits the oxidative stress damage and hippocampal cell apoptosis induced by Sevoflurane through activating MEK1/ERK signaling pathway in infant rats. Cell cycle (Georgetown, Tex.). vol 19. issue 6. 2021-02-23. PMID:32089060. |
silencing of pten reduced sevoflurane-induced os damage in hippocampal cells of infant rats.our study demonstrates that pten silencing inhibits the os damage and cell apoptosis in hippocampal cells induced by sevoflurane through activating mek1/erk signaling pathway in infant rats. |
2021-02-23 |
2023-08-13 |
rat |
| Wenrui Li, Xiaolu Guan, Li Su. Phosphatase and Tensin Homolog (PTEN) of Japanese Flounder-Its Regulation by miRNA and Role in Autophagy, Apoptosis and Pathogen Infection. International journal of molecular sciences. vol 21. issue 20. 2021-02-23. PMID:33086544. |
phosphatase and tensin homolog (pten) of japanese flounder-its regulation by mirna and role in autophagy, apoptosis and pathogen infection. |
2021-02-23 |
2023-08-13 |
Not clear |
| Soon Young Hwang, Ngoc Hoan Nguyen, Tae Jung Kim, Youngsoo Lee, Mi Ae Kang, Jong-Soo Le. Non-Thermal Plasma Couples Oxidative Stress to TRAIL Sensitization through DR5 Upregulation. International journal of molecular sciences. vol 21. issue 15. 2021-02-19. PMID:32722598. |
dr5 (trail-r2) transcription by chop is upregulated in a pam-generated ros/rns-dependent manner, and pam itself upregulates pten expression mediated by suppression of mir-425 which is involved in akt inactivation, leading to increased apoptosis induction. |
2021-02-19 |
2023-08-13 |
Not clear |
| Ying Li, Jie Sun, Lei Gu, Xufang Ga. Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells. Molecular medicine reports. vol 22. issue 1. 2021-02-16. PMID:32377750. |
furthermore, when ctrp6 and rhoa were overexpressed at the same time, rhoa abolished the protective effects of ctrp6 overexpression on ogd/r‑induced inflammation, oxidative stress and apoptosis, while the presence of a pten inhibitor recovered the protective effects of ctrp6. |
2021-02-16 |
2023-08-13 |
Not clear |
| Zhan Wang, Yuxin Song, Xingwen Han, Peng Qu, Wenji Wan. Long noncoding RNA PTENP1 affects the recovery of spinal cord injury by regulating the expression of miR-19b and miR-21. Journal of cellular physiology. vol 235. issue 4. 2021-02-05. PMID:31583718. |
furthermore, pten level and apoptosis index of neuron cells was the highest in the sci group, while the treatment with exosomes+ptenp1-shrna reduced the pten expression to a level similar to that in the sham group. |
2021-02-05 |
2023-08-13 |
Not clear |
| Zhan Wang, Yuxin Song, Xingwen Han, Peng Qu, Wenji Wan. Long noncoding RNA PTENP1 affects the recovery of spinal cord injury by regulating the expression of miR-19b and miR-21. Journal of cellular physiology. vol 235. issue 4. 2021-02-05. PMID:31583718. |
the upregulation of mir-21/mir-19b also suppressed the apoptosis of neuron cells by downregulating the pten expression. |
2021-02-05 |
2023-08-13 |
Not clear |
| Y-B Zhu, N Ding, H-L Yi, Z-Q L. The expression of overexpressed PTEN enhanced IR-induced apoptosis of myocardial cells. European review for medical and pharmacological sciences. vol 24. issue 13. 2021-02-03. PMID:32706034. |
the expression of overexpressed pten enhanced ir-induced apoptosis of myocardial cells. |
2021-02-03 |
2023-08-13 |
Not clear |
| Y-B Zhu, N Ding, H-L Yi, Z-Q L. The expression of overexpressed PTEN enhanced IR-induced apoptosis of myocardial cells. European review for medical and pharmacological sciences. vol 24. issue 13. 2021-02-03. PMID:32706034. |
since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "the expression of overexpressed pten enhanced ir-induced apoptosis of myocardial cells, by y.-b. |
2021-02-03 |
2023-08-13 |
Not clear |
