| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gefei Wu, Jiasheng Hu, Hongmin Zhu, Shuhua Wu, Sheng Huang, Zhisheng Li. Treatment with melatonin ameliorates febrile convulsion via modulating the MEG3/miR‑223/PTEN/AKT signaling pathway. International journal of molecular medicine. vol 48. issue 2. 2021-06-24. PMID:34165162. |
protein levels of pten and cleaved caspase‑3 increased in the apoptosis group, whereas treatment with mt decreased the protein level of pten. |
2021-06-24 |
2023-08-13 |
Not clear |
| Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo, Yaping Y. PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. Stem cell research & therapy. vol 11. issue 1. 2021-06-18. PMID:32228695. |
pten inhibitor vo-ohpic attenuates gc-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating nrf2 signaling and inhibiting mitochondrial apoptosis pathway. |
2021-06-18 |
2023-08-13 |
Not clear |
| Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo, Yaping Y. PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. Stem cell research & therapy. vol 11. issue 1. 2021-06-18. PMID:32228695. |
phosphatase and tensin homolog (pten) is a tumor suppressor gene that promotes cell apoptosis, and its expression was found to be elevated in gc-associated onfh patients. |
2021-06-18 |
2023-08-13 |
Not clear |
| Xudong Yao, Shengnan Yu, Xingzhi Jing, Jiachao Guo, Kai Sun, Fengjing Guo, Yaping Y. PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. Stem cell research & therapy. vol 11. issue 1. 2021-06-18. PMID:32228695. |
however, whether direct inhibition of pten attenuates gc-associated apoptosis and dysfunction of the epcs remains largely unknown. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kai Zheng, Ying Wan. MiR-193a-3p Promotes Fracture Healing via Targeting PTEN Gene. Molecular biotechnology. vol 63. issue 7. 2021-06-11. PMID:33813678. |
pten was demonstrated to be a target gene of mir-9-5p and reversed the effect of mir-193a-3p on cell viability and apoptosis (p < 0.001). |
2021-06-11 |
2023-08-13 |
mouse |
| Lina Han, Yu Wang, Shulun Su. Curcumin inhibits proliferation of hepatocellular carcinoma cells through down regulation of DJ-1. Cancer biomarkers : section A of Disease markers. vol 29. issue 1. 2021-06-08. PMID:32417759. |
in addition, smmc-7721 or hepg2 cells were divided into two groups: cur+pcdna3.1-blank and cur+pcdna3.1-dj-1 for analysis of the expression of dj-1, pten and p-akt, cell apoptosis and proliferation. |
2021-06-08 |
2023-08-13 |
human |
| Lina Han, Yu Wang, Shulun Su. Curcumin inhibits proliferation of hepatocellular carcinoma cells through down regulation of DJ-1. Cancer biomarkers : section A of Disease markers. vol 29. issue 1. 2021-06-08. PMID:32417759. |
transfection of pcdna3.1-dj-1 significantly increased dj-1 and p-akt expression, promoted cell proliferation, but decreased pten expression and cell apoptosis. |
2021-06-08 |
2023-08-13 |
human |
| Lianjie Hou, Xiong Tong, Shuyun Lin, Mingfang Yu, Wen-Chu Ye, Meiying Xi. MiR-221/222 Ameliorates Deoxynivalenol-Induced Apoptosis and Proliferation Inhibition in Intestinal Epithelial Cells by Targeting PTEN. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095117. |
mir-221/222 ameliorates deoxynivalenol-induced apoptosis and proliferation inhibition in intestinal epithelial cells by targeting pten. |
2021-06-08 |
2023-08-13 |
mouse |
| Lianjie Hou, Xiong Tong, Shuyun Lin, Mingfang Yu, Wen-Chu Ye, Meiying Xi. MiR-221/222 Ameliorates Deoxynivalenol-Induced Apoptosis and Proliferation Inhibition in Intestinal Epithelial Cells by Targeting PTEN. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095117. |
through the pten interfering experiment, we found don-induced apoptosis and proliferation inhibition relied on pten. |
2021-06-08 |
2023-08-13 |
mouse |
| Lianjie Hou, Xiong Tong, Shuyun Lin, Mingfang Yu, Wen-Chu Ye, Meiying Xi. MiR-221/222 Ameliorates Deoxynivalenol-Induced Apoptosis and Proliferation Inhibition in Intestinal Epithelial Cells by Targeting PTEN. Frontiers in cell and developmental biology. vol 9. 2021-06-08. PMID:34095117. |
finally, through adenovirus to overexpress mir-221/222 in mice intestinal epithelial cells specifically, our results showed that mir-221/222 ameliorated don-induced apoptosis and proliferation inhibition in intestinal epithelial cells by targeting pten. |
2021-06-08 |
2023-08-13 |
mouse |
| Yuanwu Cao, Chang Jiang, Haodong Lin, Zixian Che. Silencing of Long Noncoding RNA Growth Arrest-Specific 5 Alleviates Neuronal Cell Apoptosis and Inflammatory Responses Through Sponging microRNA-93 to Repress PTEN Expression in Spinal Cord Injury. Frontiers in cellular neuroscience. vol 15. 2021-06-01. PMID:34054430. |
