| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhuangqiang Wang, Xiaopeng Cui, Gaopeng Hao, Jiefeng H. Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma. Open life sciences. vol 16. issue 1. 2021-10-12. PMID:34632072. |
concurrently, the overexpression of pten leads to the activation of mitochondria facilitated intrinsic apoptosis, evidenced by upregulated cytochrome c, caspase 3, and caspase 9. |
2021-10-12 |
2023-08-13 |
human |
| Huibin Lu, Xinwei Han, Jianzhuang Ren, Kewei Ren, Zongming Li, Quanhui Zhan. Metformin attenuates synergic effect of diabetes mellitus and Helicobacter pylori infection on gastric cancer cells proliferation by suppressing PTEN expression. Journal of cellular and molecular medicine. vol 25. issue 10. 2021-10-04. PMID:33760349. |
the reduced pten level led to increased proliferation and inhibited apoptosis of hgc-27 cells. |
2021-10-04 |
2023-08-13 |
Not clear |
| Chandra K Singh, Gagan Chhabra, Mary A Ndiaye, Imtiaz A Siddiqui, Jennifer E Panackal, Charlotte A Mintie, Nihal Ahma. Quercetin-Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers. vol 12. issue 8. 2021-10-02. PMID:32748838. |
utilizing pca pcr array analysis with prevention tumor tissues, we identified that quercetin-resveratrol modulates genes involved in promoter methylation, cell cycle, apoptosis, fatty acid metabolism, transcription factors, androgen response, pi3k/akt and pten signaling. |
2021-10-02 |
2023-08-13 |
mouse |
| Yan Li, Miao Zhang, Fan L. LncRNA AY343892 inhibits breast cancer development by positively regulating BRCA1-mediated transcription of PTEN. Histology and histopathology. vol 35. issue 10. 2021-10-01. PMID:32754899. |
moreover, pten silence can also countervail the inhibitory effect of overexpressed bcra1 or ay343892 on the expressions of genes related to proliferation and apoptosis in breast cancer. |
2021-10-01 |
2023-08-13 |
Not clear |
| Guojun Yang, Hao Qin, Bing Liu, Xinhong Zhao, Hang Yi. Mesenchymal stem cells-derived exosomes modulate vascular endothelial injury via miR-144-5p/PTEN in intracranial aneurysm. Human cell. vol 34. issue 5. 2021-10-01. PMID:34240392. |
this study suggests that mir-144-5p elevates pten expression, thereby boosting apoptosis and attenuating viability of vecs in ia. |
2021-10-01 |
2023-08-13 |
rat |
| Ayaz Ali, Wei-Wen Kuo, Chia-Hua Kuo, Jeng-Fan Lo, Michael Y C Chen, Jayasimha R Daddam, Tsung-Jung Ho, Vijaya Padma Viswanadha, Marthandam Asokan Shibu, Chih-Yang Huan. E3 ligase activity of Carboxyl terminus of Hsc70 interacting protein (CHIP) in Wharton's jelly derived mesenchymal stem cells improves their persistence under hyperglycemic stress and promotes the prophylactic effects against diabetic cardiac damages. Bioengineering & translational medicine. vol 6. issue 3. 2021-10-01. PMID:34589606. |
in this study, we found that high glucose (hg) conditions induced loss of chaperone homeostasis, stabilized pten, triggered the downstream signaling cascade, and induced apoptosis and oxidative stress in wharton's jelly derived mesenchymal stem cells (wjmscs). |
2021-10-01 |
2023-08-13 |
Not clear |
| Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Men. Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury. Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34506261. |
argon increased the proliferation of cardiomyocytes induced by ogd, decreased the release of ldh in cell culture medium, increased mir-21 expression in cells, decreased the expression of mir-21 target proteins pdcd4 and pten, decreased the levels of inflammatory factors (interleukin-1β [il-1β], interleukin-6 [il-6], and interleukin-8 [il-8]) and oxidative stress factors (ros and mda), increased the sod content, and decreased the cell apoptosis rate. |
2021-09-27 |
2023-08-13 |
Not clear |
| Ting Liu, Juan Wang, Lei Sun, Miao Li, Xin He, Jue Jiang, Qi Zho. Piwi-interacting RNA-651 promotes cell proliferation and migration and inhibits apoptosis in breast cancer by facilitating DNMT1-mediated PTEN promoter methylation. Cell cycle (Georgetown, Tex.). vol 20. issue 16. 2021-09-24. PMID:34313525. |
piwi-interacting rna-651 promotes cell proliferation and migration and inhibits apoptosis in breast cancer by facilitating dnmt1-mediated pten promoter methylation. |
2021-09-24 |
2023-08-13 |
human |
| Ting Liu, Juan Wang, Lei Sun, Miao Li, Xin He, Jue Jiang, Qi Zho. Piwi-interacting RNA-651 promotes cell proliferation and migration and inhibits apoptosis in breast cancer by facilitating DNMT1-mediated PTEN promoter methylation. Cell cycle (Georgetown, Tex.). vol 20. issue 16. 2021-09-24. PMID:34313525. |