| Floriana Morgillo, Carminia Maria Della Corte, Morena Fasano, Fortunato Ciardiell. Mechanisms of resistance to EGFR-targeted drugs: lung cancer. ESMO open. vol 1. issue 3. 2021-01-26. PMID:27843613. |
several mechanisms of resistance have been described to egfr-tkis, such as the occurrence of secondary mutation (t790m, c797s), the activation of alternative signalling (met, hgf, axl, hh, igf-1r), the aberrance of the downstream pathways (akt mutations, loss of pten), the impairment of the egfr-tkis-mediated apoptosis pathway (bcl2-like 11/bim deletion polymorphism) and histological transformation. |
2021-01-26 |
2023-08-13 |
Not clear |
| Yinmei Zhang, Junxiong Wang, Boxin Yang, Rui Qiao, Aiwei Li, Han Guo, Jie Ding, Hui Li, Hong Ye, Di Wu, Liyan Cui, Shuo Yan. Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury. Frontiers in cell and developmental biology. vol 8. 2021-01-11. PMID:33415108. |
uscs-exos were rich in mir-216a-5p, which targeted phosphatase and tensin homolog (pten) and regulated cell apoptosis through the akt pathway. |
2021-01-11 |
2023-08-13 |
human |
| Yinmei Zhang, Junxiong Wang, Boxin Yang, Rui Qiao, Aiwei Li, Han Guo, Jie Ding, Hui Li, Hong Ye, Di Wu, Liyan Cui, Shuo Yan. Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury. Frontiers in cell and developmental biology. vol 8. 2021-01-11. PMID:33415108. |
exposure of hypoxic hk-2 cells to uscs-exos pretreated with anti-mir-216a-5p can prevent the increase of mir-216-5p and akt phosphorylation levels, restore pten expression, and promote apoptosis. |
2021-01-11 |
2023-08-13 |
human |
| Yinmei Zhang, Junxiong Wang, Boxin Yang, Rui Qiao, Aiwei Li, Han Guo, Jie Ding, Hui Li, Hong Ye, Di Wu, Liyan Cui, Shuo Yan. Transfer of MicroRNA-216a-5p From Exosomes Secreted by Human Urine-Derived Stem Cells Reduces Renal Ischemia/Reperfusion Injury. Frontiers in cell and developmental biology. vol 8. 2021-01-11. PMID:33415108. |
in rats with i/r injury, intravenous infusion of uscs-exos can effectively induce apoptosis suppression and functional protection, which is associated with decreased pten. |
2021-01-11 |
2023-08-13 |
human |
| Bo Li, Song Luan, Jing Chen, Yue Zhou, Tingting Wang, Zhijuan Li, Yili Fu, Aixia Zhai, Changlong B. The MSC-Derived Exosomal lncRNA H19 Promotes Wound Healing in Diabetic Foot Ulcers by Upregulating PTEN via MicroRNA-152-3p. Molecular therapy. Nucleic acids. vol 19. 2021-01-10. PMID:31958697. |
taken together, msc-derived exosomal lncrna h19 prevented the apoptosis and inflammation of fibroblasts by impairing mir-152-3p-mediated pten inhibition, leading to the stimulated wound-healing process in dfu. |
2021-01-10 |
2023-08-13 |
mouse |
| Gelin Liu, Shengxian Liu, Guanlin Xing, Fang Wan. lncRNA PVT1/MicroRNA-17-5p/PTEN Axis Regulates Secretion of E2 and P4, Proliferation, and Apoptosis of Ovarian Granulosa Cells in PCOS. Molecular therapy. Nucleic acids. vol 20. 2021-01-10. PMID:32179451. |
our study suggests that inhibited pvt1 and overexpressed mir-17-5p result in downregulation of pten and promotion of cell proliferation, as well as inhibition of apoptosis of ovarian granulosa cells in pcos. |
2021-01-10 |
2023-08-13 |
Not clear |
| Jifeng Zou, Huafang Su, Changling Zou, Xiaodong Liang, Zhenghua Fe. Ginsenoside Rg3 suppresses the growth of gemcitabine-resistant pancreatic cancer cells by upregulating lncRNA-CASC2 and activating PTEN signaling. Journal of biochemical and molecular toxicology. vol 34. issue 6. 2021-01-07. PMID:32104955. |
the level of long noncoding rna cancer susceptibility candidate 2 (casc2) and pten expression was upregulated by the ginsenoside rg3 treatment, and casc2/pten signaling was involved in the ginsenoside rg3-induced cell growth suppression and apoptosis in gem-resistant pancreatic cancer cells. |
2021-01-07 |
2023-08-13 |
Not clear |