| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fengdong Li, Jinjin Fu, Li Fan, Shuangshuang Lu, Huahui Zhang, Xiaoying Wang, Zhanju Li. Overexpression of circAtp9b in ulcerative colitis is induced by lipopolysaccharides and upregulates PTEN to promote the apoptosis of colonic epithelial cells. Experimental and therapeutic medicine. vol 22. issue 6. 2021-10-23. PMID:34675997. |
the role of circatp9b and pten in regulating the apoptosis of hcnepcs under lps treatment was evaluated using flow cytometry. |
2021-10-23 |
2023-08-13 |
human |
| Fengdong Li, Jinjin Fu, Li Fan, Shuangshuang Lu, Huahui Zhang, Xiaoying Wang, Zhanju Li. Overexpression of circAtp9b in ulcerative colitis is induced by lipopolysaccharides and upregulates PTEN to promote the apoptosis of colonic epithelial cells. Experimental and therapeutic medicine. vol 22. issue 6. 2021-10-23. PMID:34675997. |
apoptosis analysis demonstrated that overexpression of circatp9b and pten promoted the apoptosis of hcnepcs. |
2021-10-23 |
2023-08-13 |
human |
| Fengdong Li, Jinjin Fu, Li Fan, Shuangshuang Lu, Huahui Zhang, Xiaoying Wang, Zhanju Li. Overexpression of circAtp9b in ulcerative colitis is induced by lipopolysaccharides and upregulates PTEN to promote the apoptosis of colonic epithelial cells. Experimental and therapeutic medicine. vol 22. issue 6. 2021-10-23. PMID:34675997. |
in conclusion, overexpression of circatp9b in uc was induced by lps and it positively upregulated pten to promote the apoptosis of hcnepcs induced by lps. |
2021-10-23 |
2023-08-13 |
human |
| Jie Luo, Jiao Mu, Meng Zhang, Beibei Zhao, Lin Li. SPAG6-silencing enhances decitabine-induced apoptosis and demethylation of PTEN in SKM-1 cells and in a xenograft mouse model. Leukemia & lymphoma. vol 62. issue 9. 2021-10-22. PMID:33843428. |
spag6-silencing enhances decitabine-induced apoptosis and demethylation of pten in skm-1 cells and in a xenograft mouse model. |
2021-10-22 |
2023-08-13 |
mouse |
| Linmei Zhu, Ruixia Chen, Chunlin Jiang, Qingsheng Xie, Wenshuai Zhao, Xiaohong Gao, Haiming Huan. Mechanism underlying long non‑coding RNA ILF3‑AS1‑mediated inhibition of cervical cancer cell proliferation, invasion and migration, and promotion of apoptosis. Molecular medicine reports. vol 24. issue 2. 2021-10-22. PMID:34080029. |
in conclusion, the present study indicated that ilf3‑as1 inhibited cc cell proliferation and migration, and promoted cc cell apoptosis by inhibiting epithelial‑mesenchymal transition, and ilf3‑as1 overexpression partially reversed the inhibitory effect of mir‑454‑3p on pten expression. |
2021-10-22 |
2023-08-13 |
human |
| Zhiguo Niu, Xin Li, Shuxiao Dong, Jianhui Gao, Qingsong Huang, Huijie Yang, Hui Qian, Shu Zhuo, Ting Zhuang, Jian Zhu, Yinlu Ding, Wenrong X. The E3 Ubiquitin Ligase HOIP inhibits Cancer Cell Apoptosis via modulating PTEN stability. Journal of Cancer. vol 12. issue 21. 2021-10-22. PMID:34659546. |
the e3 ubiquitin ligase hoip inhibits cancer cell apoptosis via modulating pten stability. |
2021-10-22 |
2023-08-13 |
Not clear |
| Zhiguo Niu, Xin Li, Shuxiao Dong, Jianhui Gao, Qingsong Huang, Huijie Yang, Hui Qian, Shu Zhuo, Ting Zhuang, Jian Zhu, Yinlu Ding, Wenrong X. The E3 Ubiquitin Ligase HOIP inhibits Cancer Cell Apoptosis via modulating PTEN stability. Journal of Cancer. vol 12. issue 21. 2021-10-22. PMID:34659546. |