silencing of long noncoding rna growth arrest-specific 5 alleviates neuronal cell apoptosis and inflammatory responses through sponging microrna-93 to repress pten expression in spinal cord injury. |
2021-06-01 |
2023-08-13 |
mouse |
| Rohit Karn, Isaac Arnold Emerso. Molecular dynamic study on PTEN frameshift mutations in breast cancer provide c2 domain as a potential biomarker. Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33183179. |
pten is a tumour suppressor gene known for regulating apoptosis, cell growth, and many other pathways. |
2021-05-28 |
2023-08-13 |
Not clear |
| Yan Chen, Ji-Lin Yang, Zhen-Zhen Xue, Qiu-Chen Cai, Chun Hou, Hong-Juan Li, Liu-Xin Zhao, Yin Zhang, Cheng-Wei Gao, Li Cong, Tian-Zuo Wang, Dong-Mei Chen, Guo-Sheng Li, Shi-Qing Luo, Qian Yao, Chan-Juan Yang, Qi-Shun Zhu, Chuan-Hai Ca. Effects and mechanism of microRNA‑218 against lung cancer. Molecular medicine reports. vol 23. issue 1. 2021-05-19. PMID:33179084. |
in conclusion, mir‑218 could simultaneously suppress cell proliferation and tumor invasiveness and induce cell apoptosis by increasing pten and yy1 expression, while decreasing bcl‑2 and bmi‑1 in xuanwei lung cancer. |
2021-05-19 |
2023-08-13 |
Not clear |
| Chang-Jin Lee, Min-Ji Yoon, Dong Hyun Kim, Tae Uk Kim, Youn-Jung Kan. Profilin-1; a novel regulator of DNA damage response and repair machinery in keratinocytes. Molecular biology reports. vol 48. issue 2. 2021-05-18. PMID:33590416. |
pfn1 depletion accelerated dna damage-mediated apoptosis exhibiting pten loss of function instigated by increased phosphorylated inactivation followed by high levels of akt activation. |
2021-05-18 |
2023-08-13 |
Not clear |
| Dong Chen, Yihong Guo, Yaqiu Chen, Qiaonan Guo, Junyi Chen, Yining Li, Qiuping Zheng, Minyao Jiang, Ming Xi, Lu Chen. LncRNA growth arrest-specific transcript 5 targets miR-21 gene and regulates bladder cancer cell proliferation and apoptosis through PTEN. Cancer medicine. vol 9. issue 8. 2021-05-14. PMID:32069387. |
lncrna growth arrest-specific transcript 5 targets mir-21 gene and regulates bladder cancer cell proliferation and apoptosis through pten. |
2021-05-14 |
2023-08-13 |
Not clear |
| Lanqiao Wang, Lanxi Wang, Xu Shi, Shiwen X. Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis. Journal of hazardous materials. vol 398. 2021-05-14. PMID:32768820. |
phosphatase and tensin homolog deleted on chromosome ten (pten) plays an important role in controlling apoptosis and necrosis by negatively regulating the phosphatidylinositol 3-kinase/threonine kinase (pi3k/akt) pathway. |
2021-05-14 |
2023-08-13 |
Not clear |
| Yanpeng Zhou, Xun Shi, Shengfei Li, Quan Gan, Zhengjun Cu. microRNA-181a promotes the proliferation of hypertrophic scar fibroblasts and inhibits their apoptosis via targeting phosphatase and tensin homolog. Annals of palliative medicine. vol 10. issue 4. 2021-05-14. PMID:33966404. |
this study aimed to compare the expression of microrna (mir)-181a and phosphatase and tensin homolog (pten) in hypertrophic scar tissue and cells and to explore the effects of mir-181a and pten on the proliferation and apoptosis of the human scar fibroblast cell line hsfb. |
2021-05-14 |
2023-08-13 |
human |
| Yun Liu, Baohuan Cai, Yating Chong, Hualei Zhang, Chesley-Anne Kemp, Sumin Lu, Chang-Sheng Chang, Mingqiang Ren, John K Cowell, Tianxiang H. Downregulation of PUMA underlies resistance to FGFR1 inhibitors in the stem cell leukemia/lymphoma syndrome. Cell death & disease. vol 11. issue 10. 2021-05-13. PMID:33082322. |
treatment with different tyrosine kinase inhibitors (tkis) revealed that, in both fgfr1 mutation and pten deletion-mediated resistance, sustained akt activation in resistant cells leads to compromised puma activation, resulting in suppression of tki-induced apoptosis. |
2021-05-13 |
2023-08-13 |
mouse |
| Rui Hu, WenNa Dong, QingJian Liang, FeiFei Wang, MuFei Ou, ZhongHua Li, YingHao Ren, XuJian Wu, Yuan Liu, Weina Wan. A Litopenaeus vannamei p70S6K gene is involved in the antioxidative and apoptosis under low temperature. Fish & shellfish immunology. vol 106. 2021-05-10. PMID:32858183. |
in summary, these results indicated that lvp70s6k play a crucial role in oxidative and apoptosis, which was able to negatively regulate by pten. |
2021-05-10 |
2023-08-13 |
Not clear |
| H-Y Fu, L Shen, X-S Gao, D-X Cui, Z-Y Cu. SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration. European review for medical and pharmacological sciences. vol 24. issue 17. 2021-05-10. PMID:32964957. |
previous studies have shown that pten plays crucial roles in cell survival and apoptosis. |
2021-05-10 |
2023-08-13 |
Not clear |