this study reveals that pir-651 promotes proliferation and migration and induces apoptosis of breast cancer cells by facilitating dnmt1-mediated pten promoter methylation, which may provide a potential therapeutic mechanism for breast cancer. |
2021-09-24 |
2023-08-13 |
human |
| Lijun Li, Li Li, Lian Hu, Ting Li, Dan Xie, Xiaoliu Li. Long non‑coding RNA HAND2‑AS1/miR‑106a/PTEN axis re‑sensitizes cisplatin‑resistant ovarian cells to cisplatin treatment. Molecular medicine reports. vol 24. issue 5. 2021-09-18. PMID:34476500. |
it inhibited cell apoptosis through the bcl‑2/caspase‑3 apoptotic signaling pathway and downregulated the protein levels of pten and upregulated pi3k/akt signaling activity. |
2021-09-18 |
2023-08-13 |
Not clear |
| Liqiang Lin, Xiaoli Liu, Baotao L. Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33332708. |
long non-coding rna meg3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via pten up-regulation by binding to microrna-21. |
2021-09-15 |
2023-08-13 |
mouse |
| Liqiang Lin, Xiaoli Liu, Baotao L. Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33332708. |
exogenous transfection was done to change the levels of meg3, mir-21 and pten in hk-1 cells to investigate their effects on the autophagy and apoptosis of npc cells. |
2021-09-15 |
2023-08-13 |
mouse |
| Liqiang Lin, Xiaoli Liu, Baotao L. Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33332708. |
the results suggested that meg3 overexpression in hk-1 cells up-regulated pten and down-regulated mir-21, by which meg3 further inhibited autophagy and apoptosis ability of npc cells. |
2021-09-15 |
2023-08-13 |
mouse |
| Liqiang Lin, Xiaoli Liu, Baotao L. Long non-coding RNA MEG3 promotes autophagy and apoptosis of nasopharyngeal carcinoma cells via PTEN up-regulation by binding to microRNA-21. Journal of cellular and molecular medicine. vol 25. issue 1. 2021-09-15. PMID:33332708. |
collectively, meg3 promotes the autophagy and apoptosis of npc cells via enhancing pten expression by binding to mir-21. |
2021-09-15 |
2023-08-13 |
mouse |
| Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Li. CircRNA_0026344 via miR-21 is involved in cigarette smoke-induced autophagy and apoptosis of alveolar epithelial cells in emphysema. Cell biology and toxicology. 2021-09-15. PMID:34524572. |
in the present investigation, cs, acting on alveolar epithelial cells, caused higher levels of mir-21, p-erk, and cleaved-caspase 3 and led to lower levels of circrna_0026344 and pten, which induced autophagy and apoptosis. |
2021-09-15 |
2023-08-13 |
Not clear |
| Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Li. CircRNA_0026344 via miR-21 is involved in cigarette smoke-induced autophagy and apoptosis of alveolar epithelial cells in emphysema. Cell biology and toxicology. 2021-09-15. PMID:34524572. |
mir-21 suppressed the expression of pten, which was involved in the regulation of autophagy and apoptosis. |
2021-09-15 |
2023-08-13 |
Not clear |
| Jing Zhao, Haibo Xia, Yan Wu, Lu Lu, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Li. CircRNA_0026344 via miR-21 is involved in cigarette smoke-induced autophagy and apoptosis of alveolar epithelial cells in emphysema. Cell biology and toxicology. 2021-09-15. PMID:34524572. |
these results demonstrated that, in alveolar epithelial cells, cs decreases circrna_0026344 levels, which sponge mir-21 to inhibit the mir-21 target, pten, which, in turn, activates erk and thereby promotes autophagy and apoptosis, leading to emphysema. |
2021-09-15 |
2023-08-13 |
Not clear |
| Akimasa Takahashi, Abdelrahman Yousif, Linda Hong, IIana Chefet. Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell. Journal of molecular medicine (Berlin, Germany). vol 99. issue 5. 2021-09-13. PMID:33641066. |
depletion of oocytes with damaged dna occurs through different cell death mechanisms, such as apoptosis, autophagy, and necroptosis, mediated by the phosphatase and tensin homolog (pten)/phosphoinositide 3-kinase (pi3k)/protein kinase b (akt)/forkhead transcription factors 3 (foxo3) pathway. |
2021-09-13 |
2023-08-13 |
mouse |
| Jin Woo Shin, Se-Hee Kim, Jin Young Yoo. PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504554. |
pten downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells. |
2021-09-11 |
2023-08-13 |
human |
| Jin Woo Shin, Se-Hee Kim, Jin Young Yoo. PTEN downregulation induces apoptosis and cell cycle arrest in uterine cervical cancer cells. Experimental and therapeutic medicine. vol 22. issue 4. 2021-09-11. PMID:34504554. |
it was found that pten silencing promoted apoptosis and cell-cycle arrest, accompanied by a significant decrease in the proportion of cells in the s1 phase of the cell cycle. |
2021-09-11 |
2023-08-13 |
human |