depletion of hoip causes cell cycle arrest and apoptosis, which effects could be rescued by pten silencing. |
2021-10-22 |
2023-08-13 |
Not clear |
| Yong-Tae Ahn, Ik Jae Shin, Jong-Myoung Kim, Youn Sook Kim, Chu Lee, Seong-A Ju, Won G A. Counteracting the activation of pAkt by inhibition of MEK/Erk inhibition reduces actin disruption-mediated apoptosis in PTEN-null PC3M prostate cancer cell lines. Oncology letters. vol 6. issue 5. 2021-10-21. PMID:24179529. |
deletion of phosphatase and tensin homolog (pten), a tumor suppressor gene involved in the regulation of the cell cycle and apoptosis, leads to cytoskeleton disruption and double-strand breaks (dsbs). |
2021-10-21 |
2023-08-12 |
Not clear |
| Xiaohong Li, Kai Huang, Jianbin Y. Inhibition of microRNA-21 upregulates the expression of programmed cell death 4 and phosphatase tensin homologue in the A431 squamous cell carcinoma cell line. Oncology letters. vol 8. issue 1. 2021-10-21. PMID:24959246. |
in the present study, anti-mir-21 was transfected into the a431 cell line, and the expression of mir-21, pdcd4 and pten and the level of cell apoptosis were detected by quantitative polymerase chain reaction, immunocytochemistry and western blotting, and terminal deoxynucleotidyl transferase-mediated dutp nick end labeling, respectively. |
2021-10-21 |
2023-08-13 |
Not clear |
| Qiufeng Qi, Yang Ling, Ming Zhu, Linyan Zhou, Meizhen Wan, Yanqing Bao, Yongping Li. Promoter region methylation and loss of protein expression of PTEN and significance in cervical cancer. Biomedical reports. vol 2. issue 5. 2021-10-21. PMID:25054006. |
downregulated pten expression is involved in the pathogenesis, invasion and metastasis of cervical cancer, possibly by regulating the balance between apoptosis and proliferation. |
2021-10-21 |
2023-08-13 |
human |
| Zhiruo Miao, Zhiying Miao, Shengchen Wang, Xu Shi, Shiwen X. Quercetin antagonizes imidacloprid-induced mitochondrial apoptosis through PTEN/PI3K/AKT in grass carp hepatocytes. Environmental pollution (Barking, Essex : 1987). vol 290. 2021-10-20. PMID:34488159. |
furthermore, we elucidated that que could inhibit the expression of phosphatase and tensin homolog deleted on chromosome 10 (pten), thus activating phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) pathway to attenuate imi-induced apoptosis. |
2021-10-20 |
2023-08-13 |
cat |
| Yifan Wang, Xin Wang, Huizhen Wang, Jingfu Bao, Nan Jia, Huimi Huang, Aiqing L. PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-α and mTOR through PI3K/Akt pathway. Experimental cell research. vol 406. issue 1. 2021-10-19. PMID:34242625. |
pten protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating hif1-α and mtor through pi3k/akt pathway. |
2021-10-19 |
2023-08-13 |
mouse |
| Yifan Wang, Xin Wang, Huizhen Wang, Jingfu Bao, Nan Jia, Huimi Huang, Aiqing L. PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-α and mTOR through PI3K/Akt pathway. Experimental cell research. vol 406. issue 1. 2021-10-19. PMID:34242625. |
our data indicated that the renoprotective effect of pten worked via pi3k/akt/mtor pathway and pi3k/akt/hif1-α pathway, hence alleviating apoptosis and improving autophagy respectively. |
2021-10-19 |
2023-08-13 |
mouse |
| Yifan Wang, Xin Wang, Huizhen Wang, Jingfu Bao, Nan Jia, Huimi Huang, Aiqing L. PTEN protects kidney against acute kidney injury by alleviating apoptosis and promoting autophagy via regulating HIF1-α and mTOR through PI3K/Akt pathway. Experimental cell research. vol 406. issue 1. 2021-10-19. PMID:34242625. |
our findings provide valuable insights into the molecular mechanism underlying renoprotection of pten on autophagy and apoptosis induced by renal iri, which offers a novel therapeutic target for the treatment of aki. |
2021-10-19 |
2023-08-13 |
mouse |
| Shaowei Yin, Yilin Meng, Caixia Liu, Yuan Wan. MIUH Inhibits the Hippocampal Neuron Growth in Fetal Rat by Affecting the PTEN Pathway. Neurochemical research. vol 46. issue 8. 2021-10-18. PMID:34003417. |
miuh may inhibit neuronal proliferation and promote neuronal apoptosis and autophagy by regulating the pten signaling pathway. |
2021-10-18 |
2023-08-13 |
rat |
| Núria Eritja, Raúl Navaridas, Anna Ruiz-Mitjana, Maria Vidal-Sabanés, Joaquim Egea, Mario Encinas, Xavier Matias-Guiu, Xavier Dolce. Endometrial PTEN Deficiency Leads to SMAD2/3 Nuclear Translocation. Cancers. vol 13. issue 19. 2021-10-16. PMID:34638474. |
we have previously demonstrated that both pten and smad2/3 display tumor-suppressive functions in the endometrium, and genetic ablation of either gene results in sustained activation of pi3k/akt signaling that suppresses tgf-β-induced apoptosis and enhances cell proliferation of mouse endometrial cells. |
2021-10-16 |
2023-08-13 |
mouse |
| Zhao-Hui Dai, Zhi-Ming Jiang, Hua Tu, Li Mao, Gui-Lin Song, Zhong-Bao Yang, Fang Liu, Md Sayed Ali Sheik. miR-129 Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the Expression of PTEN in Rats. BioMed research international. vol 2021. 2021-10-13. PMID:34435045. |
consistently, h/r significantly increased the apoptosis of h9c2 cells, concomitant with the downregulation of mir-129, upregulation of pten and caspase-3, and insufficient phosphorylation of akt, while mir-129 mimic obviously inhibited the expression of pten and caspase-3, increased the akt phosphorylation, and decreased the cell apoptosis. |
2021-10-13 |
2023-08-13 |
rat |
| Zhao-Hui Dai, Zhi-Ming Jiang, Hua Tu, Li Mao, Gui-Lin Song, Zhong-Bao Yang, Fang Liu, Md Sayed Ali Sheik. miR-129 Attenuates Myocardial Ischemia Reperfusion Injury by Regulating the Expression of PTEN in Rats. BioMed research international. vol 2021. 2021-10-13. PMID:34435045. |
to our best knowledge, this study firstly found that the low expression of mir-129 accelerates the myocardial cell apoptosis by directly targeting 3'utr of pten. |
2021-10-13 |
2023-08-13 |
rat |
| Zhuangqiang Wang, Xiaopeng Cui, Gaopeng Hao, Jiefeng H. Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma. Open life sciences. vol 16. issue 1. 2021-10-12. PMID:34632072. |
also, perversely upregulated pi3k/akt signaling huh7 cells are highly resistant to treatment with chemotherapy drugs (docetaxel and sorafenib) and acquired apoptosis resistance through downregulation of tumor suppressor protein pten (phosphatase and tensin homolog deleted on chromosome ten). |
2021-10-12 |
2023-08-13 |
human |
| Zhuangqiang Wang, Xiaopeng Cui, Gaopeng Hao, Jiefeng H. Aberrant expression of PI3K/AKT signaling is involved in apoptosis resistance of hepatocellular carcinoma. Open life sciences. vol 16. issue 1. 2021-10-12. PMID:34632072. |
hence, we have investigated the effect of pten overexpression on apoptosis induction in huh7 cells. |
2021-10-12 |
2023-08-13 |
human |